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Journal of Asian Natural Products Research最新文献

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Alkaloids from cigar.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-03-20 DOI: 10.1080/10286020.2025.2475477
Qing-Yang Wu, Guang-Hai Zhang, Feng Wei, Yin-Ke Li, Guang-Hui Kong, Xiang-Hai Cai
{"title":"Alkaloids from cigar.","authors":"Qing-Yang Wu, Guang-Hai Zhang, Feng Wei, Yin-Ke Li, Guang-Hui Kong, Xiang-Hai Cai","doi":"10.1080/10286020.2025.2475477","DOIUrl":"https://doi.org/10.1080/10286020.2025.2475477","url":null,"abstract":"<p><p>Phytochemical investigation on cigar tobacco led to identification of 16 alkaloids including two undescribed nicotine dimeric analogs, cigatobines A-B (<b>1-2</b>), as well as new natural products pyridylnicotine (<b>3</b>), cis-5'-(2-oxopropyl)-nicotine (<b>8</b>) 4-(formamido)-1-(3-pyridyl)-1-butanone (<b>14</b>), 5,6-dihydropyridin-2(1H)-one (<b>15</b>). Some chemical mechanisms including Minisci reaction and nucleophilic addition reaction were involved in formation of dimeric nicotine and its derivatives. Molecular docking on this type alkaloids with the α7-nAChR receptor disclosed five active compounds with binding affinity scores of -8.077 of <b>2</b>, -7.805 of nicotine, -7.804 of <b>8</b>, -5.788 of <b>1</b>, -5.707 of <b>3</b>, -7.452 of epibatidine. This study disclosed the difference in alkaloids between cigar and tobacco.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two new bergamotane-type sesquiterpeniods from the plant endophytic fungus Paraconiothyrium brasiliense.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-03-20 DOI: 10.1080/10286020.2025.2477631
Ying Shi, Ling Liu
{"title":"Two new bergamotane-type sesquiterpeniods from the plant endophytic fungus <i>Paraconiothyrium brasiliense</i>.","authors":"Ying Shi, Ling Liu","doi":"10.1080/10286020.2025.2477631","DOIUrl":"https://doi.org/10.1080/10286020.2025.2477631","url":null,"abstract":"<p><p>One new bergamotane-type sesquiterpeniod lactam brasilactam A (<b>1</b>) and one new bergamotane-type sesquiterpeniod spiroketal lactone brasiketalolide A (<b>2</b>), along with two known compounds ampullicin (<b>3</b>) and isoampullicin (<b>4</b>) were isolated from the crude extract of the plant endophytic fungus <i>Paraconiothynium brasiliense</i> Verkley. The structures of the new compounds were elucidated on the basis of extensive 2D NMR techniques. The absolute configurations of <b>1</b> and <b>2</b> were assigned by <sup>13</sup>C NMR and electronic circular dichroism (ECD) calculations. Furthermore, compounds <b>1 </b>-<b> 4</b> were tested for their cytotoxicity against four human cancer cell lines.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional and biological characterization of Lactobacillus plantarum with isatin for use as probiotics for therapeutic options.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-03-20 DOI: 10.1080/10286020.2025.2475469
Ramya Ravindhiran, Mahalakshmi Subramanian, Madhumitha Rajalingam, Madhumitha Gunasekaran, Karthiga Sivarajan, Kumarappan Chidambaram, Kavitha Dhandapani
