Materials Today Bio最新文献_第6页

Applications of piezoelectric biomaterials in dental treatments: A review of recent advancements and future prospects 压电生物材料在牙科治疗中的应用：最新进展和未来展望综述

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-10-04 DOI: 10.1016/j.mtbio.2024.101288

Kaichen Zeng , Yifan Lin , Shirong Liu , Ziyan Wang , Lvhua Guo

引用次数: 0

Modulating dual carrier-transfer channels and band structure in carbon nitride to amplify ROS storm for enhanced cancer photodynamic therapy 调节氮化碳中的双载流子传输通道和能带结构，放大 ROS 风暴，增强癌症光动力疗法的效果

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-10-04 DOI: 10.1016/j.mtbio.2024.101287

Meixian Liu , Yuan Zhang , Fa Jiang , Wenzhao Guan , Jing Cui , Liwei Liu , Qingpeng Xie , Jia Wang , Shuyun Xue , Jiawen Gu , Zhanfeng Zheng , Xiuyun Ren , Xing Wang

{"title":"Modulating dual carrier-transfer channels and band structure in carbon nitride to amplify ROS storm for enhanced cancer photodynamic therapy","authors":"Meixian Liu , Yuan Zhang , Fa Jiang , Wenzhao Guan , Jing Cui , Liwei Liu , Qingpeng Xie , Jia Wang , Shuyun Xue , Jiawen Gu , Zhanfeng Zheng , Xiuyun Ren , Xing Wang","doi":"10.1016/j.mtbio.2024.101287","DOIUrl":"10.1016/j.mtbio.2024.101287","url":null,"abstract":"<div><div>Graphite carbon nitride (CN) eliminates cancer cells by converting H<sub>2</sub>O<sub>2</sub> to highly toxic •OH under visible light. However, its in vivo applications are constrained by insufficient endogenous H<sub>2</sub>O<sub>2</sub>, accumulation of OH<sup>−</sup> and finite photocarriers. We designed Fe/N<sub>V</sub>-CN, co-modified CN with nitrogen vacancies (N<sub>V</sub>) and ferric ions (Fe<sup>3+</sup>). N<sub>V</sub> and Fe<sup>3+</sup>, not only adjust the band structure of CN through quantum confinement effect and the altered coupled oscillations of atomic orbitals to facilitates •OH production by oxidizing OH<sup>−</sup>, but also construct dual carrier-transfer channels for electrons and holes to respective active sites by introducing stepped electrostatic potential and shortening three-electron bonds, thereby involving more carriers in •OH production. Fe/N<sub>V</sub>-CN, the novel reactor, effectually produces vast •OH under illumination by expanding OH<sup>−</sup> as the raw material of •OH and augmenting carriers at active sites, which induces cancer cell apoptosis by disrupting mitochondrial function for significant shrinkage of Cal27 cell-induced tumor under illumination. This work provides not only an effective photosensitizer avoiding the accumulation of OH<sup>−</sup> for cancer therapy but also a novel strategy by constructing dual carrier-transfer channels on semiconductor photosensitizers for improving the therapeutic effect of photodynamic therapy.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101287"},"PeriodicalIF":8.7,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A hybrid construct with tailored 3D structure for directing pre-vascularization in engineered tissues 具有定制三维结构的混合构建体，用于引导工程组织中的预血管形成

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-10-04 DOI: 10.1016/j.mtbio.2024.101291

Sara C. Neves , Aureliana Sousa , Diana S. Nascimento , Iasmim D. Orge , Sílvia A. Ferreira , Carlos Mota , Lorenzo Moroni , Cristina C. Barrias , Pedro L. Granja

