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Journal of Asian Natural Products Research最新文献

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Cytotoxic cycloartane-type triterpenoids from the leaves of aglaia shawiana. 沙棘叶的细胞毒性环artan型三萜。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-10-03 DOI: 10.1080/10286020.2025.2564409
Ricson Pemimpin Hutagaol, Tjandrawati Mozef, Nurlela, Febi Nurilmala, Gian Primahana, Muhammad Eka Prasetya, Sofa Fajriah, Vionita Ristina
{"title":"Cytotoxic cycloartane-type triterpenoids from the leaves of <i>aglaia shawiana</i>.","authors":"Ricson Pemimpin Hutagaol, Tjandrawati Mozef, Nurlela, Febi Nurilmala, Gian Primahana, Muhammad Eka Prasetya, Sofa Fajriah, Vionita Ristina","doi":"10.1080/10286020.2025.2564409","DOIUrl":"https://doi.org/10.1080/10286020.2025.2564409","url":null,"abstract":"<p><p>Three cycloartane-type triterpenoids have been isolated from the leaves of <i>Aglaia shawiana,</i> and the structure was determined as a new compound Shawianin A (<b>1</b>), along with two known compounds cycloartane-3<i>β</i>,29-diol-24-one (<b>2</b>), and (24 <i>R</i>)-cycloartane-3<i>β</i>,24,25- triol (<b>3</b>). Their structures were elucidated on the basis of 1D and 2D-nuclear magnetic resonance (NMR) analysis, as well as high-resolution mass spectrometry (HR-MS), infrared (IR), and ultraviolet (UV). Comparative data analysis was also carried out with appropriate reference journals and through a biosynthesis approach of the cycloartane type of triterpene compound. All of the compounds were evaluated for their cytotoxic effects against MCF-7 breast cancer cells and showed cytotoxicity with IC<sub>50</sub> values of >100 µg/ml.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling the neuroprotective mystery of Kaixinsan: identifying and validating the neuroprotective ingredients under the perspective of gut – brain axis regulation 揭开开心散的神经保护奥秘：肠脑轴调节视角下神经保护成分的鉴定与验证。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-10-03 DOI: 10.1080/10286020.2025.2468310
Jia-Le Ren , Xiao-Li Zhang , Li-Juan Zhao , Gui-Ying Wen , Jia-Fan Liu , Qing-Yu Meng , Zhen Yang , Li-Li Song , Yan-Jun Zhang
{"title":"Unveiling the neuroprotective mystery of Kaixinsan: identifying and validating the neuroprotective ingredients under the perspective of gut – brain axis regulation","authors":"Jia-Le Ren ,&nbsp;Xiao-Li Zhang ,&nbsp;Li-Juan Zhao ,&nbsp;Gui-Ying Wen ,&nbsp;Jia-Fan Liu ,&nbsp;Qing-Yu Meng ,&nbsp;Zhen Yang ,&nbsp;Li-Li Song ,&nbsp;Yan-Jun Zhang","doi":"10.1080/10286020.2025.2468310","DOIUrl":"10.1080/10286020.2025.2468310","url":null,"abstract":"<div><div>Kaixinsan (KXS) shows potential in treating cognitive dysfunction and can regulate the gut-brain axis. However, its effective components remain unclear. In this study, the components of KXS extract distributed in serum, brain, heart, liver, lung, kidney, and ileum were detected. By analyzing the number and the concentration of identified components distributed in different tissues, potential active components of KXS were obtained. Then, the screened components were confirmed by evaluating their ability to inhibit Aβ<sub>25-35</sub>-induced neuronal apoptosis in SH-SY5Y cells. Finally, Ginsenoside Rg1, Ginsenoside Ro, α-asarone, 2,4,5-trimethoxybenzoic acid, and 3’,6-disinapoylsucrose were found to be the potential active ingredients of KXS.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 10","pages":"Pages 1510-1527"},"PeriodicalIF":1.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcriptome analysis and molecular docking reveal the activation of FOXO4, TNFSF15 and CASP9 in HeLa cells treated with DCM fraction from Clinacanthus nutans (C. nutans) 转录组分析和分子对接显示，在用Clinacanthus nutans (C. nutans) DCM提取物处理HeLa细胞后，FOXO4、TNFSF15和CASP9被激活。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-10-03 DOI: 10.1080/10286020.2025.2469691
