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Journal of Asian Natural Products Research最新文献

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Atramacronoid A induces the PANoptosis-like cell death of human breast cancer cells through the CASP-3/PARP-GSDMD-MLKL pathways. Atramacronoid A可通过CASP-3/PARP-GSDMD-MLKL途径诱导人乳腺癌细胞的泛凋亡样细胞死亡。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-12-01 Epub Date: 2024-07-03 DOI: 10.1080/10286020.2024.2368841
Jing-Rong Li, Ling-Yu Li, Hai-Xin Zhang, Ming-Qin Zhong, Zhong-Mei Zou
{"title":"Atramacronoid A induces the PANoptosis-like cell death of human breast cancer cells through the CASP-3/PARP-GSDMD-MLKL pathways.","authors":"Jing-Rong Li, Ling-Yu Li, Hai-Xin Zhang, Ming-Qin Zhong, Zhong-Mei Zou","doi":"10.1080/10286020.2024.2368841","DOIUrl":"10.1080/10286020.2024.2368841","url":null,"abstract":"<p><p>Breast cancer is the most common malignant tumor and a major cause of mortality among women worldwide. Atramacronoid A (AM-A) is a unique natural sesquiterpene lactone isolated from the rhizome of <i>Atractylodes macrocephala</i> Koidz (known as Baizhu in Chinese). Our study demonstrated that AM-A triggers a specific form of cell death resembling PANoptosis-like cell death. Further analysis indicated that AM-A-induced PANoptosis-like cell death is associated with the CASP-3/PARP-GSDMD-MLKL pathways, which are mediated by mitochondrial dysfunction. These results suggest the potential of AM-A as a lead compound and offer insights for the development of therapeutic agents for breast cancer from natural products.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Five new glycosides from the culms of Phyllostachys nigra var. henonis. 从黑木耳变种秆中提取的五种新苷。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-12-01 Epub Date: 2024-07-04 DOI: 10.1080/10286020.2024.2366450
Bao Zhang, Hai-Hua Yuan, Jia Sun, Hang Xun, Jie Wang, Feng Qiu, Jian-Jun Wang, Xi Yao, Jin Wang, Wei Fan, Feng Tang
{"title":"Five new glycosides from the culms of <i>Phyllostachys nigra</i> var. <i>henonis</i>.","authors":"Bao Zhang, Hai-Hua Yuan, Jia Sun, Hang Xun, Jie Wang, Feng Qiu, Jian-Jun Wang, Xi Yao, Jin Wang, Wei Fan, Feng Tang","doi":"10.1080/10286020.2024.2366450","DOIUrl":"10.1080/10286020.2024.2366450","url":null,"abstract":"<p><p>Five new glycosides, namely methyl 3-methoxybenzoate-4,5-di-<i>O</i>-<i>β</i>-D-glucopyranoside <b>(1)</b>, (1a<i>S</i>,3a<i>S</i>,3<i>R</i>)-3-(4'-<i>O</i>-<i>β</i>-D-glucopyranosyl-3'-methoxyphenyl)-5,6-dioxa-bicyclo[3.3.0]octane-1-one <b>(2)</b>, quinolin-4(1<i>H</i>)-one-3-<i>O</i>-<i>β</i>-D-glucopyranoside <b>(3)</b>, 3-methoxy-propiophenone 4-<i>O</i>-(6'-<i>β</i>-D-xylopyranosyl)-<i>β</i>-D-glucopyranoside <b>(4)</b>, methyl 3-methoxybenzoate 4-<i>O</i>-(6'-<i>β</i>-D-xylopyranosyl)-<i>β</i>-D-glucopyranoside <b>(5)</b>, and one known compound, bambulignan B <b>(6)</b> were isolated from the culms of <i>Phyllostachys nigra</i> var<i>. henonis</i>. Their structures were determined using spectroscopic analysis. All compounds were evaluated for their DPPH radical scavenging activity. Compound <b>6</b> exhibited antioxidant activity with IC<sub>50</sub> value of 59.5 μM (positive control, L-ascorbic acid, IC<sub>50</sub> = 12.4 μM; 2,6-ditertbutyl-4-methyl phenol, IC<sub>50</sub> = 11.8 μM).</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of radish seeds (Semen Raphani) on the absorption and transportation of ginsenosides in the Caco-2 cell model: a UPLC-ESI-MS analysis. 萝卜籽（Semen Raphani）对人参皂苷在 Caco-2 细胞模型中的吸收和运输的影响：UPLC-ESI-MS 分析。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-12-01 Epub Date: 2024-06-13 DOI: 10.1080/10286020.2024.2366008
Hui Li, Wen-Shuo Zhang, Rui Liu, Wei Wang, Li-Li Jiao, Zhi Liu, Wei Wu
