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Journal of Asian Natural Products Research最新文献

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Hyperwightianols I-N, six new meroterpenoids from Hypericum wightianum. 从金丝桃中提取的6个新萜类化合物-超重醇I-N。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-10-14 DOI: 10.1080/10286020.2025.2567445
Chuan-Lu Fu, Ping Ying, Wei-Ming Huang, Ze Liu, Zi-Wei Jia, Qiang Zheng, You-Jun Wu, Ling-Yi Kong, Wen-Jun Xu
{"title":"Hyperwightianols I-N, six new meroterpenoids from <i>Hypericum wightianum</i>.","authors":"Chuan-Lu Fu, Ping Ying, Wei-Ming Huang, Ze Liu, Zi-Wei Jia, Qiang Zheng, You-Jun Wu, Ling-Yi Kong, Wen-Jun Xu","doi":"10.1080/10286020.2025.2567445","DOIUrl":"https://doi.org/10.1080/10286020.2025.2567445","url":null,"abstract":"<p><p>Six undescribed meroterpenoids, designated as hyperwightianols I-N (<b>1-6</b>), were isolated from the dried whole herb of <i>Hypericum wightianum</i>. The structures of these compounds were elucidated through comprehensive spectroscopic analyses, including high-resolution mass spectrometry (HRMS), 1D & 2D nuclear magnetic resonance spectroscopy (NMR), as well as electronic circular dichroism (ECD). Compounds <b>1-3</b> featured a chromone core hybridized with a monoterpene unit (geranyl or geranyl-derived groups), while <b>4-6</b> were characterized by benzoic acid or cinnamic acid cores hybridized with a lavandulyl unit. In all cases, the monoterpene fragments were linked to the core structures via C-4 ether bond.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.3,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modulation of gut microbiota composition by three traditional mineral medicines in mice. 三种传统矿质药对小鼠肠道菌群组成的调节作用。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-10-08 DOI: 10.1080/10286020.2025.2564412
Meng-Jie Li, Na Li, Yang-Yang Dong, Ling-Li Wu, Hong-Lin Zhang, Xuan-Chen Chen, Dong-Rui Zhou
{"title":"Modulation of gut microbiota composition by three traditional mineral medicines in mice.","authors":"Meng-Jie Li, Na Li, Yang-Yang Dong, Ling-Li Wu, Hong-Lin Zhang, Xuan-Chen Chen, Dong-Rui Zhou","doi":"10.1080/10286020.2025.2564412","DOIUrl":"https://doi.org/10.1080/10286020.2025.2564412","url":null,"abstract":"<p><p>Traditional Chinese medicine (TCM) formulations rely on syndrome differentiation and empirical knowledge, lacking modern scientific support. This study examined the modulation of three mineral medicines-Halloysitum Album (HA), Calcaribus Loess Nodus (CLN), and Smectite (SMT)-on murine gut microbiota using 16S rRNA sequencing, to develop TCM formulations targeting specific beneficial bacteria. HA selectively promoted <i>Faecalibacterium rodentium</i>, CLN enhanced the probiotic <i>Lactobacillus reuteri</i>, while SMT specifically stimulated <i>Roseburia</i> proliferation. Mechanistic studies revealed that SMT modulated microbiota via biofilm formation. These findings suggest that formulating TCM compounds targeting beneficial intestinal bacteria could provide new theoretical support for TCM compatibility principles.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-15"},"PeriodicalIF":1.3,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two new polymethoxyflavones with fully substituted A-ring from the peels of Citrus reticulata "dahongpao". 从大红袍柑桔果皮中分离出两个新的具有全取代a环的多甲氧基黄酮。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-10-08 DOI: 10.1080/10286020.2025.2567403
Juan Li, Yang-He Liu, Hao-Yuan Zheng, Qiang Zhan, Bin Xiao, Ding Liu, Chun-Lei Zhang
