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Journal of Asian Natural Products Research最新文献

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11α-hydroxydysobinin: a new limonoid from Chisocheton macrophyllus seeds (Meliaceae). 11α-hydroxydysobinin：一种新发现的类柠檬素。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-16 DOI: 10.1080/10286020.2025.2525332
Lulu Wilden Azzahra, Wahyu Safriansyah, Muhammad Badrul Huda, Desi Harneti, Tri Mayanti, Kindi Farabi, Rani Maharani, Unang Supratman
{"title":"11<i>α</i>-hydroxydysobinin: a new limonoid from <i>Chisocheton macrophyllus</i> seeds (Meliaceae).","authors":"Lulu Wilden Azzahra, Wahyu Safriansyah, Muhammad Badrul Huda, Desi Harneti, Tri Mayanti, Kindi Farabi, Rani Maharani, Unang Supratman","doi":"10.1080/10286020.2025.2525332","DOIUrl":"https://doi.org/10.1080/10286020.2025.2525332","url":null,"abstract":"<p><p>A new limonoid compound 11<i>α</i>-hydroxydisobinin (<b>1</b>), along with a known limonoid compound (<b>2</b>), was isolated from ethyl acetate extract of <i>Chisocheton macrophyllus</i> (Meliaceae) seeds. The structure and stereochemical configuration of compound <b>1</b> was characterized by HR-ESI-MS, UV, IR, NMR, and ECD analysis through quantum chemical calculations (TD-DFT analysis and DP4+ NMR). Both limonoids were tested for their cytotoxic activities against MCF-7 breast cancer cells with IC<sub>50</sub> values of 112.5 and 51.7 µM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in drug design strategies for phototherapy based on tumor cell death mechanisms. 基于肿瘤细胞死亡机制的光疗药物设计策略研究进展。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-16 DOI: 10.1080/10286020.2025.2530748
Zheng-Hao Chen, Xin-De Li, Mei-Zhen Luo, Wu-Yu Mao, Shuai Huang, Xian-Li Zhou
{"title":"Advances in drug design strategies for phototherapy based on tumor cell death mechanisms.","authors":"Zheng-Hao Chen, Xin-De Li, Mei-Zhen Luo, Wu-Yu Mao, Shuai Huang, Xian-Li Zhou","doi":"10.1080/10286020.2025.2530748","DOIUrl":"https://doi.org/10.1080/10286020.2025.2530748","url":null,"abstract":"<p><p>Photodynamic therapy (PDT) is a promising non-invasive tumor treatment. Researchers study cell death mechanisms-apoptosis, necrosis, and autophagy-to improve photosensitizer design for precise tumor destruction while sparing normal tissue. This review summarizes these biological causes of cell death. It focuses on recent innovations in PDT drug development and therapeutic techniques, specifically detailing how photosensitizers kill cancer cells. The paper also highlights clinical challenges faced by therapies targeting these common mechanisms and the potential of novel mechanisms. It aims to provide new perspectives on tumor death mechanisms and PDT drug development, offering a basis for novel smart PDT systems.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-33"},"PeriodicalIF":1.3,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mexicanolide limonoids from Khaya ivorensis with anti-hyaluronidase activities. 具有抗透明质酸酶活性的墨西哥红素类柠檬素。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-16 DOI: 10.1080/10286020.2025.2526828
Fei Zhu, Fu-Xue Liu, Ai-Yu He, Miao-Qi Shi, Xin-Lan Ren, Zeng Xu, Chen Yang, Jie Hang
{"title":"Mexicanolide limonoids from <i>Khaya ivorensis</i> with anti-hyaluronidase activities.","authors":"Fei Zhu, Fu-Xue Liu, Ai-Yu He, Miao-Qi Shi, Xin-Lan Ren, Zeng Xu, Chen Yang, Jie Hang","doi":"10.1080/10286020.2025.2526828","DOIUrl":"https://doi.org/10.1080/10286020.2025.2526828","url":null,"abstract":"<p><p>Phytochemical study on 80% methanol extract from the seeds of <i>Khaya ivorensis</i> resulted into the isolation of three undescribed mexicanolide limonoids, ivorensisines A-C (<b>1</b>-<b>3</b>). Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (<sup>1</sup>H-<sup>1</sup>H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated components were evaluated <i>in vitro</i> for anti-hyaluronidase activities. As a result, limonoid <b>3</b> exhibited significant anti-hyaluronidase activity (IC<sub>50</sub> = 8.46 μg/ml) three times more than the positive control drug oleanolic acid (IC<sub>50</sub> = 39.98 μg/ml).</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.3,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical constituents from the fibrous roots of Anemarrhena asphodeloides and their in vitro cytotoxic activity. 山参纤维根化学成分及其体外细胞毒活性研究。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-16 DOI: 10.1080/10286020.2025.2529993
Zhen-Dong Liao, Rou Sun, Ren-Zhong Wang, Hong-Su Zhao, Qi Huang, Feng-Qing Xu, De-Ling Wu
