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Preclinical determination of wound-healing activity of halibut oil cream in rat model of burn wound. 临床前测定大比目鱼油膏在大鼠烧伤模型中的伤口愈合活性。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-12-01 Epub Date: 2024-07-01 DOI: 10.1080/10286020.2024.2368835
S T Shukla, Anu Kaushik, Samiullah Allahbaksh Auti, Dinesh Kumar, Supriya Kumar Das
{"title":"Preclinical determination of wound-healing activity of halibut oil cream in rat model of burn wound.","authors":"S T Shukla, Anu Kaushik, Samiullah Allahbaksh Auti, Dinesh Kumar, Supriya Kumar Das","doi":"10.1080/10286020.2024.2368835","DOIUrl":"10.1080/10286020.2024.2368835","url":null,"abstract":"<p><p>This study investigated the effects of halibut oil cream, containing omega-3 fatty acids, vitamins A and D, and hydroxyproline, on burn wound healing in rats. Acute dermal toxicity tests confirmed its nontoxicity. Wistar rats were divided into five groups: a control, a positive control treated with silver sulfadiazine 1% (SSD), and three groups treated with 3%, 9%, and 27% halibut oil cream Formulation (HBOF). The SSD and HBOF groups showed significant healing improvements compared to the control. Histopathological analysis indicated increased collagen production in the HBOF groups, suggesting halibut oil cream's potential as a topical treatment for burn wounds.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sesquilignans PD from Zanthoxylum nitidum var. tomentosum exerts antitumor effects via the ROS/MAPK pathway in liver cancer cells. 从 Zanthoxylum nitidum var. tomentosum 中提取的 Sesquilignans PD 可通过 ROS/MAPK 途径对肝癌细胞产生抗肿瘤作用。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-12-01 Epub Date: 2024-07-03 DOI: 10.1080/10286020.2024.2371032
Cai-Wen Fan, Li Luo, Mei-Shan Li, Yun-Qiong Gu, Yi-Lin Fang, Feng Qin, Heng-Shan Wang
{"title":"Sesquilignans PD from <i>Zanthoxylum nitidum</i> var. <i>tomentosum</i> exerts antitumor effects <i>via</i> the ROS/MAPK pathway in liver cancer cells.","authors":"Cai-Wen Fan, Li Luo, Mei-Shan Li, Yun-Qiong Gu, Yi-Lin Fang, Feng Qin, Heng-Shan Wang","doi":"10.1080/10286020.2024.2371032","DOIUrl":"10.1080/10286020.2024.2371032","url":null,"abstract":"<p><p>Sesquilignans <b>PD</b> is a natural phenylpropanoid compound that was isolated from <i>Zanthoxylum nitidum</i> var. <i>tomentosum</i>. In this study, we assessed the antitumor effect of <b>PD</b> on SK-Hep-1 and HepG2 cells and the underlying molecular mechanisms. The results revealed that <b>PD</b> markedly inhibited the proliferation and migration of both liver cancer cells. Moreover, <b>PD</b> induced apoptosis, autophagy, and reactive oxygen species (ROS) production in liver cancer cells. Notably, <b>PD</b> increased the protein levels of p-p38 MAPK and p-ERK1/2 in liver cancer cells. This is the first report on the anticancer effect of <b>PD</b>, which is mediated <i>via</i> increased ROS production and MAPK signaling activation.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The changes of intestinal microbiota and metabolomics during the inhibition of bladder cancer by liquiritigenin. 利尿苷抑制膀胱癌过程中肠道微生物群和代谢组学的变化
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-12-01 Epub Date: 2024-06-13 DOI: 10.1080/10286020.2024.2366010
Zhao Zhai, Jie Fu, Meng-Liang Ye, Jing-Yue Wang, Hao-Jian Zhang, Hang Yu, Xin-Yu Yang, Hui Xu, Jia-Chun Hu, Jin-Yue Lu, Heng-Tong Zuo, Yi Zhao, Jian-Ye Song, Yong Zhang, Yan Wang, Nian-Zeng Xing
