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Journal of Asian Natural Products Research最新文献

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Atramacronoid A induces the PANoptosis-like cell death of human breast cancer cells through the CASP-3/PARP-GSDMD-MLKL pathways. Atramacronoid A可通过CASP-3/PARP-GSDMD-MLKL途径诱导人乳腺癌细胞的泛凋亡样细胞死亡。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-12-01 Epub Date: 2024-07-03 DOI: 10.1080/10286020.2024.2368841
Jing-Rong Li, Ling-Yu Li, Hai-Xin Zhang, Ming-Qin Zhong, Zhong-Mei Zou
{"title":"Atramacronoid A induces the PANoptosis-like cell death of human breast cancer cells through the CASP-3/PARP-GSDMD-MLKL pathways.","authors":"Jing-Rong Li, Ling-Yu Li, Hai-Xin Zhang, Ming-Qin Zhong, Zhong-Mei Zou","doi":"10.1080/10286020.2024.2368841","DOIUrl":"10.1080/10286020.2024.2368841","url":null,"abstract":"<p><p>Breast cancer is the most common malignant tumor and a major cause of mortality among women worldwide. Atramacronoid A (AM-A) is a unique natural sesquiterpene lactone isolated from the rhizome of <i>Atractylodes macrocephala</i> Koidz (known as Baizhu in Chinese). Our study demonstrated that AM-A triggers a specific form of cell death resembling PANoptosis-like cell death. Further analysis indicated that AM-A-induced PANoptosis-like cell death is associated with the CASP-3/PARP-GSDMD-MLKL pathways, which are mediated by mitochondrial dysfunction. These results suggest the potential of AM-A as a lead compound and offer insights for the development of therapeutic agents for breast cancer from natural products.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1475-1488"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Five new glycosides from the culms of Phyllostachys nigra var. henonis. 从黑木耳变种秆中提取的五种新苷。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-12-01 Epub Date: 2024-07-04 DOI: 10.1080/10286020.2024.2366450
Bao Zhang, Hai-Hua Yuan, Jia Sun, Hang Xun, Jie Wang, Feng Qiu, Jian-Jun Wang, Xi Yao, Jin Wang, Wei Fan, Feng Tang
{"title":"Five new glycosides from the culms of <i>Phyllostachys nigra</i> var. <i>henonis</i>.","authors":"Bao Zhang, Hai-Hua Yuan, Jia Sun, Hang Xun, Jie Wang, Feng Qiu, Jian-Jun Wang, Xi Yao, Jin Wang, Wei Fan, Feng Tang","doi":"10.1080/10286020.2024.2366450","DOIUrl":"10.1080/10286020.2024.2366450","url":null,"abstract":"<p><p>Five new glycosides, namely methyl 3-methoxybenzoate-4,5-di-<i>O</i>-<i>β</i>-D-glucopyranoside <b>(1)</b>, (1a<i>S</i>,3a<i>S</i>,3<i>R</i>)-3-(4'-<i>O</i>-<i>β</i>-D-glucopyranosyl-3'-methoxyphenyl)-5,6-dioxa-bicyclo[3.3.0]octane-1-one <b>(2)</b>, quinolin-4(1<i>H</i>)-one-3-<i>O</i>-<i>β</i>-D-glucopyranoside <b>(3)</b>, 3-methoxy-propiophenone 4-<i>O</i>-(6'-<i>β</i>-D-xylopyranosyl)-<i>β</i>-D-glucopyranoside <b>(4)</b>, methyl 3-methoxybenzoate 4-<i>O</i>-(6'-<i>β</i>-D-xylopyranosyl)-<i>β</i>-D-glucopyranoside <b>(5)</b>, and one known compound, bambulignan B <b>(6)</b> were isolated from the culms of <i>Phyllostachys nigra</i> var<i>. henonis</i>. Their structures were determined using spectroscopic analysis. All compounds were evaluated for their DPPH radical scavenging activity. Compound <b>6</b> exhibited antioxidant activity with IC<sub>50</sub> value of 59.5 μM (positive control, L-ascorbic acid, IC<sub>50</sub> = 12.4 μM; 2,6-ditertbutyl-4-methyl phenol, IC<sub>50</sub> = 11.8 μM).</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1421-1429"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of radish seeds (Semen Raphani) on the absorption and transportation of ginsenosides in the Caco-2 cell model: a UPLC-ESI-MS analysis. 萝卜籽（Semen Raphani）对人参皂苷在 Caco-2 细胞模型中的吸收和运输的影响：UPLC-ESI-MS 分析。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-12-01 Epub Date: 2024-06-13 DOI: 10.1080/10286020.2024.2366008
Hui Li, Wen-Shuo Zhang, Rui Liu, Wei Wang, Li-Li Jiao, Zhi Liu, Wei Wu
