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Journal of Asian Natural Products Research最新文献

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Synthesis of scaberol C amino acid ester derivatives with anti-cancer activity 具有抗癌活性的葶苈醇 C 氨基酸酯衍生物的合成
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-01 DOI: 10.1080/10286020.2024.2380737
Cheng-Long Li , Zheng Han , Dong-Ya Luo , Hui Ren , Li Ye , Guo-Dong Yao , Qing-Bo Liu
{"title":"Synthesis of scaberol C amino acid ester derivatives with anti-cancer activity","authors":"Cheng-Long Li ,&nbsp;Zheng Han ,&nbsp;Dong-Ya Luo ,&nbsp;Hui Ren ,&nbsp;Li Ye ,&nbsp;Guo-Dong Yao ,&nbsp;Qing-Bo Liu","doi":"10.1080/10286020.2024.2380737","DOIUrl":"10.1080/10286020.2024.2380737","url":null,"abstract":"<div><div>A series of amino acid ester trifluoroacetate derivatives was synthesized from scaberol C. They were screened for their inhibitory activity against Non-Small Cell Lung Cancer (NSCLC) cells. Among them, compound <strong>2 l</strong> showed significant cytotoxicity against A549 and H460 cells (IC<sub>50</sub>), and was more active than cisplatin (DDP). The epidermal growth factor receptor (EGFR) was overexpressed in NSCLC, which was the target of multiple cancer therapies and a strong prognostic indicator. Our previous studies reported that the target of scaberol C derivatives against NSCLC cells was EGFR. And then molecular docking analysis and molecular dynamics (MD) simulations indicated that <strong>2 l</strong> can stably and covalently bind to the EGFR target protein.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 2","pages":"Pages 189-206"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141785214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A review on phytochemicals as combating weapon for multidrug resistance in cancer 综述植物化学物质作为抗击癌症多药耐药性的武器。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-01 DOI: 10.1080/10286020.2024.2386678
Sharwan Gupta , Anuradha Mehra , Rekha Sangwan
{"title":"A review on phytochemicals as combating weapon for multidrug resistance in cancer","authors":"Sharwan Gupta ,&nbsp;Anuradha Mehra ,&nbsp;Rekha Sangwan","doi":"10.1080/10286020.2024.2386678","DOIUrl":"10.1080/10286020.2024.2386678","url":null,"abstract":"<div><div>One can recognize multidrug resistance (MDR) and residue as a biggest difficulty in cancer specialist. Chemotherapy-resistant cancer may be successfully treated by combining MDR-reversing phytochemicals with anticancer drugs. Though, clinical application of phytochemicals either alone or in conjunction with chemotherapy is still in its early stages or requires more research to determine their safety and efficacy. In this review we highlighted topics related to MDR in cancer, including an introduction to subject, mechanism of action of efflux pump, specific proteins involved in drug resistance, altered drug targets, increased drug metabolism, and potential role of phytochemicals in overcoming drug resistance.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 2","pages":"Pages 107-125"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141909868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening of GLP-1r agonists from natural products using affinity ultrafiltration screening coupled with UPLC-ESI-Orbitrap-MS technology: a case study of Panax ginseng 利用 UPLC-ESI-Orbitrap-MS 技术进行亲和超滤筛选，从天然产品中筛选 GLP-1r 激动剂：三七案例研究。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-01 DOI: 10.1080/10286020.2024.2378821
Hong-Ping Wang , Zhao-Zhou Lin , Qiong Yin , Jing Du
