Materials Today Bio最新文献

{"title":"Biomimetic self-assembly nanoparticles inhibit serpinB9 and synergistically enhance COD-induced ferroptosis for cancer therapy","authors":"Ruyue Han ,&nbsp;Pengcheng Sun ,&nbsp;Min Zhou ,&nbsp;Wenjie Xu ,&nbsp;Xinyan Hao ,&nbsp;Yanjin Peng ,&nbsp;Yucheng Tang ,&nbsp;Xinying Liu ,&nbsp;Hai Huang ,&nbsp;Mengen Guo ,&nbsp;Tiantian Tang ,&nbsp;Xiongbin Hu ,&nbsp;Daxiong Xiang ,&nbsp;Junyong Wu","doi":"10.1016/j.mtbio.2025.101982","DOIUrl":"10.1016/j.mtbio.2025.101982","url":null,"abstract":"<div><div>Granzyme B (GrB), a crucial serine protease stored in immune cells, plays a pivotal role in combating tumors primarily through GrB-induced apoptosis. However, the elevated expression of SerpinB9 (Sb9), which is a physiological inhibitor of GrB, within tumors acts as an impediment to GrB-induced apoptosis. Protocatechuic acid (PCA), a phenolic acid, has demonstrated promising antitumor potential through ability to inhibit the biological function of Sb9 and enhance the GrB-induced apoptosis. Ferroptosis, an innovative therapeutic strategy for cancer treatment, is also hindered by elevated cholesterol levels within tumors, which suppress ferroptosis and undermine immune function, further reducing GrB secretion. To address these challenges, we engineered multifunctional COD-FePT@PCA NPs@CM (CPM), consisting of metal–phenolic framework nanoparticles loaded with PCA and cholesterol oxidase (COD), which were further encapsulated with macrophage membranes (CM) to construct a biomimetic drug delivery system with enhanced safety and stability. Our findings revealed that CPM exhibited significant antitumor effects both in vitro and in vivo, exhibiting superior stability and optimal biocompatibility. The results revealed that CPM effectively inhibited Sb9 expression and enhanced ferroptosis by downregulating glutathione peroxidase 4 (GPX4) and ferroptosis suppressor protein 1 (FSP1), thereby increasing GrB secretion and promoting GrB-induced apoptosis. In vivo studies further confirmed that CPM exhibited potent therapeutic efficacy in tumor-bearing mice and metastasis. Concurrently, the proportion of DC maturation, macrophage polarization, and CTL infiltration was significantly increased, highlighting CPM's ability to elicit robust antitumor immune responses. This study underscores the potential of CPM as a multifunctional therapeutic agent that simultaneously integrates Sb9 inhibition, ferroptosis induction, and immunotherapy, offering a promising strategy for cancer treatment.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 101982"},"PeriodicalIF":8.7,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144290868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D bioprinting of a perfusable skin-on-chip model suitable for drug testing and wound healing studies","authors":"Federico Maggiotto ,&nbsp;Eva Dalla Valle ,&nbsp;Anna Fietta ,&nbsp;Lorenzo Maria Visentin ,&nbsp;Monica Giomo ,&nbsp;Elisa Cimetta","doi":"10.1016/j.mtbio.2025.101974","DOIUrl":"10.1016/j.mtbio.2025.101974","url":null,"abstract":"<div><div>The skin, as the body's largest organ, serves critical functions including physical protection, thermoregulation, sensation, and immunity, making it a key focus in tissue engineering. Recently, 3D bioprinting has emerged as a promising method for fabricating skin substitutes, offering potential applications in both drug testing and clinical treatments for severe skin injuries. This technology enables the precise deposition of cells within a biomaterial matrix to create complex tissue structures with controlled microenvironments. A major challenge in 3D bioprinted skin models is incorporating a vascular system for adequate nutrient and oxygen distribution. Here, we present a novel approach for creating a perfusable 3D vascularized skin model using two bioinks: gelatin methacryloyl (GelMA) for the dermal and epidermal layers and Pluronic F127 as a sacrificial material for vascular channel formation. This method integrates three cell types, neonatal foreskin fibroblasts, human epidermal keratinocytes, and human umbilical vein endothelial cells, to establish a biomimetic skin construct. By employing sacrificial bioprinting techniques, we successfully developed a skin model with vascularized structures that can be used for advanced <em>in-vitro</em> studies and regenerative therapies.