Materials Today Bio最新文献

{"title":"Rational design of immunological programs for functional regenerative niches.","authors":"Zhumei Zhuang, Pengming Wang, Yixiao Liu, Lili Song, Xianzhu Zhang, Hongwei Ouyang","doi":"10.1016/j.mtbio.2026.103451","DOIUrl":"10.1016/j.mtbio.2026.103451","url":null,"abstract":"<p><p>The immune system is a master conductor of tissue repair, yet its therapeutic potential remains underexploited. Moving beyond descriptive biology, we propose 'immunoprogramming' as an active design paradigm that synergistically integrates stem cells and biomaterials to steer host immunity toward pro-regenerative outcomes. Here, we decode the source-specific immunomodulatory signatures of stem cells-from bone marrow and adipose tissue to dental and iPSC-derived populations-and establish how the biochemical and biophysical language of engineered biomaterials can directly command innate and adaptive immune cell fate. Crucially, we emphasize that within integrated cell-scaffold constructs, a bidirectional crosstalk emerges: the biomaterial primes the stem cell, which in turn execute enhanced context-specific immunomodulation. To translate this synergy into a design discipline, we introduce the Synergistic Immuno-Instructional System (SIIS) framework, which modularizes Cell-Source-Specific Immuno-Modules (CSIMs), Biomaterial-Based Immuno-Code (BIC), and Tissue-Specific Immuno-Niche (TSIN). Finally, we discuss translational challenges and advocate for next generation 'immuno-informed' therapeutics that evolve from passive replacement to active immune niche engineering, charting a course for intelligent regenerative medicine.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"39 ","pages":"103451"},"PeriodicalIF":11.0,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13382434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148604631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic eradication of NDM-1 <i>Klebsiella pneumoniae</i> biofilm infection by a Meropenem/EDTA Co-delivery system based on gelatin microspheres.","authors":"Zhaoyou Chu, Shu Fang, Wanyue Fu, Jun Liang, Yayun Wu, Ling Xu, Hanqing Zhang, Jiyang Wang, Haisheng Qian, Min Shao","doi":"10.1016/j.mtbio.2026.103441","DOIUrl":"10.1016/j.mtbio.2026.103441","url":null,"abstract":"<p><p>New Delhi metallo-β-lactamase (NDM)-producing drug-resistant bacteria often form stubborn biofilms and cause severe pneumonia, resulting in conventional antibiotic failure. In this study, we developed gelatin-genipin microspheres co-loaded with EDTA and meropenem (GEM) for targeted treatment of NDM pneumonia. EDTA exerted dual functions: it chelated Zn²⁺ to inactivate NDM enzyme and restore meropenem activity (FIC = 0.046875), while also disrupting bacterial biofilms through chelation. GEM microspheres enable accelerated drug release in the artificial phlegm environment. In a mouse model of NDM pneumonia, GEM microspheres can enhance the recruitment of neutrophils and M1 cells at the early stage (12 h) through bacterial clearance, modulate the secretion of interferon-γ by CD8⁺ T cells and natural killer cells, and reshape the pulmonary immune microenvironment. Furthermore, GEM treatment reduced pathological pulmonary immune cell infiltration and excessive inflammation at late time points (days 3-7). Taken together, GEM microspheres integrate biofilm disruption, enzyme inhibition, synergistic bactericidal effects, and immunoregulation, representing a promising strategy against NDM drug-resistant bacterial pneumonia.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"39 ","pages":"103441"},"PeriodicalIF":11.0,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13383260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148604649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioengineering DNA-based hydrogels for regenerative medicine: A review of programmable design, chemical synthesis and therapeutic potential.","authors":"Shihui Xu, Eon-Bee Lee, Yiming Shen, Yongtao Wang, Xue Zhang","doi":"10.1016/j.mtbio.2026.103448","DOIUrl":"10.1016/j.mtbio.2026.103448","url":null,"abstract":"<p><p>DNA hydrogels have emerged as a transformative class of intelligent biomaterials for regenerative medicine, leveraging the unique programmability, precise molecular recognition, and excellent biocompatibility. Although substantial progress has been made in the development of DNA hydrogels for biomedical applications, a comprehensive understanding about how construction strategies govern physicochemical properties, biological functions, and regenerative medicine remains fragmented. This review systematically examines the molecular design principles, construction strategies, and advanced functionalities of DNA hydrogels, with a focus on their translation into tissue engineering and clinical applications. Physicochemical and biological properties are discussed to underpin their performance. The diverse biomedical applications are further highlighted, particularly for their regenerative potential in repairing bone, cartilage, cardiovascular, skin, and neural tissues. Additionally, they play a crucial role in tumor therapy and the regeneration of tumor-resected tissues. This review may provide a rational framework to guide the development of DNA hydrogels toward precisely regenerative medicine and personalized therapies.