{"title":"Chemical constituents from the fibrous roots of <i>Anemarrhena asphodeloides</i> and their <i>in vitro</i> cytotoxic activity.","authors":"Zhen-Dong Liao, Rou Sun, Ren-Zhong Wang, Hong-Su Zhao, Qi Huang, Feng-Qing Xu, De-Ling Wu","doi":"10.1080/10286020.2025.2529993","DOIUrl":"https://doi.org/10.1080/10286020.2025.2529993","url":null,"abstract":"<p><p>To explore chemical constituents in the fibrous roots of <i>Anemarrhena asphodeloides</i>, 12 compounds were obtained, including three undescribed compounds <b>(1-3)</b> and nine known related compounds <b>(4-12)</b>. Their structures were determined by spectroscopic analyses, including 1D, 2D NMR, and HRESIMS data. The cytotoxic activity of all isolates was evaluated against two human hepatoma carcinoma cells (HepG2 and Hep3B) <i>in vitro</i>. Among them, compounds <b>1</b>, <b>2,</b> and <b>4</b> exhibited inhibitory effects at high concentration of 50 μM. Compound <b>4</b> showed cytotoxic activities against HepG2 and Hep3B cell lines with the IC<sub>50</sub> values of 14.80 ± 0.58 and 10.89 ± 0.46 μM, respectively.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Green synthesis approach for quinoxalines and their derivatives utilizing waste orange peel extract CuO nanoparticles. 利用废橙皮萃取物纳米CuO绿色合成喹诺啉类药物及其衍生物。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-14 DOI: 10.1080/10286020.2025.2523487
Trupti Chavan, Jui Tambe, Sneha Gunjal, Hemchandra K Chaudhari, Vrushali Raut
{"title":"Green synthesis approach for quinoxalines and their derivatives utilizing waste orange peel extract CuO nanoparticles.","authors":"Trupti Chavan, Jui Tambe, Sneha Gunjal, Hemchandra K Chaudhari, Vrushali Raut","doi":"10.1080/10286020.2025.2523487","DOIUrl":"https://doi.org/10.1080/10286020.2025.2523487","url":null,"abstract":"<p><p>The eco-friendly synthesis of quinoxaline and its derivatives was achieved using copper oxide nanoparticles (CuONPs). These green CuO NPs were prepared utilizing a waste orange peel extract, which acts as both a reducing and stabilizing agent. The nanoparticles were then used as a renewable catalyst in the formation of quinoxaline and its derivatives. Characterization of the green CuO NPs was performed using PXRD and SEM techniques. This approach provides numerous benefits, including high yields, straightforward methodology, catalyst recyclability and an uncomplicated workup process.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.3,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Minor lactones from a water decoction of the hook-bearing stem of Uncaria rhynchophylla. 钩藤钩茎水煎液中提取的少量内酯。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-14 DOI: 10.1080/10286020.2025.2525322
Fang-Ting Wei, Le-Ling Song, Jin-Qiu Ren, Xiao-Qiang Lei, Qing-Lan Guo, Jian-Gong Shi
{"title":"Minor lactones from a water decoction of the hook-bearing stem of <i>Uncaria rhynchophylla</i>.","authors":"Fang-Ting Wei, Le-Ling Song, Jin-Qiu Ren, Xiao-Qiang Lei, Qing-Lan Guo, Jian-Gong Shi","doi":"10.1080/10286020.2025.2525322","DOIUrl":"https://doi.org/10.1080/10286020.2025.2525322","url":null,"abstract":"<p><p>Six undescribed minor lactones (uncarterolides A-F, <b>1</b>-<b>6</b>) were isolated from a water decoction of the hook-bearing stems of <i>Uncaria rhynchophylla</i> (gou-teng). Their structures were determined by spectroscopic data analysis, along with electronic circular dichroism (ECD) and NMR calculations. Compounds <b>3-6</b> are abnormal homo-monoterpene enolic ether lactones sharing structural features with monoterpene alkaloids from gou-teng, as well as compounds <b>3</b> and <b>6</b> attenuated APAP-induced HepG2 cell damage by increasing the cell viability from 59.39% to 75.87% and 74.43%, respectively.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.3,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Network pharmacology research and experimental verification of dietary flavonoid fisetin in treating myocardial hypertrophy. 膳食黄酮类非瑟酮治疗心肌肥厚的网络药理学研究及实验验证。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-14 DOI: 10.1080/10286020.2025.2526826
Hui Chen, Li-Li Jiang, Chun-Mei Luo, Tian-Yu Chen, Chang-Han Ouyang
