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Journal of Asian Natural Products Research最新文献

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Four new alkaloids from Dactylicapnos grandifoliolata. 大叶菖蒲中4个新生物碱。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-14 DOI: 10.1080/10286020.2025.2527884
Xin-Yu Liu, Jing Wu, Feng Wei, Mei-Fen Bao, Hui-Yuan Gao, Xiang-Hai Cai
{"title":"Four new alkaloids from <i>Dactylicapnos grandifoliolata</i>.","authors":"Xin-Yu Liu, Jing Wu, Feng Wei, Mei-Fen Bao, Hui-Yuan Gao, Xiang-Hai Cai","doi":"10.1080/10286020.2025.2527884","DOIUrl":"https://doi.org/10.1080/10286020.2025.2527884","url":null,"abstract":"<p><p>The first phytochemical investigation on <i>D. grandifoliolata</i> yielded twenty-four alkaloids, including four new ones, <i>N</i>-butylacetamide magnococline (<b>1</b>), fumariflorine methyl ester (<b>6</b>), (<i>R</i>)-corydalisol-2<i>β</i>-<i>N</i>-oxide (<b>9</b>), and (<i>R</i>)-coryximine-2<i>α</i>-<i>N</i>-oxide (<b>10</b>). Among them, compound <b>1</b> was an <i>N-</i>butylacetamide-substituted benzylisoquinoline alkaloid. Compounds <b>9</b> and <b>10</b> were <i>N</i>-oxides of benzylisoquinoline alkaloids. The structures of the new alkaloids were determined through comprehensive spectroscopic analysis and ECD calculations.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.3,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three new shikimate-conjugated meroterpenoids from Alternaria alternata isolated from an entomopathogenic fungus Apis mellifera. 从昆虫病原真菌蜜蜂中分离得到的三个新的莽草碱共轭角萜类化合物。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-04 DOI: 10.1080/10286020.2025.2521542
Ya-Nan Tian, Yu-Wei Niu, Ke-Liang Chen, Yang Liu, Chen-Yu Yang, Xing-Bao Jia, Yang Yang, Yun-Bao Liu
{"title":"Three new shikimate-conjugated meroterpenoids from <i>Alternaria alternata</i> isolated from an entomopathogenic fungus <i>Apis mellifera</i>.","authors":"Ya-Nan Tian, Yu-Wei Niu, Ke-Liang Chen, Yang Liu, Chen-Yu Yang, Xing-Bao Jia, Yang Yang, Yun-Bao Liu","doi":"10.1080/10286020.2025.2521542","DOIUrl":"https://doi.org/10.1080/10286020.2025.2521542","url":null,"abstract":"<p><p>Three new shikimate-conjugated meroterpenes, tricycloalternarenes Z1-Z3 (<b>1</b>-<b>3</b>), were isolated from <i>Alternaria alternate</i>, an endophytic fungus residing in <i>Apis mellifera</i>. The structures of new compounds were characterized by analyses of their NMR and HRESIMS data. The absolute configurations were assigned through electronic circular dichroism (ECD) calculations and CD spectra. Bioassay results showed that tricycloalternarene Z1 (<b>1</b>) exhibited moderate anti-inflammatory activity against the LPS-induced production of NO in RAW 264.7 cells, with an IC<sub>50</sub> value of 0.93 <i>µ</i>M.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the potential anticancer targets and mechanistic pathways of Elsholtzia densa essential oil based on network pharmacology 基于网络药理学的密枝精油潜在抗癌靶点及作用机制探讨。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-03 DOI: 10.1080/10286020.2024.2446294
Qian Wang , Xiao-Ying Wang , Jin Tao , Jin-Tao Nie , Yi-Han Zhou , Jing Huang , Jia-Yuan Zhao , Ya-Nan Wang
{"title":"Exploring the potential anticancer targets and mechanistic pathways of Elsholtzia densa essential oil based on network pharmacology","authors":"Qian Wang ,&nbsp;Xiao-Ying Wang ,&nbsp;Jin Tao ,&nbsp;Jin-Tao Nie ,&nbsp;Yi-Han Zhou ,&nbsp;Jing Huang ,&nbsp;Jia-Yuan Zhao ,&nbsp;Ya-Nan Wang","doi":"10.1080/10286020.2024.2446294","DOIUrl":"10.1080/10286020.2024.2446294","url":null,"abstract":"<div><div>This study aimed to assess the composition of <em>Elsholtzia densa</em> essential oil (EBE) and identify potential targets for inhibiting human hepatocellular