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"39 ","pages":"103448"},"PeriodicalIF":11.0,"publicationDate":"2026-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13393442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immuno-engineered conductive hydrogels: Bridging neural signaling and microenvironmental remodeling for neural repair.","authors":"Ying Zhang, Xiaoxuan Han, Zhaowei Li, Jingru Zhou, Shude Yang, Deteng Zhang, Xu Sun","doi":"10.1016/j.mtbio.2026.103447","DOIUrl":"10.1016/j.mtbio.2026.103447","url":null,"abstract":"<p><p>Nervous system injuries and diseases present formidable regenerative challenges, largely due to hostile inflammatory microenvironments that impede endogenous repair mechanisms. Conductive nanocomposite hydrogels have emerged as a transformative class of immuno-engineered biomaterials designed to actively overcome these barriers. Beyond providing electroactive scaffolds to restore neural signaling, these advanced platforms integrate functional nanomaterials (e.g., carbon-based, MXene, and conductive polymers) within biocompatible polymer networks to facilitate targeted immunomodulation. Their core scientific significance lies in their synergistic capacity to simultaneously scavenge pathological reactive oxygen species (ROS) and steer macrophage polarization towards a pro-regenerative phenotype, thereby reprogramming the inhibitory injury niche into a permissive, pro-healing milieu. This review systematically elucidates the design principles spanning crosslinking strategies to nanomaterial selection that underpin these dual functions. We critically summarize recent breakthroughs in applying these multifunctional hydrogels to treat spinal cord injury, traumatic brain injury, stroke, and peripheral nerve defects, where they demonstrate enhanced functional recovery. By bridging the fields of conductive biomaterials and immunomodulation, this work not only surveys the state-of-the-art but also provides a unified framework for developing next-generation therapeutic platforms that couple bioelectronic cues with precise immune modulation, offering a novel paradigm for neural regeneration medicine.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"39 ","pages":"103447"},"PeriodicalIF":11.0,"publicationDate":"2026-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13392967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tea egg-inspired high mechanical strength hydrogel microneedle patch combined with tea polyphenol-magnesium nanoparticles promotes spinal cord injury repair.","authors":"Lin Lin, Jingze Li, Guosong Han, Zhixiang Li","doi":"10.1016/j.mtbio.2026.103444","DOIUrl":"10.1016/j.mtbio.2026.103444","url":null,"abstract":"<p><p>Restoring motor function remains a primary goal in the treatment of spinal cord injury (SCI). However, the inflammatory microenvironment that develops after injury poses a significant barrier to effective neural repair. Addressing this challenge requires the development of bioactive scaffolds with potent anti-inflammatory and antioxidant properties, as well as reduced implantation-induced damage. In this study, we created a novel composite biomaterial scaffold with high mechanical strength and excellent anti-inflammatory and antioxidant capabilities by dispersing in situ self-assembled tea polyphenol-magnesium nanoparticles (TPs-Mg NPs) into gelatin methacryloyl hydrogel (GelMA) microneedle patches (TPs-Mg MN). Our results demonstrate that TPs-Mg MN effectively modulates the inflammatory response by promoting macrophage polarization through suppression of the NF-κB signaling pathway, thereby alleviating reactive oxygen species (ROS)-mediated oxidative damage. Following implantation in a rat SCI model, TPs-Mg MN significantly enhanced motor functional recovery. Behavioral analyses revealed that this recovery was achieved through multiple mechanisms, including reduced oxidative stress, inflammation, and scar formation at the injury site, as well as enhanced angiogenesis and neurogenesis within the spinal cord tissue. This study presents a multifunctional combinatorial strategy for mitigating ROS-induced oxidative stress, offering broad potential applications in SCI and other central nervous system disorders.