{"title":"Impact of radish seeds (Semen Raphani) on the absorption and transportation of ginsenosides in the Caco-2 cell model: a UPLC-ESI-MS analysis.","authors":"Hui Li, Wen-Shuo Zhang, Rui Liu, Wei Wang, Li-Li Jiao, Zhi Liu, Wei Wu","doi":"10.1080/10286020.2024.2366008","DOIUrl":"10.1080/10286020.2024.2366008","url":null,"abstract":"<p><p>This study examined the impact of Semen raphani on the absorption of ginsenosides from <i>Panax ginseng</i> C.A. Meyer (ginseng) using a Caco-2 cell model and Ultra-High-Performance Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry (UPLC-ESI-MS). Six primary ginsenosides (Rg1, Re, Rb1, Rb2, Rc, Rd) were quantified. Results showed that Semen Raphani increased the efflux rate of ginsenosides, particularly at higher concentrations, suggesting it inhibits their absorption. The research elucidates the intestinal absorption process of ginsenosides and the antagonistic mechanism of Semen Raphani against ginseng.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1430-1444"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral health promotion of flavonoids from Scutellaria baicalensis. 黄芩中的黄酮类化合物对口腔健康的促进作用
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-11-26 DOI: 10.1080/10286020.2024.2428797
Bai-Xiang Cai, Qing-Yang Wu, Jin-Lian Huang, Jing Wu, Yang Yu, Lei Xiao, Xiang-Hai Cai
{"title":"Oral health promotion of flavonoids from <i>Scutellaria baicalensis</i>.","authors":"Bai-Xiang Cai, Qing-Yang Wu, Jin-Lian Huang, Jing Wu, Yang Yu, Lei Xiao, Xiang-Hai Cai","doi":"10.1080/10286020.2024.2428797","DOIUrl":"https://doi.org/10.1080/10286020.2024.2428797","url":null,"abstract":"<p><p>Looking for materials from <i>Scutellaria baicalensis</i> to improve oral inflammation and eliminate bad breath led to one new compound, 5,7,2',5'-tetrahydroxy-6'-methoxyflavone (<b>1</b>) and 32 known ones. Among of them, 3 flavones (<b>11</b>, <b>17</b>, <b>18</b>), 2 dihydroflavones (<b>23</b>, <b>25</b>), 2 flavone glucosides (<b>30</b>, <b>32</b>), and a chalcone (<b>26</b>) could inhibit oral anaerobic bacteria <i>Fusobacterium nucleatum</i>, <i>Streptococcus mutans</i>, and <i>Porphyromonas gingivalis</i>. Compounds <b>3, 14</b>, <b>18</b> could inhibit oral bacterial <i>Staphylococcus aureus</i>. Compounds <b>5</b>, <b>8</b>, <b>13</b> and <b>21</b> exhibited strong inhibitory NO production. Additionally, <b>14</b> and <b>26</b> showed good COX-1/2 inhibitory effects. These results indicated <i>S. baicalensis</i> has potential oral health benefits.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.3,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medicinal plants or bioactive components with antioxidant/anti-apoptotic effects as a potential therapeutic approach in heart failure prevention and management: a literature review. 将具有抗氧化/抗细胞凋亡作用的药用植物或生物活性成分作为预防和治疗心力衰竭的潜在治疗方法：文献综述。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-11-22 DOI: 10.1080/10286020.2024.2414196
Atefeh Jalali, Maryam Kabiri, Shima Hashemi, Alireza Abdi Ardekani, Mohammad M Zarshenas
{"title":"Medicinal plants or bioactive components with antioxidant/anti-apoptotic effects as a potential therapeutic approach in heart failure prevention and management: a literature review.","authors":"Atefeh Jalali, Maryam Kabiri, Shima Hashemi, Alireza Abdi Ardekani, Mohammad M Zarshenas","doi":"10.1080/10286020.2024.2414196","DOIUrl":"https://doi.org/10.1080/10286020.2024.2414196","url":null,"abstract":"<p><p>Heart failure is described as a complicated syndrome, which is estimated that 56.2 million people were living with HF globally in 2019. Oxidative stress and apoptosis play a major role on HF development via targeting several signaling pathways in cardiac cells. This study investigated medicinal plants or their bioactive components with positive effects on HF management. In this research, keywords \"heart failure,\" \"plant,\" \"antioxidant\" or \"radical scavenging,\" \"herbal\" and \"apoptosis\" were synchronously searched through popular databases from 1990 up to 2023. Finally, the role of oxidative stress and apoptosis in HF development was searched and related signaling pathways were investigated.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-17"},"PeriodicalIF":1.3,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Total synthesis and antibacterial evaluation of lupalbigenin and isolupalbigenin. lupalbigenin 和 isolupalbigenin 的全合成和抗菌评价。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-11-21 DOI: 10.1080/10286020.2024.2428794
