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Journal of Asian Natural Products Research最新文献

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Empirical rules for efficiently determining the structures and configurations of natural compounds via 1D NMR. 通过一维核磁共振有效确定天然化合物结构和构型的经验规则。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-10-01 Epub Date: 2026-04-29 DOI: 10.1080/10286020.2026.2658485
Kuo Xu, Ya-Nan Yang, Pei-Cheng Zhang
{"title":"Empirical rules for efficiently determining the structures and configurations of natural compounds via 1D NMR.","authors":"Kuo Xu, Ya-Nan Yang, Pei-Cheng Zhang","doi":"10.1080/10286020.2026.2658485","DOIUrl":"10.1080/10286020.2026.2658485","url":null,"abstract":"<p><p>Determining the chemical structures and stereochemistry of natural compounds present in trace amounts via derivatization or hydrolysis is a considerable challenge. Nonetheless, when employing conventional deuterated reagents, consistent patterns in the subtle variations in chemical shifts and coupling constants observed in the <sup>1</sup>H or <sup>13</sup>C NMR spectra may provide a straightforward and reliable approach for the structural elucidation in specific cases. Importantly, the 1D NMR-based empirical method presented herein is simple to perform and does not require additional support from other techniques. This mini-review is the first to thoroughly compile these empirical rules by combining our research with existing studies.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1437-1447"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lignans and phenylpropanoids from the edible roots of Codonopsis pilosula. 从党参可食根中提取木脂素和苯丙素。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-10-01 Epub Date: 2025-12-25 DOI: 10.1080/10286020.2025.2606378
Xi-Lan Jiang, Lun Wang, Fu Li, Hong-Yang Zhao, Chen-Yi Yan, Yang Liu, Dong Fu, Ming-Kui Wang
{"title":"<i>Lig</i>nans and phenylpropanoids from the edible roots of <i>Codonopsis pilosula</i>.","authors":"Xi-Lan Jiang, Lun Wang, Fu Li, Hong-Yang Zhao, Chen-Yi Yan, Yang Liu, Dong Fu, Ming-Kui Wang","doi":"10.1080/10286020.2025.2606378","DOIUrl":"10.1080/10286020.2025.2606378","url":null,"abstract":"<p><p>Chemical investigation of the edible roots of <i>Codonopsis pilosula</i> yielded a new lignan (<b>1</b>), together with twenty-nine known compounds, including twenty-one lignans (<b>2-22</b>) and eight phenylpropanoids (<b>23-30</b>). The structure of the new lignan, including its absolute configuration, was determined using a combination of extensive spectroscopic analysis, NMR and ECD calculations, and comparison with literature values. The isolated lignans and phenylpropanoids (excluding <b>1</b>, <b>20</b>, <b>21</b> and <b>28</b>) were evaluated for their antioxidant activities using ABTS and DPPH radical scavenging assays. Among them, compounds <b>2-6</b>, <b>18</b> and <b>23</b> exhibited strong scavenging activities in ABTS and DPPH assays with SC<sub>50</sub> values ranging from 9.73 to 47.26 <i>μ</i>M compared with the positive control L-ascorbic acid.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1553-1565"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery of undescribed alkaloids with immunosuppressive activity from the endophytic fungus Penicillium sp. HZ-5. 内生真菌Penicillium sp. HZ-5中未描述的具有免疫抑制活性生物碱的发现。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-10-01 Epub Date: 2026-01-10 DOI: 10.1080/10286020.2025.2606379
Jie Li, Ye-Ting Zhang, Yusuf Abudula, Zhang-Rong Hou, Zheng-Yi Shi, Xin-Ye Huang, Ming Chen, Xue-Qi Lan, Ju-Bao Zhang, Chang-Xing Qi, Yong-Hui Zhang