{"title":"Screening of GLP-1r agonists from natural products using affinity ultrafiltration screening coupled with UPLC-ESI-Orbitrap-MS technology: a case study of Panax ginseng","authors":"Hong-Ping Wang ,&nbsp;Zhao-Zhou Lin ,&nbsp;Qiong Yin ,&nbsp;Jing Du","doi":"10.1080/10286020.2024.2378821","DOIUrl":"10.1080/10286020.2024.2378821","url":null,"abstract":"<div><div>In our study, a method based on affinity ultrafiltration screening coupled with UPLC-ESI-Orbitrap-MS technology was established to select Glucagon-like peptide-1 receptor (GLP-1R) agonists from natural products, and as an example, the GLP-1R agonists from <em>Panax ginseng</em> was selected using our established method. As a result, total five GLP-1R agonists were selected from <em>Panax ginseng</em> for the first time. Our results indicated that activating GLP-1R to promote insulin secretion probably was another important hypoglycemia mechanism for ginsenosides in <em>Panax ginseng</em>, which had great influence on the study of the anti-diabetes effect of ginsenosides.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 2","pages":"Pages 176-188"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pandanus tectorius fruits attenuated cell injury and oxidative stress in high glucose-induced Schwann cells by activating Nrf2/Keap1 signaling pathway.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-01-31 DOI: 10.1080/10286020.2025.2451340
Jin-Gui Zhang, Jin-Ping Cai, Yu-Xia Wu, Jia-Liang Guo, Yu-Qing Li, Chao Wang
{"title":"Pandanus tectorius fruits attenuated cell injury and oxidative stress in high glucose-induced Schwann cells by activating Nrf2/Keap1 signaling pathway.","authors":"Jin-Gui Zhang, Jin-Ping Cai, Yu-Xia Wu, Jia-Liang Guo, Yu-Qing Li, Chao Wang","doi":"10.1080/10286020.2025.2451340","DOIUrl":"https://doi.org/10.1080/10286020.2025.2451340","url":null,"abstract":"<p><p>We studied the protective effects of Pandanus tectorius fruits (PTF) on Schwann cells and sciatic nerve damage in diabetic peripheral neuropathy (DPN) rats. PTF improved RSC96 cell viability and increased Nrf2, Keap1, HO-1, and NQO1 expression. PTF reduced apoptosis and ROS in high glucose-treated cells, which was reversed by Nrf2 siRNA. Co-treatment with SFN further decreased apoptosis and ROS. PTF increased SOD, GSH-Px, NGF, IGF-1, and VEGF activities, reduced by Nrf2 knockdown but restored with SFN. MDA levels showed opposite trends. In DPN rats, PTF reduced pain and prevented nerve damage, suggesting it alleviates DPN by activating the Nrf2/Keap1 pathway.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-17"},"PeriodicalIF":1.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new steroid from Penicillium brocae G2131.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-01-31 DOI: 10.1080/10286020.2025.2451332
Jie-Yi Zhou, Chen-Yang Cui, Li-Na Mao, Qun Zhou, Zhi-Ping Wang
{"title":"A new steroid from <i>Penicillium brocae</i> G2131.","authors":"Jie-Yi Zhou, Chen-Yang Cui, Li-Na Mao, Qun Zhou, Zhi-Ping Wang","doi":"10.1080/10286020.2025.2451332","DOIUrl":"https://doi.org/10.1080/10286020.2025.2451332","url":null,"abstract":"<p><p>A comprehensive study was carried out on <i>Penicillium brocae</i> G2131, which originated from Yunnan Menghai Pu'er tea. This study resulted in the identification of five compounds, one of which is a newly discovered compound: (5aR)-6-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-5a-methyl-5,5a,6,7,8,8a-hexa hydro-2H-indeno[5,4-b]furan-2-one (<b>1</b>), four known compounds: demethylincisterol A<sub>3</sub> (<b>2</b>), (22<i>E</i>, 24 <i>R</i>)-ergosta-7,9(11),22-trien-3<i>β</i>-ol (<b>3</b>), (22<i>E</i>,24<i>R</i>)-5<i>α</i>,8<i>α</i>-epidixyer-gosta-6,22-dien-3<i>β</i>-ol (<b>4</b>) and <i>p</i>- hydroxybenzaldehyde (<b>5</b>). The structure of compound <b>1</b> was determined using a variety of spectroscopic methods such as <sup>1</sup>H spectrum,<sup>13</sup>C spectrum, HMBC, HSQC,<sup>1</sup>H-<sup>1</sup>H COSY, LC-MS, UV, IR and comparison of their NMR data with literature. The absolute configuration of compound <b>1</b> was established by comparing the experimental and ECD spectra. All compounds were tested for their anti-acetylcholine activity, however, none of them demonstrated any anti-acetylcholine activity.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and biological evaluation of oleanolic acid derivatives as potential c-kit inhibitors.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-01-31 DOI: 10.1080/10286020.2025.2451336
