Plasma-Reinforced Dual-Crosslinked Pueraria Hydrogel Coating for Synergistic Atherosclerosis Intervention

IF 10.2 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio Pub Date : 2025-09-14 DOI:10.1016/j.mtbio.2025.102313

Jingyue Wang , Ge Yin , Leila Mamizadeh Janghour , Sheng Dai , Behnam.Akhavan , Maolin Sun , Ansha Zhao

{"title":"Plasma-Reinforced Dual-Crosslinked Pueraria Hydrogel Coating for Synergistic Atherosclerosis Intervention","authors":"Jingyue Wang , Ge Yin , Leila Mamizadeh Janghour , Sheng Dai , Behnam.Akhavan , Maolin Sun , Ansha Zhao","doi":"10.1016/j.mtbio.2025.102313","DOIUrl":null,"url":null,"abstract":"<div><div>To address the clinical challenges of stent thrombosis and restenosis in atherosclerosis intervention, this study developed a dual-crosslinked hydrogel coating (PSMASH—integrating methacrylated Pueraria polysaccharide (PSMA) and thiolated derivative (PSSH) based on Pueraria lobata polysaccharide). We used an ion-assisted plasma polymerization (IAPP) technique to construct micro-nano structures and thiol-ene click reaction sites on the surface of 316L stainless steel stents. This approach enabled robust covalent integration between the coating and the substrate. Simultaneously, the dual-network architecture of the hydrogel coating (synergistic covalent and dynamic crosslinking) conferred enhanced mechanical stability and controlled degradation properties. PSMASH promoted endothelial cell recovery and modulated the pathological phenotype of smooth muscle cells under oxidative stress. This effect was mediated by the controlled release of Pueraria-derived flavonoids. This \"herb-to-device\" (HTD) strategy integrates traditional Chinese medicinal components with advanced interface engineering. It establishes a novel therapeutic platform for atherosclerosis intervention that offers superior mechanical compatibility and multi-target synergistic efficacy.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102313"},"PeriodicalIF":10.2000,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Today Bio","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S259000642500883X","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}

引用次数: 0

Abstract

To address the clinical challenges of stent thrombosis and restenosis in atherosclerosis intervention, this study developed a dual-crosslinked hydrogel coating (PSMASH—integrating methacrylated Pueraria polysaccharide (PSMA) and thiolated derivative (PSSH) based on Pueraria lobata polysaccharide). We used an ion-assisted plasma polymerization (IAPP) technique to construct micro-nano structures and thiol-ene click reaction sites on the surface of 316L stainless steel stents. This approach enabled robust covalent integration between the coating and the substrate. Simultaneously, the dual-network architecture of the hydrogel coating (synergistic covalent and dynamic crosslinking) conferred enhanced mechanical stability and controlled degradation properties. PSMASH promoted endothelial cell recovery and modulated the pathological phenotype of smooth muscle cells under oxidative stress. This effect was mediated by the controlled release of Pueraria-derived flavonoids. This "herb-to-device" (HTD) strategy integrates traditional Chinese medicinal components with advanced interface engineering. It establishes a novel therapeutic platform for atherosclerosis intervention that offers superior mechanical compatibility and multi-target synergistic efficacy.

Abstract Image

查看原文本刊更多论文

等离子增强双交联葛根水凝胶涂层协同动脉粥样硬化干预

为了解决动脉粥样硬化干预中支架血栓形成和再狭窄的临床挑战，本研究开发了一种双交联水凝胶涂层（psmsh -整合葛根多糖的甲基丙烯酸酯化（PSMA）和基于葛根多糖的硫代衍生物（PSSH））。采用离子辅助等离子体聚合（IAPP）技术在316L不锈钢支架表面构建微纳结构和巯基点击反应位点。这种方法使涂层和衬底之间的共价集成变得强大。同时，水凝胶涂层的双网络结构（协同共价和动态交联）赋予了增强的机械稳定性和可控的降解性能。PSMASH促进内皮细胞恢复，调节氧化应激下平滑肌细胞的病理表型。这种作用是由葛根类黄酮的控释介导的。这种“草药到设备”（HTD）策略将传统中药成分与先进的界面工程相结合。它为动脉粥样硬化干预提供了一个新的治疗平台，具有优越的机械相容性和多靶点协同效应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Materials Today Bio Multiple-

CiteScore

8.30

自引率

4.90%

发文量

303

审稿时长

30 days

期刊介绍： Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).