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 101974"},"PeriodicalIF":8.7,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone marrow-targeted thrombopoietin delivery via engineered platelet-derived vesicle-loaded dissolving microneedles for treating ionizing radiation-induced injury","authors":"Zhenchao Ma ,&nbsp;Yuntao Li ,&nbsp;Jiawei Zhu ,&nbsp;Sheng Qiu ,&nbsp;Yingrong Chen ,&nbsp;Hengbin Cao ,&nbsp;Shuixin Yang ,&nbsp;Xueli Jia ,&nbsp;Lixia Huo ,&nbsp;Qian Shi ,&nbsp;Shunwen Han ,&nbsp;Hao Chang ,&nbsp;Xiang Yu","doi":"10.1016/j.mtbio.2025.101980","DOIUrl":"10.1016/j.mtbio.2025.101980","url":null,"abstract":"<div><div>Exposure to a nuclear accident or a radiological attack may cause serious death events due to hematopoietic acute radiation syndrome (H-ARS). While thrombopoietin (TPO) shows promise in mitigating myelosuppression, its clinical use is restricted due to high doses, strict schedules, and systemic toxicity from conventional administration. This study developed a dissolving microneedle patch loaded with engineered activated platelet-derived vesicles encapsulating TPO (TLEVs@MN) for targeted treatment of H-ARS. Activated platelet-derived vesicles were isolated via ultracentrifugation and then modified with glutathione. Glutathione-based anti-ROS modification effectively protected vesicles from radiation-induced oxidative damage, enhancing their stability and targeting efficiency. Using mild sonication, TPO was efficiently encapsulated into engineered vesicles without compromising membrane protein integrity. Further loading into dissolving MNs facilitated minimally invasive transdermal delivery while ensuring long-term vesicle stability during storage. TLEVs@MNs effectively activated the JAK2/STAT3 pathway, restoring mitochondrial function in hematopoietic stem cells. Pharmacokinetic and biodistribution analyses demonstrated that administration of TPO using TLEVs@MNs achieved the precise TPO delivery to bone marrow hematopoietic stem and progenitor cells, significantly improving survival rates and hematopoietic recovery in irradiated animal models. These findings highlighted TLEVs@MN patch as a promosing and robust TPO delivery platform for managing IR-induced hematopoietic injury.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 101980"},"PeriodicalIF":8.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dominant follicle-targeted nanocarriers for GH delivery to alleviate premature ovarian insufficiency","authors":"Shao Yang ,&nbsp;Yawei Sun ,&nbsp;Wei Luo ,&nbsp;Xiaofeng Zhou ,&nbsp;Xiao Gu ,&nbsp;Wenzhe Zhang ,&nbsp;Huashan Zhu ,&nbsp;Wenjia Wu ,&nbsp;Xueying Wu ,&nbsp;Mengru Yu ,&nbsp;Shan Wang","doi":"10.1016/j.mtbio.2025.101930","DOIUrl":"10.1016/j.mtbio.2025.101930","url":null,"abstract":"<div><div>Premature ovarian insufficiency (POI) is characterized by ovarian functional damage, leading to infertility and severe complications. Current treatment is merely to relieve the clinical symptoms by hormone supplementation. Growth hormone (GH) shows efficacy in restoring ovarian function. However, GH has poor targeting specificity and stability, which limits its clinical application. Dominant follicles play a vital role in ovarian endocrine and reproductive function. Zona pellucida glycoprotein 3 (ZP3) is a specific component of the zona pellucida around the oocyte and is tightly associated with the dominant follicle. Therefore, we constructed a GH-loaded complex zeolitic imidazolate frameworks-8 (ZIF8)-GH@ZP3Ab, which uses ZIF8 to load GH and ZP3 antibody (ZP3Ab) to specifically bind ZP3. The results showed that ZIF8-GH@ZP3Ab had a