Materials Today Bio最新文献_第6页

Metal–organic framework–based delivery systems as nanovaccine for enhancing immunity against porcine circovirus type 2

IF 8.7 1区医学

Materials Today Bio Pub Date : 2025-03-27 DOI: 10.1016/j.mtbio.2025.101712

Luo-Gang Ding , Min Shi , Er-Di Yu , Yu-Lin Xu , Yu-Yu Zhang , Xing-Liang Geng , Fei Liu , Jian-Da Li , Zhi Chen , Jiang Yu , Jia-Qiang Wu

{"title":"Metal–organic framework–based delivery systems as nanovaccine for enhancing immunity against porcine circovirus type 2","authors":"Luo-Gang Ding , Min Shi , Er-Di Yu , Yu-Lin Xu , Yu-Yu Zhang , Xing-Liang Geng , Fei Liu , Jian-Da Li , Zhi Chen , Jiang Yu , Jia-Qiang Wu","doi":"10.1016/j.mtbio.2025.101712","DOIUrl":"10.1016/j.mtbio.2025.101712","url":null,"abstract":"<div><div>Porcine circovirus type 2 (PCV2) has caused massive economic losses to the global pig farming industry. As emerging nanomaterials, metal–organic frameworks (MOFs) have considerable potential in drug and vaccine delivery because of their unique physicochemical properties. Based on the successful expression and identification of PCV2 antigens (Cap protein), this study exploits MOF platforms to design a nanovaccine delivery system (Cap@ZIF-8-CpG) as a novel subunit vaccine, which effectively enhances the resistance of antigens to denaturation and boosts immune responses against PCV2. Results demonstrate that mice injected with a nanovaccine efficiently incorporating PCV2 antigens (Cap) and an immune enhancer (CpG) elicit robust humoral immune responses. Notably, immunoglobulin G antibody titers are considerably elevated; cytokine secretion is augmented; and the proliferation of CD8<sup>+</sup> cytotoxic T lymphocytes and CD4<sup>+</sup> T cells is effectively stimulated. Following a viral challenge, the Cap@ZIF-8-CpG nanovaccine successfully protects the health of the mice, making them resistant to PCV2 infection. This study provides a new promising direction for the development of effective and long-lasting vaccines against PCV2 and other major swine pathogens.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"32 ","pages":"Article 101712"},"PeriodicalIF":8.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactive multifunctional hydrogels accelerate burn wound healing via M2 macrophage-polarization, antioxidant and anti-inflammatory

IF 8.7 1区医学

Materials Today Bio Pub Date : 2025-03-27 DOI: 10.1016/j.mtbio.2025.101686

Erman Zhao , Xiuling Tang , Xitong Li , Jun Zhao , Saiying Wang , Gaofei Wei , Le Yang , Minggao Zhao

{"title":"Bioactive multifunctional hydrogels accelerate burn wound healing via M2 macrophage-polarization, antioxidant and anti-inflammatory","authors":"Erman Zhao , Xiuling Tang , Xitong Li , Jun Zhao , Saiying Wang , Gaofei Wei , Le Yang , Minggao Zhao","doi":"10.1016/j.mtbio.2025.101686","DOIUrl":"10.1016/j.mtbio.2025.101686","url":null,"abstract":"<div><div>Globally, more than 300,000 fatalities occur from burns annually, and burn-wound healing continues to present significant challenges owing to the wound's propensity for infections, heavy bleeding, poor angiogenesis, and persistent inflammatory responses. The immunomodulation of macrophage polarization toward the M2 phenotype facilitates the healing of burn wounds by controlling the tissue microenvironment and expediting the transition from the inflammatory phase to proliferation. Here, a polydopamine-mediated graphene oxide (GA), tannic acid (TA), and magnesium ion (Mg<sup>2+</sup>)-incorporated multifunctional gelatin (Gel) scaffold (GTMG) is developed to accelerate wound healing by modulating the inflammatory microenvironment of burn wounds. GA and Mg<sup>2+</sup> confer the scaffold with the conversion of M1-type to M2-type macrophages and vascular regeneration. TA and GA synergistically provide with antimicrobial capabilities to the hydrogel. Additionally, the multifunctional hydrogel shows strong hemostatic, anti-inflammatory and biocompatible properties. Due to its strong tissue adhesion and injectability, the hydrogel can also be used for various forms of dynamic burn wounds. <em>In vivo</em> research shows that the hydrogel may have hemostatic, anti-inflammatory, and M2-phenotypic macrophage-polarization effects, which increase the regeneration and repair effects of burn sites and shorten the burn-healing time. The results indicate that this multifunctional hydrogel offers a promising therapeutic approach for the treatment of burn wounds by altering the immunological microenvironment and accelerating the three phases of wound healing.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"32 ","pages":"Article 101686"},"PeriodicalIF":8.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The hexapeptide functionalized gold nanoparticles protect against sepsis-associated encephalopathy by forming specific protein corona and regulating macrophage activation

