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Expanding the role of alpha lipoic acid for psychiatric and neurological health. 扩大α硫辛酸对精神和神经健康的作用。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-06-03 DOI: 10.1080/10286020.2025.2509765
Ishu Garg, Harish Kumar, Raj Kumari, Anupama Singh, Ravi Maurya, Rashi Pandey, Shruti Bhatt
{"title":"Expanding the role of alpha lipoic acid for psychiatric and neurological health.","authors":"Ishu Garg, Harish Kumar, Raj Kumari, Anupama Singh, Ravi Maurya, Rashi Pandey, Shruti Bhatt","doi":"10.1080/10286020.2025.2509765","DOIUrl":"https://doi.org/10.1080/10286020.2025.2509765","url":null,"abstract":"<p><p>With the rise in health and neurological concerns around the globe, nutraceuticals are surpassing the harms of drug treatment. Alpha-lipoic acid, an organosulfur naturally abundant biomolecule that has potent protective and therapeutic effects in psychiatric and neurological disorders. Studies targeting alpha-lipoic acid in the brain have concluded that it modulates oxidative stress, neuronal aging, apoptosis, mitochondrial dysfunction, neuro-inflammation, cellular signaling, neurotransmission, and receptor functioning. Various clinical studies have been conducted, yielding satisfactory results indicating alpha-lipoic acid as a therapeutic agent for neurodegenerative and psychiatric disorders. However, further studies are still required to use alpha-lipoic acid as a monotherapeutic agent and to design a dosage regimen. The article aims to demonstrate alpha-lipoic acid as a potent biomolecule for curing and preventing psychiatric and neural disorders.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-31"},"PeriodicalIF":1.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Total synthesis of albafuran B and its osteogenic differentiation promoting effect on human mesenchymal stem cells. 白afuran B的合成及其对人间充质干细胞成骨分化的促进作用。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-06-03 DOI: 10.1080/10286020.2025.2509762
Wan-Dong Liu, Yue Jing, Bin Wang, Lin-Lin Tian, Jian Li, Xiu-Shan Yin, Hua Zhang
{"title":"Total synthesis of albafuran B and its osteogenic differentiation promoting effect on human mesenchymal stem cells.","authors":"Wan-Dong Liu, Yue Jing, Bin Wang, Lin-Lin Tian, Jian Li, Xiu-Shan Yin, Hua Zhang","doi":"10.1080/10286020.2025.2509762","DOIUrl":"https://doi.org/10.1080/10286020.2025.2509762","url":null,"abstract":"<p><p>In the current project, the total synthesis of albafuran B was achieved in four steps and 19.3% overall yield, involving two key reactions of the one-pot Corey-Fuchs reaction and Suzuki coupling. Using the same protocol, two analogs, moracin C and 4'-farnesyl-moracin M, were also successfully synthesized. The effect of albafuran B on the osteogenic differentiation of human umbilical cord-derived and adipose-derived mesenchymal stem cells was evaluated <i>via</i> alkaline phosphatase staining and alizarin red S staining. The assay results revealed that albafuran B showed good osteogenic differentiation promoting activity toward both cell lines.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endophytic microorganisms in lichen: rising stars in the biomedicine field deserving broader recognition. 地衣内生微生物：生物医学领域的后起之星，值得更广泛的认识。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-28 DOI: 10.1080/10286020.2025.2501030
Jia-Na Zhu, Meng-Long Liu, Qiu-Hua He, Hai-Yan Ding