{"title":"The changes of intestinal microbiota and metabolomics during the inhibition of bladder cancer by liquiritigenin.","authors":"Zhao Zhai, Jie Fu, Meng-Liang Ye, Jing-Yue Wang, Hao-Jian Zhang, Hang Yu, Xin-Yu Yang, Hui Xu, Jia-Chun Hu, Jin-Yue Lu, Heng-Tong Zuo, Yi Zhao, Jian-Ye Song, Yong Zhang, Yan Wang, Nian-Zeng Xing","doi":"10.1080/10286020.2024.2366010","DOIUrl":"10.1080/10286020.2024.2366010","url":null,"abstract":"<p><p>Liquiritigenin is a natural medicine. However, its inhibitory effect and its potential mechanism on bladder cancer (BCa) remain to be explored. It was found that it could be visualized that the transplanted tumours in the low-dose liquiritigenin -treated group and the high-dose liquiritigenin -treated group were smaller than those in the model group. Liquiritigenin treatment led to alterations in Lachnoclostridium, <i>Escherichia-Shigella, Alistipes</i> and <i>Akkermansia</i>. Non-targeted metabolomics analysis showed that a total of multiple differential metabolites were identified between the model group and the high-dose liquiritigenin-treated group. This provides a new direction and rationale for the antitumour effects of liquiritigenin.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phosphatidylcholine and ceramide derivatives from white rot fungus Microporus xanthropus PP17-20. 白腐霉菌 PP17-20 的磷脂酰胆碱和神经酰胺衍生物。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-12-01 Epub Date: 2024-06-28 DOI: 10.1080/10286020.2024.2368834
Phongphan Jantaharn, Audomsak Churat, Sirirat Juanan, Ek Sangvichien, Wiyada Mongkolthanaruk, Nuttika Suwannasai, Thanaset Senawong, Sirirath McCloskey
{"title":"Phosphatidylcholine and ceramide derivatives from white rot fungus <i>Microporus xanthropus</i> PP17-20.","authors":"Phongphan Jantaharn, Audomsak Churat, Sirirat Juanan, Ek Sangvichien, Wiyada Mongkolthanaruk, Nuttika Suwannasai, Thanaset Senawong, Sirirath McCloskey","doi":"10.1080/10286020.2024.2368834","DOIUrl":"10.1080/10286020.2024.2368834","url":null,"abstract":"<p><p>The undescribed phosphatidylcholine (<b>1</b>), along with twelve known compounds, was isolated from the cultures of white rot fungus <i>Microporus xanthropus</i> PP17-20. In this work the fungus was cultivated in Yeast-Malt extract medium to explore active compound production. The chemical structures were elucidated on the basis of spectroscopic and HRESIMS data. Several isolated compounds were evaluated for anti-proliferative activity against A549 and MCF-7 cancer cell lines.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery of sesquiterpene lactones with anti-inflammatory effect from Youngia japonica. 从莬丝子中发现具有抗炎作用的倍半萜内酯
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-12-01 Epub Date: 2024-07-04 DOI: 10.1080/10286020.2024.2370401
Xian-Sheng Ye, Kuan Lin, Chang-Long Leng, Yu-Ran Gui, Shu-Xiu Zhu, Hui-Ying Liu, Yi-Yuan Xia, Bin-Lian Sun, Wei Liu, Xi-Ji Shu
{"title":"Discovery of sesquiterpene lactones with anti-inflammatory effect from <i>Youngia japonica</i>.","authors":"Xian-Sheng Ye, Kuan Lin, Chang-Long Leng, Yu-Ran Gui, Shu-Xiu Zhu, Hui-Ying Liu, Yi-Yuan Xia, Bin-Lian Sun, Wei Liu, Xi-Ji Shu","doi":"10.1080/10286020.2024.2370401","DOIUrl":"10.1080/10286020.2024.2370401","url":null,"abstract":"<p><p>The preliminary study revealed that the ethyl acetate eluate of <i>Youngia japonica</i> (YJ-E) could inhibit the expression of key proteins of p-p65, p-IκBα, p-IKKα/β, and p-AKT in LPS stimulated BV2 cell. Further phytochemical study led to the isolation of eight compounds from YJ-E, including one new sesquiterpene lactone. Their structures were elucidated by several spectroscopic data, and comparing the NMR data of known compound. In addition, all of the isolates were evaluated for the anti-inflammatory effect. As a result, compounds <b>3</b> and <b>4</b> distinctly attenuated the expressions of p-IκBα, p-p65, and p-AKT in LPS stimulated BV2 cell, respectively.