发布求助
文献互助 智能选刊 最新文献

Journal of Asian Natural Products Research最新文献

筛选
英文 中文
Endophytic microorganisms in lichen: rising stars in the biomedicine field deserving broader recognition. 地衣内生微生物：生物医学领域的后起之星，值得更广泛的认识。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-28 DOI: 10.1080/10286020.2025.2501030
Jia-Na Zhu, Meng-Long Liu, Qiu-Hua He, Hai-Yan Ding
{"title":"Endophytic microorganisms in lichen: rising stars in the biomedicine field deserving broader recognition.","authors":"Jia-Na Zhu, Meng-Long Liu, Qiu-Hua He, Hai-Yan Ding","doi":"10.1080/10286020.2025.2501030","DOIUrl":"https://doi.org/10.1080/10286020.2025.2501030","url":null,"abstract":"<p><p>Lichens are renowned for their ability to thrive in extreme environments and for producing unique metabolites with considerable bioactive potential. However, their medicinal value remains largely underexplored, primarily due to slow growth rates and habitat specificity. Notably, endolichenic microorganisms, particularly fungi, are the predominant producers of these bioactive compounds, which exhibit antimicrobial, antiviral, and anticancer properties. Investigating these microorganisms and their metabolites presents promising biomedical opportunities, underscoring the importance of sustainably utilizing lichen resources and discovering novel compounds. This paper reviews the diversity and bioactive potential of endophytic microorganisms in lichens, providing valuable insights for the exploration of natural resources.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-19"},"PeriodicalIF":1.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prenylated flavones with potential antiproliferative activities from the stems and leaves of Mycetia hainanensis. 海南菌丝体茎叶中具有潜在抗增殖活性的烯丙基黄酮。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-28 DOI: 10.1080/10286020.2025.2507729
Shu-Ri Li, Lin-Xuan Li, Tian-Yu Wang, Yu-Shan Wang, Long-Cheng Cui, Jia-Yi Hu, Ye-Ping Liu, Yan-Ping Liu, Yan-Hui Fu
{"title":"Prenylated flavones with potential antiproliferative activities from the stems and leaves of <i>Mycetia hainanensis</i>.","authors":"Shu-Ri Li, Lin-Xuan Li, Tian-Yu Wang, Yu-Shan Wang, Long-Cheng Cui, Jia-Yi Hu, Ye-Ping Liu, Yan-Ping Liu, Yan-Hui Fu","doi":"10.1080/10286020.2025.2507729","DOIUrl":"https://doi.org/10.1080/10286020.2025.2507729","url":null,"abstract":"<p><p>A phytochemical study on the stems and leaves of <i>Mycetia hainanensis</i> led to the isolation and identification of a new prenylated flavone, mycehainanone (<b>1</b>), as well as seven known analogs (<b>2 </b>-<b> 8</b>). The chemical structure of <b>1</b> was determined using comprehensive spectroscopic analyses and the known compounds were identified by comparison of their spectroscopic data with those reported in the literature. The antiproliferative activities against five human cancer cell lines (JeKo-1, A549, SMMC-7721, SW480, and MCF-7 cell lines) of all isolated prenylated flavones (<b>1 </b>-<b> 8</b>) were evaluated <i>in vitro</i>. Compounds <b>1 </b>-<b> 8</b> exhibited notable antiproliferative effects against various human cancer cell lines with IC<sub>50</sub> values in range of 0.67 ± 0.02 to 38.92 ± 0.23 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two new abietane diterpenoids from Pinus massoniana. 马尾松中两个新枞烷二萜。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-28 DOI: 10.1080/10286020.2025.2509768
Xue Ma, Zhi-Long He, Bao Zhang, Li Jiang, Yong Huang, Yue-Ting Li, Yong-Jun Li
