Materials Today Bio最新文献

{"title":"Dual-metal-organic framework and gallic acid incorporated 3D-printed scaffolds: Revolutionizing refractory bone defect repair through immune-angiogenic-neurogenic synergy","authors":"Yongbo Li ,&nbsp;Yifei Guo ,&nbsp;Yuanpei Cheng ,&nbsp;Xiaodong Liu ,&nbsp;Hengren Li ,&nbsp;Chen Liu ,&nbsp;Xipeng Chen ,&nbsp;Heng Yang ,&nbsp;Xingzhi Jing ,&nbsp;Xiaoyang Liu ,&nbsp;Han Wu ,&nbsp;Min Guo ,&nbsp;Peibiao Zhang ,&nbsp;Xingang Cui","doi":"10.1016/j.mtbio.2025.102323","DOIUrl":"10.1016/j.mtbio.2025.102323","url":null,"abstract":"<div><div>Steroid-associated osteonecrosis (SAON)-related bone defects are refractory and present significant therapeutic challenges due to dysregulated multiple cellular functions and disrupted multidimensional microenvironments. Despite progress in regulating immune responses and promoting vascularization for SAON-related bone defects, effective neural innervation strategies remain limited. Notably, immune response, angiogenesis, and neural innervation are interdependent processes that collectively regulate bone regeneration. Herein, we engineered a novel 3D-printed composite scaffold with highly interconnected porosity and multiple bioactivities by integrating magnesium-copper dual-metal-organic framework (MgCu-MOF74), gallic acid (GA) and polylactic acid (PLA). MgCu-MOF74 exhibits antioxidant capacity, controllable release of metal ions, and osteo-angiogenic properties. The composite scaffold demonstrated excellent mechanical properties and degradation characteristics well suited for bone regeneration. More importantly, the incorporation of GA and dual-ion synergy enabled the scaffold to achieve pronounced multicellular modulation by promoting macrophage polarization, inducing endothelial cell-mediated angiogenesis, stimulating Schwann cell morphological maturation, and enhancing the osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs), while markedly increasing intercellular crosstalk to optimize the local multidimensional microenvironment. In vivo studies further confirmed that the scaffold effectively facilitates the repair of SAON-related bone defects by harnessing the synergistic interactions among the immune, angiogenic, and neurogenic microenvironments. This work provides an innovative strategy for treating refractory SAON - related bone defects, highlighting the potential of the developed scaffold in modulating diverse cell types and remodeling complex microenvironments.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102323"},"PeriodicalIF":10.2,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic dual chemophysical FeCu-MOF scaffold with PEMF stimulation drives angiogenic-osteogenic coupling for bone regeneration","authors":"Dongdong Guo ,&nbsp;Wenjie Wang ,&nbsp;Dongyang Zhao ,&nbsp;Tianyu Chen ,&nbsp;Xingyu Ma ,&nbsp;Yixiao Li ,&nbsp;Xiaojun Zhang","doi":"10.1016/j.mtbio.2025.102324","DOIUrl":"10.1016/j.mtbio.2025.102324","url":null,"abstract":"<div><div>Repairing large bone defects effectively requires concurrent osteogenesis and angiogenesis, a significant challenge for conventional biomaterials often limited by suboptimal structural design and an inability to provide spatiotemporally controlled bioactive cues. Here, we report a novel chemophysical dual-responsive system rationally designed to address this osteogenic-angiogenic coupling challenge. This system integrates a structurally engineered bimetallic FeCu-metal-organic framework (FeCu-MOF) within a poly(lactic acid)/hydroxyapatite (PLA/HA) scaffold. The engineered FeCu-MOF architecture enables the programmed and sustained co-release of Fe³⁺ and Cu²⁺ ions, providing tailored chemical signals. Synergistic pulsed electromagnetic field (PEMF) stimulation was introduced as a physical cue to further enhance the scaffold's bioactivity. The composite scaffolds, featuring interconnected hierarchical porosity and enhanced hydrophilicity due to FeCu-MOF incorporation, demonstrated distinct Fe³⁺/Cu²⁺ release profiles. <em>In vitro</em>, these scaffolds exhibited excellent biocompatibility and significantly promoted bone marrow mesenchymal stem cells (BMSCs) proliferation and osteogenic differentiation. Notably, this structure-derived dual-ion release also indicated pro-angiogenic potential. Crucially, daily PEMF