{"title":"Discovery of undescribed alkaloids with immunosuppressive activity from the endophytic fungus <i>Penicillium</i> sp. HZ-5.","authors":"Jie Li, Ye-Ting Zhang, Yusuf Abudula, Zhang-Rong Hou, Zheng-Yi Shi, Xin-Ye Huang, Ming Chen, Xue-Qi Lan, Ju-Bao Zhang, Chang-Xing Qi, Yong-Hui Zhang","doi":"10.1080/10286020.2025.2606379","DOIUrl":"10.1080/10286020.2025.2606379","url":null,"abstract":"<p><p>Two undescribed alkaloids, mecichorine (<b>1</b>) and talaropyrazine D (<b>2</b>), along with four known compounds were isolated from an endophytic fungus <i>Penicillium</i> sp. HZ-5. Their structures were elucidated from the spectroscopic data. Furthermore, the isolated compounds were tested for their immunosuppressive activity, and compound <b>1</b> showed moderate immunosuppressive activity on Con A-induced T-lymphocyte proliferation <i>in vitro</i>, with an IC<sub>50</sub> value of 15.2 ± 0.3 <i>µ</i>M, and the others showed no obvious activities up to 40 <i>µ</i>M.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1466-1471"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two new iridoid glycosides from the roots of Dipsacus asper. 杨柏根中两个新的环烯醚萜苷。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-10-01 Epub Date: 2026-01-09 DOI: 10.1080/10286020.2025.2608810
Xin-Li Ma, Wan-Qi Zhang, Jing-Han Zhang, Gu Zhao, Xin-Yue Li, Ming-Hui Sun, Jie Zhou, Guo-Ru Shi, De-Quan Yu, Yan-Fei Liu
{"title":"Two new iridoid glycosides from the roots of <i>Dipsacus asper</i>.","authors":"Xin-Li Ma, Wan-Qi Zhang, Jing-Han Zhang, Gu Zhao, Xin-Yue Li, Ming-Hui Sun, Jie Zhou, Guo-Ru Shi, De-Quan Yu, Yan-Fei Liu","doi":"10.1080/10286020.2025.2608810","DOIUrl":"10.1080/10286020.2025.2608810","url":null,"abstract":"<p><p>Two new iridoid glycosides, dasperosides <b>A</b>-<b>B</b> (<b>1</b>-<b>2</b>), together with two known analogues (<b>3</b>-<b>4</b>), were isolated from the air-dried roots of <i>Dipsacus asper</i>. Their structures were established from the spectroscopic data obtained and chemical evidence. Compounds <b>1</b>-<b>4</b> were tested for their cytotoxicity against six human tumor cell lines, hepatoprotective and anti-inflammatory activities.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1457-1465"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145933414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A dual-action biotin nanogel for accelerated wound healing: a bioinspired approach to antioxidant and regenerative delivery. 用于加速伤口愈合的双作用生物素纳米凝胶：一种生物启发的抗氧化和再生递送方法。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-09-29 DOI: 10.1080/10286020.2026.2736040
Samaa Abdullah, Samar Thiab, Alaa A Al-Masud, Sami H Alonazi, Hatim S AlKhatib, Imad Hamadneh
{"title":"A dual-action biotin nanogel for accelerated wound healing: a bioinspired approach to antioxidant and regenerative delivery.","authors":"Samaa Abdullah, Samar Thiab, Alaa A Al-Masud, Sami H Alonazi, Hatim S AlKhatib, Imad Hamadneh","doi":"10.1080/10286020.2026.2736040","DOIUrl":"https://doi.org/10.1080/10286020.2026.2736040","url":null,"abstract":"<p><p>A biotin-coenzyme Q10-sodium alginate (BTN-CoQ10-SA) nanogel was developed for topical wound healing through combined antioxidant and regenerative delivery. The optimized nanogel showed a particle size of ∼115 nm, zeta potential of -35.1 mV, encapsulation efficiency of 88.3%, and sustained BTN release over 24 h. In a rat excisional wound model, the nanogel achieved 95.1% wound closure by day 14 and significantly outperformed the untreated control. Treatment also increased VEGF, collagen I, and TGF-β1 expression while reducing IL-6 levels. These findings demonstrate the potential of BTN-CoQ10-SA nanogels as a sustained topical system for promoting wound repair.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-43"},"PeriodicalIF":1.6,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149074926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uncovering the anti-inflammatory and anti-angiogenesis activities of sinensetin orally administered to arthritic mice: synthesis, in vivo and in vitro evaluation. 揭示中药青藤素对关节炎小鼠的抗炎和抗血管生成活性：合成、体内和体外评价。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-09-29 DOI: 10.1080/10286020.2026.2736035
