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Journal of Asian Natural Products Research最新文献

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Synthesis and evaluation of Calenduloside E against drug-resistant Candida albicans.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-03-06 DOI: 10.1080/10286020.2025.2471467
Fei Zou, Shan Yin, Yan-Dan Wu, Rui-Na Liu, Ni-Ni Zhan, Tian-Yu Zhang, Ze-Fei Fan, Bao-Jing Li, Rui-Rui Wang, Guang-Hui Ni
{"title":"Synthesis and evaluation of Calenduloside E against drug-resistant <i>Candida albicans</i>.","authors":"Fei Zou, Shan Yin, Yan-Dan Wu, Rui-Na Liu, Ni-Ni Zhan, Tian-Yu Zhang, Ze-Fei Fan, Bao-Jing Li, Rui-Rui Wang, Guang-Hui Ni","doi":"10.1080/10286020.2025.2471467","DOIUrl":"https://doi.org/10.1080/10286020.2025.2471467","url":null,"abstract":"<p><p>Calenduloside E (CE), also known as a triterpenoid saponin, has demonstrated diverse biological activities. This paper investigates the chemical synthesis of CE, focusing on the key step of glucuronidation of oleanolic acid benzylate. Among trichloroacetimidate, bromide, and thioglucuronide as glucuronyl donors, trichloroacetimidate proved most effective, with scandium(III) trifluoromethanesulfonate identified as the optimal promoter. Notably, CE exhibited significant activity against fluconazole-resistant <i>C. albicans</i> (ATCC14053), with an MIC<sub>80</sub> of 5.5 µg/ml. Further mechanistic studies demonstrated that the combination of CE and FLC significantly inhibits the proliferation of <i>C. albicans</i> hyphae, biofilm formation, and cell membrane function.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-17"},"PeriodicalIF":1.3,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Magnoflorine ameliorates cartilage degradation in osteoarthritis through inhibition of mitochondrial reactive oxygen species-mediated activation of the NLRP3 inflammasome. 木兰花碱通过抑制线粒体活性氧介导的 NLRP3 炎症小体的激活，改善骨关节炎的软骨退化。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-03-04 DOI: 10.1080/10286020.2025.2472898
Yi Peng, Yue-Hui Huang, Xiao Luo, Mei-Chen Li, Qing-Qing Xiao, Lu Qiu, Qiang Fu
{"title":"Magnoflorine ameliorates cartilage degradation in osteoarthritis through inhibition of mitochondrial reactive oxygen species-mediated activation of the NLRP3 inflammasome.","authors":"Yi Peng, Yue-Hui Huang, Xiao Luo, Mei-Chen Li, Qing-Qing Xiao, Lu Qiu, Qiang Fu","doi":"10.1080/10286020.2025.2472898","DOIUrl":"https://doi.org/10.1080/10286020.2025.2472898","url":null,"abstract":"<p><p>This study investigated the role of magnoflorine (MAG) on cartilage protection in osteoarthritis. <i>In vitro</i> studies showed that MAG decreased the expression of inflammatory factors and inhibited extracellular matrix degradation in lipopolysaccharide- and ATP-stimulated C28/I2 cells. Importantly, MAG reduced the levels of pyroptosis-related proteins, including NLRP3, ASC, cleaved-caspase 1, GSDMD-N, IL-18, and IL-1β. Mechanistically, MAG reduced mtROS production and inhibited the activation of the NF-κB signaling pathway. <i>In vivo</i> study demonstrated that sodium iodoacetate-induced cartilage degradation and inflammatory factor release were reversed by MAG. Overall, MAG could inhibit mtROS-mediated NLRP3 inflammasome activation by suppressing mitochondrial dysfunction to ameliorate osteoarthritis.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-22"},"PeriodicalIF":1.3,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blumeatin inhibits LPS-induced inflammation of TLR4/NF-κB signaling pathway via targeting TLR4/MD-2.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-03-03 DOI: 10.1080/10286020.2025.2469690
Jun-Chao Peng, Wei-Jin Qi, Hong-Ying Wang, Wei Zhou, Xing-Jian Yu, Lu Wang