IF 8.7 1区医学

Materials Today Bio Pub Date : 2025-03-27 DOI: 10.1016/j.mtbio.2025.101704

Zichen Song , Hongguang Chen , Wenfei Xu , Xiaoye Zong , Xiaoyu Wang , Yuting Ji , Jiameng Gong , Mimi Pang , Shan-Yu Fung , Hong Yang , Yonghao Yu

{"title":"The hexapeptide functionalized gold nanoparticles protect against sepsis-associated encephalopathy by forming specific protein corona and regulating macrophage activation","authors":"Zichen Song , Hongguang Chen , Wenfei Xu , Xiaoye Zong , Xiaoyu Wang , Yuting Ji , Jiameng Gong , Mimi Pang , Shan-Yu Fung , Hong Yang , Yonghao Yu","doi":"10.1016/j.mtbio.2025.101704","DOIUrl":"10.1016/j.mtbio.2025.101704","url":null,"abstract":"<div><div>Sepsis-induced systemic inflammatory responses can often lead to brain dysfunction with impaired cognitive function and mobility, known as sepsis-associated encephalopathy (SAE). Currently, there are no effective pharmacological therapeutics to treat SAE. Herein, we demonstrated the hexapeptide functionalized gold nanoparticles P12 that reduced SAE in septic mice with a dual mechanism to down-regulate systemic inflammation. We found that intraperitoneally administered P12 could target macrophages and regulate their inflammatory responses to decrease systemic inflammation and improve mice's cognitive function and mobility with SAE. Depleting peritoneal macrophages diminished the neuroprotective effects of P12 in SAE mice, suggesting macrophages as the effector cells for the neuroprotection by P12. In addition, the proteomic analysis revealed that P12 was capable of sequestering specific circulating inflammatory proteins in the blood of septic mice by forming a protein corona, contributing to the suppression of systemic inflammation. We also found that the local administration of P12 directly to the brain parenchyma effectively inhibited microglia activation and neuroinflammation in mice with SAE. This study provides an insightful understanding of the function and mechanisms of action of P12 in regulating sepsis-associated systemic inflammation and presents a new drug-free nanotherapeutic approach to treat SAE.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"32 ","pages":"Article 101704"},"PeriodicalIF":8.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic scaffolds for the mechanotransduction stimulation in tendon tissue regeneration

IF 8.7 1区医学

Materials Today Bio Pub Date : 2025-03-26 DOI: 10.1016/j.mtbio.2025.101699

Eleonora Bianchi , Manuel Bañobre-Lopez , Marco Ruggeri , Elena Del Favero , Barbara Vigani , Caterina Ricci , Cinzia Boselli , Antonia Icaro Cornaglia , Martin Albino , Claudio Sangregorio , Alessandro Lascialfari , Jessica Zanovello , Eugenio Jannelli , Francesco Claudio Pavesi , Silvia Rossi , Luca Casettari , Giuseppina Sandri

