板蓝根中具有抗炎活性的新化合物。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-09-18 DOI:10.1080/10286020.2025.2552195

Chen-Yu Jiang, Jia-Tong Wu, Juan Pan, Wei Guan, Zhi-Chao Hao, Qing-Shan Chen, Li-Li Zhang, Hai-Xue Kuang, Yan Liu, Bing-You Yang

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引用次数: 0

摘要

从板蓝根中提取了4个新化合物：异atigotindoledioside G(1)、methyl-9S、12S、13S-trihydroxyoctadeca-10E、15E-dienoate(2)、9S、12S、13S-trihydroxyoctadeca-10E、15E-dienoic acid(3)和1个新人工产物9S、12S、13S-trihydroxyoctadeca-10E、15Z-dienoate(4)，以及14个已识别的化合物（5-18）。这些化合物的结构通过NMR波谱、HR-ESI-MS、ECD计算和文献比较进行了表征。在lps刺激的RAW264.7细胞模型中，化合物5-6和10-11表现出明显的抗炎作用，化合物1-4、12-13和17-18表现出轻微的抗炎作用。

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New compounds with anti-inflammatory activity from the roots of Isatis indigotica.

Four new compounds, isatigotindoledioside G (1), methyl-9S,12S,13S-trihydroxyoctadeca-10E,15E-dienoate (2), 9S,12S,13S-trihydroxyoctadeca-10E,15E-dienoic acid (3), and one new artificial product ethyl 9S,12S,13S-trihydroxyoctadeca-10E,15Z-dienoate (4), along with fourteen recognized compounds (5-18), were extracted from the roots of Isatis indigotica. These compounds' structures were characterized using NMR spectroscopy, HR-ESI-MS, ECD calculations, and literature comparisons. Compounds 5-6 and 10-11 showed appreciable anti-inflammatory properties, and compounds 1-4, 12-13, and 17-18 showed mild anti-inflammatory properties when evaluated in the LPS-stimulated RAW264.7 cell model.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.