Jun-Chao Peng , Wei-Jin Qi , Hong-Ying Wang , Wei Zhou , Xing-Jian Yu , Lu Wang
{"title":"Blumeatin inhibits LPS-induced inflammation of TLR4/NF-κB signaling pathway via targeting TLR4/MD-2","authors":"Jun-Chao Peng , Wei-Jin Qi , Hong-Ying Wang , Wei Zhou , Xing-Jian Yu , Lu Wang","doi":"10.1080/10286020.2025.2469690","DOIUrl":"10.1080/10286020.2025.2469690","url":null,"abstract":"<div><div>TLR4/MD-2, a protein complex to recognize LPS, has become an ideal target for the treatment of inflammation-related diseases. Blumeatin (BL), which is isolated from <em>Blumea balsamifera</em> (L.) DC has rarely been reported in the inflammation field. In this article, we targeted the TLR4/MD-2 complex to explore how BL regulates the TLR4/NF-κB inflammatory signaling pathway and inhibits LPS-induced inflammation. BL can target the hydrophobic pocket of TLR4/MD-2, inhibit the binding of LPS to TLR4/MD-2, the dimerization of TLR4 and MD-2, and the TLR4/NF-κB signaling pathway activation and the secretion of downstream inflammatory factors. BL may be used as a molecular target of TLR4/MD-2 for the treatment of inflammation-related diseases.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 10","pages":"Pages 1496-1509"},"PeriodicalIF":1.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yi Peng , Yue-Hui Huang , Xiao Luo , Mei-Chen Li , Qing-Qing Xiao , Lu Qiu , Qiang Fu
{"title":"Magnoflorine ameliorates cartilage degradation in osteoarthritis through inhibition of mitochondrial reactive oxygen species–mediated activation of the NLRP3 inflammasome","authors":"Yi Peng , Yue-Hui Huang , Xiao Luo , Mei-Chen Li , Qing-Qing Xiao , Lu Qiu , Qiang Fu","doi":"10.1080/10286020.2025.2472898","DOIUrl":"10.1080/10286020.2025.2472898","url":null,"abstract":"<div><div>This study investigated the role of magnoflorine (MAG) on cartilage protection in osteoarthritis. <em>In vitro</em> studies showed that MAG decreased the expression of inflammatory factors and inhibited extracellular matrix degradation in lipopolysaccharide- and ATP-stimulated C28/I2 cells. Importantly, MAG reduced the levels of pyroptosis-related proteins, including NLRP3, ASC, cleaved-caspase 1, GSDMD-N, IL-18, and IL-1β. Mechanistically, MAG reduced mtROS production and inhibited the activation of the NF-κB signaling pathway. <em>In vivo</em> study demonstrated that sodium iodoacetate-induced cartilage degradation and inflammatory factor release were reversed by MAG. Overall, MAG could inhibit mtROS-mediated NLRP3 inflammasome activation by suppressing mitochondrial dysfunction to ameliorate osteoarthritis.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 10","pages":"Pages 1528-1549"},"PeriodicalIF":1.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Two new bergamotane-type sesquiterpeniods from the plant endophytic fungus Paraconiothyrium brasiliense","authors":"Ying Shi , Ling Liu","doi":"10.1080/10286020.2025.2477631","DOIUrl":"10.1080/10286020.2025.2477631","url":null,"abstract":"<div><div>One new bergamotane-type sesquiterpeniod lactam brasilactam A (<strong>1</strong>) and one new bergamotane-type sesquiterpeniod spiroketal lactone brasiketalolide A (<strong>2</strong>), along with two known compounds ampullicin (<strong>3</strong>) and isoampullicin (<strong>4</strong>) were isolated from the crude extract of the plant endophytic fungus <em>Paraconiothynium brasiliense</em> Verkley. The structures of the new compounds were elucidated on the basis of extensive 2D NMR techniques. The absolute configurations of <strong>1</strong> and <strong>2</strong> were assigned by <sup>13</sup>C NMR and electronic circular dichroism (ECD) calculations. Furthermore, compounds <strong>1 </strong>−<strong> 4</strong> were tested for their cytotoxicity against four human cancer cell lines.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 10","pages":"Pages 1419-1428"},"PeriodicalIF":1.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jia-Na Zhu , Meng-Long Liu , Qiu-Hua He , Hai-Yan Ding