{"title":"Functional and biological characterization of <i>Lactobacillus plantarum</i> with isatin for use as probiotics for therapeutic options.","authors":"Ramya Ravindhiran, Mahalakshmi Subramanian, Madhumitha Rajalingam, Madhumitha Gunasekaran, Karthiga Sivarajan, Kumarappan Chidambaram, Kavitha Dhandapani","doi":"10.1080/10286020.2025.2475469","DOIUrl":"https://doi.org/10.1080/10286020.2025.2475469","url":null,"abstract":"<p><p>In our study, the functional and biological properties of the developed probiotic formulations containing <i>Lactobacillus plantarum</i> and isatin (<i>Couroupita guianensis</i>) have been evaluated. The developed probiotic formulations have demonstrated remarkable antioxidant, antimicrobial, and cholesterol-lowering properties (67.3 ± 0.57%). In addition, they exhibit high survivability in simulated oral fluid (98.8%). Furthermore, extracellular enzyme production iterates other health attributes of probiotic formulations to the human system by improving the utilization of nutrients in the intestine. In sum, the developed probiotic formulations have unveiled probiotic functions and safer applications, which could pave the way to develop functional foods or lead compounds for drug discovery.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-17"},"PeriodicalIF":1.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unlocking the potential of Radix Astragali and its active ingredients in gastric ulcer therapy.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-03-20 DOI: 10.1080/10286020.2025.2475475
Pei-Pei Zhang, Jing-Ni Tang, Bo-Yu Xiang, Liang Li, Meng-Zhou Xie, Hao-Yu Qu
{"title":"Unlocking the potential of Radix Astragali and its active ingredients in gastric ulcer therapy.","authors":"Pei-Pei Zhang, Jing-Ni Tang, Bo-Yu Xiang, Liang Li, Meng-Zhou Xie, Hao-Yu Qu","doi":"10.1080/10286020.2025.2475475","DOIUrl":"https://doi.org/10.1080/10286020.2025.2475475","url":null,"abstract":"<p><p>We studied the protective effects of Radix Astragali (RA) on gastric ulcer (GU). A literature search was conducted using databases from Web of Science, PubMed, Springer, ScienceDirect, Science Direct Chinese National Knowledge Infrastructure (CNKI), and Wanfang. The inclusion criteria for this study were limited to reports on the effects of RA, AS-IV, cycloastragenol, astragalus polysaccharide (APS), and astragalosides (AST) in the treatment of gastric ulcers. Any studies involving gastric lesions that were precancerous or cancerous were eliminated. The search period was from database inception through June 2024. The results suggested RA hold promiseas potential novel therapeutics for the therapy of GU.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-15"},"PeriodicalIF":1.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcriptome analysis and molecular docking reveal the activation of FOXO4, TNFSF15 and CASP9 in HeLa cells treated with DCM fraction from Clinacanthus nutans (C. nutans).
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-03-17 DOI: 10.1080/10286020.2025.2469691
Kristine Sandra Pey Adum, Nor Hasyimah Haron, Zaleha Md Toha, Hasni Arsad
{"title":"Transcriptome analysis and molecular docking reveal the activation of FOXO4, TNFSF15 and CASP9 in HeLa cells treated with DCM fraction from <i>Clinacanthus nutans</i> (<i>C. nutans</i>).","authors":"Kristine Sandra Pey Adum, Nor Hasyimah Haron, Zaleha Md Toha, Hasni Arsad","doi":"10.1080/10286020.2025.2469691","DOIUrl":"https://doi.org/10.1080/10286020.2025.2469691","url":null,"abstract":"<p><p><i>Clinacanthus nutans</i> (<i>C. nutans</i>) is a well-known herb in tropical Asia. Previous studies have reported the anticancer activity of <i>C. nutans</i> but the molecular mechanisms on cervical cancer are not fully understood. Therefore, our study aims to explore its effects on HeLa line and analyse the molecular interactions. Firstly, the RNA-Seq reads were processed for differentially expressed analyses. With Ingenuity Pathway Analysis (IPA) method, five cell death-related pathways with three significant genes (CASP9, FOXO4, TNFSF15) were identified. This study provides insight into the potential role of the DCM fraction of <i>C. nutans</i> mediating cell death mechanism in cervical cancer.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new pyrrolopyrazine alkaloid from the fruit of Lycium chinense.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-03-12 DOI: 10.1080/10286020.2025.2475481