good targeting ability to ovaries, especially the dominant follicles. This approach promoted the development of dominant follicles without increasing the depletion of primordial follicles. In vivo experiments demonstrated that ZIF8-GH@ZP3Ab promoted angiogenesis, reduced oxidative stress and apoptosis, and enhanced the secretion of IGF-1 in antral follicles. These effects restored ovarian function and fertility in cisplatin-induced POI in mice. In vitro experiments indicated that both ZIF8 and GH can protect granulosa cells from cisplatin-induced oxidative stress and apoptosis. In conclusion, ZIF8-GH@ZP3Ab is promising as an effective nanomedicine for the treatment of POI.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 101930"},"PeriodicalIF":8.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant RuCo nanosheet attenuates capsule fibrosis in adhesive capsulitis of shoulder by p38 MAPK signaling pathway inhibition","authors":"Beijie Qi ,&nbsp;Zhixin Chen ,&nbsp;Han Lin ,&nbsp;Yaying Sun ,&nbsp;Chengqing Yi ,&nbsp;Jiwu Chen","doi":"10.1016/j.mtbio.2025.101979","DOIUrl":"10.1016/j.mtbio.2025.101979","url":null,"abstract":"<div><div>Adhesive capsulitis of shoulder (ACS) is a prevalent orthopedic disorder characterized by pain and restricted range of motion (ROM). The pathogenesis of ACS remains unclear and current treatments have limited efficacy in terms of long-term outcomes. Here, we synthesized antioxidant RuCo nanosheets (RuCo-NSs) for the treatment of ACS. The reactive oxygen species (ROS) scavenging ability and the effect of RuCo-NSs on the activation of mouse fibroblasts NIH3T3s were investigated. In addition, RuCo-NSs were administered to the mouse model of ACS through intra-articular injection into joint capsule. Results showed that RuCo-NSs could effectively scavenge ROS in both the acellular and intracellular environments with low toxicity. Moreover, RuCo-NSs significantly suppressed the proliferation, migration and fibrogenesis of NIH3T3 via modulating the p38 mitogen-activated protein kinase (MAPK) signaling pathway. In addition, RuCo-NSs improved shoulder stiffness and inhibited capsular fibrosis in ACS mice. Our results suggest that the use of RuCo-NSs may be a potential therapy for ACS.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 101979"},"PeriodicalIF":8.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From in vitro to in vivo: Diverse applications of kirigami technology in medical devices","authors":"Fengqin Li,&nbsp;Yang Zhou,&nbsp;Yuxue Hu,&nbsp;Xiaoming Feng,&nbsp;Guizhong Tian","doi":"10.1016/j.mtbio.2025.101961","DOIUrl":"10.1016/j.mtbio.2025.101961","url":null,"abstract":"<div><div>Kirigami, as a paper-cutting art, has developed into an innovative design and manufacture strategy with the support of material diversity and modern manufacturing technology. Combining the mechanical, electrical, and magnetic properties of materials, carefully designed geometric shapes can significantly improve mechanical flexibility, two-dimensional and three-dimensional reconfiguration, and functionality. This paper focuses on medical devices, and reviews the pattern design, deformation characteristics, function realization and diversified applications of advanced kirigami technology in this field. And the design influencing factors, basic deformation mechanism and various fabrication methods of kirigami are also discussed. Medical devices are mainly classified by <em>in vitro</em> and <em>in vivo</em> applications, with different functions such as monitoring, power supply, and treatment as sub-categories. At the same time, the application potential of kirigami-based smart devices in medical applications and the auxiliary role of simulation technology in design are discussed. On this basis, the challenges and prospects of the research and development in the field of medical health inspired by kirigami are summarized and prospected.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 101961"},"PeriodicalIF":8.