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Journal of Asian Natural Products Research最新文献

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Isolation and characterization of a new diketopiperazine from Cephalotrichum sp. RD-ZLM03 isolated in Jinlun cave. 金仑洞头菌RD-ZLM03中一种新型二酮哌嗪的分离与表征。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-15 DOI: 10.1080/10286020.2025.2497284
Yi Hao, Pei-Hai Li, Rong-Xiang Wu, Cai-Xia Wei, Ting Shu, Fan-Dong Kong, Pei Wang, Li-Man Zhou
{"title":"Isolation and characterization of a new diketopiperazine from <i>Cephalotrichum</i> sp. RD-ZLM03 isolated in Jinlun cave.","authors":"Yi Hao, Pei-Hai Li, Rong-Xiang Wu, Cai-Xia Wei, Ting Shu, Fan-Dong Kong, Pei Wang, Li-Man Zhou","doi":"10.1080/10286020.2025.2497284","DOIUrl":"https://doi.org/10.1080/10286020.2025.2497284","url":null,"abstract":"<p><p>A new diketopiperazine, spirotryprostatin C (<b>1</b>), as well as nine known compounds (<b>2</b>-<b>10</b>), were isolated from the fermentation broth of the karst cave derived fungus <i>Cephalotrichum</i> sp. RD-ZLM03. Their structures were determined based on spectroscopic and X-ray diffraction analysis. Compounds <b>2</b>, <b>4</b>, <b>5</b>, <b>6</b>, <b>8</b>, <b>9</b>, and <b>10</b> showed significant proangiogenic activities at the concentration of 25 μM in the zebrafish model.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroprotective effects of Morus alba ethanolic extract against rotenone-induced neurodegeneration and motor impairments in mouse model. 桑乙醇提取物对鱼藤酮诱导的小鼠神经变性和运动损伤的神经保护作用。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-15 DOI: 10.1080/10286020.2025.2501024
Rabia Anjum, Chand Raza, Mehwish Faheem
{"title":"Neuroprotective effects of <i>Morus alba</i> ethanolic extract against rotenone-induced neurodegeneration and motor impairments in mouse model.","authors":"Rabia Anjum, Chand Raza, Mehwish Faheem","doi":"10.1080/10286020.2025.2501024","DOIUrl":"https://doi.org/10.1080/10286020.2025.2501024","url":null,"abstract":"<p><p><i>Morus alba</i> formulations impart neuroprotective properties against dementia, oxidative stress and mitochondrial impairments. The current study aimed to evaluate the neuroprotective potential of ethanolic extract of <i>Morus alba</i> (EMA) on motor impairments. GC-MS characterization of extract revealed active ingredients. Adult mice were exposed to rotenone to induce neurodegeneration and motor dysfunctions. EMA reduced striatal dopamine depletion and motor impairment. Candidate genes for anti-oxidant enzymes, dopamine transmission, synaptogenesis and mitochondrial regulator were significantly modulated in EMA exposed mice. Collectively, EMA imparted preventive action against rotenone-mediated brain damage, augmented antioxidant capabilities and prevented motor dysfunctions. It is suggested that MA as a potential medicinal plant for development of protective strategies in relevant clinical applications.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-19"},"PeriodicalIF":1.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Five new phenolics from the red resin of Dracaena cochinchinensis. 龙珠红树脂中5个新酚类物质。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-15 DOI: 10.1080/10286020.2025.2497279
Hong Shi, Nan-Pu Lin, Yong-Xian Cheng
