{"title":"Penidelanones A-F: furancarboxylic acids from the endophytic fungus <i>Penicillium daleae</i>.","authors":"Meng-Ru Yu, Yan-Bin Li, Chong Dai, Yong Shen, Yong-Hui Zhang, Chun-Mei Chen, Hu-Cheng Zhu","doi":"10.1080/10286020.2026.2662991","DOIUrl":"https://doi.org/10.1080/10286020.2026.2662991","url":null,"abstract":"<p><p>Six new furancarboxylic acids, penidelanones A - F (<b>1 </b>-<b> 6</b>), along with one known analogue, (+)-gregatin B (<b>7</b>), were discovered from the endophytic fungus, <i>Penicillium daleae</i>. Penidelanone A (<b>1</b>) is the first reported furancarboxylic acid with an amide group. Their planar structures were determined by extensive spectroscopic data, and the absolute configurations were assigned by comparison of optical values.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mei Tang, Shuo Ju, Yi-Qiong Liu, Qin He, Shuai Huang, Yang Xu, Xian-Li Zhou
{"title":"Three new diterpenoid alkaloids from <i>Delphinium trichophorum</i>.","authors":"Mei Tang, Shuo Ju, Yi-Qiong Liu, Qin He, Shuai Huang, Yang Xu, Xian-Li Zhou","doi":"10.1080/10286020.2026.2658492","DOIUrl":"https://doi.org/10.1080/10286020.2026.2658492","url":null,"abstract":"<p><p>Three previously unreported diterpenoid alkaloids were isolated from the ethanol extract of <i>Delphinium trichophorum</i> Franch and named trichophinines A-C (<b>1</b>-<b>3</b>), along with twenty-four known compounds. Compounds <b>1</b> and <b>2</b> were lycoctonine-type C<sub>19</sub>-diterpenoid alkaloids, while compound <b>3</b> was a hetisine-type C<sub>20</sub>-diterpenoid alkaloid. Their structures were delineated on the basis of spectroscopic analyses, including IR, HR-ESI-MS, 1D and 2D NMR analyses. Compounds <b>1</b>-<b>3</b> were assessed for the inhibitory activities against LPS-induced NO production in RAW 264.7 macrophage cells, and none exhibited inhibitory activity.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.3,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Huan-Yan Liu, Xi-Kang Zheng, Xiao-Rao Chen, Dan-Xuan Li, Li Shen, Wei-Nan Wang, Jun Wu
{"title":"Secondary metabolites from the mangrove endophytic fungus <i>Curvularia</i> sp. P3.","authors":"Huan-Yan Liu, Xi-Kang Zheng, Xiao-Rao Chen, Dan-Xuan Li, Li Shen, Wei-Nan Wang, Jun Wu","doi":"10.1080/10286020.2026.2658490","DOIUrl":"https://doi.org/10.1080/10286020.2026.2658490","url":null,"abstract":"<p><p>A new nonribosomal peptide-polyketide (NRP-PK) hybrid, curvularisin (<b>1</b>), and a new polyketide, spiciferone D (<b>2</b>), together with twelve known compounds (<b>3 </b>-<b> 14</b>), were isolated from the mangrove-derived endophytic fungus <i>Curvularia</i> sp. P3. Their structures were established through extensive NMR and HRMS analyses, and the absolute configuration of <b>2</b> was confirmed by ECD comparison. Cytotoxicity evaluation on five cancer cell lines (4T1, HeLa, A549, Caco-2, and LLC) revealed a promising activity of compound <b>13</b> against LLC (IC<sub>50</sub> = 5.9 μM), and a moderate effect of compound <b>12</b> against Caco-2 (IC<sub>50</sub> = 49.2 μM). Additionally, compound <b>13</b> inhibited the growth of several bacterial strains, with MIC values ranging from 32 to 64 μg/ml.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Empirical rules for efficiently determining the structures and configurations of natural compounds via 1D NMR.","authors":"Kuo Xu, Ya-Nan Yang, Pei-Cheng Zhang","doi":"10.1080/10286020.2026.2658485","DOIUrl":"https://doi.org/10.1080/10286020.2026.2658485","url":null,"abstract":"<p><p>Determining the chemical structures and stereochemistry of natural compounds present in trace amounts via derivatization or hydrolysis is a considerable challenge. Nonetheless, when employing conventional deuterated reagents, consistent patterns in the subtle variations in chemical shifts and coupling constants observed in the <sup>1</sup>H or <sup>13</sup>C NMR spectra may provide a straightforward and reliable approach for the structural elucidation in specific cases. Importantly, the 1D NMR-based empirical method presented herein is simple to perform and does not require additional support from other techniques. This mini-review is the first to thoroughly compile these empirical rules by combining our research with existing studies.