{"title":"Two new polymethoxyflavones with fully substituted A-ring from the peels of <i>Citrus reticulata</i> \"dahongpao\".","authors":"Juan Li, Yang-He Liu, Hao-Yuan Zheng, Qiang Zhan, Bin Xiao, Ding Liu, Chun-Lei Zhang","doi":"10.1080/10286020.2025.2567403","DOIUrl":"https://doi.org/10.1080/10286020.2025.2567403","url":null,"abstract":"<p><p>Phytochemical investigation of the peels of <i>Citrus reticulata</i> \"Dahongpao\" resulted in the isolation and characterization of six polymethoxyflavones. Their structures were elucidated as 5,6,7,3'-tetrahydroxy-8,4'-dimethoxyflavone (<b>1</b>), 5,6,7-trihydroxy-8,3',4'-trimethoxyflavone (<b>2</b>), 5,7,8-trihydroxy-6,3',4'-trimethoxyflavone (<b>3</b>), 5,8-dihydroxy -6,7,3',4'-tetramethoxyflavone (<b>4</b>), 5,6,7,8-tetrahydroxy-3',4'-dimethoxyflavone (<b>5</b>), and nobiletin (<b>6</b>) by analysis of their spectroscopic data. They feature a characteristic fully substituted A-ring and a 3',4'-disubstituted B-ring, analogous to nobiletin. Among them, compounds <b>1</b> and <b>2</b> are new compounds. Full assignment of NMR data for compounds <b>3</b> and <b>5</b> is presented here for the first time. Furthermore, the discrepancies in the previously reported NMR spectroscopic data of compound <b>4</b> are discussed.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.3,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comprehensive review on phytosomes as an emerging technology for delivering herbal medicines. 磷脂体作为一种新兴的给药技术的综述。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-10-08 DOI: 10.1080/10286020.2025.2564401
Preeti Aneja, Rajender Guleria, Shivali Aneja, Dev Prakash Dahiya, Ankush Goyal, Dipan Roy, Jitender Singh, Naresh Kumar Rangra
{"title":"A comprehensive review on phytosomes as an emerging technology for delivering herbal medicines.","authors":"Preeti Aneja, Rajender Guleria, Shivali Aneja, Dev Prakash Dahiya, Ankush Goyal, Dipan Roy, Jitender Singh, Naresh Kumar Rangra","doi":"10.1080/10286020.2025.2564401","DOIUrl":"https://doi.org/10.1080/10286020.2025.2564401","url":null,"abstract":"<p><p>A \"novel drug delivery system\" is a new and effective alternative pathway to administer drugs that evade the limitations of traditional methods. The natural medications can be a good approach for delivering the active ingredients to the target-specific area. However, many plant extracts and compounds face challenges like poor solubility and poor absorption. To overcome these issues, the emergence of \"phytosomes\" has been developed. Phytosomes are advanced herbal delivery systems that improve the absorption and effectiveness of plant extracts. This review highlights the key advancements in phytosomal technology, their practical benefits, and cost-effectiveness.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-19"},"PeriodicalIF":1.3,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three new compounds from the roots of Rubia cordifolia. 从芦花根中提取的三个新化合物。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-10-06 DOI: 10.1080/10286020.2025.2568630
Wan-Qi Zhang, Xin-Yue Li, Ming-Hui Sun, Jie Zhou, Guo-Ru Shi, De-Quan Yu, Yan-Fei Liu
{"title":"Three new compounds from the roots of <i>Rubia cordifolia</i>.","authors":"Wan-Qi Zhang, Xin-Yue Li, Ming-Hui Sun, Jie Zhou, Guo-Ru Shi, De-Quan Yu, Yan-Fei Liu","doi":"10.1080/10286020.2025.2568630","DOIUrl":"https://doi.org/10.1080/10286020.2025.2568630","url":null,"abstract":"<p><p>Three new compounds (<b>1</b>-<b>3)</b>, including two cyclopentanoid monoterpenes rubicoside A (<b>1</b>) and rubicocin A (<b>2</b>), and one naphthohydroquinone glycoside rubinaphthin E (<b>3</b>), together with six known analogues (<b>4</b>-<b>9)</b>, were isolated from the roots of <i>Rubia cordifolia</i>. The structures of compounds <b>1</b>-<b>3</b> were established by chemical methods and spectroscopic analysis. Compounds <b>1</b>-<b>9</b> were tested for their cytotoxicity and screened for stable transfection of recombinant dopamine receptors in HEK293 cell lines.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blumeatin inhibits LPS-induced inflammation of TLR4/NF-κB signaling pathway via targeting TLR4/MD-2 蓝肉素通过靶向TLR4/MD-2抑制lps诱导的TLR4/NF-κB信号通路炎症。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-10-03 DOI: 10.1080/10286020.2025.2469690
Jun-Chao Peng , Wei-Jin Qi , Hong-Ying Wang , Wei Zhou , Xing-Jian Yu , Lu Wang