{"title":"Endophytic microorganisms in lichen: rising stars in the biomedicine field deserving broader recognition","authors":"Jia-Na Zhu , Meng-Long Liu , Qiu-Hua He , Hai-Yan Ding","doi":"10.1080/10286020.2025.2501030","DOIUrl":"10.1080/10286020.2025.2501030","url":null,"abstract":"<div><div>Lichens are renowned for their ability to thrive in extreme environments and for producing unique metabolites with considerable bioactive potential. However, their medicinal value remains largely underexplored, primarily due to slow growth rates and habitat specificity. Notably, endolichenic microorganisms, particularly fungi, are the predominant producers of these bioactive compounds, which exhibit antimicrobial, antiviral, and anticancer properties. Investigating these microorganisms and their metabolites presents promising biomedical opportunities, underscoring the importance of sustainably utilizing lichen resources and discovering novel compounds. This paper reviews the diversity and bioactive potential of endophytic microorganisms in lichens, providing valuable insights for the exploration of natural resources.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 10","pages":"Pages 1389-1407"},"PeriodicalIF":1.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jun-Jiao Ma , Liang-Feng Zhang , Dong-Ping Xu , Zan Wang , Yan-Qiu Meng
{"title":"Design, synthesis and antitumor activity of pentacyclic triterpenoid ursolic acid derivatives and oleanolic acid derivatives based on multi-target","authors":"Jun-Jiao Ma , Liang-Feng Zhang , Dong-Ping Xu , Zan Wang , Yan-Qiu Meng","doi":"10.1080/10286020.2025.2473635","DOIUrl":"10.1080/10286020.2025.2473635","url":null,"abstract":"<div><div>Totally twelve inhibitors of Survivin and Sp1 based on ursolic acid (<strong>UA</strong>) derivatives and oleanolic acid (<strong>OA</strong>) derivatives were designed and synthesized with modification at C-2, C-3 and C-28 of <strong>UA</strong> and <strong>OA</strong>. Their structures were confirmed by HRMS,<sup>1</sup>H NMR and <sup>13</sup>C NMR. <em>In vitro</em> activity assay showed that these compounds can inhibit cell proliferation of HeLa, SKOV3, BGC-823 and HT1080 cells, especially compounds <strong>IV</strong> and <strong>X</strong> showed better inhibitory activity on these tumor cells than that of the positive control drug Gefitinib and similar to Vp-16. Mechanistically, selected compound may inhibit the proliferation of <strong>SKOV3</strong> cells and trigger apoptosis by activating Sp1 to inhibit Survivin protein expression, which may be promising leading compounds for cancer therapy.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 10","pages":"Pages 1429-1446"},"PeriodicalIF":1.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiao-Xue Li , Han Yu , Shang-Hong Song , Xiao-Hua Liu , Yu-Ning Zheng , Zhao-Hui Li , Jia-Mei Chen , Chun-Xin Xing , Xiao-Feng He , Guang-Hua Lu
