双ROS/ ph响应负载芒果苷智能微针用于伤口感染的精确治疗

IF 10.2 1区 医学 Q1 ENGINEERING, BIOMEDICAL
Zhaoping Diao, Jiajun Long, Yang Feng, Guoqing Zhang, Ganghua Yang, Jianqiu Yang, Wenbing Wan
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引用次数: 0

摘要

感染的伤口愈合仍然受到持续的细菌生物膜和失调的炎症的严重挑战,而传统的银敷料缺乏动态微环境反应,不能与组织再生协同抗菌效果。尽管传统的银敷料具有已证实的抗菌功效,但其静态性质限制了动态微环境适应和协同组织再生。为了解决这些限制,我们开发了一种智能微针贴片(PCMA MN),集成了pH/活性氧(ROS)双响应的水凝胶基质,该水凝胶基质由没食子酸接枝的壳聚糖(CG)和tspba交联的聚乙烯醇(PT)组成,用于按需释放药物,芒果苷(MF)负载的PLGA微球促进血管生成,以及一种协同的银没食子酸抗菌涂层。PCMA MNs显示出与银敷料相当的杀菌能力,同时显著加速伤口愈合14.25%。这种再生改善是由血管生成增强和巨噬细胞向再生M2表型的动态极化驱动的,它们共同解决了炎症并促进了胶原沉积。我们的生物反应平台建立了一种协调实时药代动力学和促再生免疫调节的新策略,为复杂伤口管理提供了变革潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Dual ROS/pH-responsive mangiferin-loaded smart microneedles for precision therapy of wound infections

Dual ROS/pH-responsive mangiferin-loaded smart microneedles for precision therapy of wound infections
Infected wound healing remains critically challenged by persistent bacterial biofilms and dysregulated inflammation, whereas conventional silver dressings lack dynamic microenvironment responsiveness and fail to synergize antibacterial efficacy with tissue regeneration. Although conventional silver dressings offer proven antibacterial efficacy, their static nature limits dynamic microenvironment adaptation and synergistic tissue regeneration. To resolve these limitations, we developed an intelligent microneedle patch (PCMA MN) integrating a pH/reactive oxygen species (ROS)-dual-responsive hydrogel matrix composed of gallic acid-grafted chitosan (CG) and TSPBA-crosslinked polyvinyl alcohol (PT) for on-demand drug release, mangiferin (MF)-loaded PLGA microspheres for promoting angiogenesis, and a synergistic silver-gallic acid antibacterial coating. PCMA MNs demonstrated bactericidal capacity comparable to silver dressings, while significantly accelerating wound closure by 14.25 %. This regenerative improvement was driven by enhanced angiogenesis and dynamic macrophage polarization toward regenerative M2 phenotypes, which collectively resolved inflammation and facilitated collagen deposition. Our bioresponsive platform establishes a novel strategy coordinating real-time pharmacokinetics with pro-regenerative immunomodulation, offering transformative potential for complex wound management.
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来源期刊
CiteScore
8.30
自引率
4.90%
发文量
303
审稿时长
30 days
期刊介绍: Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).
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