{"title":"Impact of radish seeds (Semen Raphani) on the absorption and transportation of ginsenosides in the Caco-2 cell model: a UPLC-ESI-MS analysis.","authors":"Hui Li, Wen-Shuo Zhang, Rui Liu, Wei Wang, Li-Li Jiao, Zhi Liu, Wei Wu","doi":"10.1080/10286020.2024.2366008","DOIUrl":"10.1080/10286020.2024.2366008","url":null,"abstract":"<p><p>This study examined the impact of Semen raphani on the absorption of ginsenosides from <i>Panax ginseng</i> C.A. Meyer (ginseng) using a Caco-2 cell model and Ultra-High-Performance Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry (UPLC-ESI-MS). Six primary ginsenosides (Rg1, Re, Rb1, Rb2, Rc, Rd) were quantified. Results showed that Semen Raphani increased the efflux rate of ginsenosides, particularly at higher concentrations, suggesting it inhibits their absorption. The research elucidates the intestinal absorption process of ginsenosides and the antagonistic mechanism of Semen Raphani against ginseng.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A rare prenylated isoflavone-quinone from the roots of Flemingia philippinensis. 从菲律宾佛兰芒根中提取的一种罕见的前酰化异黄酮醌。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-11-01 DOI: 10.1080/10286020.2024.2421918
Sheng-Li Niu, Xiao-Zhuo Han, Yan-Ping Wang, Jia-Hui Hao, Fei Mo, Can-Can Cui, Ying-Yu Wang, Lu-Yao Zhang, Ya-Ting Sun
{"title":"A rare prenylated isoflavone-quinone from the roots of <i>Flemingia philippinensis</i>.","authors":"Sheng-Li Niu, Xiao-Zhuo Han, Yan-Ping Wang, Jia-Hui Hao, Fei Mo, Can-Can Cui, Ying-Yu Wang, Lu-Yao Zhang, Ya-Ting Sun","doi":"10.1080/10286020.2024.2421918","DOIUrl":"https://doi.org/10.1080/10286020.2024.2421918","url":null,"abstract":"<p><p>In order to make more rational use of <i>Flemingia Philippinensis</i>, a systematic separation from the roots of <i>F. philippinensis</i> was performed in the current study. The investigation of chemical constituents resulted in the isolation of a rare prenylated isoflavone-quinone, fleminquinone A (<b>1</b>), together with four known analogues (<b>2-5</b>). Their structures were established by extensive physical and spectroscopic data analysis. Anti-inflammatory activities of the isolated compounds were evaluated in lipopolysaccharide induced mouse mononuclear macrophage leukemia cells RAW 264.7 model. Compound <b>1</b> exhibited significant inhibitory effects on LPS-induced NO production and COX-2. Compound <b>1</b> also significantly affected the levels of inflammatory cytokines.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Taxifolin ameliorates the D-galactose-induced aging of mouse hippocampal neurons HT-22 cells through modulating SIRT1/p53 and PI3K/AKT signaling pathways. 紫杉叶素通过调节SIRT1/p53和PI3K/AKT信号通路改善D-半乳糖诱导的小鼠海马神经元HT-22细胞衰老。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-11-01 DOI: 10.1080/10286020.2024.2421925
Xing-Long Liu, Shuang Zu, Hao Yue, An-Ning Li, Ping-Ping Sun, Jian-Guo Li, Li Yan, Li-Na Ma, Shuai Zhang
{"title":"Taxifolin ameliorates the D-galactose-induced aging of mouse hippocampal neurons HT-22 cells through modulating SIRT1/p53 and PI3K/AKT signaling pathways.","authors":"Xing-Long Liu, Shuang Zu, Hao Yue, An-Ning Li, Ping-Ping Sun, Jian-Guo Li, Li Yan, Li-Na Ma, Shuai Zhang","doi":"10.1080/10286020.2024.2421925","DOIUrl":"https://doi.org/10.1080/10286020.2024.2421925","url":null,"abstract":"<p><p>By establishing an <i>in vitro</i> model of D-Gal-induced brain neuronal cell (HT-22) senescence, it was found that TAX treatment significantly increased the activities of SOD and GSH, while decreasing MDA levels in aging HT-22 cells, indicating that TAX effectively restored the total antioxidant capacity and antioxidant enzyme activity of aging HT-22 cells induced by D-Gal, and attenuated cellular oxidative stress injury. In addition, taxifolin could also protect HT-22 cells from aging by up-regulating SIRT1 while reducing the expression of Ac-p53, indicating that TAX may be an active substance that can effectively delay cell aging.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in natural products and derivatives with antiviral activity against respiratory syncytial virus (RSV). 具有抗呼吸道合胞病毒（RSV）病毒活性的天然产品和衍生物的最新进展。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-10-19 DOI: 10.1080/10286020.2024.2417211