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dextran-functionalized cerium oxide nanoparticles for treating diabetic wound infections by synergy between antibacterial activity and immune modulation","authors":"Xiaojie Yan ,&nbsp;Wenfu Zheng ,&nbsp;Yiming Yu ,&nbsp;Rufang Liu ,&nbsp;Youhuan Gong ,&nbsp;Mengting Huang ,&nbsp;Mingde Fan ,&nbsp;Le Wang","doi":"10.1016/j.mtbio.2025.101977","DOIUrl":"10.1016/j.mtbio.2025.101977","url":null,"abstract":"<div><div>Diabetic wounds, characterized by recurrent infections, drug resistance, and immunosuppression, pose a formidable clinical challenge which can hardly be adequately managed by conventional antibiotics. Herein, we present dextran-functionalized cerium oxide nanoparticles (Dex-CeNPs) to cure bacterial infected diabetic wounds. The Dex-CeNPs not only had excellent antibacterial activity, but also promoted the shift of macrophages from the proinflammatory M1 phenotype to the proregenerative M2 phenotype. By synergizing the antibacterial activity and immune modulating activity, the Dex-CeNPs promoted the healing of methicillin-resistant <em>Staphylococcus aureus</em> (MRSA)-infected diabetic wound and prevented infection recurrence in mice. Our study provides a strategy for treating intractable diabetic wounds.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 101977"},"PeriodicalIF":8.7,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The first thermophilic phage display system","authors":"Piotr M. Skowron ,&nbsp;Ireneusz Sobolewski ,&nbsp;Katarzyna Adamowicz ,&nbsp;Joanna Morcinek-Orłowska ,&nbsp;Lidia Gaffke ,&nbsp;Weronika Jaroszewicz ,&nbsp;Beata Łubkowska ,&nbsp;Karolina Pierzynowska ,&nbsp;Agnieszka Zylicz-Stachula ,&nbsp;Grzegorz Węgrzyn","doi":"10.1016/j.mtbio.2025.101960","DOIUrl":"10.1016/j.mtbio.2025.101960","url":null,"abstract":"<div><div>Phage display technology is a powerful technique that allows to expose any peptide fused to a bacteriophage coat protein on the surface of the virion. However, the phage display systems have limitations that impair their applications in microbiology and biotechnology. We present the construction of the first thermophilic phage display system, including ‘mosaic’ system, and provide examples of its biotechnological usefulness. The system relies on TP-84 bacteriophage, infecting <em>Geobacillus stearothermophilus</em>, with proliferation temperature up to 73°C, and developing only in the lytic mode, which allows liberating virion with any attached peptide. TP-84 has a large capsid, tolerates changes in the capsid proteins arrangement and develops in the thermophilic host, preventing recombinant protein aggregation in the cytoplasm. Furthermore, we introduce ‘affinity coupling’ functionalized bionanoparticle system, allowing attachment of theoretically any size proteins or even non-proteinous ligands onto TP-84 capsid, overcoming genome/capsid size limitations. The system provides technology for generation of novel types thermostable, biodegradable biomaterials. Moreover, the duplicated major capsid protein phage was constructed, forming the first thermophilic phage gene expression system. Upon a replacement of the engineered TP84_12 gene copy by a gene to be expressed, high level recombinant proteins expression can be achieved. This versatile phage display system should be useful in many microbiological approaches, overcoming the drawbacks of previous systems.