Kristine Sandra Pey Adum , Nor Hasyimah Haron , Zaleha Md. Toha , Hasni Arsad
{"title":"Transcriptome analysis and molecular docking reveal the activation of FOXO4, TNFSF15 and CASP9 in HeLa cells treated with DCM fraction from Clinacanthus nutans (C. nutans)","authors":"Kristine Sandra Pey Adum ,&nbsp;Nor Hasyimah Haron ,&nbsp;Zaleha Md. Toha ,&nbsp;Hasni Arsad","doi":"10.1080/10286020.2025.2469691","DOIUrl":"10.1080/10286020.2025.2469691","url":null,"abstract":"<div><div><em>Clinacanthus nutans</em> (<em>C. nutans</em>) is a well-known herb in tropical Asia. Previous studies have reported the anticancer activity of <em>C. nutans</em> but the molecular mechanisms on cervical cancer are not fully understood. Therefore, our study aims to explore its effects on HeLa line and analyse the molecular interactions. Firstly, the RNA-Seq reads were processed for differentially expressed analyses. With Ingenuity Pathway Analysis (IPA) method, five cell death-related pathways with three significant genes (CASP9, FOXO4, TNFSF15) were identified. This study provides insight into the potential role of the DCM fraction of <em>C. nutans</em> mediating cell death mechanism in cervical cancer.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 10","pages":"Pages 1486-1495"},"PeriodicalIF":1.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural elucidation of anti-inflammatory withanolides from Physalis minima. 小泡Physalis minima抗炎withanolides的结构分析。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-09-29 DOI: 10.1080/10286020.2025.2564404
Zhu Yang, Kai-Xiang Tong, Qiu-Yue Lv, Song-Zi Xie, Jiang-Ping Wu, Jun Han, Zhong-Mei Zou
{"title":"Structural elucidation of anti-inflammatory withanolides from <i>Physalis minima</i>.","authors":"Zhu Yang, Kai-Xiang Tong, Qiu-Yue Lv, Song-Zi Xie, Jiang-Ping Wu, Jun Han, Zhong-Mei Zou","doi":"10.1080/10286020.2025.2564404","DOIUrl":"https://doi.org/10.1080/10286020.2025.2564404","url":null,"abstract":"<p><p>The investigation of the whole plants of <i>Physalis minima</i> led to the isolation of four novel withanolides, designated phyminiolides F-I, together with six known analogues. The structures of <b>1</b>-<b>4</b> were elucidated through comprehensive analysis of their spectroscopic data, including HRESIMS, NMR and ECD, while those of <b>5</b>-<b>10</b> were identified by comparing their spectroscopic data with the reported literature values. Biologically, compounds <b>1</b>, <b>3</b>-<b>4</b>, and <b>8</b>-<b>10</b> exhibited moderate anti-inflammatory activities by inhibiting nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated murine RAW 264.7 cells <i>in vitro</i>, with IC<sub>50</sub> values ranging from 8.72 to 23.28 <i>μ</i>M.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Norlanostane triterpenoids from artificially cultivated fruiting bodies of basidiomycete Ganoderma casuarinicola. 人工培养担子菌木麻黄灵芝子实体中的Norlanostane三萜。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-09-25 DOI: 10.1080/10286020.2025.2564414
Panida Chinthanom, Siriporn Saepua, Seangaroon Yoiprommarat, Kitlada Srichomthong, Thitiya Boonpratuang, Sujinda Sommai, Masahiko Isaka
{"title":"Norlanostane triterpenoids from artificially cultivated fruiting bodies of basidiomycete <i>Ganoderma casuarinicola</i>.","authors":"Panida Chinthanom, Siriporn Saepua, Seangaroon Yoiprommarat, Kitlada Srichomthong, Thitiya Boonpratuang, Sujinda Sommai, Masahiko Isaka","doi":"10.1080/10286020.2025.2564414","DOIUrl":"https://doi.org/10.1080/10286020.2025.2564414","url":null,"abstract":"<p><p>Two undescribed norlanostane triterpenoids, ganocasuarinones B (<b>1</b>) and C (<b>2</b>), were isolated from the cultivated fruiting bodies of basidiomycete <i>Ganoderma casuarinicola</i>. The structures of the compounds were elucidated by extensive NMR spectroscopic analyses and mass spectrometry data. The absolute configuration of <b>1</b> was established using the modified Mosher method. Ganocasuarinone C (<b>2</b>) exhibited selective cytotoxicity to MCF-7 human breast cancer cells with an IC<sub>50</sub> value of 47 µM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in the total synthesis of type III post-Iboga alkaloids. III型后iboga生物碱全合成研究进展。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-09-22 DOI: 10.1080/10286020.2025.2558642