{"title":"Five new phenolics from the red resin of <i>Dracaena cochinchinensis</i>.","authors":"Hong Shi, Nan-Pu Lin, Yong-Xian Cheng","doi":"10.1080/10286020.2025.2497279","DOIUrl":"https://doi.org/10.1080/10286020.2025.2497279","url":null,"abstract":"<p><p>Five undescribed phenolics including three new flavonoids (<b>1</b>-<b>3</b>), one new flavone glycoside (<b>4</b>) and one neolignan (<b>5</b>), together with seven known compounds were isolated from the resins of <i>Dracaena cochinchinensis</i> (Chinese dragon's blood). Their structures were elucidated based on detailed spectroscopic analysis, including 1D, 2D NMR, mass spectrometry, and electronic circular dichroism (ECD) data analysis. In addition, biological evaluation of compounds <b>1</b>-<b>5</b> on anti-renal fibrotic activities were conducted, and the results showed that compounds <b>1a</b>, <b>2</b>, and <b>5</b> display anti-renal fibrotic activities in TFG-<i>β</i> induced NRK-52e cells.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroprotective furanones from a soil-derived fungus Penicillium paxilli ga254. 从土壤真菌青霉paxilli ga254中提取神经保护呋喃酮。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-15 DOI: 10.1080/10286020.2025.2501025
Guang Li, Ya-Jing Wang, Si-Qian Zhou, Xiao-Qian Wu, Jing Li, Wen-Xuan Wang, Hong-Ping Long
{"title":"Neuroprotective furanones from a soil-derived fungus <i>Penicillium paxilli</i> ga254.","authors":"Guang Li, Ya-Jing Wang, Si-Qian Zhou, Xiao-Qian Wu, Jing Li, Wen-Xuan Wang, Hong-Ping Long","doi":"10.1080/10286020.2025.2501025","DOIUrl":"https://doi.org/10.1080/10286020.2025.2501025","url":null,"abstract":"<p><p>Three furanone derivatives (<b>1</b>-<b>3</b>), including one new compound, penicifuranone A (<b>1</b>), and one new natural product (<b>2</b>), along with one known dihydropyranone (<b>4</b>) were isolated from the solid rice medium fermentation of <i>Penicillium paxilli</i> ga254. The structures of these compounds were elucidated using comprehensive NMR spectroscopic analysis. This study represents the first report of these furanone derivatives from this fungus. Additionally, the neuroprotective effects of these compounds against oxygen-glucose deprivation/reperfusion injury in pheochromocytoma-12 cells were investigated.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-cancer effects of cordyceps sinensis, C. militaris and C. cicadae and their mechanisms of action. 冬虫夏草、蛹虫草和蝉虫草的抗癌作用及其作用机制。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-15 DOI: 10.1080/10286020.2025.2497282
Natalie Vivien Gunter, Yee Swen Ong, Zee Wei Lai, Hiroyuki Morita, Sunita Chamyuang, Amorn Owatworakit, Siau Hui Mah
{"title":"Anti-cancer effects of <i>cordyceps sinensis, C. militaris and C. cicadae</i> and their mechanisms of action.","authors":"Natalie Vivien Gunter, Yee Swen Ong, Zee Wei Lai, Hiroyuki Morita, Sunita Chamyuang, Amorn Owatworakit, Siau Hui Mah","doi":"10.1080/10286020.2025.2497282","DOIUrl":"https://doi.org/10.1080/10286020.2025.2497282","url":null,"abstract":"<p><p>Over the past decade, species of <i>Cordyceps</i>, particularly <i>C. sinensis, C. militaris</i>, and <i>C. cicadae</i>, along with their bioactive components cordycepin, ergosterol and polysaccharides, have shown significant anti-cancer potential. These effects are mediated through mechanisms including apoptosis induction, cell cycle arrest, and modulation of key signalling pathways, as reviewed here. Notably, the bioactive components exhibit greater potency than crude extracts, with cordycepin being a promising chemotherapeutic lead. Future investigations into the <i>in vivo</i> efficacy and safety profiles of <i>Cordyceps</i> extracts and their bioactive components are greatly encouraged. Additionally, structural modification of cordycepin may offer opportunities to enhance its therapeutic potential.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-25"},"PeriodicalIF":1.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progress in the study of curcumin metabolism in vivo 姜黄素体内代谢的研究进展。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-04 DOI: 10.1080/10286020.2024.2420619
Shi-Jie Zhong , Ya-Dong Xing , Lu-Yao Dong , Yi Chen , Nan Liu , Zeng-Ming Wang , Hui Zhang , Ai-Ping Zheng