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 101960"},"PeriodicalIF":8.7,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomedicine for chronic pain management: From pathophysiology to engineered drug delivery systems","authors":"Li Li ,&nbsp;Ting Li ,&nbsp;Hanxi Wang ,&nbsp;Lihan Luo ,&nbsp;Yuqi Cheng ,&nbsp;Yang Li ,&nbsp;Shanjun Huang ,&nbsp;Xueou Zhang ,&nbsp;Jiannan He ,&nbsp;Jian Guo ,&nbsp;Cao Zhang ,&nbsp;Fengjiang Zhang ,&nbsp;Longguang Tang ,&nbsp;Jianhong Xu","doi":"10.1016/j.mtbio.2025.101976","DOIUrl":"10.1016/j.mtbio.2025.101976","url":null,"abstract":"<div><div>Chronic pain represents a significant burden on individuals and society, impacting financial costs, emotional well-being, and productivity. Traditional treatments for chronic pain, such as non-steroidal anti-inflammatory drugs (NSAIDs), opioids, and local anesthetics, are commonly used but have notable limitations. Opioids carry a risk of addiction, NSAIDs pose gastrointestinal and cardiovascular risks, and the short duration of analgesic effects from single doses of local anesthetics limits their effectiveness in long-term pain management. This review aims to provide a comprehensive resource for researchers exploring innovative approaches to chronic pain treatment, with a particular focus on drug delivery systems. It delves into the classification of chronic pain, its underlying mechanisms, and the most commonly used pharmacological treatments, while critically evaluating the limitations of each strategy. Furthermore, the review highlights recent advancements in drug delivery technologies for chronic pain management, discussing both the potential opportunities and challenges of translating these innovations into clinical practice. Ultimately, the review identifies existing challenges in the field and outlines promising research directions for the future development of more effective drug delivery strategies in chronic pain management.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 101976"},"PeriodicalIF":8.7,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elastin-like polypeptide and triclosan-modified PCL membrane provides aseptic protection in tissue regeneration","authors":"Xueliang Peng ,&nbsp;Yijie Wang ,&nbsp;Shuyun Liu,&nbsp;Jiake Zhang,&nbsp;Ling Liu,&nbsp;Qian Liu,&nbsp;Xuanyi Li,&nbsp;Fulin Chen,&nbsp;Zhuoyue Chen","doi":"10.1016/j.mtbio.2025.101968","DOIUrl":"10.1016/j.mtbio.2025.101968","url":null,"abstract":"<div><div>Tissue regeneration is a spatiotemporally ordered multidimensional process involving hierarchical structures, vascularization, and metabolic-immune properties, while injury often triggers structural disorganization, inflammation, metabolic dysfunction, and mechanical impairment. Based on these findings, we designed a functionalized polycaprolactone (PCL) porous scaffold loaded with biocompatible elastin and the antibacterial drug triclosan, which specifically inhibits the growth of methicillin-resistant <em>Staphylococcus aureus</em> (MRSA). Using a bio-mimetic mussel adhesion approach, a polydopamine coating was formed on the surface of electrospun PCL membranes to provide grafting sites for elastin-like polypeptides (ELP), attaching elastin peptides and triclosan to the PCL surface. This method not only provided sites for secondary reactions but also enhanced the hydrophilicity of PCL. Compared with ordinary PCL, the modified PCL scaffold exhibited enhanced antibacterial activity against MRSA and promoted vascularization and neuralization. This is the first time that an antibacterial drug and ELP have been combined to achieve targeted suppression of bacterial resistance. The porous structure of 3D-printed PCL provides good mechanical properties, while the excellent biocompatibility of ELP promotes cell proliferation and migration, maintains a favorable regenerative microenvironment, and mitigates the short-term cytotoxicity of the antibacterial drug. To evaluate the functionalized PCL and expand its applications, <em>in vivo</em> experiments were conducted in both hypoxic subcutaneous and oxygen-rich muscle environments, demonstrating good antibacterial performance and tendencies towards vascular and neural regeneration. This study provides a solid theoretical basis and great potential for applications in wound soft tissue healing and bone injury regeneration, particularly in scenarios requiring antimicrobial resistance management.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"33 ","pages":"Article 101968"},"PeriodicalIF":8.7,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}