{"title":"Endophytic microorganisms in lichen: rising stars in the biomedicine field deserving broader recognition.","authors":"Jia-Na Zhu, Meng-Long Liu, Qiu-Hua He, Hai-Yan Ding","doi":"10.1080/10286020.2025.2501030","DOIUrl":"https://doi.org/10.1080/10286020.2025.2501030","url":null,"abstract":"<p><p>Lichens are renowned for their ability to thrive in extreme environments and for producing unique metabolites with considerable bioactive potential. However, their medicinal value remains largely underexplored, primarily due to slow growth rates and habitat specificity. Notably, endolichenic microorganisms, particularly fungi, are the predominant producers of these bioactive compounds, which exhibit antimicrobial, antiviral, and anticancer properties. Investigating these microorganisms and their metabolites presents promising biomedical opportunities, underscoring the importance of sustainably utilizing lichen resources and discovering novel compounds. This paper reviews the diversity and bioactive potential of endophytic microorganisms in lichens, providing valuable insights for the exploration of natural resources.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-19"},"PeriodicalIF":1.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prenylated flavones with potential antiproliferative activities from the stems and leaves of Mycetia hainanensis. 海南菌丝体茎叶中具有潜在抗增殖活性的烯丙基黄酮。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-28 DOI: 10.1080/10286020.2025.2507729
Shu-Ri Li, Lin-Xuan Li, Tian-Yu Wang, Yu-Shan Wang, Long-Cheng Cui, Jia-Yi Hu, Ye-Ping Liu, Yan-Ping Liu, Yan-Hui Fu
{"title":"Prenylated flavones with potential antiproliferative activities from the stems and leaves of <i>Mycetia hainanensis</i>.","authors":"Shu-Ri Li, Lin-Xuan Li, Tian-Yu Wang, Yu-Shan Wang, Long-Cheng Cui, Jia-Yi Hu, Ye-Ping Liu, Yan-Ping Liu, Yan-Hui Fu","doi":"10.1080/10286020.2025.2507729","DOIUrl":"https://doi.org/10.1080/10286020.2025.2507729","url":null,"abstract":"<p><p>A phytochemical study on the stems and leaves of <i>Mycetia hainanensis</i> led to the isolation and identification of a new prenylated flavone, mycehainanone (<b>1</b>), as well as seven known analogs (<b>2 </b>-<b> 8</b>). The chemical structure of <b>1</b> was determined using comprehensive spectroscopic analyses and the known compounds were identified by comparison of their spectroscopic data with those reported in the literature. The antiproliferative activities against five human cancer cell lines (JeKo-1, A549, SMMC-7721, SW480, and MCF-7 cell lines) of all isolated prenylated flavones (<b>1 </b>-<b> 8</b>) were evaluated <i>in vitro</i>. Compounds <b>1 </b>-<b> 8</b> exhibited notable antiproliferative effects against various human cancer cell lines with IC<sub>50</sub> values in range of 0.67 ± 0.02 to 38.92 ± 0.23 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two new abietane diterpenoids from Pinus massoniana. 马尾松中两个新枞烷二萜。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-28 DOI: 10.1080/10286020.2025.2509768
Xue Ma, Zhi-Long He, Bao Zhang, Li Jiang, Yong Huang, Yue-Ting Li, Yong-Jun Li
{"title":"Two new abietane diterpenoids from <i>Pinus massoniana</i>.","authors":"Xue Ma, Zhi-Long He, Bao Zhang, Li Jiang, Yong Huang, Yue-Ting Li, Yong-Jun Li","doi":"10.1080/10286020.2025.2509768","DOIUrl":"https://doi.org/10.1080/10286020.2025.2509768","url":null,"abstract":"<p><p>Two new abietane diterpenoids, massonianene A (<b>1</b>) and massonianene B (<b>2</b>), were isolated from the extract of <i>Pinus massoniana</i>. Their structures were elucidated based on HR-ESI-MS, IR, UV, NMR, ECD and X-ray diffraction analysis. Compound <b>2</b> exhibited significant inhibitory effect against LPS-induced NO production in RAW 264.7 cells, with an IC<sub>50</sub> value of 7.00 ± 1.73 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sesquiterpenes with anti-inflammatory activity from the stems and branches of Melicope patulinervia. 山核桃茎、枝中具有抗炎活性的倍半萜素。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-28 DOI: 10.1080/10286020.2025.2508874