{"title":"Two new abietane diterpenoids from <i>Pinus massoniana</i>.","authors":"Xue Ma, Zhi-Long He, Bao Zhang, Li Jiang, Yong Huang, Yue-Ting Li, Yong-Jun Li","doi":"10.1080/10286020.2025.2509768","DOIUrl":"https://doi.org/10.1080/10286020.2025.2509768","url":null,"abstract":"<p><p>Two new abietane diterpenoids, massonianene A (<b>1</b>) and massonianene B (<b>2</b>), were isolated from the extract of <i>Pinus massoniana</i>. Their structures were elucidated based on HR-ESI-MS, IR, UV, NMR, ECD and X-ray diffraction analysis. Compound <b>2</b> exhibited significant inhibitory effect against LPS-induced NO production in RAW 264.7 cells, with an IC<sub>50</sub> value of 7.00 ± 1.73 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sesquiterpenes with anti-inflammatory activity from the stems and branches of Melicope patulinervia. 山核桃茎、枝中具有抗炎活性的倍半萜素。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-28 DOI: 10.1080/10286020.2025.2508874
Sai Li, En-Lian Du, Qi Gong, Fei Chen, Jun-Jie Tan, Shi-Jin Qu, Hai-Yan Zhang, Chang-Heng Tan
{"title":"Sesquiterpenes with anti-inflammatory activity from the stems and branches of <i>Melicope patulinervia</i>.","authors":"Sai Li, En-Lian Du, Qi Gong, Fei Chen, Jun-Jie Tan, Shi-Jin Qu, Hai-Yan Zhang, Chang-Heng Tan","doi":"10.1080/10286020.2025.2508874","DOIUrl":"https://doi.org/10.1080/10286020.2025.2508874","url":null,"abstract":"<p><p>Five new sesquiterpenes comprising three zieranes, melicopatulones A-C (<b>1</b>-<b>3</b>) and two guaianes, melicopatulones D-E (<b>5</b>-<b>6</b>), were isolated from the stems and branches of <i>Melicope patulinervia</i>, together with melicodenones B (<b>4</b>), C (<b>7</b>) and D (<b>8</b>). Their structures with absolute configurations were elucidated on the basis of analysis of MS, NMR, and TDDFT-ECD calculations. Sesquiterpenes <b>1</b>, <b>2</b> and <b>6</b> exhibited significant inhibitory effect at 10 µM on lipopolysaccharide-induced NO production in BV-2 microglial cells.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chlorogenic acid targets SLC37A2 to inhibit macrophage activation via ER-dependent NF-κB and NLRP3 signaling pathways against sepsis-induced acute lung injury. 绿原酸靶向SLC37A2，通过er依赖性NF-κB和NLRP3信号通路抑制巨噬细胞活化，对抗败血症诱导的急性肺损伤。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-27 DOI: 10.1080/10286020.2025.2506181
Yang Chen, Xiao-Wen Zhang, Mei-Mei Zhao, Ling Li, Yang Liu, Tian-Tian Wei, Wei Yu, Bo Han, Zheng-Ping Liu, Ke-Wu Zeng
{"title":"Chlorogenic acid targets SLC37A2 to inhibit macrophage activation via ER-dependent NF-κB and NLRP3 signaling pathways against sepsis-induced acute lung injury.","authors":"Yang Chen, Xiao-Wen Zhang, Mei-Mei Zhao, Ling Li, Yang Liu, Tian-Tian Wei, Wei Yu, Bo Han, Zheng-Ping Liu, Ke-Wu Zeng","doi":"10.1080/10286020.2025.2506181","DOIUrl":"https://doi.org/10.1080/10286020.2025.2506181","url":null,"abstract":"<p><p>Sepsis-induced acute lung injury (SI-ALI) requires urgent treatment due to severe inflammation. Our study found chlorogenic acid (CGA) suppressed LPS-induced macrophage activation by lowering NO, TNF-α, and IL-6. TPP-based strategies identified SLC37A2 as the direct target of CGA, validated by CETSA/MST. Molecular docking indicated CGA-SLC37A2 hydrogen bonding. CGA alleviated endoplasmic reticulum stress via SLC37A2, inhibiting TLR4/NF-κB and NLRP3 pathways to reduce inflammation. In SI-ALI mice and zebrafish models, CGA mitigated lung injury through these mechanisms taken together. This work highlights the therapeutic potential of CGA for SI-ALI and the critical role of SLC37A2 in combating infectious pneumonia.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-22"},"PeriodicalIF":1.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monoterpene derivatives from the fruits of Illicium simonsii 淫羊藿果实中的单萜衍生物。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-23 DOI: 10.1080/10286020.2025.2504964