treatment synergistically amplified these cellular responses. <em>In vivo</em> evaluation in a rat cranial defect model confirmed the system's efficacy. While FeCu-MOF/PLA/HA scaffolds alone enhanced bone regeneration, their combination with PEMF yielded the most robust outcomes, characterized by markedly superior vascularized bone formation. Comprehensive analysis, including micro-CT, histology, and immunohistochemistry, confirmed these findings by demonstrating improved bone volume, density, and architecture, mature integrated tissue, and enhanced coupled expression of CD31 and osteogenic markers. In summary, the study validates a powerful synergistic strategy for enhanced bone regeneration. This strategy, integrating programmable, structure-derived bimetallic ion release with PEMF stimulation, successfully achieved synergistic angiogenic-osteogenic coupling, offering a promising approach for complex defect scenarios.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102324"},"PeriodicalIF":10.2,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145106710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decellularized extracellular matrix scaffolds from Pleurotus ferulae mushrooms for sustainable production of steak-like cultured meat with authentic texture","authors":"Doyeon Kim ,&nbsp;Manho Kim ,&nbsp;Chanho Lee ,&nbsp;Hyejun Jang ,&nbsp;Wijin Kim ,&nbsp;Ju Hyun Park","doi":"10.1016/j.mtbio.2025.102327","DOIUrl":"10.1016/j.mtbio.2025.102327","url":null,"abstract":"<div><div>Replicating the fibrous texture of steak-like meat remains a significant hurdle to the commercialization of cultured meat as a sustainable alternative to conventional livestock farming. Many existing scaffolds often lack the biocompatibility, scalability, or structural cues necessary to fabricate steak-like cultured meat. Here, we developed a cost-effective and sustainable scaffold derived from the decellularized extracellular matrix (dECM) of the edible mushroom, <em>Pleurotus ferulae</em>. This biomaterial was selected because of its rapid growth, low environmental impact, and inherent fibrous microarchitecture, which exhibits structural similarities to skeletal muscle. An optimized decellularization protocol was established to fabricate porous scaffolds from <em>P. ferulae</em>, and comparative analysis revealed its superior anisotropic microstructure compared to other fungal species. The <em>P</em>. <em>ferulae</em>-derived scaffold supported robust cell adhesion, proliferation, and crucially, guided the aligned differentiation of bovine muscle satellite cells into organized, parallel myotubes that structurally recapitulate native muscle tissue. Texture profile analysis demonstrated that the engineered cultured meat construct exhibited hardness, chewiness, and gumminess comparable to those of real beef, outperforming acellular controls. Furthermore, a thermal processing assay confirmed Maillard reaction-induced browning and the formation of a meat-like macroscopic appearance. Collectively, these results validate <em>P</em>. <em>ferulae</em> dECM scaffolds as a scalable, sustainable, and consumer-acceptable platform for producing steak-like cultured meat with biomimetic textural and sensory properties.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102327"},"PeriodicalIF":10.2,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145106712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sequential drug-release microsphere system for scarless wound healing","authors":"Dong Luo ,&nbsp;Linxue Huang ,&nbsp;Boxiong Bai ,&nbsp;Huiqi Zhang ,&nbsp;Wenshang Liu ,&nbsp;Beibei Wen ,&nbsp;Zhengmao Lu ,&nbsp;Xiaohui Pu ,&nbsp;Qian Chen ,&nbsp;Zhengyu Shen ,&nbsp;Meng Li","doi":"10.1016/j.mtbio.2025.102310","DOIUrl":"10.1016/j.mtbio.2025.102310","url":null,"abstract":"<div><div>The dynamic imbalance in skin wound healing is a key factor of hypertrophic scar (HS) formation. Traditional treatments often target only a certain stage of the wound healing process and fail to comprehensively address the dynamic imbalance, thus making it difficult to achieve scarless wound healing. This study developed a chronologically adaptive methacrylylated gelatin (GelMA)-based microsphere delivery system (G/E/T) that achieves comprehensive intervention in wound healing process through