Li Liao, Na Wang, Ling Mei, Bin Long, Tong Luo, Meng-Qi Wang, Lan Lu, Hong-Bo Dong
{"title":"Total synthesis and antibacterial evaluation of lupalbigenin and isolupalbigenin.","authors":"Li Liao, Na Wang, Ling Mei, Bin Long, Tong Luo, Meng-Qi Wang, Lan Lu, Hong-Bo Dong","doi":"10.1080/10286020.2024.2428794","DOIUrl":"https://doi.org/10.1080/10286020.2024.2428794","url":null,"abstract":"<p><p>Lupalbigenin (<b>1</b>) is an antibacterial isoflavone isolated from <i>Maclura cochinchinensis</i> (Lour.) Corner (Moraceae). In this study, we achieved the first gram-scale synthesis of lupalbigenin (<b>1</b>) from commercially available genistein (<b>2</b>), with a yield of 47.7%. The key step was a Claisen rearrangement that simultaneously installed two prenyl groups at the C-6 and C-11 positions of lupalbigenin (<b>1</b>). Antimicrobial activity assays revealed that lupalbigenin (<b>1</b>) exhibited rapid bactericidal activity, inhibited α-hemolysin and biofilm formation, and disrupted bacterial cell membranes. These findings suggest that lupalbigenin (<b>1</b>) is a promising candidate for the development of novel antibiotics to combat bacterial infections.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery of two new long chain fatty acid esters of flavonol glycoside from Pollen Typhae Carbonisatus and their protective effects on HBMECs. 从花粉草中发现两种新的长链脂肪酸酯黄酮醇苷及其对 HBMEC 的保护作用
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-11-21 DOI: 10.1080/10286020.2024.2428238
Min-Jie Liu, Dong-Quan Gu, Ren-Zhong Wang, Kai-Di Wang, Si-Yu Wu, Shuang Han, De-Ling Wu, Feng-Qing Xu, Wu-Xi Zhou
{"title":"Discovery of two new long chain fatty acid esters of flavonol glycoside from Pollen Typhae Carbonisatus and their protective effects on HBMECs.","authors":"Min-Jie Liu, Dong-Quan Gu, Ren-Zhong Wang, Kai-Di Wang, Si-Yu Wu, Shuang Han, De-Ling Wu, Feng-Qing Xu, Wu-Xi Zhou","doi":"10.1080/10286020.2024.2428238","DOIUrl":"https://doi.org/10.1080/10286020.2024.2428238","url":null,"abstract":"<p><p>ABATRACTTwo new compounds, namely, isorhamnenin-3-<i>O</i>-neohesperidin-6''-linoleic acid ester (<b>1</b>) and isorhamnenin-3-<i>O</i>-neohesperidin-6''-palmitate (<b>2</b>), along with 17 known compounds, were isolated from Pollen Typhae Carbonisatus (PTC). Their structures were elucidated on the basis of one-dimensional (1D)-, two-dimensional (2D)-nuclear magnetic resonance (NMR), and high-resolution electrospray ionization mass spectrometry (HRESIMS) spectroscopic data analyses. The two new compounds (<b>1</b> and <b>2</b>) exhibited a protective effect in a dose-dependent manner and promoted tube generation in the oxygen-glucose deprivation/reoxygenation (OGD/R)-induced human brain microvascular endothelial cells (HBMECs).</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Talarindigotin A: a cytotoxic indigotin derivative, from the mangrove endophytic fungus Talaromyces amestolkiae SCNU-F0041. Talarindigotin A：一种细胞毒性靛红衍生物，来自红树林内生真菌 Talaromyces amestolkiae SCNU-F0041。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-11-20 DOI: 10.1080/10286020.2024.2428228
Jia-Lin Li, Ling-Ling Liu, Zi-Rong Lin, Hai-Qi Zeng, Zhe Zhou, Yu-Hua Long