Ameena Tur Rasool, Erguang Li, Ahsan Nazir
{"title":"Recent advances in natural products and derivatives with antiviral activity against respiratory syncytial virus (RSV).","authors":"Ameena Tur Rasool, Erguang Li, Ahsan Nazir","doi":"10.1080/10286020.2024.2417211","DOIUrl":"https://doi.org/10.1080/10286020.2024.2417211","url":null,"abstract":"<p><p>Respiratory syncytial virus (RSV) is a widespread viral infection that causes millions of high-risk illnesses annually. Medicinal herbs such as ginseng root, echinacea purpurea, and radix astragali have a positive effect on antiviral activity by preventing viral adhesion, syncytial development, inhibiting viral internalization, relieving respiratory inflammation, strengthening the immune system, and stimulating the release of interferons. The potential benefits of natural products in terms of lower costs, better patient outcomes, and fewer adverse effects are discussed. This review examines the current evidence on the prevention and control of RSV with natural ingredients and the challenges and opportunities in clinical practice.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monoterpene indole glycoalkaloids from the hook-bearing branches of Uncaria rhynchophylla. 钩藤含钩枝中的单萜吲哚甘氨酰生物碱。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-10-16 DOI: 10.1080/10286020.2024.2410460
Lu Rao, Fei Chen, Ming-Hui Gao, Jun-Jie Tan, Shi-Jin Qu, Chang-Heng Tan
{"title":"Monoterpene indole glycoalkaloids from the hook-bearing branches of <i>Uncaria rhynchophylla</i>.","authors":"Lu Rao, Fei Chen, Ming-Hui Gao, Jun-Jie Tan, Shi-Jin Qu, Chang-Heng Tan","doi":"10.1080/10286020.2024.2410460","DOIUrl":"https://doi.org/10.1080/10286020.2024.2410460","url":null,"abstract":"<p><p>Twelve monoterpene indole glycoalkaloids, comprising of three new ones, 19-<i>epi</i>-rhynchophylloside A (<b>1</b>), 7-<i>epi</i>-rhynchophylloside A (<b>2</b>), and 7-<i>epi</i>-anthocephalusine A (<b>3</b>), were isolated from the hook-bearing branches of <i>Uncaria rhynchophylla</i>. The structures and absolute configurations of <b>1-3</b> were elucidated by analysis of MS, NMR, ECD, and single-crystal X-ray diffraction or TDDFT-ECD calculations. Glycoalkaloids <b>1</b> and <b>3</b> showed significant immunosuppressive activity against the proliferation of B lymphocyte induced by LPS with broad selective index.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Caenorhabditis elegans as in vivo model for the screening of natural plants-derived novel anti-aging compounds: a short introduction. 作为体内模型筛选天然植物提取的新型抗衰老化合物的草履虫：简短介绍。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-10-15 DOI: 10.1080/10286020.2024.2414189
Samah H O Zarroug