{"title":"Magnetic scaffolds for the mechanotransduction stimulation in tendon tissue regeneration","authors":"Eleonora Bianchi , Manuel Bañobre-Lopez , Marco Ruggeri , Elena Del Favero , Barbara Vigani , Caterina Ricci , Cinzia Boselli , Antonia Icaro Cornaglia , Martin Albino , Claudio Sangregorio , Alessandro Lascialfari , Jessica Zanovello , Eugenio Jannelli , Francesco Claudio Pavesi , Silvia Rossi , Luca Casettari , Giuseppina Sandri","doi":"10.1016/j.mtbio.2025.101699","DOIUrl":"10.1016/j.mtbio.2025.101699","url":null,"abstract":"<div><div>Nowadays, tendon injuries represent a global health issue that annually affects millions of individuals. An innovative approach for their treatment is represented by the development of tissue engineered scaffolds able to support the host cells adhesion, differentiation, and proliferation. However, the scaffold alone could be insufficient to guarantee an improvement of healing control. Magnetite nanoparticles (Fe<sub>3</sub>O<sub>4</sub> NPs) are gaining interest due to their unique properties. In particular, when combined with bio-mimetic scaffolds, they should lead to the cells mechano-stimulation, improving the tenogenic differentiation and allowing a deeper tissue reparation.</div><div>The aim of this work is the study and the development of scaffolds based on polyhydroxybutyrate and gelatin and doped with Fe<sub>3</sub>O<sub>4</sub> NPs. The scaffolds are characterized by an aligned fibrous shape able to mimic the tendon fascicles. Moreover, they possess a superparamagnetic behavior and a slow degradation rate that should guarantee structural support during the tissue regeneration. The magnetic scaffolds promote cell proliferation and alignment onto the matrix, in particular when combined with the application of an external magnetic field. Also, the cells are able to differentiate and produce collagen I extracellular matrix. Finally, the magnetic scaffold <em>in vivo</em> promotes complete tissue healing after 1 week of treatment when combined with the external magnetic stimulation.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"32 ","pages":"Article 101699"},"PeriodicalIF":8.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction of a programmed activation nanosystem based on intracellular hypoxia in cisplatin-resistant tumor cells for reversing cisplatin resistance

IF 8.7 1区医学

Materials Today Bio Pub Date : 2025-03-26 DOI: 10.1016/j.mtbio.2025.101709

Yurong Liu , Longqing Si , Yunheng Liu , Song Li , Xiaokang Zhang , Shaojing Jiang , Wenjing Liu , Xiaolin Li , Lianguo Zhang , Hongxia Zheng , Zhonghao Liu , Jinghui Hu , Jing Chen

{"title":"Construction of a programmed activation nanosystem based on intracellular hypoxia in cisplatin-resistant tumor cells for reversing cisplatin resistance","authors":"Yurong Liu , Longqing Si , Yunheng Liu , Song Li , Xiaokang Zhang , Shaojing Jiang , Wenjing Liu , Xiaolin Li , Lianguo Zhang , Hongxia Zheng , Zhonghao Liu , Jinghui Hu , Jing Chen","doi":"10.1016/j.mtbio.2025.101709","DOIUrl":"10.1016/j.mtbio.2025.101709","url":null,"abstract":"<div><div>Cancer poses a significant threat to human life and health. Cancers treated with cisplatin invariably develop drug resistance. This challenge can be overcome by identifying and exploiting the vulnerabilities acquired by drug-resistant cancer cells, paving the way for finding effective novel treatment options for cisplatin-resistant cancers. Our previous study revealed that cisplatin resistance in cancer cells comes at the cost of increased intracellular hypoxia. In this study, we used 2-nitroimidazole modified hyaluronic acid (HA-NI) as the carrier. The cisplatin-resistant tumor cell specific intracellular hypoxia programmed activation nanomedicine (T/C@HN NPs) was constructed by the hypoxic toxic drug tirapazamine (TPZ) and encapsulating chlorin e6 (Ce6) into HA-NI using polymer assembly technology. The amphiphilic carrier could release free Ce6 molecules under the stimulation of intracellular hypoxic environment, and exhibit specific \"activated state\" photodynamic properties in cisplatin-resistant tumor cells. Upon irradiation, Ce6-mediated photodynamic therapy further intensifies hypoxia, amplifying its cytotoxicity. This project systematically evaluated the effects of T/C@HN NPs on the identification and recognition of cisplatin-resistant tumors using drug-resistant patient-derived xenograft (PDX) models. This study provides a promising avenue for the development of novel treatment of cisplatin-resistant tumors.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"32 ","pages":"Article 101709"},"PeriodicalIF":8.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyaluronic acid-based hydrogel microspheres with multi-responsive properties for antibacterial therapy and bone regeneration in Staphylococcus aureus-infected skull defects 具有多重响应特性的透明质酸基水凝胶微球用于金黄色葡萄球菌感染的颅骨缺损的抗菌治疗和骨再生