precisely orchestrated sequential release of epigallocatechin gallate (EGCG) and triamcinolone acetonide (TA). In vitro studies have confirmed that the G/E/T microsphere system, utilizing this sequential release mechanism, not only alleviates oxidative stress and inflammatory responses in the early stages but also persistently inhibits the excessive proliferation and migration of fibroblasts in the later phases, demonstrating stage-specific therapeutic precision. Moreover, validated through mouse full-thickness wound model and rabbit ear HS model, the system exhibited remarkable scarless healing outcomes. The \"sequential release and dual-agent synergy\" design paradigm provides an innovative strategy for scarless wound healing while establishing a foundational framework for developing sequential multidrug delivery systems targeting complex pathological processes.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102310"},"PeriodicalIF":10.2,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional nanoplatform as nano-inducer of ferroptosis for targeted recognition and imaging-guided therapy of metastatic prostate cancer","authors":"Liang He ,&nbsp;Hao Liang ,&nbsp;Jixue Wang ,&nbsp;Annan Liu ,&nbsp;Lei Li ,&nbsp;Ji Lu ,&nbsp;Ze Wang ,&nbsp;Andrew K. Whittaker ,&nbsp;Quan Lin","doi":"10.1016/j.mtbio.2025.102317","DOIUrl":"10.1016/j.mtbio.2025.102317","url":null,"abstract":"<div><div>Metastasis prostate cancer (PCa) precision detection and effective treatment remain significant challenge in clinic. Ferroptosis brought promising therapeutic strategy for the treatment of metastatic PCa, effectively inducing ferroptosis in PCa cells represents key to improve therapeutic efficacy. Herein, we developed a multifunctional nanoplatform Fe/Au nanodots-bombesin (FGN-BBN) as the ferroptosis nano-inducer to generate large amount of ROS to induce ferroptosis through an “open-source throttling” strategy for targeted imaging-guided therapy of metastatic PCa. On the one hand, FGN-BBN serves as an efficient biomimetic nanozyme and photothermal agent, exhibiting great POD-like activity and generating abundant reactive oxygen species (ROS) via photothermal-enhanced chemodynamic therapy (CDT) to induce ferroptosis, which is achieving “open source” aspect. On the other hand, FGN-BBN exhibit GPx-like activity that depletes overexpressed glutathione (GSH) within the tumor microenvironment, thereby preventing the neutralization of ROS and achieving the “throttling” effect. Furthermore, bombesin facilitates targeted delivery of the nanozyme to metastatic PCa cells, synergistically enhancing ferroptosis activity. In terms of diagnosis, FGN-BBN possesses targeted recognition capabilities and enables multimode bioimaging including fluorescence (FL), computed tomography (CT), and magnetic resonance imaging (MRI), allowing for the “visualization” of tumor localization and real-time imaging-guided therapy. In summary, the multifunctional nanoplatform integrates multienzyme activity, targeted recognition, multimodal imaging, photothermal therapy, and CDT to induce high-efficiency ferroptosis, offering an effective theranostic strategy for metastatic PCa.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102317"},"PeriodicalIF":10.2,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholesterol modified defense peptide as an EMP2-siRNA delivery system for synergistic immunogene therapy against breast cancer","authors":"Xiaoyun Wang ,&nbsp;Siliang Chen ,&nbsp;Gu He ,&nbsp;Yanghui Zhu ,&nbsp;Nan Zhang ,&nbsp;Changyang Gong ,&nbsp;Xiang Li ,&nbsp;Yujuan Chen","doi":"10.1016/j.mtbio.2025.102321","DOIUrl":"10.1016/j.mtbio.2025.102321","url":null,"abstract":"<div><div>Epithelial membrane protein 2 (EMP2) plays crucial roles in cell proliferation, migration, and adhesion. Despite its importance, conventional EMP2 RNAi therapy shows limited efficacy in vivo. We therefore developed a novel RNA-delivery system utilizing self-assembling defense peptide-cholesterol conjugates for efficient EMP2-siRNA transfection. The engineered HH2-siEMP2 nanoparticles exhibited optimal size and positive surface charge, conferring excellent serum stability and enhanced cellular uptake in breast cancer cell lines. These nanoparticles effectively silenced EMP2 expression, leading to significant suppression of tumor migration and invasion in both in vitro and in vivo models. Beyond direct anti-tumor effects, the HH2-C conjugate demonstrated immunomodulatory properties by promoting Th1 cell expansion, reducing Th2 cells and immunosuppressive Tregs, and restoring Th17/Treg balance. These findings establish EMP2 as a promising therapeutic target in breast cancer and highlight the potential of HH2-C-based nanoparticles as a dual-function platform combining efficient siRNA delivery with immunostimulatory activity.