carcinoma cell proliferation. The plants were collected from four regions: Jiuzhi, Qinghai; Ruoergai, Sichuan; Aba, Sichuan; and Jiulong, Sichuan. Four EBEs (named No. 1 to No. 4) were analyzed by gas chromatograph-mass spectrometer. EBEs significantly inhibited human hepatocellular carcinoma cells. The EBE collected from Jiuzhi exhibited the most potent inhibitory effect. Core targets identified included MAPK3, EGFR, ESR1, CASP3, PTGS2, BCL2L1, and MAPK14. Notably, the four EBEs prevented hepatocellular carcinoma cell proliferation via neuroactive ligand-receptor interactions and apoptosis pathways.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 7","pages":"Pages 1038-1057"},"PeriodicalIF":1.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new biflavanol from bark of Nothotsuga longibracteata 从长苞木杉树皮中分离出一种新的双黄烷醇。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-03 DOI: 10.1080/10286020.2024.2446282
Yi-Lin Wu , Min-Jian Dong , Cheng-Xin Sun , Mao-Sheng Zhang , Shi-Ji Xiao
{"title":"A new biflavanol from bark of Nothotsuga longibracteata","authors":"Yi-Lin Wu ,&nbsp;Min-Jian Dong ,&nbsp;Cheng-Xin Sun ,&nbsp;Mao-Sheng Zhang ,&nbsp;Shi-Ji Xiao","doi":"10.1080/10286020.2024.2446282","DOIUrl":"10.1080/10286020.2024.2446282","url":null,"abstract":"<div><div>Seven flavanol derivatives, including three biflavanoids (<strong>1</strong>–<strong>3</strong>), two flavonoids (<strong>4</strong> and <strong>5</strong>), and two spirobiflavonoids (<strong>6</strong> and <strong>7</strong>), were isolated from the bark of <em>Nothotsuga longibracteata</em>. The structure of the undescribed compound <strong>1</strong> was elucidated based on HR-ESIMS, NMR spectroscopy, and electronic circular dichroism (ECD) calculations. All isolated flavanol derivatives were screened for their antioxidant capacity to scavenge DPPH and ABTS<sup>+</sup>.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 7","pages":"Pages 1080-1086"},"PeriodicalIF":1.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simultaneous determination of nine compounds from the roots of Euphorbia fischeriana, Euphorbia ebracteolata and Stellera chamaejasme and their anti-tumor activities 同时测定大戟、大戟和狼毒根中9种化合物的抗肿瘤活性
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-03 DOI: 10.1080/10286020.2024.2442444
Lin-Mei Zhang , Yu Yan , Fan Zhang , Kang Ding , Jia Zhang , Hua Yang , Wei-Ku Zhang , Jun He , Jie-Kun Xu
{"title":"Simultaneous determination of nine compounds from the roots of Euphorbia fischeriana, Euphorbia ebracteolata and Stellera chamaejasme and their anti-tumor activities","authors":"Lin-Mei Zhang ,&nbsp;Yu Yan ,&nbsp;Fan Zhang ,&nbsp;Kang Ding ,&nbsp;Jia Zhang ,&nbsp;Hua Yang ,&nbsp;Wei-Ku Zhang ,&nbsp;Jun He ,&nbsp;Jie-Kun Xu","doi":"10.1080/10286020.2024.2442444","DOIUrl":"10.1080/10286020.2024.2442444","url":null,"abstract":"<div><div>Langdu is generally considered as the roots of <em>Euphorbia fischeriana</em>, <em>Euphorbia ebracteolata</em> and <em>Stellera chamaejasme</em>. However, whether these three plants can substitute for one another has always been a concern. This article aims to clarify the differences among the three Langdu species in chemical constituents and anti-tumor effects. This study provides a qualitative and quantitative analysis of eight diterpenoids and one flavonoid in Langdu samples and IC<sub>50</sub> curves for these compounds, which can serve as a basis for identification and usage.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 7","pages":"Pages 1013-1024"},"PeriodicalIF":1.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploration and computational assessment of ochrocephalamine G from Oxytropis ochrocephala as an anti-HBV candidate 赭棘豆中赭脑胺G作为抗hbv候选物的探索和计算评估。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-03 DOI: 10.1080/10286020.2024.2441773