{"title":"<i>Caenorhabditis elegans</i> as <i>in vivo</i> model for the screening of natural plants-derived novel anti-aging compounds: a short introduction.","authors":"Samah H O Zarroug","doi":"10.1080/10286020.2024.2414189","DOIUrl":"https://doi.org/10.1080/10286020.2024.2414189","url":null,"abstract":"<p><p>The global aging population highlights the need for effective anti-aging treatments. Natural products show promise, but thorough evaluation requires <i>in vivo</i> models due to the complexity of aging. Ethical concerns are driving a shift from traditional models like rabbits and mice to alternatives such as <i>Caenorhabditis elegans</i>. This microscopic nematode, with its short life cycle, genetic similarities to humans, and cost-effectiveness, is ideal for testing anti-aging compounds. We review studies using <i>C. elegans</i> to assess natural products, suggesting it could serve as a primary model for -evaluating the safety and efficacy of plant-derived anti-aging compounds.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A regio-specific 4'-O-methyltransferase from Epimedium pseudowushanense regiospecifically catalyzing 8-prenylkeampferol to icaritin. 一种来自淫羊藿的区域特异性 4'-O-甲基转移酶，可将 8-异戊烯基莰菲醇催化为冰片苷。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-10-07 DOI: 10.1080/10286020.2024.2411710
Ke-Ping Feng, Ji-Mei Liu, Ri-Dao Chen, Qiao-Man Fei, Ke-Bo Xie, Da-Wei Chen, Jun-Gui Dai
{"title":"A regio-specific 4<i>'</i>-<i>O</i>-methyltransferase from <i>Epimedium pseudowushanense</i> regiospecifically catalyzing 8-prenylkeampferol to icaritin.","authors":"Ke-Ping Feng, Ji-Mei Liu, Ri-Dao Chen, Qiao-Man Fei, Ke-Bo Xie, Da-Wei Chen, Jun-Gui Dai","doi":"10.1080/10286020.2024.2411710","DOIUrl":"https://doi.org/10.1080/10286020.2024.2411710","url":null,"abstract":"<p><p><i>Epimedium</i> is widely used in traditional Chinese medicine and contains rich bioactive compounds. These compounds often have a methyl group at their 4'-OH position catalyzed by methyltransferases. Therefore, studying methyltransferases in <i>Epimedium</i> plants is of great significance. In this study, a flavonol methyltransferase, EpOMT4, was isolated from <i>Epimedium pseudowushanense</i> B.L. Guo. The recombinant enzyme regiospecifically transferred a methyl group to the 4'-OH position of 8-prenylkaempferol forming icaritin. The study demonstrates that enzymatic methylation of flavonoids in <i>Epimedium</i> plants holds significant potential and could provide a promising alternative method for the biosynthetic production of bioactive methylated prenylflavonoids.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three new coumarins from Notopterygium incisum with potential anti-inflammatory activity. 具有潜在抗炎活性的 Notopterygium incisum 中的三种新香豆素。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-10-07 DOI: 10.1080/10286020.2024.2411704
Xue-Yan Huo, Meng-Dan Liu, Yu-Hui Chen, Yun-Jie Hu, Chen-Yi Yan, Da-Le Guo, Yu-Cheng Gu, Li-Jun Huang, Yun Deng
{"title":"Three new coumarins from <i>Notopterygium incisum</i> with potential anti-inflammatory activity.","authors":"Xue-Yan Huo, Meng-Dan Liu, Yu-Hui Chen, Yun-Jie Hu, Chen-Yi Yan, Da-Le Guo, Yu-Cheng Gu, Li-Jun Huang, Yun Deng","doi":"10.1080/10286020.2024.2411704","DOIUrl":"https://doi.org/10.1080/10286020.2024.2411704","url":null,"abstract":"<p><p>Three previously undescribed coumarins (<b>1</b>-<b>3</b>) were obtained from the roots of <i>Notopterygium incisum</i>. Their chemical structures were elucidated using a variety of spectroscopic techniques and chemical calculations. The inhibitory effects of these new compounds on NO production and pro-inflammatory factors (<i>IL-1β</i>, <i>IL-6</i>, and <i>TNF-α</i>) in LPS-stimulated RAW 264.7 cells were investigated. Further studies revealed that compound <b>1</b> suppressed the expression of COX-2 and iNOS while also reduced ROS accumulation. Western blot analysis demonstrated that compound <b>1</b> could inhibit the PI3K/AKT pathway by decreasing the levels of p-PI3K and p-AKT. Collectively, these findings suggest that compounds <b>1</b>-<b>3</b> exhibit promising anti-inflammatory properties.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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