Abdulmenem Bakkouri, Mun Fei Yam, Chong-Yew Lee
{"title":"Uncovering the anti-inflammatory and anti-angiogenesis activities of sinensetin orally administered to arthritic mice: synthesis, <i>in vivo</i> and <i>in vitro</i> evaluation.","authors":"Abdulmenem Bakkouri, Mun Fei Yam, Chong-Yew Lee","doi":"10.1080/10286020.2026.2736035","DOIUrl":"https://doi.org/10.1080/10286020.2026.2736035","url":null,"abstract":"<p><p>Sinensetin, a prominent flavone from <i>Orthosiphon stamineus</i> is a promising constituent for anti-rheumatoid arthritis. This study evaluated the oral anti-inflammatory and anti-angiogenic efficacy of sinensetin. In carrageenan-induced arthritic mice, oral sinensetin (25-100 mg/kg) significantly reduced paw edema with dose-correlated plasma kinetics, confirming functional oral bioavailability despite a delayed onset compared to intraperitoneal administration. Ex vivo rat aortic ring and in vitro human endothelial assays revealed that sinensetin robustly suppressed microvessel outgrowth and cell migration via VEGF downregulation. These findings demonstrate that sinensetin is an orally bioavailable agent capable of suppressing inflammation and angiogenesis.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-18"},"PeriodicalIF":1.6,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149074922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two new C15-nupharidines from the rhizomes of Nuphar pumila. 牛蒡根状茎中两个新的c15 -nupharidine。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-09-28 DOI: 10.1080/10286020.2026.2738699
Xue-Li Zhi, Sheng-Dan Mi, Ying Li, Yan Huang, Jiang Li, Guo-Dong Yao, Guo-Zhu Su, Yong Li
{"title":"Two new C<sub>15</sub>-nupharidines from the rhizomes of <i>Nuphar pumila</i>.","authors":"Xue-Li Zhi, Sheng-Dan Mi, Ying Li, Yan Huang, Jiang Li, Guo-Dong Yao, Guo-Zhu Su, Yong Li","doi":"10.1080/10286020.2026.2738699","DOIUrl":"https://doi.org/10.1080/10286020.2026.2738699","url":null,"abstract":"<p><p>Two new C<sub>15</sub>-nupharidines compounds (<b>1</b>, <b>2</b>), named (-)-nuphamic acid and (-)-nuphamine-11-<i>O</i>-<i>β</i>-<sub>D</sub>-glucopyranoside, together with two known analogues (<b>3</b>, <b>4</b>), were isolated from the rhizomes of <i>Nuphar pumila</i>. Their structures were determined by analysis of spectroscopic data, including HRESIMS, 1D and 2D NMR, as well as calculated and experimental ECD data. <i>In vitro</i> evaluation of protein tyrosine phosphatase-1B (PTP1B) activity revealed that compound <b>1</b> inhibited the enzyme with an IC<sub>50</sub> value of 25.6 ± 7.6 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.6,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149074869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two novel C21 steroidal glycosides from Cynanchum auriculatum. 两种新的木耳念珠C21甾体苷。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-09-14 DOI: 10.1080/10286020.2026.2729223
Chao Chen, Lu-Yuan Zhang, Hong-Bo Lou, Kai-Liang Pu, Yun-Lu Li, Hai-Rong Lu, Guo-Song Wen, Yong Shen