Mi Li , Guo-Zhu Su , Hai-Qiang Wang , Xiao-Jing Wang , Li Li , Yu-Huan Li , Shuang-Gang Ma , Shi-Shan Yu
{"title":"Monoterpene derivatives from the fruits of Illicium simonsii","authors":"Mi Li ,&nbsp;Guo-Zhu Su ,&nbsp;Hai-Qiang Wang ,&nbsp;Xiao-Jing Wang ,&nbsp;Li Li ,&nbsp;Yu-Huan Li ,&nbsp;Shuang-Gang Ma ,&nbsp;Shi-Shan Yu","doi":"10.1080/10286020.2025.2504964","DOIUrl":"10.1080/10286020.2025.2504964","url":null,"abstract":"<div><div>Three previously undescribed monoterpene derivatives, illisimoncins A–C (<strong>1</strong>–<strong>3</strong>) and one undescribed 2-formylpyrrole alkaloid (<strong>4</strong>) were isolated from the fruits of <em>Illicium simonsii</em> together with five known monoterpenes (<strong>5</strong>-<strong>9</strong>). Structural elucidation of compounds <strong>1</strong>-<strong>4</strong> was elucidated through comprehensive spectroscopic analyses and their absolute configurations were determined by the dimolybdenum tetraacetate [Mo<sub>2</sub>(AcO)<sub>4</sub>]-induced ICD experiment and modified Mosher’s method. Compounds <strong>2</strong> and <strong>7</strong> showed antiviral activities against Coxsackievirus B3 with IC<sub>50</sub> values of 57.74 and 23.24 µM, respectively.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 6","pages":"Pages 834-843"},"PeriodicalIF":1.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biotransformation and activity identification of icariin in human intestinal fungus Pichia occidentalis. 西毕赤酵母中淫羊藿苷的生物转化及活性鉴定。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-21 DOI: 10.1080/10286020.2025.2493937
Jia-Shuo Li, Ru-Xin Yao, Qing Lv, Gang Wang, Xue Wang, Yu-Fei Wang, Fang-Yu Yang, Guo-Biao Liang, Zhuang Miao
{"title":"Biotransformation and activity identification of icariin in human intestinal fungus <i>Pichia occidentalis</i>.","authors":"Jia-Shuo Li, Ru-Xin Yao, Qing Lv, Gang Wang, Xue Wang, Yu-Fei Wang, Fang-Yu Yang, Guo-Biao Liang, Zhuang Miao","doi":"10.1080/10286020.2025.2493937","DOIUrl":"https://doi.org/10.1080/10286020.2025.2493937","url":null,"abstract":"<p><p>Compared to icariin, icariside II demonstrates superior absorption and metabolic properties along with enhanced bioactivity. In this study, using DXM-Glc fluorescence assay, <i>Pichia occidentalis</i> was identified as an intestinal fungus expressing functional glucosidase, which could efficiently convert icariin to icariside II via glycosidic bond hydrolysis, revealing the fungus-mediated intestinal glycoside metabolism pathway and determining the optimal conditions for the conversion, including temperature, drug loading, pH and reaction time. Meanwhile, icariside II exhibited anti-glioma activity, and its mechanism of action involved the inhibition of the activation of NF-κB signaling pathway in glioma cells.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatoprotective diterpenes from the nodes of Pinus massoniana. 马尾松结中保肝二萜的研究。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-21 DOI: 10.1080/10286020.2025.2506527
Jia-Qi Chen, Ling-Zhi Zhang, Jie Ma, Chuang-Jun Li, Ying-Da Zang, Hua Sun, Dong-Ming Zhang