Zhen-Yu Kuai, Zheng-Fei Zhu, Xuan Zeng, Yan-Qiu Meng
{"title":"Synthesis and biological evaluation of oleanolic acid derivatives as potential c-kit inhibitors.","authors":"Zhen-Yu Kuai, Zheng-Fei Zhu, Xuan Zeng, Yan-Qiu Meng","doi":"10.1080/10286020.2025.2451336","DOIUrl":"https://doi.org/10.1080/10286020.2025.2451336","url":null,"abstract":"<p><p>The 3-O-(4'-imidazole)-12-en-olean-28-amide derivatives <b>7-1</b> to <b>7-11</b> through modification the C-3 and C-28 of the natural product oleanolic acid were prepared, and their structures were confirmed by MS,<sup>1</sup>H NMR and <sup>13</sup>C NMR. The antitumor activities of these compounds against breast cancer MCF-7 and gastric cancer SGC7901 cells <i>in vitro</i> were determined by MTT assay. Cell tests showed that the antitumor activities of compound <b>7-10</b> exhibited significant antitumor activity which was equivalent to the positive control drug nilotinib, and the affinity was verified by molecular dynamics experiment <i>in vitro</i>. Molecular docking showed that compound <b>7-10</b> have high binding ability with c-kit. Therefore, compound <b>7-10</b> has the potential to become a new c-kit inhibitor, which deserves further research.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analytical method development and validation for monosaccharide profiling in Lignosus rhinocerotis using rP-HPLC.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-01-31 DOI: 10.1080/10286020.2025.2453852
Solehah Mohd Rosdan Bushra, Ruzilawati Abu Bakar, Asma Abdullah Nurul
{"title":"Analytical method development and validation for monosaccharide profiling in <i>Lignosus rhinocerotis</i> using rP-HPLC.","authors":"Solehah Mohd Rosdan Bushra, Ruzilawati Abu Bakar, Asma Abdullah Nurul","doi":"10.1080/10286020.2025.2453852","DOIUrl":"https://doi.org/10.1080/10286020.2025.2453852","url":null,"abstract":"<p><p><i>Lignosus rhinocerotis</i> is rich in polysaccharide with diverse -bioactivities. This study developed a pre-column derivatization reversed-phase high-performance liquid chromatography (RP-HPLC) method for analyzing monosaccharides in <i>Lignosus rhinocerotis</i> polysaccharides (LRP). LRP underwent hydrolysis, derivatization, and separation on a Cosmosil 5C18-MS-II column at 254 nm. Baseline separation of eight standard monosaccharides was achieved within 45 min. Calibration curves, precision, and accuracy were validated. Quantitative analysis revealed LRP as a heteropolysaccharide containing mannose, ribose, rhamnose, glucose, galactose, xylose, and arabinose, with 100.28-111.02% recovery. This optimized RP-HPLC offers a simple, reproducible, and accurate tool for LRP monosaccharides analysis, facilitating in understanding its structure-function relationship.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the potential anticancer targets and mechanistic pathways of Elsholtzia densa essential oil based on network pharmacology. 基于网络药理学的密枝精油潜在抗癌靶点及作用机制探讨。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-01-10 DOI: 10.1080/10286020.2024.2446294
Qian Wang, Xiao-Ying Wang, Jin Tao, Jin-Tao Nie, Yi-Han Zhou, Jing Huang, Jia-Yuan Zhao, Ya-Nan Wang