Hui Liu, Yu-Xin Fan, Rui-Wen Xu, Yan-Jie Zhu, Gui-Min Xue, Yan-Jun Sun, Wei-Sheng Feng, Hui Chen
{"title":"A new pyrrolopyrazine alkaloid from the fruit of <i>Lycium chinense</i>.","authors":"Hui Liu, Yu-Xin Fan, Rui-Wen Xu, Yan-Jie Zhu, Gui-Min Xue, Yan-Jun Sun, Wei-Sheng Feng, Hui Chen","doi":"10.1080/10286020.2025.2475481","DOIUrl":"https://doi.org/10.1080/10286020.2025.2475481","url":null,"abstract":"<p><p>A new pyrrolopyrazine alkaloid, named lycipyrazine A (<b>1</b>), alone with seven known alkaloids (<b>2</b>-<b>8</b>), were isolated from the fruit of <i>Lycium chinense.</i> The structure of new compound <b>1</b> was determined using extensive 1D and 2D spectroscopic analyses, while its absolute configuration was determined by comparison of its experimental and calculated ECD spectra. Their <i>α</i>-glucosidase inhibitory activity was screened using acarbose as a positive control. Compound <b>4</b> showed strong inhibitory activity against <i>α</i>-glucosidase (IC<sub>50</sub> = 3.04 ± 0.38 μM). This study enriched the structural diversity of alkaloids in <i>L. chinense</i> and provided further clues for searching new antidiabetic agents from natural sources.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.3,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lifei Qingchang Tang attenuates acute lung injury via the NF-κB and MAPK signaling pathways.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-03-12 DOI: 10.1080/10286020.2025.2473648
Qi-Fen Huang, Jia-Min Zeng, Yuan-Long Hu, Wan-Yan Li, Qing-He Yu, Peng Wang, Pei-Hua Ren, Yang Peng, Wei-Jie Guan, Ran Lin, Zhen-Qiu Li, Wei-Lu Tan, Han-Ping Zhu, Shou-Xie Huang, Da-Peng Zhang, Zi-Chen Jie, Zhi-Juan Wu, Zhi-Min Zhang
{"title":"Lifei Qingchang Tang attenuates acute lung injury <i>via</i> the NF-κB and MAPK signaling pathways.","authors":"Qi-Fen Huang, Jia-Min Zeng, Yuan-Long Hu, Wan-Yan Li, Qing-He Yu, Peng Wang, Pei-Hua Ren, Yang Peng, Wei-Jie Guan, Ran Lin, Zhen-Qiu Li, Wei-Lu Tan, Han-Ping Zhu, Shou-Xie Huang, Da-Peng Zhang, Zi-Chen Jie, Zhi-Juan Wu, Zhi-Min Zhang","doi":"10.1080/10286020.2025.2473648","DOIUrl":"https://doi.org/10.1080/10286020.2025.2473648","url":null,"abstract":"<p><p>Acute lung injury (ALI) has high morbidity and mortality. Lifei Qingchang Tang (LFQCT), a traditional Chinese medicine, has antioxidant and anti-inflammatory properties but its mechanism in ALI remains unclear. <i>In vitro</i>, LFQCT reduced intracellular Ca<sup>2+</sup>, ROS, and NO in LPS-induced RAW 264.7 cells, suppressed pro-inflammatory mediators (TNF-α, IL-1β, and IL-6), iNOS, and COX-2, and blocked phosphorylation of IKK-α/β, p65, ERK1/2, JNK1/2, and p38. It also inhibited p65 activation and nuclear translocation. <i>In vivo</i>, LFQCT attenuated ALI in mice by reducing cytokines in serum, BALF, and lung tissues, improving pulmonary function and survival rates, being a potential new treatment.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-16"},"PeriodicalIF":1.3,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resveratrol: a potential alternative therapeutic agent for patients suffering from chronic obstructive pulmonary disease (COPD).