{"title":"Progress in the study of curcumin metabolism in vivo","authors":"Shi-Jie Zhong ,&nbsp;Ya-Dong Xing ,&nbsp;Lu-Yao Dong ,&nbsp;Yi Chen ,&nbsp;Nan Liu ,&nbsp;Zeng-Ming Wang ,&nbsp;Hui Zhang ,&nbsp;Ai-Ping Zheng","doi":"10.1080/10286020.2024.2420619","DOIUrl":"10.1080/10286020.2024.2420619","url":null,"abstract":"<div><div>Curcumin has diverse biological functions, especially antioxidant and anti-inflammatory properties, but clinical trials have been hindered by its low bioavailability and pharmacokinetic properties. To achieve therapeutic efficacy, understanding curcumin’s <em>in vivo</em> metabolism is crucial. We reviewed current research on curcumin metabolism in PubMed, Google Scholar, and CNKI. This article outlines curcumin’s metabolic processes in the body via oral and intravenous injection. It suggests that upon entering the human body, curcumin may undergo oxidation, reduction, binding, and microbial community influence.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 5","pages":"Pages 639-657"},"PeriodicalIF":1.3,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the therapeutic potential of Annona reticulata extract: molecular docking, dynamics, and ADMET properties for cancer treatment and anti-inflammatory activity 探索网纹花提取物的治疗潜力：用于癌症治疗和抗炎活性的分子对接、动力学和 ADMET 特性。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-04 DOI: 10.1080/10286020.2024.2435983
Pratheep Thangaraj , Ekambaram Gayathiri , Palanisamy Prakash , Dhivya Viswanathan , Mostafizur Rahaman , Saravanan Pandiaraj , Nagarajan. S , Rekha Anantharaman , Rajakumar Govindasamy
{"title":"Exploring the therapeutic potential of Annona reticulata extract: molecular docking, dynamics, and ADMET properties for cancer treatment and anti-inflammatory activity","authors":"Pratheep Thangaraj ,&nbsp;Ekambaram Gayathiri ,&nbsp;Palanisamy Prakash ,&nbsp;Dhivya Viswanathan ,&nbsp;Mostafizur Rahaman ,&nbsp;Saravanan Pandiaraj ,&nbsp;Nagarajan. S ,&nbsp;Rekha Anantharaman ,&nbsp;Rajakumar Govindasamy","doi":"10.1080/10286020.2024.2435983","DOIUrl":"10.1080/10286020.2024.2435983","url":null,"abstract":"<div><div>Colorectal cancer remains a global health challenge, prompting the exploration of natural compounds for treatment. <em>Annona reticulata</em> shows promise as a source of activity biomolecules. This study analyzed the dynamics, molecular docking and ADMET properties of the extract, highlighting interaction with inflammatory protein. Key findings include compounds with binding energies of −9.61 and −9.01 kcal/mol for 5fia and 7cx2 receptors. Simulations over 100 ns assessed RMSD, RMSF, SASA, and H-bonding, confirming stability and favorable ADME/toxicity profiles. These results highlight <em>A. reticulata</em> as a promising candidate for developing anti-inflammatory and anticancer drugs.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (358KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 5","pages":"Pages 709-731"},"PeriodicalIF":1.3,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urolithin B inhibits LPS-induced macrophage M1 polarization via miR155-5p mediated MAPK/NF-кB pathway 尿素B通过miR155-5p介导的MAPK/NF-кB途径抑制lps诱导的巨噬细胞M1极化。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-04 DOI: 10.1080/10286020.2024.2435984
Wulipan Tuohudaali , Teng-Fei Ji , Wan-Ting Ding , Chen-Yang Li , Jian-Shen Bianba , Ren Ci , Jun Zhao
{"title":"Urolithin B inhibits LPS-induced macrophage M1 polarization via miR155-5p mediated MAPK/NF-кB pathway","authors":"Wulipan Tuohudaali ,&nbsp;Teng-Fei Ji ,&nbsp;Wan-Ting Ding ,&nbsp;Chen-Yang Li ,&nbsp;Jian-Shen Bianba ,&nbsp;Ren Ci ,&nbsp;Jun Zhao","doi":"10.1080/10286020.2024.2435984","DOIUrl":"10.1080/10286020.2024.2435984","url":null,"abstract":"<div><div>This study investigated inhibiting mechanisms of Urolithin B (Uro B) on macrophage M1 polarization. Uro B (50 μM) could inhibit the PGE2, COX-2, NO, iNOS, TNF-α, IL-1β and IL-6 levels compared with model group (<em>P</em> &lt; 0.05) as well as the CD86 and F4/80 expression. The miR155-5p overexpression could increase the p38 MAPK, JNK, ERK mRNA activities (<em>P</em> &lt; 0.05), Uro B (50 μM) could reverse changes in these indicators (<em>P</em> &lt; 0.05). Moreover, Uro B (50 μM) could inhibit the TLR4, Src, IκBα, NF-κBp65 and their phosphorylated protein expression (<em>P</em> &lt; 0.05). Therefore, Uro B may inhibit macrophage M1 polarization via miR155-5p mediated MAPK/NF-кB pathway.