{"title":"Four new phenolic compounds from stems and leaves of Hemerocallis citrina (Daylily)","authors":"Xiao-Xue Li , Han Yu , Shang-Hong Song , Xiao-Hua Liu , Yu-Ning Zheng , Zhao-Hui Li , Jia-Mei Chen , Chun-Xin Xing , Xiao-Feng He , Guang-Hua Lu","doi":"10.1080/10286020.2025.2483806","DOIUrl":"10.1080/10286020.2025.2483806","url":null,"abstract":"<div><div>Four new phenolic compounds, hemerodiphenylethanes A–D (<strong>1–4</strong>), along with eight known compounds methyl 2,4-dihydroxy-6-[2-(4-hydroxyphenyl) ethyl] benzoate (<strong>5</strong>), methyl 2,4-dihydroxy-6-(4-hydroxyphenethyl)-3-methylbenzoate (<strong>6</strong>), neochlorogenic acid (<strong>7</strong>), isoquercetin (<strong>8</strong>), isorhamnetin-3-O-β-D-galactoside (<strong>9</strong>), velutin (<strong>10</strong>), rutin (<strong>11</strong>), and (+)-syringaresinol (<strong>12</strong>), were isolated from the stems and leaves of <em>Hemerocallis citrina</em> Baroni (Daylily). Their structures were elucidated based on HR-ESI-MS, 1D- and 2D-NMR spectra, and ECD calculations. Among them, both compounds <strong>10</strong> and <strong>12</strong> were isolated from the genus <em>Hemerocallis</em>, and compounds <strong>5</strong> and <strong>6</strong> were isolated from this plant species for the first time. These compounds showed antioxidant activity as determined by IC<sub>50</sub> values of DPPH and ABTS<sup>+</sup> in a radical scavenging experiment.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 10","pages":"Pages 1408-1418"},"PeriodicalIF":1.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exploring sulphated polysaccharides from marine bivalves: Unveiling potent anti-gastric cancer activity through cell cycle arrest and apoptosis","authors":"Deepakrajasekar Padmanaban , Pavithra Rajkumar , Mahalakshmi Vijayakumar , Vennila Jayaprakash , Niranjni Sekar , Rajasekar Valayapathi , Aarthi Azhagudurai , Arulvasu Chinnasamy","doi":"10.1080/10286020.2025.2468319","DOIUrl":"10.1080/10286020.2025.2468319","url":null,"abstract":"<div><div>This study investigates the extraction of partially purified sulphated polysaccharides from marine bivalves through enzymatic digestion followed by sequential deproteinization and evaluates their anti-gastric cancer activity. Chemical analysis confirmed high uronic acid and sulfate content, with FT-IR validating characteristic functional groups. <em>Donax variabilis</em> polysaccharide demonstrated significant, dose-dependent anti-proliferative effects against AGS cells. Mechanistic studies revealed morphological changes, ROS generation, LDH release, and mitochondrial membrane disruption, leading to apoptosis. Flow cytometry confirmed G0/G1 phase arrest. These findings suggest that <em>D. variabilis</em> sulphated polysaccharides exhibit potent anti-gastric cancer properties, likely through oxidative stress and mitochondrial dysfunction, warranting further investigation for therapeutic applications.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 10","pages":"Pages 1464-1485"},"PeriodicalIF":1.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fei Zou , Shan Yin , Yan-Dan Wu , Rui-Na Liu , Ni-Ni Zhan , Tian-Yu Zhang , Ze-Fei Fan , Bao-Jing Li , Rui-Rui Wang , Guang-Hui Ni
{"title":"Synthesis and evaluation of Calenduloside E against drug-resistant Candida albicans","authors":"Fei Zou , Shan Yin , Yan-Dan Wu , Rui-Na Liu , Ni-Ni Zhan , Tian-Yu Zhang , Ze-Fei Fan , Bao-Jing Li , Rui-Rui Wang , Guang-Hui Ni","doi":"10.1080/10286020.2025.2471467","DOIUrl":"10.1080/10286020.2025.2471467","url":null,"abstract":"<div><div>Calenduloside E (CE), also known as a triterpenoid saponin, has demonstrated diverse biological activities. This paper investigates the chemical synthesis of CE, focusing on the key step of glucuronidation of oleanolic acid benzylate. Among trichloroacetimidate, bromide, and thioglucuronide as glucuronyl donors, trichloroacetimidate proved most effective, with scandium(III) trifluoromethanesulfonate identified as the optimal promoter. Notably, CE exhibited significant activity against fluconazole-resistant <em>C. albicans</em> (ATCC14053), with an MIC<sub>80</sub> of 5.5 µg/ml. Further mechanistic studies demonstrated that the combination of CE and FLC significantly inhibits the proliferation of <em>C. albicans</em> hyphae, biofilm formation, and cell membrane function.