{"title":"Exploring the potential anticancer targets and mechanistic pathways of <i>Elsholtzia densa</i> essential oil based on network pharmacology.","authors":"Qian Wang, Xiao-Ying Wang, Jin Tao, Jin-Tao Nie, Yi-Han Zhou, Jing Huang, Jia-Yuan Zhao, Ya-Nan Wang","doi":"10.1080/10286020.2024.2446294","DOIUrl":"https://doi.org/10.1080/10286020.2024.2446294","url":null,"abstract":"<p><p>This study aimed to assess the composition of <i>Elsholtzia densa</i> essential oil (EBE) and identify potential targets for inhibiting human hepatocellular carcinoma cell proliferation. The plants were collected from four regions: Jiuzhi, Qinghai; Ruoergai, Sichuan; Aba, Sichuan; and Jiulong, Sichuan. Four EBEs (named No. 1 to No. 4) were analyzed by gas chromatograph-mass spectrometer. EBEs significantly inhibited human hepatocellular carcinoma cells. The EBE collected from Jiuzhi exhibited the most potent inhibitory effect. Core targets identified included MAPK3, EGFR, ESR1, CASP3, PTGS2, BCL2L1, and MAPK14. Notably, the four EBEs prevented hepatocellular carcinoma cell proliferation via neuroactive ligand-receptor interactions and apoptosis pathways.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-20"},"PeriodicalIF":1.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of intestinal bacterial carboxylesterase-mediated metabolites and the potential antitumour molecular mechanism of angoroside C. 肠道细菌羧酸酯酶代谢产物及赤霉素C潜在的抗肿瘤分子机制分析。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-01-10 DOI: 10.1080/10286020.2024.2441823
Jian-Ye Song, Xiang Hui, Ru Feng, Yi Zhao, Jia-Chun Hu, Jing-Yu Jin, Jin-Yue Lu, Hui Xu, Jing-Yue Wang, Heng-Tong Zuo, Meng-Liang Ye, Yan Wang
{"title":"Analysis of intestinal bacterial carboxylesterase-mediated metabolites and the potential antitumour molecular mechanism of angoroside C.","authors":"Jian-Ye Song, Xiang Hui, Ru Feng, Yi Zhao, Jia-Chun Hu, Jing-Yu Jin, Jin-Yue Lu, Hui Xu, Jing-Yue Wang, Heng-Tong Zuo, Meng-Liang Ye, Yan Wang","doi":"10.1080/10286020.2024.2441823","DOIUrl":"https://doi.org/10.1080/10286020.2024.2441823","url":null,"abstract":"<p><p>Angoroside C (AgrC) is a compound with many pharmacological properties. However, its antitumour potential has not been well studied. The low bioavailability of AgrC suggests a strong link to gut bacteria. Therefore, we identified and quantified four AgrC metabolites in gut microbiota. Molecular docking and inhibitor-based experiments demonstrated that carboxylesterase played a key role in AgrC metabolism. Both AgrC and its metabolites inhibited the viability of CT-26 cells, and potential antitumour targets were further explored. Additionally, AgrC significantly increased the levels of propionic, butyric, valeric and isovaleric acids. This provides a new insight for the antitumour effects of AgrC.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-18"},"PeriodicalIF":1.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cynatroside B2, a new anti-inflammatory C21 steroid from the roots and rhizomes of Vincetoxicum atratum. Cynatroside B2，一种新的抗炎甾体C21，从白花长春花根和根茎中提取。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-01-10 DOI: 10.1080/10286020.2024.2446302
Jing-Yu Zhang, Yi-Nuo Shi, Sheng Dong, Chen Ji, Yang Yu, Jiu-Zhi Yuan, Chong-Ning Lv, Jin-Cai Lu
{"title":"Cynatroside B<sub>2</sub>, a new anti-inflammatory C<sub>21</sub> steroid from the roots and rhizomes of <i>Vincetoxicum atratum</i>.","authors":"Jing-Yu Zhang, Yi-Nuo Shi, Sheng Dong, Chen Ji, Yang Yu, Jiu-Zhi Yuan, Chong-Ning Lv, Jin-Cai Lu","doi":"10.1080/10286020.2024.2446302","DOIUrl":"https://doi.org/10.1080/10286020.2024.2446302","url":null,"abstract":"<p><p>A series of C<sub>21</sub> steroidal glycosides were isolated from the roots and rhizomes of <i>Vincetoxicum atratum</i> (Bunge) C. Morren et Decne., including a new compound, cynatroside B<sub>2</sub> (<b>1</b>), and seven known compounds (<b>2</b>-<b>8</b>). Their structures were identified by comprehensive spectroscopic analyses, including NMR and HR-ESI-MS spectral data. The isolated steroids were evaluated for their anti-inflammatory activity against lipopolysaccharide-induced mouse macrophage RAW264.7 cells. Compound <b>1</b> displayed a significant inhibitory effect on NO, TNF-<i>α</i> and IL-1<i>β</i>.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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