Xian-Yue Zhang, Xin Wang, Yue-Jie Zhu, Hong-Yan Shen, Guang Li
{"title":"Recent advances in the total synthesis of type III post-Iboga alkaloids.","authors":"Xian-Yue Zhang, Xin Wang, Yue-Jie Zhu, Hong-Yan Shen, Guang Li","doi":"10.1080/10286020.2025.2558642","DOIUrl":"https://doi.org/10.1080/10286020.2025.2558642","url":null,"abstract":"<p><p>The total synthesis of post-Iboga alkaloids poses formidable challenges. So far, three groups have produced notable advancements through their endeavor. Sunkyu Han's group employed a ring-opening functionalization approach to accomplish semi-synthesis. Fu-she Han's group developed an asymmetric Michael/aldol tandem reaction to construct the aza-[3.3.1] bridged skeleton. Namba's group reported a one-pot tandem cyclization strategy to rapidly assemble the pentacyclic core of (±)-tronocarpine. This review focuses on the synthetic advances made from 2019 onward toward type III post-Iboga alkaloids, highlighting key strategic elements and synthetic milestones, and aims to inspire future endeavors in the total synthesis of this unique family.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.3,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New compounds with anti-inflammatory activity from the roots of Isatis indigotica. 板蓝根中具有抗炎活性的新化合物。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-09-18 DOI: 10.1080/10286020.2025.2552195
Chen-Yu Jiang, Jia-Tong Wu, Juan Pan, Wei Guan, Zhi-Chao Hao, Qing-Shan Chen, Li-Li Zhang, Hai-Xue Kuang, Yan Liu, Bing-You Yang
{"title":"New compounds with anti-inflammatory activity from the roots of <i>Isatis indigotica</i>.","authors":"Chen-Yu Jiang, Jia-Tong Wu, Juan Pan, Wei Guan, Zhi-Chao Hao, Qing-Shan Chen, Li-Li Zhang, Hai-Xue Kuang, Yan Liu, Bing-You Yang","doi":"10.1080/10286020.2025.2552195","DOIUrl":"https://doi.org/10.1080/10286020.2025.2552195","url":null,"abstract":"<p><p>Four new compounds, isatigotindoledioside G (<b>1</b>), methyl-9<i>S</i>,12<i>S</i>,13<i>S</i>-trihydroxyoctadeca-10<i>E</i>,15<i>E</i>-dienoate (<b>2</b>), 9<i>S</i>,12<i>S</i>,13<i>S</i>-trihydroxyoctadeca-10<i>E</i>,15<i>E</i>-dienoic acid (<b>3</b>), and one new artificial product ethyl 9<i>S</i>,12<i>S</i>,13<i>S</i>-trihydroxyoctadeca-10<i>E</i>,15<i>Z</i>-dienoate (<b>4</b>), along with fourteen recognized compounds (<b>5-18</b>), were extracted from the roots of <i>Isatis indigotica</i>. These compounds' structures were characterized using NMR spectroscopy, HR-ESI-MS, ECD calculations, and literature comparisons. Compounds <b>5-6</b> and <b>10-11</b> showed appreciable anti-inflammatory properties, and compounds <b>1-4</b>, <b>12-13</b>, and <b>17-18</b> showed mild anti-inflammatory properties when evaluated in the LPS-stimulated RAW264.7 cell model.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative pharmacokinetic studies on ginsenosides in the common and ultrafine granular powder of Panax ginseng by using UHPLC-MS/MS. 采用UHPLC-MS/MS对人参普通粉和超微颗粒粉中人参皂苷的药动学进行比较研究。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-09-16 DOI: 10.1080/10286020.2025.2552200
Ya-Ran Teng, Saibire Aishana, Meng Zhang, Kai-Yue Zhang, Ren-Song Huang, Hui Li, Wei Wu