Ya-Kun Zhang , Zhan Xue , Jian-Bo Tong , Jing Tan , Min Yang , Yan-Rong Zeng , Cheng-Jian Tan
{"title":"Exploration and computational assessment of ochrocephalamine G from Oxytropis ochrocephala as an anti-HBV candidate","authors":"Ya-Kun Zhang ,&nbsp;Zhan Xue ,&nbsp;Jian-Bo Tong ,&nbsp;Jing Tan ,&nbsp;Min Yang ,&nbsp;Yan-Rong Zeng ,&nbsp;Cheng-Jian Tan","doi":"10.1080/10286020.2024.2441773","DOIUrl":"10.1080/10286020.2024.2441773","url":null,"abstract":"<div><div>Three compounds, including a novel quinolizidine alkaloid, ochrocephalamine G (<strong>1</strong>), were isolated from <em>Oxytropis ochrocephala</em>. Structural elucidation was achieved through spectroscopic analysis and electronic circular dichroism. Biological assays showed that ochrocephalamine G (100 μM) inhibited HBsAg and HBeAg by 8.28% and 16.17%, respectively. Computational studies, including molecular docking and dynamics simulations, revealed its binding mode with HBV core protein, providing a solid foundation for developing <em>O. ochrocephala</em> as an anti-HBV therapeutic agent.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 7","pages":"Pages 1058-1071"},"PeriodicalIF":1.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatoprotective diterpenes from the nodes of Pinus massoniana 马尾松结中保肝二萜的研究。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-03 DOI: 10.1080/10286020.2025.2506527
Jia-Qi Chen , Ling-Zhi Zhang , Jie Ma , Chuang-Jun Li , Ying-Da Zang , Hua Sun , Dong-Ming Zhang
{"title":"Hepatoprotective diterpenes from the nodes of Pinus massoniana","authors":"Jia-Qi Chen ,&nbsp;Ling-Zhi Zhang ,&nbsp;Jie Ma ,&nbsp;Chuang-Jun Li ,&nbsp;Ying-Da Zang ,&nbsp;Hua Sun ,&nbsp;Dong-Ming Zhang","doi":"10.1080/10286020.2025.2506527","DOIUrl":"10.1080/10286020.2025.2506527","url":null,"abstract":"<div><div>Three new diterpenes, named pinusins D-F (<strong>1</strong>-<strong>3</strong>), were isolated from the Chinese medicine “<em>Pini Lignum Nodi</em>” (the dried tuberculate or branched nodes of <em>Pinus massoniana</em>), along with twelve known diterpenes. The structures of these new compounds were determined using detailed spectroscopic methods and ECD calculations. Compounds <strong>4</strong>-<strong>15</strong> displayed moderate hepatoprotective activity against H<sub>2</sub>O<sub>2</sub>-induced oxidative damage in HepG2 cells, while compounds <strong>5</strong>-<strong>15</strong> exhibited markedly enhanced efficacy ­surpassing that of bicyclol (positive control).</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 7","pages":"Pages 995-1004"},"PeriodicalIF":1.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pachyphyllanone, a new cycloartane triterpenoid isolated from Aglaia pachyphylla and its cytotoxic activity 厚叶木酮：一种从厚叶木中分离得到的新的环ar烷类三萜及其细胞毒活性。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-03 DOI: 10.1080/10286020.2024.2446280
Wahyu Safriansyah , Endang Juliansyah ,  Rustaman , Al Arofatus Naini , Kindi Farabi , Mohamad Nurul Azmi , Mohamad Azlan Nafiah , Hadi Kuncoro , Unang Supratman , Sofa Fajriah , Desi Harneti
{"title":"Pachyphyllanone, a new cycloartane triterpenoid isolated from Aglaia pachyphylla and its cytotoxic activity","authors":"Wahyu Safriansyah ,&nbsp;Endang Juliansyah ,&nbsp; Rustaman ,&nbsp;Al Arofatus Naini ,&nbsp;Kindi Farabi ,&nbsp;Mohamad Nurul Azmi ,&nbsp;Mohamad Azlan Nafiah ,&nbsp;Hadi Kuncoro ,&nbsp;Unang Supratman ,&nbsp;Sofa Fajriah ,&nbsp;Desi Harneti","doi":"10.1080/10286020.2024.2446280","DOIUrl":"10.1080/10286020.2024.2446280","url":null,"abstract":"<div><div><em>Aglaia pachyphylla</em> is a species from the <em>Aglaia</em> genus (Meliaceae) and the chemical constituent has not been widely explored. A new cycloartane-type triterpenoid, pachyphyllanone (<strong>1</strong>), along with four known compounds (<strong>2</strong>-<strong>5</strong>) were isolated from <em>Aglaia pachyphylla</em> Miq. Furthermore, the structure of the new compound was elucidated by the interpretation of spectroscopic data, including 1D and 2D-NMR, as well as ECD and NMR calculations (DP4+ analysis). Compounds <strong>1</strong>-<strong>5</strong> showed cytotoxic activities against MCF-7 with IC<sub>50</sub> values ranging from 160.74 to 299.75 μM.