{"title":"Network pharmacology research and experimental verification of dietary flavonoid fisetin in treating myocardial hypertrophy.","authors":"Hui Chen, Li-Li Jiang, Chun-Mei Luo, Tian-Yu Chen, Chang-Han Ouyang","doi":"10.1080/10286020.2025.2526826","DOIUrl":"https://doi.org/10.1080/10286020.2025.2526826","url":null,"abstract":"<p><p>In this study, network pharmacology was developed to study the mechanism of fisetin in the treatment of myocardial hypertrophy. A total of 41 common targets were obtained through multi-database screening, and the core targets were determined by PPI network analysis. KEGG enrichment suggested that the effects of fisetin were mainly related to PI3K-AKT and apoptotic pathways. Western blot experiments confirmed that fisetin inhibited endoplasmic reticulum stress and apoptosis by regulating the expression of PI3K, AKT, GRP78, CHOP and Bax proteins. Our results provide promising guidance for the subsequent clinical application of fisetin in the treatment of myocardial hypertrophy.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-15"},"PeriodicalIF":1.3,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytotoxic limonoids from the twigs of Chisocheton paniculatus. 细枝小枝的细胞毒性类柠檬素。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-14 DOI: 10.1080/10286020.2025.2525316
Peng Yu, Mu-Yi Yang, Xiong-Wei Hu, Jia Liu
{"title":"Cytotoxic limonoids from the twigs of <i>Chisocheton paniculatus</i>.","authors":"Peng Yu, Mu-Yi Yang, Xiong-Wei Hu, Jia Liu","doi":"10.1080/10286020.2025.2525316","DOIUrl":"https://doi.org/10.1080/10286020.2025.2525316","url":null,"abstract":"<p><p>A chemical study on 80% methanol extract of the twigs of <i>Chisocheton paniculatus</i> led to the isolation of two novel limonoids, paniculatusines A and B (<b>1</b> and <b>2</b>). The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (HMQC, and HMBC) NMR spectroscopy, as well as high resolution mass spectrometry. The isolated limonoids were tested <i>in vitro</i> for cytotoxic activities against 5 hepatocellular carcinoma cell lines (SMMC-7721, Bel-7402, MHCC97, HepG2, and Hep3B). Consequently, limonoid <b>1</b> exhibited some cytotoxic activities against all the tested tumor cell lines with IC<sub>50</sub> values less than 20 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.3,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Four new alkaloids from Dactylicapnos grandifoliolata. 大叶菖蒲中4个新生物碱。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-14 DOI: 10.1080/10286020.2025.2527884
Xin-Yu Liu, Jing Wu, Feng Wei, Mei-Fen Bao, Hui-Yuan Gao, Xiang-Hai Cai
{"title":"Four new alkaloids from <i>Dactylicapnos grandifoliolata</i>.","authors":"Xin-Yu Liu, Jing Wu, Feng Wei, Mei-Fen Bao, Hui-Yuan Gao, Xiang-Hai Cai","doi":"10.1080/10286020.2025.2527884","DOIUrl":"https://doi.org/10.1080/10286020.2025.2527884","url":null,"abstract":"<p><p>The first phytochemical investigation on <i>D. grandifoliolata</i> yielded twenty-four alkaloids, including four new ones, <i>N</i>-butylacetamide magnococline (<b>1</b>), fumariflorine methyl ester (<b>6</b>), (<i>R</i>)-corydalisol-2<i>β</i>-<i>N</i>-oxide (<b>9</b>), and (<i>R</i>)-coryximine-2<i>α</i>-<i>N</i>-oxide (<b>10</b>). Among them, compound <b>1</b> was an <i>N-</i>butylacetamide-substituted benzylisoquinoline alkaloid. Compounds <b>9</b> and <b>10</b> were <i>N</i>-oxides of benzylisoquinoline alkaloids. The structures of the new alkaloids were determined through comprehensive spectroscopic analysis and ECD calculations.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.3,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three new shikimate-conjugated meroterpenoids from Alternaria alternata isolated from an entomopathogenic fungus Apis mellifera. 从昆虫病原真菌蜜蜂中分离得到的三个新的莽草碱共轭角萜类化合物。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-04 DOI: 10.1080/10286020.2025.2521542
Ya-Nan Tian, Yu-Wei Niu, Ke-Liang Chen, Yang Liu, Chen-Yu Yang, Xing-Bao Jia, Yang Yang, Yun-Bao Liu
{"title":"Three new shikimate-conjugated meroterpenoids from <i>Alternaria alternata</i> isolated from an entomopathogenic fungus <i>Apis mellifera</i>.","authors":"Ya-Nan Tian, Yu-Wei Niu, Ke-Liang Chen, Yang Liu, Chen-Yu Yang, Xing-Bao Jia, Yang Yang, Yun-Bao Liu","doi":"10.1080/10286020.2025.2521542","DOIUrl":"https://doi.org/10.1080/10286020.2025.2521542","url":null,"abstract":"<p><p>Three new shikimate-conjugated meroterpenes, tricycloalternarenes Z1-Z3 (<b>1</b>-<b>3</b>), were isolated from <i>Alternaria alternate</i>, an endophytic fungus residing in <i>Apis mellifera</i>. The structures of new compounds were characterized by analyses of their NMR and HRESIMS data. The absolute configurations were assigned through electronic circular dichroism (ECD) calculations and CD spectra. Bioassay results showed that tricycloalternarene Z1 (<b>1</b>) exhibited moderate anti-inflammatory activity against the LPS-induced production of NO in RAW 264.7 cells, with an IC<sub>50</sub> value of 0.93 <i>µ</i>M.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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