{"title":"Blumeatin inhibits LPS-induced inflammation of TLR4/NF-κB signaling pathway via targeting TLR4/MD-2.","authors":"Jun-Chao Peng, Wei-Jin Qi, Hong-Ying Wang, Wei Zhou, Xing-Jian Yu, Lu Wang","doi":"10.1080/10286020.2025.2469690","DOIUrl":"https://doi.org/10.1080/10286020.2025.2469690","url":null,"abstract":"<p><p>TLR4/MD-2, a protein complex to recognize LPS, has become an ideal target for the treatment of inflammation-related diseases. Blumeatin (BL), which is isolated from <i>Blumea balsamifera</i> (L.) DC has rarely been reported in the inflammation field. In this article, we targeted the TLR4/MD-2 complex to explore how BL regulates the TLR4/NF-κB inflammatory signaling pathway and inhibits LPS-induced inflammation. BL can target the hydrophobic pocket of TLR4/MD-2, inhibit the binding of LPS to TLR4/MD-2, the dimerization of TLR4 and MD-2, and the TLR4/NF-κB signaling pathway activation and the secretion of downstream inflammatory factors. BL may be used as a molecular target of TLR4/MD-2 for the treatment of inflammation-related diseases.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Xiexin Tang restores gut barrier function by regulating the differentiation of CD4+ T cells via GPRs and HDACs in T2DM rats.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-03-03 DOI: 10.1080/10286020.2025.2459603
Mei-Juan Liu, Yun Zhang, Ke Zhu, Wen-Wen Li, Chen Liu, Shu Jiang, Er-Xin Shang, Jin-Ao Duan
{"title":"Xiexin Tang restores gut barrier function by regulating the differentiation of CD4<sup>+</sup> T cells via GPRs and HDACs in T2DM rats.","authors":"Mei-Juan Liu, Yun Zhang, Ke Zhu, Wen-Wen Li, Chen Liu, Shu Jiang, Er-Xin Shang, Jin-Ao Duan","doi":"10.1080/10286020.2025.2459603","DOIUrl":"https://doi.org/10.1080/10286020.2025.2459603","url":null,"abstract":"<p><p>This study aimed to explore the potential mechanism of Xiexin Tang in improving type 2 diabetes mellitus from the perspective of intestinal barrier function. The results indicated that Xiexin Tang could notably promote the expression of GPRs while suppressing the expression of HDACs in colon epithelial cells, then significantly elevate the levels of TGF-β1 and IL-18 to regulate the differentiation of T cells and further maintain the intestinal immune homeostasis. Meanwhile, it could markedly inhibit the inflammatory signaling pathway to improve intestinal barrier function, relieving type 2 diabetes mellitus.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-15"},"PeriodicalIF":1.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utilizing network pharmacology and experimental validation to explore the mechanisms of the Qijiafuzheng formula promoting CD8+ T-cell infiltration in the microenvironment of lung adenocarcinoma through STAT1/CXCL10.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-03-03 DOI: 10.1080/10286020.2025.2467311
Tao Yang, Jian Chen, Zhao-Nan He, Zhong Li, Min Jiang
{"title":"Utilizing network pharmacology and experimental validation to explore the mechanisms of the Qijiafuzheng formula promoting CD8+ T-cell infiltration in the microenvironment of lung adenocarcinoma through STAT1/CXCL10.","authors":"Tao Yang, Jian Chen, Zhao-Nan He, Zhong Li, Min Jiang","doi":"10.1080/10286020.2025.2467311","DOIUrl":"https://doi.org/10.1080/10286020.2025.2467311","url":null,"abstract":"<p><p>Qijiafuzheng formula (QJFZF), a Traditional Chinese Medicine used to treat lung cancer and mitigate chemotherapy side effects, was studied to clarify its impact on the tumor immune microenvironment (TIME). Using network pharmacology and experimental validation, 39 overlapping targets were identified from 579 QJFZF-related and 752 lung adenocarcinoma (LUAD)-TIME targets. Key genes (CCL3, IL10, CXCL10, FOXP3, CD86) correlated negatively with tumor purity and positively with CD8+ T-cell infiltration. CXCL10 emerged as the core target, with experiments showing QJFZF activates the STAT1/CXCL10 pathway to enhance CD8+ T-cell recruitment in LUAD-TIME. This study elucidates QJFZF's immunomodulatory mechanisms, supporting its clinical application.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-19"},"PeriodicalIF":1.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling the neuroprotective mystery of Kaixinsan: identifying and validating the neuroprotective ingredients under the perspective of gut - brain axis regulation.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-03-03 DOI: 10.1080/10286020.2025.2468310