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102321"},"PeriodicalIF":10.2,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholesterol surface-modified oncolytic adenovirus enriched with apolipoprotein E penetrates the blood-brain barrier to target glioblastoma immunotherapy","authors":"Aodi Niu ,&nbsp;Yuqing Lv ,&nbsp;Yuxuan Chen ,&nbsp;Yuxuan Liu ,&nbsp;Chengjian Luo ,&nbsp;Mengqing Zheng ,&nbsp;Yeyu Shen ,&nbsp;Junjia He ,&nbsp;Dongni Yao ,&nbsp;Huanrong Lan ,&nbsp;Hai Zou ,&nbsp;Tong Ge ,&nbsp;Xiaozhou Mou","doi":"10.1016/j.mtbio.2025.102319","DOIUrl":"10.1016/j.mtbio.2025.102319","url":null,"abstract":"<div><div>Glioblastoma (GBM) remains a therapeutic challenge due to its aggressive behaviour and the limitation of drug delivery by the blood-brain barrier (BBB). Conventional oncolytic adenoviruses (OAs) suffer from poor targeting efficiency. To overcome this limitation, we developed a cholesterol-modified OA (OA@Cho). This engineered virus actively regulates protein corona formation in the bloodstream, selectively enriching apolipoprotein E (ApoE). By exploiting low-density lipoprotein receptor (LDLR)-mediated BBB transcytosis, OA@Cho achieves precise glioma targeting and enhances therapeutic delivery. Critically, upon reaching the GBM site, OA@Cho induces an anti-tumor immune response, turning \"cold\" tumors into \"hot\" tumors by inducing immunogenic cell death (ICD). The proposed \"surface modification-ApoE enrichment-receptor-mediated\" paradigm establishes a transformative platform that enables oncolytic viruses to bypass biological barriers, thereby advancing targeted viral therapies against CNS malignancies with high translational relevance.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102319"},"PeriodicalIF":10.2,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Light-triggered carbon monoxide-induced activation of enhanced ferritinophagy-mediated ferroptosis for bone metastases therapy","authors":"Qin Liu ,&nbsp;Jian Zhang ,&nbsp;Lujie Yu ,&nbsp;Yaohua Chen ,&nbsp;Chiyv Zhang ,&nbsp;Juan Li ,&nbsp;Shutong Wu ,&nbsp;Xiaochun Zheng ,&nbsp;Rong Dai ,&nbsp;Ziliang Zheng ,&nbsp;Ruiping Zhang","doi":"10.1016/j.mtbio.2025.102322","DOIUrl":"10.1016/j.mtbio.2025.102322","url":null,"abstract":"<div><div>Bone metastases, as a common disabling and life-threatening complication in the advanced stages of various solid tumors, continue to pose substantial therapeutic challenges due to high drug toxicity and tumor resistance. To overcome the limited efficacy and safety concerns of existing treatments, we developed a novel iron-based photocatalytic nanoplatform (ENCF), guided by second near-infrared (NIR-II) imaging, for the precise treatment of bone metastases. This platform enables in situ photocatalytic release of CO and utilizes exposed iron active sites to synergistically induce ferroptosis through a cascade of oxidative stress, autophagy and iron metabolism disruption under 808 nm laser activation. Mechanistic investigations revealed that the ENCF platform significantly downregulates PCBP2, a key regulator of ferritinophagy, while activating LC3- and ATG5-mediated autophagic pathways to accelerate FTH1 degradation and Fe²⁺ release, thereby disturbing intracellular iron homeostasis. Concurrently, the released CO disrupts mitochondrial electron transport and inhibits ATP synthesis, leading to excessive ROS accumulation, enhanced suppression of GPX4 , accelerated lipid peroxidation, and the initiation of a robust ferroptotic response. Benefiting from its deep-tissue photoactivation, high catalytic efficiency, and multi-target synergistic mechanisms, ENCF achieved potent tumor suppression with selective accumulation at metastatic sites in a bone metastasis model. Collectively, this study establishes a multi-pronged therapeutic strategy via “CO release–autophagy enhancement–ferroptosis activation,” offering a promising and innovative approach for the precise treatment of bone metastases.