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 7","pages":"Pages 1072-1079"},"PeriodicalIF":1.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Five new phenolics from the red resin of Dracaena cochinchinensis 龙珠红树脂中5个新酚类物质。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-03 DOI: 10.1080/10286020.2025.2497279
Hong Shi , Nan-Pu Lin , Yong-Xian Cheng
{"title":"Five new phenolics from the red resin of Dracaena cochinchinensis","authors":"Hong Shi ,&nbsp;Nan-Pu Lin ,&nbsp;Yong-Xian Cheng","doi":"10.1080/10286020.2025.2497279","DOIUrl":"10.1080/10286020.2025.2497279","url":null,"abstract":"<div><div>Five undescribed phenolics including three new flavonoids (<strong>1</strong>-<strong>3</strong>), one new flavone glycoside (<strong>4</strong>) and one neolignan (<strong>5</strong>), together with seven known compounds were isolated from the resins of <em>Dracaena cochinchinensis</em> (Chinese dragon’s blood). Their structures were elucidated based on detailed spectroscopic analysis, including 1D, 2D NMR, mass spectrometry, and electronic circular dichroism (ECD) data analysis. In addition, biological evaluation of compounds <strong>1</strong>–<strong>5</strong> on anti-renal fibrotic activities were conducted, and the results showed that compounds <strong>1a</strong>, <strong>2</strong>, and <strong>5</strong> display anti-renal fibrotic activities in TFG-<em>β</em> induced NRK-52e cells.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 7","pages":"Pages 966-976"},"PeriodicalIF":1.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three new terpenoid derivatives from the deep-sea-derived fungus Aspergillus sydowii DFFSCS007 深海来源真菌西多曲霉DFFSCS007的三个新的萜类衍生物。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-03 DOI: 10.1080/10286020.2024.2443086
Xu-Meng Ren , Ke-Yue Wu , Shu-Hua Qi
{"title":"Three new terpenoid derivatives from the deep-sea-derived fungus Aspergillus sydowii DFFSCS007","authors":"Xu-Meng Ren ,&nbsp;Ke-Yue Wu ,&nbsp;Shu-Hua Qi","doi":"10.1080/10286020.2024.2443086","DOIUrl":"10.1080/10286020.2024.2443086","url":null,"abstract":"<div><div>Three new terpenoid derivatives (1<em>S</em>,6<em>R</em>,7<em>S</em>)-hydrobenzosydowic acid (<strong>1</strong>), (1 <em>R</em>,6<em>S</em>,7<em>S</em>)-hydrobenzosydowic acid (<strong>2</strong>), and (7 <em>R</em>,10<em>R</em>)-11-dehydroxy-iso-10-hydroxysydowic acid (<strong>3</strong>), along with the known analogues (<em>S</em>)-2-(1-(4-nitrobenzoyl)pyrrolidine-2-carboxamido)benzoic acid (<strong>4</strong>) and trihydroxybutyl ester of 4-carboxydiorcinol (<strong>5</strong>) were isolated from the deep-sea-derived fungus <em>Aspergillus sydowii</em> DFFSCS007. Their structures were determined by spectroscopic analysis. Compound <strong>4</strong> with a nitrobenzene group was isolated from nature for the first time. The antibacterial activities of <strong>1</strong>-<strong>5</strong> and cytotoxicity of <strong>1</strong>-<strong>3</strong> were also evaluated.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 7","pages":"Pages 1005-1012"},"PeriodicalIF":1.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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