{"title":"A hybrid construct with tailored 3D structure for directing pre-vascularization in engineered tissues","authors":"Sara C. Neves , Aureliana Sousa , Diana S. Nascimento , Iasmim D. Orge , Sílvia A. Ferreira , Carlos Mota , Lorenzo Moroni , Cristina C. Barrias , Pedro L. Granja","doi":"10.1016/j.mtbio.2024.101291","DOIUrl":"10.1016/j.mtbio.2024.101291","url":null,"abstract":"<div><div>Hybrid 3D constructs combining different structural components afford unique opportunities to engineer functional tissues. Creating functional microvascular networks within these constructs is crucial for promoting integration with host vessels and ensuring successful engraftment. Here, we present a hybrid 3D system in which poly (ethylene oxide terephthalate)/poly (butylene terephthalate) fibrous scaffolds are combined with pectin hydrogels to provide internal topography and guide the formation of microvascular beds. The sequence/method of seeding human endothelial cells (EC) and mesenchymal stromal cells (MSC) into the system had a significant impact on microvessel formation. Optimal results were obtained when EC were directly seeded onto the fibrous scaffold, followed by the addition of hydrogel-embedded MSC. This approach facilitated the development of highly oriented microvascular networks along the fibers. These networks were lumenized, supported by a basement membrane, and stabilized by pericyte-like cells, persisting for at least 28 days in vitro. Furthermore, culture under pro-angiogenic and osteoinductive conditions induced MSC osteogenic differentiation without impairing microvessel formation. Upon subcutaneous implantation in mice, the pre-vascularized constructs were infiltrated by host vessels, and human microvessels were still present after 2 weeks. Overall, the proposed hybrid 3D system, combined with an optimized cell-seeding protocol, offers an effective approach for directing the formation of robust and geometrically oriented microvessels, making it promising for tissue engineering applications.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101291"},"PeriodicalIF":8.7,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D digital light process bioprinting: Cutting-edge platforms for resolution of organ fabrication 三维数字光工艺生物打印：解决器官制造问题的尖端平台

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-10-02 DOI: 10.1016/j.mtbio.2024.101284

Yun Geun Jeong , James J. Yoo , Sang Jin Lee , Moon Suk Kim

引用次数: 0

Light-based 3D bioprinting techniques for illuminating the advances of vascular tissue engineering 用光基三维生物打印技术照亮血管组织工程的发展之路

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-10-02 DOI: 10.1016/j.mtbio.2024.101286

Wei Li , Jinhua Li , Chen Pan , Jae-Seong Lee , Byoung Soo Kim , Ge Gao

{"title":"Light-based 3D bioprinting techniques for illuminating the advances of vascular tissue engineering","authors":"Wei Li , Jinhua Li , Chen Pan , Jae-Seong Lee , Byoung Soo Kim , Ge Gao","doi":"10.1016/j.mtbio.2024.101286","DOIUrl":"10.1016/j.mtbio.2024.101286","url":null,"abstract":"<div><div>Vascular tissue engineering faces significant challenges in creating <em>in vitro</em> vascular disease models, implantable vascular grafts, and vascularized tissue/organ constructs due to limitations in manufacturing precision, structural complexity, replicating the composited architecture, and mimicking the mechanical properties of natural vessels. Light-based 3D bioprinting, leveraging the unique advantages of light including high resolution, rapid curing, multi-material adaptability, and tunable photochemistry, offers transformative solutions to these obstacles. With the emergence of diverse light-based 3D bioprinting techniques and innovative strategies, the advances in vascular tissue engineering have been significantly accelerated. This review provides an overview of the human vascular system and its physiological functions, followed by an in-depth discussion of advancements in light-based 3D bioprinting, including light-dominated and light-assisted techniques. We explore the application of these technologies in vascular tissue engineering for creating <em>in vitro</em> vascular disease models recapitulating key pathological features, implantable blood vessel grafts, and tissue analogs with the integration of capillary-like vasculatures. Finally, we provide readers with insights into the future perspectives of light-based 3D bioprinting to revolutionize vascular tissue engineering.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101286"},"PeriodicalIF":8.7,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrostatic attachment of exosome onto a 3D-fabricated calcium silicate/polycaprolactone for enhanced bone regeneration 将外泌体静电吸附到三维制造的硅酸钙/聚己内酯上，促进骨再生

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-10-01 DOI: 10.1016/j.mtbio.2024.101283

Ju Hyun Yun , Hye-Young Lee , Se Hyun Yeou , Jeon Yeob Jang , Chul-Ho Kim , Yoo Seob Shin , Darryl D. D'Lima