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mangiferin, a component of Mangifera indica leaf extracts, inhibits lipid synthesis in human sebocytes. 芒果叶提取物中的一种成分芒果苷能抑制人体皮脂细胞的脂质合成。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-12-01 Epub Date: 2024-07-01 DOI: 10.1080/10286020.2024.2369279
Da-Min Jung, Sangsoo Lee, Eun-Mi Kim, Chong Won Choi, Kee K Kim
{"title":"Mangiferin, a component of <i>Mangifera indica</i> leaf extracts, inhibits lipid synthesis in human sebocytes.","authors":"Da-Min Jung, Sangsoo Lee, Eun-Mi Kim, Chong Won Choi, Kee K Kim","doi":"10.1080/10286020.2024.2369279","DOIUrl":"10.1080/10286020.2024.2369279","url":null,"abstract":"<p><p>Inhibition of lipid synthesis in sebocytes is essential for acne treatments. The effects of natural product-derived substances on lipid synthesis are unknown. This study investigated the effects of water extract of <i>Mangifera indica</i> leaves (WEML) on lipid synthesis in human sebocytes. Sebocyte differentiation in low serum conditions increased lipid accumulation and proliferator-activated receptor γ expression. WEML treatment significantly inhibited lipid accumulation and adipogenic mRNA expression in sebocytes. Mangiferin, a bioactive compound in WEML, also reduced lipid accumulation and adipogenic mRNA expression via the AKT pathway. Thus, WEML and mangiferin effectively inhibit lipid synthesis in sebocytes, showing promise for acne treatment.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Survey of natural products reported by Asian research groups in 2023. 2023 年亚洲研究小组报告的天然产品调查。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-12-01 Epub Date: 2024-10-25 DOI: 10.1080/10286020.2024.2412762
Yan-Fei Liu, Shi-Shan Yu
{"title":"Survey of natural products reported by Asian research groups in 2023.","authors":"Yan-Fei Liu, Shi-Shan Yu","doi":"10.1080/10286020.2024.2412762","DOIUrl":"10.1080/10286020.2024.2412762","url":null,"abstract":"<p><p>The new natural products reported in 2023 in peer-reviewed articles in journals with good reputations were reviewed and analyzed. The advances made by Asian research groups in the field of natural products chemistry in 2023 were summarized. Compounds with unique structural features and/or promising bioactivities originating from Asian natural sources were discussed based on their structural classification.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the mechanism of Si-Miao-Yong-An decoction on heart failure based on molecular docking and network pharmacology. 基于分子对接和网络药理学的思茅永安煎剂对心力衰竭的作用机制探索
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-12-01 Epub Date: 2024-07-03 DOI: 10.1080/10286020.2024.2370409
Han Qiu, Sheng-Nan Zhao, Jin-Ling Han, Miao Yu, Ruo-Di Wang, Jing-Ru Fang, Yan-Zhu Luo, Ling-Juan Zhu, Xin-Sheng Yao