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"39 ","pages":"103444"},"PeriodicalIF":11.0,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13382442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148604794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic integration of flexible bioelectroactive nanofibrous conduits and electrical stimulation for accelerated peripheral nerve regeneration.","authors":"Rong Cheng, Meng Li, Jianming Wang, Lu Han, Wei Cui, Yanfeng Xi, Lingli Guo, Yukun Luo, Ride Wang, Shengbo Sang","doi":"10.1016/j.mtbio.2026.103442","DOIUrl":"10.1016/j.mtbio.2026.103442","url":null,"abstract":"<p><p>Repair of peripheral nerve injuries remains a major clinical challenge, motivating the development of bioelectroactive nerve guidance conduits (NGCs) capable of reconstructing the structural and electrophysiological microenvironment required for effective regeneration. Here, we report flexible bioelectroactive nerve guidance conduits (CPC-NGCs) that integrate mechanical compliance with efficient bioelectrical signal transmission, address challenges associated with the repair of peripheral nerve defects. These conduits are fabricated from chitosan, polyethylene oxide, and carbon nanotubes (CNTs) via electrospinning, forming a conductive nanofibrous network with a biomimetic fibrous architecture that supports peripheral nerve regeneration. By systematically regulating CNTs content, the hydrophilicity, conductivity, and mechanical properties of the conduits were optimized to achieve stable electrical performance and tissue adaptability. In vitro studies demonstrated that CPC-NGCs promoted PC12 cell viability, neurite extension, and neuronal differentiation. Electrical stimulation (ES) further enhanced neurite alignment and maturation-related marker expression. Moreover, the combination of CPC-NGCs and ES promoted Schwann cell elongation and maturation while modulating macrophage polarization toward a pro-regenerative M2 phenotype, thereby establishing a favorable microenvironment for nerve repair. In a 10 mm rat sciatic nerve defect model, electrically activated CPC-NGCs significantly enhanced axonal regeneration and remyelination, resulting in improved electrophysiological performance, sensory recovery, and motor functional restoration. Histological analyses further confirmed the reconstruction of structurally mature nerve tissue with reduced fibrosis. These findings demonstrate that the synergistic integration of biomimetic conductive conduits and electrical stimulation effectively promotes peripheral nerve regeneration through coordinated regulation of neuronal differentiation, Schwann cell maturation, and immune microenvironment remodeling.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"39 ","pages":"103442"},"PeriodicalIF":11.0,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Black phosphorus/calcium silicate-functionalized 3D hierarchical scaffolds: Coupling photothermal therapy with ion microenvironment-induced mineralization for bone repair.","authors":"Xinyue Guan, Siyu Xu, Wenxin Meng, Quanli Li, Yuhui Liu, Chuan Wu, Zhongrong Chen, Guomin Wu","doi":"10.1016/j.mtbio.2026.103446","DOIUrl":"10.1016/j.mtbio.2026.103446","url":null,"abstract":"<p><p>The repair of large-scale bone defects remains a significant challenge in clinical orthopedics, often complicated by bacterial infection and limited self-healing capacity. Therefore, developing artificial scaffolds that can simultaneously prevent infection and orchestrate a regenerative microenvironment is critical for successful therapy. Herein, a hierarchical 3D scaffold (CaSiO₃/PCL NFs + BP@PCL MSs) integrating calcium silicate (CaSiO₃)-doped polycaprolactone (PCL) nanofibers and black phosphorus (BP)-encapsulated microspheres is engineered via combined electrospinning and electrospraying techniques. This design constructs a biomimetic architecture with dual photothermal-ionic regulation capabilities. Under near-infrared (NIR) irradiation, the scaffold exhibits superior photothermal conversion, which rapidly eradicates bacteria while accelerating the release of therapeutic ions to establish a pro-mineralization niche. Further in vitro and in vivo evaluations demonstrate that the scaffold exhibits excellent in situ mineralization capability while simultaneously promoting cell proliferation, migration, and osteogenic differentiation. Furthermore, the implanted scaffold effectively promotes vascularized bone regeneration at defect sites. This strategy, synergizing photothermal therapy with an optimized ionic microenvironment, provides a promising approach for bone tissue engineering applications.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"39 ","pages":"103446"},"PeriodicalIF":11.0,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13383259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148604607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Immediate tumor killing and long-term anti-tumor immunoreaction induced by Bufalin-loaded phototherapeutic Janus membrane in CRC postoperative therapy\" [Mater. Today Bio 37 (2026) 102824].","authors":"Xi Yu, Yujie He, Jiani Zhong, Yue Li, Yuan Zhu, Yingying Chen, Jingbo Yin, Zeting Yuan, Peihao Yin","doi":"10.1016/j.mtbio.2026.103437","DOIUrl":"https://doi.org/10.1016/j.mtbio.2026.103437","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1016/j.mtbio.2026.102824.].