{"title":"Two novel C<sub>21</sub> steroidal glycosides from <i>Cynanchum auriculatum</i>.","authors":"Chao Chen, Lu-Yuan Zhang, Hong-Bo Lou, Kai-Liang Pu, Yun-Lu Li, Hai-Rong Lu, Guo-Song Wen, Yong Shen","doi":"10.1080/10286020.2026.2729223","DOIUrl":"https://doi.org/10.1080/10286020.2026.2729223","url":null,"abstract":"<p><p>Two new C<sub>21</sub> steroidal glycosides, metaplexigenin TC1 (<b>1</b>) and cynanchogenin TC2 (<b>2</b>), were isolated from the roots of <i>Cynanchum auriculatum</i>. Their structures were determined to be meta--plexigenin 3-<i>O-α</i>-L-cymaropyranosyl-(1→4)-<i>β</i>-D-cymaropyranosyl-(1→4)-<i>α</i>-L-cymaropyr-anosyl-(1→4)-<i>β</i>-D-digitoxopyranoside (<b>1</b>) and cynanchogenin 3-<i>O-β</i>-D-cymaropyranos-yl-(1→4)-<i>α</i>-L-diginopyranosyl-(1→4)-<i>β</i>-D-oleandropyranosyl-(1→4)-<i>β-</i>D-cymaropyr-anoside (<b>2</b>) by IR, HRESIMS and NMR experiments. The <i>in vitro</i> NO release inhibition assays gave IC<sub>50</sub> values of 76.5 and 53.0 μmol/L, respectively.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.6,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148968692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NPB-1575 improves ischemic brain injury by regulating microglial polarization via IRS2 signaling pathway. NPB-1575通过IRS2信号通路调节小胶质细胞极化，改善缺血性脑损伤。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-09-04 DOI: 10.1080/10286020.2026.2726155
Meng-Yao Liu, Xin-Nan Li, Nian-Ying Shang, Li-Wen Zhang, Song-Yang Sui, An-Hua Tao, Jing-Shu Tang, Lei Wu, Jun-Gui Dai, Ying Peng
{"title":"NPB-1575 improves ischemic brain injury by regulating microglial polarization via IRS2 signaling pathway.","authors":"Meng-Yao Liu, Xin-Nan Li, Nian-Ying Shang, Li-Wen Zhang, Song-Yang Sui, An-Hua Tao, Jing-Shu Tang, Lei Wu, Jun-Gui Dai, Ying Peng","doi":"10.1080/10286020.2026.2726155","DOIUrl":"https://doi.org/10.1080/10286020.2026.2726155","url":null,"abstract":"","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-16"},"PeriodicalIF":1.6,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dammarane-type saponins from the leaves of Sapium sebiferum with inhibitory effects on NO production. 皂荚叶中丹麻烷型皂苷对NO产生的抑制作用。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-09-02 DOI: 10.1080/10286020.2026.2726157
Ninh Khac Ban, Dan Thi Thuy Hang, Tran My Linh, Ninh Khac Thanh Tung, Bui Van Thanh, Bui Huu Tai, Phan Van Kiem, Nguyen Phuong Thao
{"title":"Dammarane-type saponins from the leaves of <i>Sapium sebiferum</i> with inhibitory effects on NO production.","authors":"Ninh Khac Ban, Dan Thi Thuy Hang, Tran My Linh, Ninh Khac Thanh Tung, Bui Van Thanh, Bui Huu Tai, Phan Van Kiem, Nguyen Phuong Thao","doi":"10.1080/10286020.2026.2726157","DOIUrl":"https://doi.org/10.1080/10286020.2026.2726157","url":null,"abstract":"<p><p>Chromatographic separation of the leaves of <i>Sapium sebiferum</i> afforded two previously undescribed dammarane-type triterpenoid glycosides, sapibisides A and B (<b>1</b> and <b>2</b>), together with 12 related known analogues (<b>3</b>-<b>14</b>). The structures of these compounds were elucidated by extensive analysis of HRESIMS, 1D and 2D NMR spectroscopic data and comparison with previously reported data. The inhibitory activities of compounds <b>1</b>-<b>14</b> against LPS-induced NO production in RAW264.7 macrophages were evaluated. Compounds <b>1</b>, <b>3</b>, <b>9</b>, and <b>13</b> exhibited moderate inhibitory activity, with IC<sub>50</sub> values ranging from 31.2 to 45.7 <i>μ</i>M, compared to the positive control, dexamethasone, which showed an IC<sub>50</sub> value of 13.6 <i>μ</i>M.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.6,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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