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 5","pages":"Pages 787-796"},"PeriodicalIF":1.3,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Culcinoside E, a new sulfated steroidal biglycoside from the starfish Culcita novaeguineae Culcinoside E：一种从新海星Culcita novaeguineae中提取的磺化甾体大糖苷。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-04 DOI: 10.1080/10286020.2024.2434564
Le Thi Vien , Tran Thi Hong Hanh , Tran Hong Quang , Nguyen Dang Ngai , Dao Viet Ha , Nguyen Xuan Cuong
{"title":"Culcinoside E, a new sulfated steroidal biglycoside from the starfish Culcita novaeguineae","authors":"Le Thi Vien ,&nbsp;Tran Thi Hong Hanh ,&nbsp;Tran Hong Quang ,&nbsp;Nguyen Dang Ngai ,&nbsp;Dao Viet Ha ,&nbsp;Nguyen Xuan Cuong","doi":"10.1080/10286020.2024.2434564","DOIUrl":"10.1080/10286020.2024.2434564","url":null,"abstract":"<div><div>Using various chromatographic separations, six steroid glycoside derivatives, including one new compound named culcinoside E (<strong>1</strong>), were isolated from the methanol extract of the starfish <em>Culcita novaeguineae</em>. Their structures were confirmed by detailed analysis of the 1D, 2D NMR, and HR ESI QTOF mass spectra. Among isolated compounds, culcinoside E (<strong>1</strong>), diplasterioside A (<strong>5</strong>), and thornasteroside A (<strong>6</strong>) inhibited growth of <em>Enterococcus faecalis</em>, whereas culcitoside C<sub>1</sub> (<strong>3</strong>) was active on <em>Candida albicans</em>.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 5","pages":"Pages 797-803"},"PeriodicalIF":1.3,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Garcinia cowa bark extract induces oxidative stress mediated cellular apoptosis in Leishmania donovani parasite modulated by its active phytosterol constituent 藤黄树皮提取物通过其活性植物甾醇成分的调节，诱导由氧化应激介导的唐氏利什曼原虫细胞凋亡。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-04 DOI: 10.1080/10286020.2024.2429145
Nibedita Pyne , Ishita Bhattacharya , Santanu Paul
{"title":"Garcinia cowa bark extract induces oxidative stress mediated cellular apoptosis in Leishmania donovani parasite modulated by its active phytosterol constituent","authors":"Nibedita Pyne ,&nbsp;Ishita Bhattacharya ,&nbsp;Santanu Paul","doi":"10.1080/10286020.2024.2429145","DOIUrl":"10.1080/10286020.2024.2429145","url":null,"abstract":"<div><div>Visceral leishmaniasis still remains a leading cause of parasitic deaths, with modern pentavalent antimonials showing limited efficacy and health risks. The methanolic bark extract of the Northeastern Indian plant, <em>Garcinia cowa</em>, demonstrated potent leishmanicidal effects against the parasite <em>Leishmania donovani</em>, demonstrating IC<sub>50</sub> values of 20–36 µg/ml, with selective toxicity for parasites over healthy cells. It induced parasite death through elevated oxidative and nitrosative stress elements, reduced arginase activity, nuclear fragmentation, cell cycle arrest, and apoptosis. A GC-MS study and molecular docking identified stigmasterol as a primary component, an antileishmanial compound that inhibits <em>Leishmania donovani</em> parasite efficiently.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 5","pages":"Pages 747-769"},"PeriodicalIF":1.3,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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