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Journal of Asian Natural Products Research最新文献

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Saikosaponin D, a triterpene saponin from Bupleurum falcatum, restores circadian rhythm and attenuates hepatic fibrosis via Esr1-Per2 axis.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-04-09 DOI: 10.1080/10286020.2025.2482068
Yu-Gang Fu, Jun-Min Wang, Si-Min Gu, Chong Chen, Yan-Ping Wang, Yi-Yuan Zheng, Yong Li
{"title":"Saikosaponin D, a triterpene saponin from <i>Bupleurum falcatum</i>, restores circadian rhythm and attenuates hepatic fibrosis via Esr1-Per2 axis.","authors":"Yu-Gang Fu, Jun-Min Wang, Si-Min Gu, Chong Chen, Yan-Ping Wang, Yi-Yuan Zheng, Yong Li","doi":"10.1080/10286020.2025.2482068","DOIUrl":"https://doi.org/10.1080/10286020.2025.2482068","url":null,"abstract":"<p><p>Hepatic fibrosis, a precursor to chronic liver diseases, is linked to circadian rhythm disruptions. This study investigates the anti-fibrotic effects of saikosaponin D (SSd) from <i>Bupleurum falcatum L</i>. and its regulation of circadian genes. Transcriptomic and single-cell analyses revealed circadian gene dysregulation, particularly Period 2 (Per2), in liver fibrosis and hepatic stellate cells. SSd upregulated Per2 transcription via estrogen receptor 1 (Esr1), as confirmed by siRNA, real-time quantitative polymerase chain reaction, and Western blot analyses. <i>In vivo</i>, SSd alleviated fibrosis and hepatitis, increasing Esr1 but not Per2 protein levels. These findings suggest SSd exerts anti-fibrotic effects by modulating Esr1-mediated Per2 transcription.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-18"},"PeriodicalIF":1.3,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three undescribed diterpenoids from Pini Lignum Nodi with hepatoprotective activities.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-04-04 DOI: 10.1080/10286020.2025.2481289
Jia-Qi Chen, Ling-Zhi Zhang, Jie Ma, Chuang-Jun Li, Ying-Da Zang, Hua Sun, Dong-Ming Zhang
{"title":"Three undescribed diterpenoids from Pini Lignum Nodi with hepatoprotective activities.","authors":"Jia-Qi Chen, Ling-Zhi Zhang, Jie Ma, Chuang-Jun Li, Ying-Da Zang, Hua Sun, Dong-Ming Zhang","doi":"10.1080/10286020.2025.2481289","DOIUrl":"https://doi.org/10.1080/10286020.2025.2481289","url":null,"abstract":"<p><p>Three new abietane-type diterpenes, named pinusins A-C (<b>1</b>-<b>3</b>) were isolated from Pini Lignum Nodi (the dried tuberculate or branched nodes of <i>Pinus massoniana</i> Lamb.), together with five known diterpenoids (<b>4</b>-<b>8</b>), a flavonoid (<b>9</b>) and a monoterpene (<b>10</b>). The structures of these compounds were elucidated based on detailed spectroscopic analyses (1D, 2D NMR, HRESIMS, IR, and UV), while ECD calculations determined their absolute configurations. All compounds were assayed <i>in vitro</i> for their protective activities against acetaminophen (APAP)-induced hepatotoxicity at 10 <i>μ</i>M. Compounds <b>1</b>-<b>4</b>, <b>9</b>, and <b>10</b> experimentally exerted protective effects against APAP-induced HepG2 cell damage.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical constituents from Calophyllum polyanthum and their biological activity.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-04-03 DOI: 10.1080/10286020.2025.2481274
Yin-Xia Yang, Li-Hua Gong, Fu-Hua Peng, Jian-Guo Hu, Tao Jiang, Bin Li, Yue Yang, Jing-Ying Peng, Xue-Mei Gao
{"title":"Chemical constituents from <i>Calophyllum polyanthum</i> and their biological activity.","authors":"Yin-Xia Yang, Li-Hua Gong, Fu-Hua Peng, Jian-Guo Hu, Tao Jiang, Bin Li, Yue Yang, Jing-Ying Peng, Xue-Mei Gao","doi":"10.1080/10286020.2025.2481274","DOIUrl":"https://doi.org/10.1080/10286020.2025.2481274","url":null,"abstract":"<p><p>Phytochemical investigation of <i>Calophyllum polyanthum</i> led to the isolation of six xanthones, six chromanone derivatives, one coumarin, one glycoside and one flavonoid, including two new xanthones named caledonixanthone M (<b>1</b>), caledonixanthone N (<b>2</b>) and thirteen known compounds (<b>3-15</b>). Among them, the structures of <b>1</b> and <b>2</b> were elucidated by analysis of spectroscopic data. Some known compounds showed potent <i>α</i>-glucosidase inhibitory and cytotoxic activity. Especially, compound <b>14</b> showed moderate inhibitory activities on <i>α</i>-glucosidase with IC<sub>50</sub> value of 79.41 ± 0.22 µM, and compound <b>5</b> displayed anticancer effect on A549 non-small cell lung cancer cells.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Baicalin: an active natural product with potential medicinal values.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-04-03 DOI: 10.1080/10286020.2025.2482054