{"title":"Blumeatin inhibits LPS-induced inflammation of TLR4/NF-κB signaling pathway via targeting TLR4/MD-2","authors":"Jun-Chao Peng ,&nbsp;Wei-Jin Qi ,&nbsp;Hong-Ying Wang ,&nbsp;Wei Zhou ,&nbsp;Xing-Jian Yu ,&nbsp;Lu Wang","doi":"10.1080/10286020.2025.2469690","DOIUrl":"10.1080/10286020.2025.2469690","url":null,"abstract":"<div><div>TLR4/MD-2, a protein complex to recognize LPS, has become an ideal target for the treatment of inflammation-related diseases. Blumeatin (BL), which is isolated from <em>Blumea balsamifera</em> (L.) DC has rarely been reported in the inflammation field. In this article, we targeted the TLR4/MD-2 complex to explore how BL regulates the TLR4/NF-κB inflammatory signaling pathway and inhibits LPS-induced inflammation. BL can target the hydrophobic pocket of TLR4/MD-2, inhibit the binding of LPS to TLR4/MD-2, the dimerization of TLR4 and MD-2, and the TLR4/NF-κB signaling pathway activation and the secretion of downstream inflammatory factors. BL may be used as a molecular target of TLR4/MD-2 for the treatment of inflammation-related diseases.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 10","pages":"Pages 1496-1509"},"PeriodicalIF":1.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Magnoflorine ameliorates cartilage degradation in osteoarthritis through inhibition of mitochondrial reactive oxygen species–mediated activation of the NLRP3 inflammasome 木兰花碱通过抑制线粒体活性氧介导的 NLRP3 炎症小体的激活，改善骨关节炎的软骨退化。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-10-03 DOI: 10.1080/10286020.2025.2472898
Yi Peng , Yue-Hui Huang , Xiao Luo , Mei-Chen Li , Qing-Qing Xiao , Lu Qiu , Qiang Fu
{"title":"Magnoflorine ameliorates cartilage degradation in osteoarthritis through inhibition of mitochondrial reactive oxygen species–mediated activation of the NLRP3 inflammasome","authors":"Yi Peng ,&nbsp;Yue-Hui Huang ,&nbsp;Xiao Luo ,&nbsp;Mei-Chen Li ,&nbsp;Qing-Qing Xiao ,&nbsp;Lu Qiu ,&nbsp;Qiang Fu","doi":"10.1080/10286020.2025.2472898","DOIUrl":"10.1080/10286020.2025.2472898","url":null,"abstract":"<div><div>This study investigated the role of magnoflorine (MAG) on cartilage protection in osteoarthritis. <em>In vitro</em> studies showed that MAG decreased the expression of inflammatory factors and inhibited extracellular matrix degradation in lipopolysaccharide- and ATP-stimulated C28/I2 cells. Importantly, MAG reduced the levels of pyroptosis-related proteins, including NLRP3, ASC, cleaved-caspase 1, GSDMD-N, IL-18, and IL-1β. Mechanistically, MAG reduced mtROS production and inhibited the activation of the NF-κB signaling pathway. <em>In vivo</em> study demonstrated that sodium iodoacetate-induced cartilage degradation and inflammatory factor release were reversed by MAG. Overall, MAG could inhibit mtROS-mediated NLRP3 inflammasome activation by suppressing mitochondrial dysfunction to ameliorate osteoarthritis.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 10","pages":"Pages 1528-1549"},"PeriodicalIF":1.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two new bergamotane-type sesquiterpeniods from the plant endophytic fungus Paraconiothyrium brasiliense 从植物内生真菌巴西附龙中分离的两个新的佛手柑烷型倍半萜类化合物。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-10-03 DOI: 10.1080/10286020.2025.2477631
Ying Shi , Ling Liu
{"title":"Two new bergamotane-type sesquiterpeniods from the plant endophytic fungus Paraconiothyrium brasiliense","authors":"Ying Shi ,&nbsp;Ling Liu","doi":"10.1080/10286020.2025.2477631","DOIUrl":"10.1080/10286020.2025.2477631","url":null,"abstract":"<div><div>One new bergamotane-type sesquiterpeniod lactam brasilactam A (<strong>1</strong>) and one new bergamotane-type sesquiterpeniod spiroketal lactone brasiketalolide A (<strong>2</strong>), along with two known compounds ampullicin (<strong>3</strong>) and isoampullicin (<strong>4</strong>) were isolated from the crude extract of the plant endophytic fungus <em>Paraconiothynium brasiliense</em> Verkley. The structures of the new compounds were elucidated on the basis of extensive 2D NMR techniques. The absolute configurations of <strong>1</strong> and <strong>2</strong> were assigned by <sup>13</sup>C NMR and electronic circular dichroism (ECD) calculations. Furthermore, compounds <strong>1 </strong>−<strong> 4</strong> were tested for their cytotoxicity against four human cancer cell lines.