{"title":"Talarindigotin A: a cytotoxic indigotin derivative, from the mangrove endophytic fungus <i>Talaromyces amestolkiae</i> SCNU-F0041.","authors":"Jia-Lin Li, Ling-Ling Liu, Zi-Rong Lin, Hai-Qi Zeng, Zhe Zhou, Yu-Hua Long","doi":"10.1080/10286020.2024.2428228","DOIUrl":"https://doi.org/10.1080/10286020.2024.2428228","url":null,"abstract":"<p><p>A new indigotin alkaloid, named talarindigotin A (<b>1</b>), along with the analogue 5H, 6H-quinindolin-11-one (<b>2</b>) were isolated from the mangrove endophytic fungus <i>Talaromyces amestolkiae</i> SCNU-F0041. Their structures were assigned on the basis of NMR, HRMS, and single-crystal X-ray diffraction analysis. In the cytotoxic bioassay, compound <b>1</b> showed great cytotoxicity against HepG2, Hela, HCT116, and Huh7 human cancer cell lines with IC<sub>50</sub> values ranging from 2.08 to 4.58 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.3,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Garcinia cowa bark extract induces oxidative stress mediated cellular apoptosis in Leishmania donovani parasite modulated by its active phytosterol constituent. 藤黄树皮提取物通过其活性植物甾醇成分的调节，诱导由氧化应激介导的唐氏利什曼原虫细胞凋亡。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-11-20 DOI: 10.1080/10286020.2024.2429145
Nibedita Pyne, Ishita Bhattacharya, Santanu Paul
{"title":"<i>Garcinia cowa</i> bark extract induces oxidative stress mediated cellular apoptosis in <i>Leishmania donovani</i> parasite modulated by its active phytosterol constituent.","authors":"Nibedita Pyne, Ishita Bhattacharya, Santanu Paul","doi":"10.1080/10286020.2024.2429145","DOIUrl":"https://doi.org/10.1080/10286020.2024.2429145","url":null,"abstract":"<p><p>Visceral leishmaniasis still remains a leading cause of parasitic deaths, with modern pentavalent antimonials showing limited efficacy and health risks. The methanolic bark extract of the Northeastern Indian plant, <i>Garcinia cowa</i>, demonstrated potent leishmanicidal effects against the parasite <i>Leishmania donovani</i>, demonstrating IC<sub>50</sub> values of 20-36 µg/ml, with selective toxicity for parasites over healthy cells. It induced parasite death through elevated oxidative and nitrosative stress elements, reduced arginase activity, nuclear fragmentation, cell cycle arrest, and apoptosis. A GC-MS study and molecular docking identified stigmasterol as a primary component, an antileishmanial compound that inhibits <i>Leishmania donovani</i> parasite efficiently.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-23"},"PeriodicalIF":1.3,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New 3-acyl derivatives of glaucocalyxin A: designed, synthesis and in vitro antibacterial activities. 琉璃苣毒素 A 的新 3-酰基衍生物：设计、合成和体外抗菌活性。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-11-20 DOI: 10.1080/10286020.2024.2429136
Wei-Xian Yang, Wei-Qing Zhang, Mei-Qi Wei, Mei-Hui Duan, Xian-Ji Liu, Chen Yan
{"title":"New 3-acyl derivatives of glaucocalyxin A: designed, synthesis and <i>in vitro</i> antibacterial activities.","authors":"Wei-Xian Yang, Wei-Qing Zhang, Mei-Qi Wei, Mei-Hui Duan, Xian-Ji Liu, Chen Yan","doi":"10.1080/10286020.2024.2429136","DOIUrl":"https://doi.org/10.1080/10286020.2024.2429136","url":null,"abstract":"<p><p>To discover novel antimicrobial drug, 22 novel acylated derivatives were synthesized by A-ring modification of glaucocalyxin A. The structures of these derivatives were confirmed by NMR and MS data. <i>In vitro</i> antimicrobial activity of these compounds was evaluated against <i>E. faecium</i>, <i>E. faecalis</i>, MRSA, <i>E. coli</i>, <i>A. baumannii</i> and <i>K. pneumoniae</i>. The results showed compound <b>3d</b> against <i>E. faecium</i>, <i>E. faecalis</i> and MRSA with a minimum inhibitory concentration of 4 μg/ml. And further molecular docking revealed that compound <b>3d</b> has a higher binding affinity. In conclusion, compound <b>3d</b> has the potential to develop into a new drug against drug-resistant bacteria.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.3,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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