IF 8.7 1区医学

Materials Today Bio Pub Date : 2025-03-26 DOI: 10.1016/j.mtbio.2025.101676

Xiaolong Lin , Shuli Deng , Tao Fu , Yuqing Lei , Ying Wang , Jiapei Yao , Yaojun Lu , Yong Huang , Jingjing Shang , Jingjing Chen , Xindie Zhou

{"title":"Hyaluronic acid-based hydrogel microspheres with multi-responsive properties for antibacterial therapy and bone regeneration in Staphylococcus aureus-infected skull defects","authors":"Xiaolong Lin , Shuli Deng , Tao Fu , Yuqing Lei , Ying Wang , Jiapei Yao , Yaojun Lu , Yong Huang , Jingjing Shang , Jingjing Chen , Xindie Zhou","doi":"10.1016/j.mtbio.2025.101676","DOIUrl":"10.1016/j.mtbio.2025.101676","url":null,"abstract":"<div><div>This study introduces hyaluronic acid-based (HA) hydrogel microspheres loaded with zinc oxide nanoparticles (ZnO-NPs) for the treatment of infectious bone defects. The microspheres were fabricated using a 3D-printing process, with a formulation consisting of 6 wt% HAD (methacrylated HA), 3 wt% AOHA (AMP-conjugated oxidized HA), 1 % BOHA (phenylboric acid-conjugated HA), 0.5 % photoinitiator, and 0.05 % ZnO-NPs. <em>In vitro</em>, the hydrogel microspheres demonstrated significant antibacterial activity against <em>Staphylococcus aureus</em>, with colony counts and biofilm inhibition assays showing a marked reduction in bacterial growth after 12 and 24 h. The release of antimicrobial peptides (AMPs) was enhanced in acidic conditions and in the presence of hyaluronidase. The microspheres also promoted osteogenic differentiation of bone marrow stromal cells (BMSCs), as evidenced by increased expression of osteogenic markers (ALP, OCN, OPN, and COL-1). <em>In vivo</em>, the hydrogel microspheres were tested in a rat skull defect model, showing significant bone regeneration, improved angiogenesis, and an anti-inflammatory response. These results indicate that ABOHA@ZnO hydrogel microspheres provide a promising strategy for treating infectious bone defects by combining antimicrobial, osteogenic.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"32 ","pages":"Article 101676"},"PeriodicalIF":8.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microenvironment-sensitive hydrogels as promising drug delivery systems for co-encapsulating microbial homeostasis probiotics and anti-inflammatory drugs to treat periodontitis

IF 8.7 1区医学

Materials Today Bio Pub Date : 2025-03-26 DOI: 10.1016/j.mtbio.2025.101711

Yi Quan , Huihui Shao , Nuoya Wang , Zhonggao Gao , Mingji Jin

{"title":"Microenvironment-sensitive hydrogels as promising drug delivery systems for co-encapsulating microbial homeostasis probiotics and anti-inflammatory drugs to treat periodontitis","authors":"Yi Quan , Huihui Shao , Nuoya Wang , Zhonggao Gao , Mingji Jin","doi":"10.1016/j.mtbio.2025.101711","DOIUrl":"10.1016/j.mtbio.2025.101711","url":null,"abstract":"<div><div>Developing and utilizing effective local antimicrobial agents can help treat periodontitis while minimizing the risks associated with systemic antibiotic use. Recent studies have shown that the mucosal adhesion properties of hydrogels can play a potential role in the treatment of periodontitis. The hydrogel can improve the contact and retention time of drugs in the periodontal pocket. Through the adhesion of mucosa, it interacts with the mucin coating surface of epithelium and teeth to form a specific interface force. The hydrogel exhibits strong mucosal adhesion (adhesion strength: 5–6 N/cm<sup>2</sup>) and prolonged retention in periodontal pockets (≥6 h), enabling sustained drug release through dynamic sol-gel transitions triggered by pH and reactive oxygen species (ROS). This design overcomes the limitations of poor mechanical stability in conventional formulations. The dynamic balance of oral microbiota plays an important role in maintaining oral health. Probiotics, by colonizing the oral cavity, transform the infected site from an environment rich in inflammatory cytokines to a more benign environment, inhibit harmful pathogenic microorganisms, and contribute to overall health. Microenvironment sensitive hydrogels can perform dynamic sol gel transformation in situ, and can accurately control drug release when exposed to various stimuli (such as temperature change, light, pH change, reactive oxygen species, etc.). Oral probiotics and anti-inflammatory drugs are encapsulated in hydrogels to inhibit the proliferation and adhesion of oral pathogens by planting in the mouth and producing metabolites, effectively preventing and treating oral diseases.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"32 ","pages":"Article 101711"},"PeriodicalIF":8.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering a dynamic extracellular matrix using thrombospondin-1 to propel hepatocyte organoids reprogramming and improve mouse liver regeneration post-transplantation