Yong-Qiang Wen, Ya-Zhou Wang, Chen-Xu Zhao, Bao-Yu Zhao, Jian-Guo Wang
{"title":"Baicalin: an active natural product with potential medicinal values.","authors":"Yong-Qiang Wen, Ya-Zhou Wang, Chen-Xu Zhao, Bao-Yu Zhao, Jian-Guo Wang","doi":"10.1080/10286020.2025.2482054","DOIUrl":"https://doi.org/10.1080/10286020.2025.2482054","url":null,"abstract":"<p><p>Baicalin, a flavonoid derived from the dicotyledonous plant <i>Scutellaria baicalensis</i> Georgi (SBG), is applied to treat various -disorders due to its various pharmacological effects such as anti-inflammatory, antiviral, antibacterial, liver-protecting, lipid-lowering, and neuroprotection. However, baicalin's limited solubility hampers absorption. This article reviews baicalin's pharmacological properties, including pharmacokinetics, cytotoxicity, drug interactions, and therapeutic potential, especially for cardiovascular diseases, obesity, and liver-lipid disorders, aiming to promote its development in medicine, dairy and livestock feed, nutritional health products and cosmetics for humans and other fields.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-25"},"PeriodicalIF":1.3,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of homoisoflavonoids in fresh and dried Portulaca oleracea L. by HPLC-DAD-ESIMS2.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-04-02 DOI: 10.1080/10286020.2025.2482057
Hong-Qing Wang, Jun-Hua Sun, Jian-Bo Liu, Hong-Jie Shao, Zhan-Rong Zhou, Ruo-Yun Chen, Jie Kang
{"title":"Characterization of homoisoflavonoids in fresh and dried <i>Portulaca oleracea</i> L. by HPLC-DAD-ESIMS<sup>2</sup>.","authors":"Hong-Qing Wang, Jun-Hua Sun, Jian-Bo Liu, Hong-Jie Shao, Zhan-Rong Zhou, Ruo-Yun Chen, Jie Kang","doi":"10.1080/10286020.2025.2482057","DOIUrl":"https://doi.org/10.1080/10286020.2025.2482057","url":null,"abstract":"<p><p>In the study, three types of homoisoflavonoids were isolated from the roots of fresh <i>Portulaca oleracea</i> L. The electrospray ionization (ESI) mass spectral fragmentation pathways of these compounds were proposed. The fragmentation rules were successfully applied for the analysis of the homoisoflavonoids of the fresh and dried <i>Portulaca oleracea</i> L. A total of 28 homoisoflavonoids were identified or tentatively characterized by HPLC-DAD-ESIMS<sup>2</sup>. There were no significant differences of homoisoflavonoids detected in this batch of dried and fresh herbs of <i>P. oleracea</i> L. More samples from various areas are needed to further compare the differences of homoisoflavonoids between them.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Salidroside attenuates sepsis-induced acute kidney injury by inhibiting ferroptosis.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-04-02 DOI: 10.1080/10286020.2025.2481291
Ling-Ling Zhen, Ming-Tong Hou, Sheng-Bao Wang
{"title":"Salidroside attenuates sepsis-induced acute kidney injury by inhibiting ferroptosis.","authors":"Ling-Ling Zhen, Ming-Tong Hou, Sheng-Bao Wang","doi":"10.1080/10286020.2025.2481291","DOIUrl":"https://doi.org/10.1080/10286020.2025.2481291","url":null,"abstract":"<p><p>Salidroside is a traditional Chinese medicine with multiple pharmacological activities such as anti-inflammatory and antioxidant properties, while acute kidney injury (AKI) is a common sepsis-induced acute inflammatory response. Using transcriptomics combined with metabolomics, this study identifies arachidonic acid metabolism-associated ferroptosis as an important mechanism for salidroside to improve sepsis-induced AKI (SI-AKI).</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-15"},"PeriodicalIF":1.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery of immunosuppressive secondary metabolites from Hypericum patulum.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-03-27 DOI: 10.1080/10286020.2025.2481285
Fei Song, Jie Li, Bin-Bin Song, Zheng-Yi Shi, Zhang-Rong Hou, Ye-Ting Zhang, Yu-Lin Duan, Jian-Ping Wang, Chang-Xing Qi, Yong-Hui Zhang
{"title":"Discovery of immunosuppressive secondary metabolites from <i>Hypericum patulum</i>.","authors":"Fei Song, Jie Li, Bin-Bin Song, Zheng-Yi Shi, Zhang-Rong Hou, Ye-Ting Zhang, Yu-Lin Duan, Jian-Ping Wang, Chang-Xing Qi, Yong-Hui Zhang","doi":"10.1080/10286020.2025.2481285","DOIUrl":"https://doi.org/10.1080/10286020.2025.2481285","url":null,"abstract":"<p><p>The chemical study of <i>Hypericum patulum</i> provided a new degraded lupane-type triterpenoid, patutriter A (<b>1</b>), and seven known compounds (<b>2</b>-<b>8</b>). Their structures were identified by spectroscopic techniques and single crystal diffraction experiment. Structurally, patutriter A (<b>1</b>) was a new lupane with a 28-<i>nor</i>-skeleton. More importantly, compounds <b>3</b>-<b>5</b> exhibited moderate immunosuppressive effects that inhibit the anti-CD3/anti-CD28 monoclonal antibodies (mAbs) and concanavalin A (ConA) stimulated murine splenocytes proliferation, with IC<sub>50</sub> values from (15.25 ± 1.78) μM to (22.58 ± 3.47) μM, disclosing that those compounds might serve as potential lead compounds in the development of new immunosuppressants.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.3,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shaoyao-Gancao decoction improves dyslipidemia in rats with polycystic ovary syndrome by reshaping the gut microbiota and regulating the bile acid/FXR pathway.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-03-25 DOI: 10.1080/10286020.2025.2482072