{"title":"Hepatoprotective diterpenes from the nodes of <i>Pinus massoniana</i>.","authors":"Jia-Qi Chen, Ling-Zhi Zhang, Jie Ma, Chuang-Jun Li, Ying-Da Zang, Hua Sun, Dong-Ming Zhang","doi":"10.1080/10286020.2025.2506527","DOIUrl":"https://doi.org/10.1080/10286020.2025.2506527","url":null,"abstract":"<p><p>Three new diterpenes, named pinusins D-F (<b>1</b>-<b>3</b>), were isolated from the Chinese medicine \"<i>Pini Lignum Nodi</i>\" (the dried tuberculate or branched nodes of <i>Pinus massoniana</i>), along with twelve known diterpenes. The structures of these new compounds were determined using detailed spectroscopic methods and ECD calculations. Compounds <b>4</b>-<b>15</b> displayed moderate hepatoprotective activity against H<sub>2</sub>O<sub>2</sub>-induced oxidative damage in HepG2 cells, while compounds <b>5</b>-<b>15</b> exhibited markedly enhanced efficacy -surpassing that of bicyclol (positive control).</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synergistic effect and biochemical evaluation of kolaviron and quercetin on rat-model benign prostate hyperplasia. 克拉维铁与槲皮素对大鼠良性前列腺增生模型的协同作用及生化评价。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-17 DOI: 10.1080/10286020.2025.2501022
Ujong P Ujong, Mbang E Ibor, Iwara A Iwara, Mbeh U Eteng
{"title":"Synergistic effect and biochemical evaluation of kolaviron and quercetin on rat-model benign prostate hyperplasia.","authors":"Ujong P Ujong, Mbang E Ibor, Iwara A Iwara, Mbeh U Eteng","doi":"10.1080/10286020.2025.2501022","DOIUrl":"https://doi.org/10.1080/10286020.2025.2501022","url":null,"abstract":"<p><p>This study examined the effects of kolaviron and quercetin, individually and combined, on biochemical and histopathological changes in testosterone-induced benign prostatic hyperplasia (BPH) in male Wistar rats. Forty-two rats were divided into six groups, with BPH induced in all but the control group. Treatments included kolaviron, quercetin, their combination, and finasteride. BPH increased PSA, 5-α reductase, DHT, kidney and liver function markers, and altered lipid profiles. Treatments reduced these elevations and improved testosterone and HDL-c levels. Findings suggest that kolaviron and quercetin effectively ameliorate BPH, indicating their potential as affordable, non-invasive options for BPH management.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-16"},"PeriodicalIF":1.3,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytotoxic limonoids from the barks of Chisocheton siamensis. 猕猴桃树皮的细胞毒性类柠檬素。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-16 DOI: 10.1080/10286020.2025.2501020
Xue-Hua Li, Jian-Jun Lei, Yang Chi, Xin-Pei Wang, Yu-Wei Xiao, Qian Sun, He Zhang
{"title":"Cytotoxic limonoids from the barks of <i>Chisocheton siamensis</i>.","authors":"Xue-Hua Li, Jian-Jun Lei, Yang Chi, Xin-Pei Wang, Yu-Wei Xiao, Qian Sun, He Zhang","doi":"10.1080/10286020.2025.2501020","DOIUrl":"https://doi.org/10.1080/10286020.2025.2501020","url":null,"abstract":"<p><p>A phytochemical study of 90% methanol extract of the barks of <i>Chisocheton siamensis</i> afforded three undescribed limonoids, siamensisines A-C (<b>1</b>-<b>3</b>). The structures of the new compounds were elucidated by spectroscopic analysis (NMR, IR, UV, and MS). The isolated limonoids were tested <i>in vitro</i> for cytotoxic activities against 5 pancreatic cell lines. As a result, limonoid <b>3</b> exhibited some cytotoxic activities against all the tested tumor cell lines with IC<sub>50</sub> values less than 20 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信