IF 8.7 1区医学

Materials Today Bio Pub Date : 2025-03-25 DOI: 10.1016/j.mtbio.2025.101700

Zi-Yan Xu , Min Wang , Jing-Yan Shi , Ye Liu , Chao Yu , Xin-Yi Zhang , Chen-Wei Zhang , Qi-Feng He , Chao Pan , Jin Zhou , Hua Xiao , Hong-Yong Cao , Yong Ma

{"title":"Engineering a dynamic extracellular matrix using thrombospondin-1 to propel hepatocyte organoids reprogramming and improve mouse liver regeneration post-transplantation","authors":"Zi-Yan Xu , Min Wang , Jing-Yan Shi , Ye Liu , Chao Yu , Xin-Yi Zhang , Chen-Wei Zhang , Qi-Feng He , Chao Pan , Jin Zhou , Hua Xiao , Hong-Yong Cao , Yong Ma","doi":"10.1016/j.mtbio.2025.101700","DOIUrl":"10.1016/j.mtbio.2025.101700","url":null,"abstract":"<div><div>Hepatocyte organoids (HOs) hold significant potential for constructing bioartificial liver construction, toxicology research, and liver failure therapies. However, challenges such as difficulties in induced pluripotent stem cells (iPSCs) harvest and differentiation, safety concerns of tumor-derived matrices, and limited primary cell regulation hinder clinical applications. In this study, we developed a non-tumor-derived decellularized extracellular matrix (dECM) system with tunable mechanical properties and viscoelasticity to enhance stem cell proliferation and organoid functionality using thrombospondin-1 (THBS1). Nanoindentation and transcriptomic analysis revealed that THBS1 mediates adaptation and remodeling between organoids and ECM proteins, exhibiting native tissue-like viscoelasticity and up-regulated reprogramming transcriptional factors KLF4 and SOX2 via the YAP/TAZ pathway. Transplanting HOs presenting reprogramming effects into a 70 % hepatectomy model demonstrated improved liver regeneration, underscoring the potential of the THBS1-based dynamic ECM system in organoids manipulation and liver regeneration.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"32 ","pages":"Article 101700"},"PeriodicalIF":8.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A cerium nanocluster for effective alleviation of inflammatory bowel disease by scavenging RONS and regulating gut microbiome

IF 8.7 1区医学

Materials Today Bio Pub Date : 2025-03-25 DOI: 10.1016/j.mtbio.2025.101705

Dan Yang , Rong Wang , Lei Zhao , Ye Xu , Yufeng Zhu , Jingyan Zhang , Zhiguo Zhou , Yun Sun , Shiping Yang , Hong Yang , Wu Wang