Jia-Le Ren, Xiao-Li Zhang, Li-Juan Zhao, Gui-Ying Wen, Jia-Fan Liu, Qing-Yu Meng, Zhen Yang, Li-Li Song, Yan-Jun Zhang
{"title":"Unveiling the neuroprotective mystery of Kaixinsan: identifying and validating the neuroprotective ingredients under the perspective of gut - brain axis regulation.","authors":"Jia-Le Ren, Xiao-Li Zhang, Li-Juan Zhao, Gui-Ying Wen, Jia-Fan Liu, Qing-Yu Meng, Zhen Yang, Li-Li Song, Yan-Jun Zhang","doi":"10.1080/10286020.2025.2468310","DOIUrl":"https://doi.org/10.1080/10286020.2025.2468310","url":null,"abstract":"<p><p>Kaixinsan (KXS) shows potential in treating cognitive dysfunction and can regulate the gut-brain axis. However, its effective components remain unclear. In this study, the components of KXS extract distributed in serum, brain, heart, liver, lung, kidney, and ileum were detected. By analyzing the number and the concentration of identified components distributed in different tissues, potential active components of KXS were obtained. Then, the screened components were confirmed by evaluating their ability to inhibit Aβ<sub>25-35</sub>-induced neuronal apoptosis in SH-SY5Y cells. Finally, Ginsenoside Rg1, Ginsenoside Ro, α-asarone, 2,4,5-trimethoxybenzoic acid, and 3',6-disinapoylsucrose were found to be the potential active ingredients of KXS.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-18"},"PeriodicalIF":1.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction. 更正。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-03-01 Epub Date: 2024-08-14 DOI: 10.1080/10286020.2024.2390261
{"title":"Correction.","authors":"","doi":"10.1080/10286020.2024.2390261","DOIUrl":"10.1080/10286020.2024.2390261","url":null,"abstract":"","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"478"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monoterpenoid indole alkaloids from the stems and leaves of Tabernaemontana bovina and their potential antiproliferative activities.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-25 DOI: 10.1080/10286020.2025.2459604
Shu-Ri Li, Xiao-Ya Fu, Ye-Ping Liu, Rui Qiu, Bing-Yan Sun, Jing-Su Yu, An-Jiao Wu, Hui Yang, Yan-Ping Liu, Yan-Hui Fu
{"title":"Monoterpenoid indole alkaloids from the stems and leaves of <i>Tabernaemontana bovina</i> and their potential antiproliferative activities.","authors":"Shu-Ri Li, Xiao-Ya Fu, Ye-Ping Liu, Rui Qiu, Bing-Yan Sun, Jing-Su Yu, An-Jiao Wu, Hui Yang, Yan-Ping Liu, Yan-Hui Fu","doi":"10.1080/10286020.2025.2459604","DOIUrl":"https://doi.org/10.1080/10286020.2025.2459604","url":null,"abstract":"<p><p>A phytochemical study on the stems and leaves of <i>Tabernaemontana bovina</i> led to the isolation and identification of a new monoterpenoid indole alkaloid, taberboviline (<b>1</b>), together with seven known monoterpenoid indole alkaloids (2-8). The chemical structure of <b>1</b> was elucidated on the basis of extensive spectral data analyses and the known compounds were identified by comparing their experimental spectral data with the reported data in the literature. All isolated indole alkaloids were evaluated for their antiproliferative activities against five human cancer cell lines <i>in vitro</i>. Monoterpenoid indole alkaloids <b>1</b>-<b>8</b> exhibited notable antiproliferative activities against five human cancer cell lines with IC<sub>50</sub> values ranging from 0.58 ± 0.05 to 26.19 ± 0.16 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioactive steroids from marine-derived fungi: a review (2015-2023).