Sai Li, En-Lian Du, Qi Gong, Fei Chen, Jun-Jie Tan, Shi-Jin Qu, Hai-Yan Zhang, Chang-Heng Tan
{"title":"Sesquiterpenes with anti-inflammatory activity from the stems and branches of <i>Melicope patulinervia</i>.","authors":"Sai Li, En-Lian Du, Qi Gong, Fei Chen, Jun-Jie Tan, Shi-Jin Qu, Hai-Yan Zhang, Chang-Heng Tan","doi":"10.1080/10286020.2025.2508874","DOIUrl":"https://doi.org/10.1080/10286020.2025.2508874","url":null,"abstract":"<p><p>Five new sesquiterpenes comprising three zieranes, melicopatulones A-C (<b>1</b>-<b>3</b>) and two guaianes, melicopatulones D-E (<b>5</b>-<b>6</b>), were isolated from the stems and branches of <i>Melicope patulinervia</i>, together with melicodenones B (<b>4</b>), C (<b>7</b>) and D (<b>8</b>). Their structures with absolute configurations were elucidated on the basis of analysis of MS, NMR, and TDDFT-ECD calculations. Sesquiterpenes <b>1</b>, <b>2</b> and <b>6</b> exhibited significant inhibitory effect at 10 µM on lipopolysaccharide-induced NO production in BV-2 microglial cells.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chlorogenic acid targets SLC37A2 to inhibit macrophage activation via ER-dependent NF-κB and NLRP3 signaling pathways against sepsis-induced acute lung injury. 绿原酸靶向SLC37A2，通过er依赖性NF-κB和NLRP3信号通路抑制巨噬细胞活化，对抗败血症诱导的急性肺损伤。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-27 DOI: 10.1080/10286020.2025.2506181
Yang Chen, Xiao-Wen Zhang, Mei-Mei Zhao, Ling Li, Yang Liu, Tian-Tian Wei, Wei Yu, Bo Han, Zheng-Ping Liu, Ke-Wu Zeng
{"title":"Chlorogenic acid targets SLC37A2 to inhibit macrophage activation via ER-dependent NF-κB and NLRP3 signaling pathways against sepsis-induced acute lung injury.","authors":"Yang Chen, Xiao-Wen Zhang, Mei-Mei Zhao, Ling Li, Yang Liu, Tian-Tian Wei, Wei Yu, Bo Han, Zheng-Ping Liu, Ke-Wu Zeng","doi":"10.1080/10286020.2025.2506181","DOIUrl":"https://doi.org/10.1080/10286020.2025.2506181","url":null,"abstract":"<p><p>Sepsis-induced acute lung injury (SI-ALI) requires urgent treatment due to severe inflammation. Our study found chlorogenic acid (CGA) suppressed LPS-induced macrophage activation by lowering NO, TNF-α, and IL-6. TPP-based strategies identified SLC37A2 as the direct target of CGA, validated by CETSA/MST. Molecular docking indicated CGA-SLC37A2 hydrogen bonding. CGA alleviated endoplasmic reticulum stress via SLC37A2, inhibiting TLR4/NF-κB and NLRP3 pathways to reduce inflammation. In SI-ALI mice and zebrafish models, CGA mitigated lung injury through these mechanisms taken together. This work highlights the therapeutic potential of CGA for SI-ALI and the critical role of SLC37A2 in combating infectious pneumonia.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-22"},"PeriodicalIF":1.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monoterpene derivatives from the fruits of Illicium simonsii 淫羊藿果实中的单萜衍生物。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-23 DOI: 10.1080/10286020.2025.2504964
Mi Li , Guo-Zhu Su , Hai-Qiang Wang , Xiao-Jing Wang , Li Li , Yu-Huan Li , Shuang-Gang Ma , Shi-Shan Yu