{"title":"Comparative pharmacokinetic studies on ginsenosides in the common and ultrafine granular powder of <i>Panax ginseng</i> by using UHPLC-MS/MS.","authors":"Ya-Ran Teng, Saibire Aishana, Meng Zhang, Kai-Yue Zhang, Ren-Song Huang, Hui Li, Wei Wu","doi":"10.1080/10286020.2025.2552200","DOIUrl":"https://doi.org/10.1080/10286020.2025.2552200","url":null,"abstract":"<p><p>Using UHPLC-MS/MS, we compared ginseng ultrafine granular powder (UGP) with common powder (CP). UGP showed higher solubility and faster dissolution. In SD rats, relative bioavailability increased markedly (Rc/Rb2/Rb1/Re/Rd: +113.80%, +104.80%, +81.37%, +70.62%, +33.54%). Re reached Cmax at 2 h in UGP vs 4 h in CP and showed a double peak. Rb1 had the highest Cmax (400.82 vs 220.20 ng/ml). The observed improvements may be attributable to the reduced particle size and increased surface area of UGP. These data support optimized clinical use and formulation of ginseng.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-16"},"PeriodicalIF":1.3,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on effective substance in six kinds of Chinese herbal medicines containing phenylpropanoids and multi-target therapeutic mechanisms for treatment of hyperuricemia through in silico and in vitro experiments. 通过体内和体外实验研究六种苯丙类中草药治疗高尿酸血症的有效物质及多靶点治疗机制。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-09-15 DOI: 10.1080/10286020.2025.2558644
Jia-Min Hu, Yi-Di Wu, Lu-Xi Cao, Xiao-Ning Nie, Jia-Ying Sun
{"title":"Study on effective substance in six kinds of <i>Chinese herbal medicines</i> containing phenylpropanoids and multi-target therapeutic mechanisms for treatment of hyperuricemia through <i>in silico</i> and <i>in vitro</i> experiments.","authors":"Jia-Min Hu, Yi-Di Wu, Lu-Xi Cao, Xiao-Ning Nie, Jia-Ying Sun","doi":"10.1080/10286020.2025.2558644","DOIUrl":"https://doi.org/10.1080/10286020.2025.2558644","url":null,"abstract":"<p><p>Hyperuricemia is an increasingly serious metabolic disease. However, xanthine oxidase inhibitors (XOIs) can fundamentally solve the problem of uric acid overproduction. In this paper, through virtual screening and network pharmacology, 73 potential compounds are discovered from six <i>Chinese herbal medicines</i> containing phenylpropanoids. These compounds treat hyperuricemia through crucial targets XDH, IL6, TLR4, HIF1A, HSP90AA1 and MMP2 synergistic effect. Further assay activities of inhibitory xanthine oxidase and antioxidant discover that taxifolin, morin and ellagic acid are deserved further study as the most promising anti-hyperuricemia multi-target XOIs candidates. Therefore, this study provides certain theoretical foundation for exploring effective treatment of hyperuricemia.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-32"},"PeriodicalIF":1.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new polyketide, asperone A, isolated from the endophytic fungus Aspergillus versicolor JGC-G1 and its antifungal activity. 从内生真菌杂色曲霉JGC-G1中分离到一个新的聚酮物asperone A及其抗真菌活性。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-09-15 DOI: 10.1080/10286020.2025.2558637
Fang Yue, Ling-Yan Liu, Chang Li, Xu-Ri Wan, Xuan Lu, Yue-Hu Pei, Yi-Hui Yang
{"title":"A new polyketide, asperone A, isolated from the endophytic fungus <i>Aspergillus versicolor</i> JGC-G1 and its antifungal activity.","authors":"Fang Yue, Ling-Yan Liu, Chang Li, Xu-Ri Wan, Xuan Lu, Yue-Hu Pei, Yi-Hui Yang","doi":"10.1080/10286020.2025.2558637","DOIUrl":"https://doi.org/10.1080/10286020.2025.2558637","url":null,"abstract":"<p><p>ABSTRCTOne previously undescribed polyketide compound (<b>1</b>) and eight known ones (<b>2-9</b>) were isolated from the endophytic fungus <i>Aspergillus versicolor</i> JGC-G1. Their chemical structures were elucidated by HRESIMS, 1D and 2D NMR analysis, experimental ECD, and calculated ECD data. Nine polyketide compounds were assessed for antifungal activity against <i>Candida albicans</i> CMCC 98001 and <i>Aspergillus niger</i> R330. Compounds <b>1</b> and <b>7</b> showed significant antifungal effect against these two fungi, with the MICs ranging from 0.781 to 3.125 μg/ml.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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