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 10","pages":"Pages 1419-1428"},"PeriodicalIF":1.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endophytic microorganisms in lichen: rising stars in the biomedicine field deserving broader recognition 地衣内生微生物：生物医学领域的后起之星，值得更广泛的认识。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-10-03 DOI: 10.1080/10286020.2025.2501030
Jia-Na Zhu , Meng-Long Liu , Qiu-Hua He , Hai-Yan Ding
{"title":"Endophytic microorganisms in lichen: rising stars in the biomedicine field deserving broader recognition","authors":"Jia-Na Zhu ,&nbsp;Meng-Long Liu ,&nbsp;Qiu-Hua He ,&nbsp;Hai-Yan Ding","doi":"10.1080/10286020.2025.2501030","DOIUrl":"10.1080/10286020.2025.2501030","url":null,"abstract":"<div><div>Lichens are renowned for their ability to thrive in extreme environments and for producing unique metabolites with considerable bioactive potential. However, their medicinal value remains largely underexplored, primarily due to slow growth rates and habitat specificity. Notably, endolichenic microorganisms, particularly fungi, are the predominant producers of these bioactive compounds, which exhibit antimicrobial, antiviral, and anticancer properties. Investigating these microorganisms and their metabolites presents promising biomedical opportunities, underscoring the importance of sustainably utilizing lichen resources and discovering novel compounds. This paper reviews the diversity and bioactive potential of endophytic microorganisms in lichens, providing valuable insights for the exploration of natural resources.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 10","pages":"Pages 1389-1407"},"PeriodicalIF":1.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design, synthesis and antitumor activity of pentacyclic triterpenoid ursolic acid derivatives and oleanolic acid derivatives based on multi-target 基于多靶点的五环三萜熊果酸衍生物和齐墩果酸衍生物的设计、合成及其抗肿瘤活性。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-10-03 DOI: 10.1080/10286020.2025.2473635
Jun-Jiao Ma , Liang-Feng Zhang , Dong-Ping Xu , Zan Wang , Yan-Qiu Meng
{"title":"Design, synthesis and antitumor activity of pentacyclic triterpenoid ursolic acid derivatives and oleanolic acid derivatives based on multi-target","authors":"Jun-Jiao Ma ,&nbsp;Liang-Feng Zhang ,&nbsp;Dong-Ping Xu ,&nbsp;Zan Wang ,&nbsp;Yan-Qiu Meng","doi":"10.1080/10286020.2025.2473635","DOIUrl":"10.1080/10286020.2025.2473635","url":null,"abstract":"<div><div>Totally twelve inhibitors of Survivin and Sp1 based on ursolic acid (<strong>UA</strong>) derivatives and oleanolic acid (<strong>OA</strong>) derivatives were designed and synthesized with modification at C-2, C-3 and C-28 of <strong>UA</strong> and <strong>OA</strong>. Their structures were confirmed by HRMS,<sup>1</sup>H NMR and <sup>13</sup>C NMR. <em>In vitro</em> activity assay showed that these compounds can inhibit cell proliferation of HeLa, SKOV3, BGC-823 and HT1080 cells, especially compounds <strong>IV</strong> and <strong>X</strong> showed better inhibitory activity on these tumor cells than that of the positive control drug Gefitinib and similar to Vp-16. Mechanistically, selected compound may inhibit the proliferation of <strong>SKOV3</strong> cells and trigger apoptosis by activating Sp1 to inhibit Survivin protein expression, which may be promising leading compounds for cancer therapy.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 10","pages":"Pages 1429-1446"},"PeriodicalIF":1.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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