{"title":"A cerium nanocluster for effective alleviation of inflammatory bowel disease by scavenging RONS and regulating gut microbiome","authors":"Dan Yang , Rong Wang , Lei Zhao , Ye Xu , Yufeng Zhu , Jingyan Zhang , Zhiguo Zhou , Yun Sun , Shiping Yang , Hong Yang , Wu Wang","doi":"10.1016/j.mtbio.2025.101705","DOIUrl":"10.1016/j.mtbio.2025.101705","url":null,"abstract":"<div><div>Inflammatory bowel disease (IBD) is characterized by excessive generation of reactive oxygen species and reactive nitrogen species (RONS) within the pro-inflammatory microenvironment. Conventional treatments often have serious side effects, making IBD management challenging. Here, a new cerium cluster, Ce12, with a formula of [Ce<sub>12</sub>(<em>μ</em><sub>3</sub>-O)<sub>8</sub>(<em>μ</em><sub>3</sub>-OH)<sub>8</sub>(<em>μ</em><sub>2</sub>-OH)<sub>6</sub>(ADA)<sub>18</sub>]∙3H<sub>2</sub>O∙3CH<sub>3</sub>CN (ADA<sup>−</sup> = 1-adamantanecarboxylate) was prepared and capped with β-cyclodextrin (β-CD) through self-assembly process involving the adamantane moiety of Ce12 and β-CD, resulting in Ce12@CD nanoparticles (NPs). Ce12@CD NPs, with good stability and biocompatibility, exhibit excellent reactive RONS scavenging activities due to the presence of a fraction of Ce<sup>3+</sup> ions, offering potential for treating inflammatory diseases. Treatment significantly alleviated body weight loss, colon length reduction, and pathological injury of colon in mice with dextran sodium sulfate (DSS)-elicited colitis, thereby repairing the intestinal mucosal barrier and reducing inflammation. RNA sequence analysis revealed that the therapeutic effects of Ce12@CD NPs are highly correlated with IL-17 and TNF signaling pathways, thereby reducing inflammatory factors such as IL-1β and TNF-α, and alleviating intestinal inflammation. Additionally, Ce12@CD NPs successfully modulated DSS-induced gut microbiota imbalances. This work highlights the unique catalytic activity of Ce12@CD NPs in removing RONS and mimicking biological enzymes, showcasing their potential therapeutic applications for inflammatory disorders.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"32 ","pages":"Article 101705"},"PeriodicalIF":8.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reducing the availability of endogenous copper and glucose for cascade starvation therapy and chemodynamic therapy

IF 8.7 1区医学

Materials Today Bio Pub Date : 2025-03-24 DOI: 10.1016/j.mtbio.2025.101702

Chunhui Wang , Pingting Ye , Mengyao Chen, Ruihao Li, Yixuan Wen, Yu Wang, Xiaohan Tong, Chunyan Dong, Shuo Shi

{"title":"Reducing the availability of endogenous copper and glucose for cascade starvation therapy and chemodynamic therapy","authors":"Chunhui Wang , Pingting Ye , Mengyao Chen, Ruihao Li, Yixuan Wen, Yu Wang, Xiaohan Tong, Chunyan Dong, Shuo Shi","doi":"10.1016/j.mtbio.2025.101702","DOIUrl":"10.1016/j.mtbio.2025.101702","url":null,"abstract":"<div><div>The rapid growth of tumors relies heavily on a continuous supply of essential nutrients, including glucose and copper. Disrupting the nutrient supply to tumors has become an increasingly focal point in tumor therapy. However, solely blocking the energy supply typically only hinders further tumor growth and may not effectively eliminate existing tumor cells. Herein, a multifunctional cascade nanoreactor (HPP/TPEN@GC) endowed with N, N, N′, N′-tetrakis(2-pyridinylmethyl)-1,2-ethanediamine (TPEN, a copper chelator) and glucose oxidase (GOx) is designed to disrupt both glycolysis and mitochondrial metabolism, which further induce cascade chemodynamic therapy (CDT). HPP/TPEN@GC can react with endogenous copper and glucose, thereby reducing their availability. The absence of copper prevents proper assembly and function of mitochondrial complex IV (CIV), hindering mitochondrial metabolism; the lack of glucose cuts off glycolysis and leads to a tumor specific starvation. Meanwhile, the reactions catalyzed by HPP/TPEN@GC contribute to the generation of Fenton-like catalysts and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), which can further react to produce highly toxic hydroxyl radical (·OH) for CDT. Taken together, the multifunctional cascade nanoreactor reduces the availability of endogenous copper and glucose, and further takes advantage of them to generate ·OH for cascade starvation-chemodynamic therapy. Collectively, this work represents a distinctive therapeutic paradigm to harness endogenous copper and glucose, which should inspire further studies to take full advantage of endogenous nutrients to combat various diseases, including tumors.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"32 ","pages":"Article 101702"},"PeriodicalIF":8.7,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0