{"title":"Electrostatic attachment of exosome onto a 3D-fabricated calcium silicate/polycaprolactone for enhanced bone regeneration","authors":"Ju Hyun Yun , Hye-Young Lee , Se Hyun Yeou , Jeon Yeob Jang , Chul-Ho Kim , Yoo Seob Shin , Darryl D. D'Lima","doi":"10.1016/j.mtbio.2024.101283","DOIUrl":"10.1016/j.mtbio.2024.101283","url":null,"abstract":"<div><div>Exosomes have garnered attention for use in bone regeneration, but their low activity, rapid degradation, and inaccurate delivery have been obstacles to their use in clinical applications. As such, there exists a need for an exosome-integrated delivery platform. Calcium silicate (Ca-Si) is considered one of the most promising bioceramics for bone regeneration because of its remarkable ability to promote hydroxyapatite formation, osteoblast proliferation, and differentiation. However, Ca-Si has limitations, such as a high degradation rate leading to high pH values. Here, we propose a bone regeneration platform: three-dimensional-fabricated Ca-Si scaffolds immersed in polycaprolactone (PCL) coated with exosomes. This setup enhanced porosity, mechanical strength, and natural hydroxyapatite formation. Ca-Si incorporation increased the quantity of attached exosomes on the scaffold and enabled more sustainable control of their release compared to bare PCL. The exosome-coated scaffold exhibited excellent cell attachment and osteogenic differentiation, significantly increasing biocompatibility and the <em>in situ</em> recruitment of stem cells when transplanted into the subcutaneous tissue of mice. The bone regenerating efficacy of the exosome-attached scaffold was confirmed using a mouse calvarial bone defect animal model. These findings suggest a potential application of exosome-coated Ca-Si/PCL scaffolds as an osteogenic platform for critical bone defects.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101283"},"PeriodicalIF":8.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simultaneous targeting and suppression of heat shock protein 60 to overcome heat resistance and induce mitochondrial death of tumor cells in photothermal immunotherapy 在光热免疫疗法中同时靶向和抑制热休克蛋白 60 以克服耐热性并诱导肿瘤细胞线粒体死亡

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-09-29 DOI: 10.1016/j.mtbio.2024.101282

Yiling Meng , Tao Wen , Xuanxin Liu , Aiyun Yang , Jie Meng , Jian Liu , Jianhua Wang , Haiyan Xu

{"title":"Simultaneous targeting and suppression of heat shock protein 60 to overcome heat resistance and induce mitochondrial death of tumor cells in photothermal immunotherapy","authors":"Yiling Meng , Tao Wen , Xuanxin Liu , Aiyun Yang , Jie Meng , Jian Liu , Jianhua Wang , Haiyan Xu","doi":"10.1016/j.mtbio.2024.101282","DOIUrl":"10.1016/j.mtbio.2024.101282","url":null,"abstract":"<div><div>As the most aggressive and metastatic subtype of breast cancer, clinical demands of triple negative breast cancer (TNBC) have far not been met. Heat shock protein 60 (HSP60) is over expressed in tumor cells and impair the efficacy of photothermal therapy. In this work, a conjugate composed of self-designed peptide targeting HSP60 and gold nanorods was constructed, referred to as AuNR-P17. Results showed that AuNR-P17 was able to simultaneously down regulate the level of HSP60 and locate in the mitochondria where HSP60 is enriched in the tumor cells of TNBC, which also impeded the interaction between HSP60 and integrin α<sub>3</sub>, thereby reducing the tumor cells' heat tolerance and metastatic capabilities. At the same time, AuNR-P17 induced remarkable mitochondrial apoptosis when exposed to the laser irradiation of 808 nm. The dual functions of AuNR-P17 led to the decrement of BCL-2 and the activation of p53 and cleaved caspase-3. The danger associated molecular patterns (DAMPs) generated from the mitochondrial apoptosis elicited strong and long-term specific immune responses against TNBC <em>in vivo</em> and ultimately inhibited the tumor metastasis and recurrence with significantly prolonged survival (>100 days) on TNBC mice. In conclusion, this study demonstrated HSP60 a promising potential therapeutic target for triple negative breast cancer and exhibited powerful capacity of AuNR-P17 in photothermal immune therapy.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101282"},"PeriodicalIF":8.7,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the frontiers: The potential and challenges of bioactive scaffolds in osteosarcoma treatment and bone regeneration 探索前沿：生物活性支架在骨肉瘤治疗和骨再生中的潜力与挑战

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-09-29 DOI: 10.1016/j.mtbio.2024.101276

Huaiyuan Zhang , Yu Wang , Huifen Qiang , Dewen Leng , Luling Yang , Xueneng Hu , Feiyan Chen , Tinglin Zhang , Jie Gao , Zuochong Yu