{"title":"Monoterpene derivatives from the fruits of Illicium simonsii","authors":"Mi Li ,&nbsp;Guo-Zhu Su ,&nbsp;Hai-Qiang Wang ,&nbsp;Xiao-Jing Wang ,&nbsp;Li Li ,&nbsp;Yu-Huan Li ,&nbsp;Shuang-Gang Ma ,&nbsp;Shi-Shan Yu","doi":"10.1080/10286020.2025.2504964","DOIUrl":"10.1080/10286020.2025.2504964","url":null,"abstract":"<div><div>Three previously undescribed monoterpene derivatives, illisimoncins A–C (<strong>1</strong>–<strong>3</strong>) and one undescribed 2-formylpyrrole alkaloid (<strong>4</strong>) were isolated from the fruits of <em>Illicium simonsii</em> together with five known monoterpenes (<strong>5</strong>-<strong>9</strong>). Structural elucidation of compounds <strong>1</strong>-<strong>4</strong> was elucidated through comprehensive spectroscopic analyses and their absolute configurations were determined by the dimolybdenum tetraacetate [Mo<sub>2</sub>(AcO)<sub>4</sub>]-induced ICD experiment and modified Mosher’s method. Compounds <strong>2</strong> and <strong>7</strong> showed antiviral activities against Coxsackievirus B3 with IC<sub>50</sub> values of 57.74 and 23.24 µM, respectively.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 6","pages":"Pages 834-843"},"PeriodicalIF":1.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biotransformation and activity identification of icariin in human intestinal fungus Pichia occidentalis. 西毕赤酵母中淫羊藿苷的生物转化及活性鉴定。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-21 DOI: 10.1080/10286020.2025.2493937
Jia-Shuo Li, Ru-Xin Yao, Qing Lv, Gang Wang, Xue Wang, Yu-Fei Wang, Fang-Yu Yang, Guo-Biao Liang, Zhuang Miao
{"title":"Biotransformation and activity identification of icariin in human intestinal fungus <i>Pichia occidentalis</i>.","authors":"Jia-Shuo Li, Ru-Xin Yao, Qing Lv, Gang Wang, Xue Wang, Yu-Fei Wang, Fang-Yu Yang, Guo-Biao Liang, Zhuang Miao","doi":"10.1080/10286020.2025.2493937","DOIUrl":"https://doi.org/10.1080/10286020.2025.2493937","url":null,"abstract":"<p><p>Compared to icariin, icariside II demonstrates superior absorption and metabolic properties along with enhanced bioactivity. In this study, using DXM-Glc fluorescence assay, <i>Pichia occidentalis</i> was identified as an intestinal fungus expressing functional glucosidase, which could efficiently convert icariin to icariside II via glycosidic bond hydrolysis, revealing the fungus-mediated intestinal glycoside metabolism pathway and determining the optimal conditions for the conversion, including temperature, drug loading, pH and reaction time. Meanwhile, icariside II exhibited anti-glioma activity, and its mechanism of action involved the inhibition of the activation of NF-κB signaling pathway in glioma cells.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatoprotective diterpenes from the nodes of Pinus massoniana. 马尾松结中保肝二萜的研究。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-21 DOI: 10.1080/10286020.2025.2506527
Jia-Qi Chen, Ling-Zhi Zhang, Jie Ma, Chuang-Jun Li, Ying-Da Zang, Hua Sun, Dong-Ming Zhang
{"title":"Hepatoprotective diterpenes from the nodes of <i>Pinus massoniana</i>.","authors":"Jia-Qi Chen, Ling-Zhi Zhang, Jie Ma, Chuang-Jun Li, Ying-Da Zang, Hua Sun, Dong-Ming Zhang","doi":"10.1080/10286020.2025.2506527","DOIUrl":"https://doi.org/10.1080/10286020.2025.2506527","url":null,"abstract":"<p><p>Three new diterpenes, named pinusins D-F (<b>1</b>-<b>3</b>), were isolated from the Chinese medicine \"<i>Pini Lignum Nodi</i>\" (the dried tuberculate or branched nodes of <i>Pinus massoniana</i>), along with twelve known diterpenes. The structures of these new compounds were determined using detailed spectroscopic methods and ECD calculations. Compounds <b>4</b>-<b>15</b> displayed moderate hepatoprotective activity against H<sub>2</sub>O<sub>2</sub>-induced oxidative damage in HepG2 cells, while compounds <b>5</b>-<b>15</b> exhibited markedly enhanced efficacy -surpassing that of bicyclol (positive control).</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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