{"title":"Exploring the mechanism of Si-Miao-Yong-An decoction on heart failure based on molecular docking and network pharmacology.","authors":"Han Qiu, Sheng-Nan Zhao, Jin-Ling Han, Miao Yu, Ruo-Di Wang, Jing-Ru Fang, Yan-Zhu Luo, Ling-Juan Zhu, Xin-Sheng Yao","doi":"10.1080/10286020.2024.2370409","DOIUrl":"10.1080/10286020.2024.2370409","url":null,"abstract":"<p><p>The SwissTargetPrediction was employed to predict the potential drug targets of the active component of Si-Miao-Yong-An decoction (SMYAD). The therapeutic targets for HF were searched in the Genecard database, and Cytoscape3.9.1 software was used to construct the \"drug-component-target-disease network\" diagram. In addition, the String platform was used to construct Protein-Protein Interaction (PPI) network, and the DAVID database was used for GO and KEGG analysis. AutoDockTools-1.5.6 software was used for molecular docking verification. Network pharmacology studies have shown that AKT 1, ALB, and CASP 3 are the key targets of action of SMYAD against heart failure. The active compounds are quercetin and kaempferol.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms and therapeutic potential of chinonin in nervous system diseases. 奇诺宁在神经系统疾病中的作用机制和治疗潜力。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-12-01 Epub Date: 2024-07-08 DOI: 10.1080/10286020.2024.2371040
Zhang Hui, Wang Lai-Fa, Wang Xue-Qin, Deng Ling, He Bin-Sheng, Jian-Ming Li
{"title":"Mechanisms and therapeutic potential of chinonin in nervous system diseases.","authors":"Zhang Hui, Wang Lai-Fa, Wang Xue-Qin, Deng Ling, He Bin-Sheng, Jian-Ming Li","doi":"10.1080/10286020.2024.2371040","DOIUrl":"10.1080/10286020.2024.2371040","url":null,"abstract":"<p><p>The flavonoid compound chinonin is one of the main active components of <i>Rhizoma anemarrhena</i> with multiple activities, including anti-inflammatory and antioxidant properties, protection of mitochondrial function and regulation of immunity. In this paper, we reviewed recent research progress on the protective effect of chinonin on brain injury in neurological diseases. \"Chinonin\" OR \"Mangiferin\" AND \"Nervous system diseases\" OR \"Neuroprotection\" was used as the terms for search in PumMed. After discarding duplicated and irrelevant articles, a total of 23 articles relevant to chinonin published between 2012 and 2023 were identified in our study.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new phenanthrene with a spirolactone ring from Dendrobium ochreatum. 石斛中新发现的具有螺内酯环的菲。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-12-01 Epub Date: 2024-06-21 DOI: 10.1080/10286020.2024.2368831
Natthaphitcha Khunsantiphong, May Thazin Thant, Chattarika Pengdee, Thanarat Salahong, Hnin Ei Ei Khine, Pithi Chanvorachote, Chatchai Chaotham, Boonchoo Sritularak
{"title":"A new phenanthrene with a spirolactone ring from <i>Dendrobium ochreatum</i>.","authors":"Natthaphitcha Khunsantiphong, May Thazin Thant, Chattarika Pengdee, Thanarat Salahong, Hnin Ei Ei Khine, Pithi Chanvorachote, Chatchai Chaotham, Boonchoo Sritularak","doi":"10.1080/10286020.2024.2368831","DOIUrl":"10.1080/10286020.2024.2368831","url":null,"abstract":"<p><p>Dendroochreatene (<b>1</b>), a new phenanthrene derivative with a spirolactone ring, was isolated from the whole <i>Dendrobium ochreatum</i> plant together with 11 known compounds (<b>2</b>-<b>12</b>). The structure of the new compound was elucidated spectroscopically and phenolic compounds were firstly reported from <i>D. ochreatum.</i> Moscatilin (<b>4</b>), major compound isolated from <i>D. ochreatum,</i> was found to be cytotoxic toward H460 lung-cancer cells, with an IC<sub>50</sub> value of 147.3 ± 0.9 µM, while loddigesiinol C (<b>7</b>), C-<i>α</i>-methoxy derivative was inactive.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141432046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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