{"title":"Exploring the frontiers: The potential and challenges of bioactive scaffolds in osteosarcoma treatment and bone regeneration","authors":"Huaiyuan Zhang , Yu Wang , Huifen Qiang , Dewen Leng , Luling Yang , Xueneng Hu , Feiyan Chen , Tinglin Zhang , Jie Gao , Zuochong Yu","doi":"10.1016/j.mtbio.2024.101276","DOIUrl":"10.1016/j.mtbio.2024.101276","url":null,"abstract":"<div><div>The standard treatment for osteosarcoma combines surgery with chemotherapy, yet it is fraught with challenges such as postoperative tumor recurrence and chemotherapy-induced side effects. Additionally, bone defects after surgery often surpass the body's regenerative ability, affecting patient recovery. Bioengineering offers a novel approach through the use of bioactive scaffolds crafted from metals, ceramics, and hydrogels for bone defect repair. However, these scaffolds are typically devoid of antitumor properties, necessitating the integration of therapeutic agents. The development of a multifunctional therapeutic platform incorporating chemotherapeutic drugs, photothermal agents (PTAs), photosensitizers (PIs), sound sensitizers (SSs), magnetic thermotherapeutic agents (MTAs), and naturally occurring antitumor compounds addresses this limitation. This platform is engineered to target osteosarcoma cells while also facilitating bone tissue repair and regeneration. This review synthesizes recent advancements in integrated bioactive scaffolds (IBSs), underscoring their dual role in combating osteosarcoma and enhancing bone regeneration. We also examine the current limitations of IBSs and propose future research trajectories to overcome these hurdles.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101276"},"PeriodicalIF":8.7,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing retention and permeation of rapamycin for osteoarthritis therapy using a two-stage drug delivery system 利用两级给药系统提高雷帕霉素在骨关节炎治疗中的保留率和渗透率

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-09-28 DOI: 10.1016/j.mtbio.2024.101279

Guangyong Lin , Huirong Huang , Meng Sun , Zhinan He , Shengjie Li , Xindan Liang , Yuqi Yan , Chenyu Qiu , Shize Li , Xinyu Zhao , Wanling Zhu , Longfa Kou , Ruijie Chen

{"title":"Enhancing retention and permeation of rapamycin for osteoarthritis therapy using a two-stage drug delivery system","authors":"Guangyong Lin , Huirong Huang , Meng Sun , Zhinan He , Shengjie Li , Xindan Liang , Yuqi Yan , Chenyu Qiu , Shize Li , Xinyu Zhao , Wanling Zhu , Longfa Kou , Ruijie Chen","doi":"10.1016/j.mtbio.2024.101279","DOIUrl":"10.1016/j.mtbio.2024.101279","url":null,"abstract":"<div><div>Osteoarthritis (OA) remains a challenging degenerative joint disease, largely associated with chondrocyte apoptosis during its development. Preserving chondrocytes stands as a promising strategy for OA treatment. Rapamycin (RP) exhibits chondrocyte protection by fostering autophagy. Nevertheless, the swift clearance of intra-articular injections and the dense cartilage extracellular matrix (ECM) hinder RP from effectively reaching chondrocytes. Herein, we developed a \"two-stage\" drug delivery system (RP@PEG-PA@P-Lipo). This system comprises primary nanoparticles (P-Lipo), liposomes modified with a collagen II targeting peptide (WYRGRLC), and secondary nanoparticles (RP@PEG-PA), PEG-modified PAMAM encapsulating rapamycin (RP). RP@PEG-PA@P-Lipo demonstrates adherence to the cartilage surface with WYRGRLC, substantially prolonging retention within the joint cavity. Subsequently, released RP@PEG-PA can effectively penetrate the cartilage and deliver RP to chondrocytes through small size and charge-driven forces. <em>In vitro</em> and <em>in vivo</em> experiments corroborate its notable therapeutic effects on OA. This study holds promise in offering a novel approach for clinical drug delivery and OA treatment.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101279"},"PeriodicalIF":8.7,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Remodeling the tumor immune microenvironment through hydrogel encapsulated G-Rh2 in situ vaccine and systemic immunotherapy 通过水凝胶包裹 G-Rh2 原位疫苗和全身免疫疗法重塑肿瘤免疫微环境

IF 8.7 1区医学

Materials Today Bio Pub Date : 2024-09-27 DOI: 10.1016/j.mtbio.2024.101281

Chunhua Li , Dan Lei , Yudong Huang , Yuanhao Jing , Wanru Wang , Lanqi Cen , Zijian Wei , Anni Chen , Xiaoyu Feng , Yushu Wang , Lixia Yu , Ying Chen , Rutian Li

引用次数: 0