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 10","pages":"Pages 1447-1463"},"PeriodicalIF":1.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hui Liu , Yu-Xin Fan , Rui-Wen Xu , Yan-Jie Zhu , Gui-Min Xue , Yan-Jun Sun , Wei-Sheng Feng , Hui Chen
{"title":"A new pyrrolopyrazine alkaloid from the fruit of Lycium chinense","authors":"Hui Liu , Yu-Xin Fan , Rui-Wen Xu , Yan-Jie Zhu , Gui-Min Xue , Yan-Jun Sun , Wei-Sheng Feng , Hui Chen","doi":"10.1080/10286020.2025.2475481","DOIUrl":"10.1080/10286020.2025.2475481","url":null,"abstract":"<div><div>A new pyrrolopyrazine alkaloid, named lycipyrazine A (<strong>1</strong>), alone with seven known alkaloids (<strong>2</strong>-<strong>8</strong>), were isolated from the fruit of <em>Lycium chinense.</em> The structure of new compound <strong>1</strong> was determined using extensive 1D and 2D spectroscopic analyses, while its absolute configuration was determined by comparison of its experimental and calculated ECD spectra. Their <em>α</em>-glucosidase inhibitory activity was screened using acarbose as a positive control. Compound <strong>4</strong> showed strong inhibitory activity against <em>α</em>-glucosidase (IC<sub>50</sub> = 3.04 ± 0.38 μM). This study enriched the structural diversity of alkaloids in <em>L. chinense</em> and provided further clues for searching new antidiabetic agents from natural sources.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 10","pages":"Pages 1550-1555"},"PeriodicalIF":1.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Le Viet Ha Tran, Huu Canh Vo, Vinh Han La, Quoc Tuan Le, Minh Canh Nguyen, Duc Trung Le, Thi Thu Hien Do, Huynh Nguyen Khanh Tran
{"title":"Hyrtiosin, a novel pyridinium-conjugated indole derivative from vietnamese marine sponge <i>hyrtios erectus</i>.","authors":"Le Viet Ha Tran, Huu Canh Vo, Vinh Han La, Quoc Tuan Le, Minh Canh Nguyen, Duc Trung Le, Thi Thu Hien Do, Huynh Nguyen Khanh Tran","doi":"10.1080/10286020.2025.2565343","DOIUrl":"https://doi.org/10.1080/10286020.2025.2565343","url":null,"abstract":"<p><p>The present phytochemical investigation of methanol extract from Vietnamese marine sponge, <i>Hyrtios erectus</i>, resulted to the isolation and structure elucidation of five compounds consisting of a new pyridinium-conjugated indole derivative (hyrtiosin, <b>1</b>), together with four known alkaloids identified as gramine (<b>2</b>), indole-3-carboxaldehyde (<b>3</b>), 3-(methoxymethyl)indole (<b>4</b>) and <i>N</i>-methylnicotinic acid or trigonelline (<b>5</b>). Chemical structures of isolated compounds were established using modern spectroscopic methods including NMR (<sup>1</sup>H,<sup>13</sup>C, COSY, HSQC, HMBC), HR-ESIMS, UV and IR. Compound <b>1</b> is rare occurrence of natural products with an acetyl moiety linked to <i>N</i>-1. The isolated compounds were tested with inhibitory activity of NO production and growth of bacterial strains. Among them, only compound <b>1</b> displayed the weak inhibition of nitric oxide production with an IC<sub>50</sub> value of 38.2 μM, others unfortunately have no activity in both of assays. All of them are first report both of isolation, structural elucidation and bioactivities from specie <i>H. erectus.</i></p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}