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102322"},"PeriodicalIF":10.2,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting chaperone-mediated autophagy to regulate osteoclast activity as a therapeutic strategy for osteoporosis","authors":"Yunhui Zhang ,&nbsp;Quanfeng Li ,&nbsp;Xiaoshuai Peng ,&nbsp;Pengfei Ji ,&nbsp;Yibin Zhang ,&nbsp;Jiahao Jin ,&nbsp;Zihao Yuan ,&nbsp;Jianan Jiang ,&nbsp;Guangqi Tian ,&nbsp;Mingxi Cai ,&nbsp;Pei Feng ,&nbsp;Yanfeng Wu ,&nbsp;Wenjie Liu ,&nbsp;Peng Wang","doi":"10.1016/j.mtbio.2025.102311","DOIUrl":"10.1016/j.mtbio.2025.102311","url":null,"abstract":"<div><div>Osteoporosis is an age-related bone metabolic disease characterized by a persistent bone mass decrease and bone structure destruction. Osteoclasts, important cells in the bone remodelling process, are closely associated with the onset and progression of osteoporosis; however, the regulatory mechanisms involved remain unclear. In this study, TFE3 cytoplasmic translocation inhibited LAMP2A expression in osteoclasts and precursors in elderly individuals with osteoporosis and the downregulation of LAMP2A expression mediated the attenuation of chaperone-mediated autophagy (CMA). This inhibition prevented intracellular CCR5 degradation, increased the osteoclast differentiation of osteoclast precursor cells, and enhanced the bone resorption activity of mature osteoclasts, leading to bone loss and remodelling. In addition, we constructed osteoclast-targeted nanoparticles carrying CMA activators and demonstrated that enhancing osteoclast CMA activity in vivo inhibited the abnormal bone resorption activity of osteoclasts, thereby effectively increasing bone mass and alleviating osteoporosis progression. This study revealed that LAMP2A-mediated CMA activity in osteoclasts and their precursors negatively regulates osteoclast differentiation and bone resorption activities both in vivo and in vitro. The attenuation of LAMP2A-mediated CMA activity plays an important role in the development of osteoporosis, and enhancing LAMP2A-mediated CMA activity represents a potential therapeutic strategy for osteoporosis.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102311"},"PeriodicalIF":10.2,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in metal ions overloading for tumors: Mechanisms, nanomaterials, and therapies","authors":"Qiufang Gong ,&nbsp;Lili Shi ,&nbsp;Lutong Wen ,&nbsp;Yanni Zhang ,&nbsp;Zaifeng Chen ,&nbsp;Xiaojie Wei ,&nbsp;Xuejiao Song ,&nbsp;Jingbo Dong ,&nbsp;Chao Liang","doi":"10.1016/j.mtbio.2025.102320","DOIUrl":"10.1016/j.mtbio.2025.102320","url":null,"abstract":"<div><div>Metal ions serve as indispensable regulators in fundamental biological processes, maintaining critical physiological functions including osmotic equilibrium, acid-base regulation, intracellular signaling, and biomolecular recognition. Perturbations of ionic homeostasis can disrupt cellular integrity, leading to functional impairment and ultimately programmed cell death. Capitalizing on this paradigm, emerging nanotherapeutic approaches have pioneered the strategic induction of tumor-selective ions overloading as a potent anticancer strategy. This comprehensive review critically evaluates the roles of key metal ions (Na⁺, K⁺, Ca²⁺, Cu²⁺, Zn²⁺, Fe^2+/3+, Mn²⁺) in tumor progression and their mechanisms of action when overaccumulated, and highlights innovative nanomaterial designs that exploit ions overloading to induce apoptosis, pyroptosis, or immunogenic cell death. Meanwhile, the combinatorial approaches integrating ions-overloading with other therapy including immunotherapy, chemodynamic therapy et al. would be discussed. By integrating the mechanisms and contemporary research advances, this work provides a conceptual framework for developing next-generation of ions-disrupting nanomedicines and identifies promising directions for combinatorial anticancer regimens.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"35 ","pages":"Article 102320"},"PeriodicalIF":10.2,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145106778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}