</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"39 ","pages":"103437"},"PeriodicalIF":11.0,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13457173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiscale biomimetic design for peripheral nerve repair: Beyond passive bridging.","authors":"Mouyuan Sun, Zhixu He, Yaxian Luo, Luying Qin, Binhao Jin, Shuangyang Li, Xuankai Fan, Jingyu Zhang, Xinyi Feng, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Yan Tu, Mengfei Yu","doi":"10.1016/j.mtbio.2026.103433","DOIUrl":"10.1016/j.mtbio.2026.103433","url":null,"abstract":"<p><p>Peripheral nerve injury persists as a formidable clinical challenge, particularly in long-gap and complex lesions where surgical intervention frequently yields suboptimal functional restoration. Current nerve guidance conduits (NGCs) afford limited advantage owing to their passive bridging nature, incapable of recapitulating the native nerve's hierarchical architecture, bioactive microenvironment, or temporally coordinated repair programs. Informed by bibliometric and meta-analytic evidence, this review redefines biomimetic peripheral nerve repair as an orchestrated transition from passive bridging to biologically instructed, adaptive neural interfaces. Departing from a mere enumeration of structural, functional, spatiotemporal, and cross-species biomimicry, each axis is endowed with a specific functional mandate. Structural biomimicry imposes directional and hierarchical guidance, functional biomimicry re-establishes the regenerative niche, spatiotemporal biomimicry synchronizes with stage-dependent repair requirements, and cross-species biomimicry expands the reservoir of transferable design principles. The ways in which these cues converge, compete, or synergize within composite conduits are systematically examined, together with the imperative of prioritizing their configurations for manufacturability, sterilization, regulatory feasibility, and long-gap validation. This synthesis crystallizes a design logic for next-generation NGCs, guiding their evolution from static scaffolds toward adaptive, manufacturable, and clinically translatable regenerative interfaces.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"39 ","pages":"103433"},"PeriodicalIF":11.0,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13380063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148497681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triple-helical ligands for collagen-binding proteins improve cartilage extracellular matrix production in nasal chondrocytes.","authors":"Audrey Ziverec, Jeanne Grangy, Ysatis Pécheux, Delphine Vertu-Ciolino, Richard Farndale, Birgit Leitinger, Marielle Pasdeloup, Frédéric Mallein-Gerin, Jean-Daniel Malcor","doi":"10.1016/j.mtbio.2026.103434","DOIUrl":"10.1016/j.mtbio.2026.103434","url":null,"abstract":"<p><p>The use of articular chondrocytes for cartilage repair is constrained by donor-site morbidity, poor proliferation, and difficulties to maintain a stable phenotype. As a result, nasal chondrocytes (NCs) have recently emerged as an alternative cell source. To better establish the potential of NCs in tissue engineering, we have explored their response to the activation of collagen-binding proteins (integrins, discoidin domain receptors (DDRs) andthe secreted protein acidic cysteine-rich (SPARC)) which are essential to cartilage homeostasis. Ligands for these proteins were synthesized as triple-helical peptides (THPs) that mimic the biological and structural properties of collagen, and were covalently linked to PEG or alginate hydrogels hosting human NCs. Compared to human adipose-tissue mesenchymal stem cells, NCs over-expressed chondrogenic markers, yielding higher Sox9 translocation and type II collagen production. THP ligands significantly improved the expression of key cartilage extracellular matrix components in hydrogels, at both the RNA and protein level, for up to 21 days of culture. In particular, THP ligands for DDRs and SPARC led to increased glycosaminoglycan and collagen deposition. In addition, THPs limited fibrocartilage formation, matrix metalloproteinase 13 expression and chondrocytes hypertrophy after 7 days of culture in hydrogels. This work introduces a biomimetic strategy to drive the early stages of the formation of an engineered cartilage tissue from NCs, by replicating key cell/collagen interactions. It provides a preliminary effort to combine an accessible cell source with functionalized biomaterials for cartilage repair.</p>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"39 ","pages":"103434"},"PeriodicalIF":11.0,"publicationDate":"2026-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}