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-03-10 DOI: 10.1080/10286020.2025.2459597
Ong Yan Ren, Yasmeen Siddiqui, Mohammed Tahir Ansari, Asgar Ali
{"title":"Resveratrol: a potential alternative therapeutic agent for patients suffering from chronic obstructive pulmonary disease (COPD).","authors":"Ong Yan Ren, Yasmeen Siddiqui, Mohammed Tahir Ansari, Asgar Ali","doi":"10.1080/10286020.2025.2459597","DOIUrl":"https://doi.org/10.1080/10286020.2025.2459597","url":null,"abstract":"<p><p>This review explores the therapeutic potential of resveratrol, focusing on its molecular and cellular effects on Chronic Obstructive Pulmonary Disease (COPD), bioavailability enhancement strategies, and development challenges for applications in food, pharmaceuticals, and postharvest sectors. Resveratrol protects lungs by activating SIRT1, reducing oxidative stress via ROS regulation through Nrf2-mediated antioxidant enzymes. It shows promise as an alternative to corticosteroids in COPD and cancer treatment. Encapsulation innovations in resveratrol offer opportunities for food fortification, minimizing risks of chemical degradation and isomerization during storage, paving the way for its broader utility in health and nutrition applications.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-15"},"PeriodicalIF":1.3,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two new cyclopentanoid monoterpenes from the fruits of Catalpa ovate.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-03-08 DOI: 10.1080/10286020.2025.2467333
Ming-Hui Sun, Jie Zhou, Guo-Ru Shi, Wan-Qi Zhang, Xin-Yue Li, Jing-Han Zhang, Xin-Li Ma, Gu Zhao, De-Quan Yu, Yan-Fei Liu
{"title":"Two new cyclopentanoid monoterpenes from the fruits of <i>Catalpa ovate</i>.","authors":"Ming-Hui Sun, Jie Zhou, Guo-Ru Shi, Wan-Qi Zhang, Xin-Yue Li, Jing-Han Zhang, Xin-Li Ma, Gu Zhao, De-Quan Yu, Yan-Fei Liu","doi":"10.1080/10286020.2025.2467333","DOIUrl":"10.1080/10286020.2025.2467333","url":null,"abstract":"<p><p>Two new cyclopentanoid monoterpenes, catalpovatins A-B (<b>1</b>-<b>2</b>), together with nine known compounds (<b>3</b>-<b>11</b>), were isolated from the fruits of <i>Catalpa ovate</i> G. Don. The structures of these compounds were elucidated based on their spectroscopic data. All isolated compounds were evaluated for cytotoxicity against six human tumor cell lines, hepatoprotective activity and anti-inflammatory activity.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.3,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and evaluation of Calenduloside E against drug-resistant Candida albicans.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-03-06 DOI: 10.1080/10286020.2025.2471467
Fei Zou, Shan Yin, Yan-Dan Wu, Rui-Na Liu, Ni-Ni Zhan, Tian-Yu Zhang, Ze-Fei Fan, Bao-Jing Li, Rui-Rui Wang, Guang-Hui Ni
{"title":"Synthesis and evaluation of Calenduloside E against drug-resistant <i>Candida albicans</i>.","authors":"Fei Zou, Shan Yin, Yan-Dan Wu, Rui-Na Liu, Ni-Ni Zhan, Tian-Yu Zhang, Ze-Fei Fan, Bao-Jing Li, Rui-Rui Wang, Guang-Hui Ni","doi":"10.1080/10286020.2025.2471467","DOIUrl":"https://doi.org/10.1080/10286020.2025.2471467","url":null,"abstract":"<p><p>Calenduloside E (CE), also known as a triterpenoid saponin, has demonstrated diverse biological activities. This paper investigates the chemical synthesis of CE, focusing on the key step of glucuronidation of oleanolic acid benzylate. Among trichloroacetimidate, bromide, and thioglucuronide as glucuronyl donors, trichloroacetimidate proved most effective, with scandium(III) trifluoromethanesulfonate identified as the optimal promoter. Notably, CE exhibited significant activity against fluconazole-resistant <i>C. albicans</i> (ATCC14053), with an MIC<sub>80</sub> of 5.5 µg/ml. Further mechanistic studies demonstrated that the combination of CE and FLC significantly inhibits the proliferation of <i>C. albicans</i> hyphae, biofilm formation, and cell membrane function.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-17"},"PeriodicalIF":1.3,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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