Jia-Qi Duan, Yi-Fan Sun, Xin Wang, Hai-Yu Liu, Zhuang-Peng Chang, Yun-Yun Shao, Jun-Jin Liu, Rui-Gang Hou
{"title":"Shaoyao-Gancao decoction improves dyslipidemia in rats with polycystic ovary syndrome by reshaping the gut microbiota and regulating the bile acid/FXR pathway.","authors":"Jia-Qi Duan, Yi-Fan Sun, Xin Wang, Hai-Yu Liu, Zhuang-Peng Chang, Yun-Yun Shao, Jun-Jin Liu, Rui-Gang Hou","doi":"10.1080/10286020.2025.2482072","DOIUrl":"https://doi.org/10.1080/10286020.2025.2482072","url":null,"abstract":"<p><p>This study aims to investigate the potential mechanism of Shaoyao-Gancao Decoction (SGD) in treating polycystic ovary syndrome (PCOS). Our results suggested that SGD effectively regulated estrous cycles, reduced body weight and serum lipid levels in PCOS rats. Additionally, SGD administration significantly remodeled the structure of gut microbiota, especially the BA-related bacteria. The mRNA expressions of BAs metabolism pathway-related genes were significantly changed by SGD treatment. Furthermore, transplantation of fecal microbiota from SGD rats verified these results. In conclusion, SGD could ameliorate dyslipidemia in PCOS rats by remodeling the structure of the gut microbiome and regulating the bile acid/FXR pathway.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.3,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New polyketides from the mangrove-associated endophytic fungus Phomopsis sp. DHS-11.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-03-24 DOI: 10.1080/10286020.2025.2482069
Zhi-Kai Guo, Bi-Ting Chen, Dan-Dan Chen, Xiao-Ling Deng, Jing Xu
{"title":"New polyketides from the mangrove-associated endophytic fungus <i>Phomopsis</i> sp. DHS-11.","authors":"Zhi-Kai Guo, Bi-Ting Chen, Dan-Dan Chen, Xiao-Ling Deng, Jing Xu","doi":"10.1080/10286020.2025.2482069","DOIUrl":"https://doi.org/10.1080/10286020.2025.2482069","url":null,"abstract":"<p><p>Chemical investigation of the mangrove-derived fungus <i>Phomopsis</i> sp. DHS-11 led to the isolation of three new pyrone derivatives (<b>1</b>-<b>3</b>), and a new natural product (<b>4</b>). Their structures were identified by NMR spectroscopy and mass spectrometry. The configurations for the new pyrone derivatives were tentatively solved by comparison of <sup>13</sup>C NMR data and analysis of the coupling constants and NOESY correlations. Compounds <b>2</b> and <b>3</b> exhibited significant cytotoxicity against HepG2 with IC<sub>50</sub> values of 4.66 ± 0.35 µM and 6.07 ± 0.48 µM, respectively. Compound <b>3</b> showed moderate cytotoxicity against Hela cells with IC<sub>50</sub> value of 20.2 ± 4.93 µM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Baicalein: unveiling the multifaceted marvel of hepatoprotection and beyond.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-03-24 DOI: 10.1080/10286020.2025.2481273
Ashish Dogra
{"title":"Baicalein: unveiling the multifaceted marvel of hepatoprotection and beyond.","authors":"Ashish Dogra","doi":"10.1080/10286020.2025.2481273","DOIUrl":"https://doi.org/10.1080/10286020.2025.2481273","url":null,"abstract":"<p><p>Flavonoids are bioactive compounds derived from plants that play a crucial role in human health. Baicalein is a prominent phytoconstituent with multifaceted therapeutic potential against various diseases. This review explores recent advancements in understanding baicalein's hepatoprotective action against different toxicity models (acetaminophen, cisplatin, doxorubicin, CCL<sub>4</sub>, monocrotaline, & d-galactosamine). Furthermore, we report the key pharmacological activities of baicalein against neurotoxicity (6-OHDA, rotenone, d-galactose, stroke, alzheimer, & sclerosis), inflammation (arthritis, pulmonary fibrosis, & LPS-induced sepsis), cancer (breast, prostate, gall bladder, gastric, & pancreatic), & diabetes. Overall, baicalein has potential to influence diverse biological networks, making it a promising candidate for both dietary supplementation and therapeutic development.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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