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-24 DOI: 10.1080/10286020.2025.2464690
Xue-Yang Ma, Huan-Nan Wang, Li-Xiang Sun, Jin Sun, Shi-Hao Jin, Fang-Xu Dai, Chun-Mei Sai, Zhen Zhang
{"title":"Bioactive steroids from marine-derived fungi: a review (2015-2023).","authors":"Xue-Yang Ma, Huan-Nan Wang, Li-Xiang Sun, Jin Sun, Shi-Hao Jin, Fang-Xu Dai, Chun-Mei Sai, Zhen Zhang","doi":"10.1080/10286020.2025.2464690","DOIUrl":"https://doi.org/10.1080/10286020.2025.2464690","url":null,"abstract":"<p><p>Marine fungi, rich in unique secondary metabolites with diverse activities, are a valuable source for novel lead compounds. Steroids, a prominent class of bioactive compounds from marine fungi, have been extensively studied for their diverse pharmacological properties. This review describes the structural diversity, bioactivities, and sources of 175 marine fungal steroids (2015-2023), mainly from <i>Aspergillus</i>, <i>Penicillium</i>, <i>Talaromyces</i>, etc., in seaweed, mangroves, sediments, and marine animals like sponges and corals. Among them, 74 steroids exhibit antibacterial, antitumor, enzyme inhibitory, antiviral, and other activities, providing valuable leads for steroid drug development and advancing marine pharmaceutical research.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-27"},"PeriodicalIF":1.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimization of ultrasonic-assisted extraction of flavonoids from Ficus carica leaves and its chemical composition, antioxidant and UVB-protective properties.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-24 DOI: 10.1080/10286020.2025.2467324
Wei Liu, Meriem Fizir, Jia-Wei Shi, Lu-Xing Zhang, Wei Lin, Zhi-Liang Chen, Jing Ding
{"title":"Optimization of ultrasonic-assisted extraction of flavonoids from <i>Ficus carica</i> leaves and its chemical composition, antioxidant and UVB-protective properties.","authors":"Wei Liu, Meriem Fizir, Jia-Wei Shi, Lu-Xing Zhang, Wei Lin, Zhi-Liang Chen, Jing Ding","doi":"10.1080/10286020.2025.2467324","DOIUrl":"https://doi.org/10.1080/10286020.2025.2467324","url":null,"abstract":"<p><p>This study explored the protective effects of <i>Ficus carica</i> leaves (FCLs) against UVB radiation. Using response surface methodology (RSM), optimal extraction conditions for flavonoids were established, yielding 35.28 mg/g. HPLC-MS/MS analysis identified the components and various tests assessed their antioxidant and UVB protective capabilities. A sunscreen formulation with 0.10 wt% FCLs achieved an SPF of 25.6, surpassing commercial products (SPF 25). Additionally, FCLs extracts reduced <i>E. coli</i> mortality and protected zebrafish tail fin from damage after UVB exposure. These findings suggest FCLs are promising for sunscreen and antioxidant applications and may benefit psoriasis and vitiligo treatment.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-19"},"PeriodicalIF":1.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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