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.3,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Xanthonolignoids from <i>Hypericum curvisepalum</i> with quorum sensing inhibitory activity against <i>Chromobacterium violaceum</i>.","authors":"Qiu-Ying He, Sheng-Qiang Yang, Yik-Ling Chew, Zi-Yin Mai, Bo-Yi Fan, Jie-Lian Huang, Qian-Hui Chen, Li-Ping Teng, Gen-Cheng Liang","doi":"10.1080/10286020.2026.2658493","DOIUrl":"https://doi.org/10.1080/10286020.2026.2658493","url":null,"abstract":"<p><p>Three undescribed xanthonolignoids (<b>1</b>-<b>3</b>), together with eight known analogs (<b>4</b>-<b>11</b>), were isolated from <i>Hypericum curvisepalum</i>. Their structures were elucidated by mass and NMR spectroscopic analyses. In bioassays against <i>Chromobacterium violaceum</i> ATCC 12472, compounds <b>1</b>, <b>4</b>, <b>6</b>, <b>7</b> and <b>9</b> exhibited potential quorum sensing (QS) inhibitory activity at 250 μM, with violacein inhibition rates of 84.92%, 74.96%, 70.47%, 71.43% and 76.87%, respectively. Furthermore, the three new compounds dose-dependently inhibited biofilm formation and significantly suppressed both swimming and swarming motility of <i>C. violaceum</i> ATCC 12472.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.3,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Genome mining guided discovery of new pentangular polyketides from the marine rare actinomycete <i>Actinoalloteichus hymeniacidonis</i> DSM 45092.","authors":"Zi-Yi Yang, Li-Li Sun, Zhuang-Jie Fang, Yu-Chan Chen, Wei-Min Zhang, Yi-Guang Zhu, Chang-Sheng Zhang, Qing-Bo Zhang","doi":"10.1080/10286020.2026.2647386","DOIUrl":"https://doi.org/10.1080/10286020.2026.2647386","url":null,"abstract":"<p><p>Genome mining has become a powerful method for linking biosynthetic gene clusters to chemical structures of their encoded natural products, driven by advances in genomic sequencing and the accumulated knowledge of natural product biosynthesis. Guided by this strategy, <i>Actinoalloteichus hymeniacidonis</i> DSM 45092 was identified as a potential producer of pentangular polyketides. Subsequently, five pentangular polyphenols were isolated from this strain, including two new compounds 19-hydroxy-KS-619-1 (<b>1</b>) and 19,20-dehydro-KS-619-1 (<b>2</b>), and three known analogues <b>3</b>-<b>5</b>. Their structures were elucidated through comprehensive spectroscopic analysis and electronic circular dichroism calculations, and all compounds were evaluated for antibacterial and cytotoxic activities.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.3,"publicationDate":"2026-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147673622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiu-Chuan Fu, Qiao Zhang, Ping Yang, Simon Gibbons, Qing Mu
{"title":"Eu(FOD)<sub>3</sub> as a shift regent ameliorates the <sup>1</sup>H NMR assignments of matrine-type quinolizidine alkaloids.","authors":"Xiu-Chuan Fu, Qiao Zhang, Ping Yang, Simon Gibbons, Qing Mu","doi":"10.1080/10286020.2026.2646674","DOIUrl":"https://doi.org/10.1080/10286020.2026.2646674","url":null,"abstract":"<p><p>Matrine-type quinolizidine alkaloids (QAs) exhibit complex <sup>1</sup>H NMR spectra due to overlapping signals from their CH<sub>2</sub> and CH groups, which were crucial for elucidating their structures. Eu(FOD)<sub>3</sub> was employed to resolve these overlaps and achieve complete NMR assignments using sophocarpine as a model. Optimal conditions were established by evaluating solvent, molar ratio, and field strength, successfully rendering all protons distinguishable and accurately assignable. This study demonstrates that shift reagents remain valuable for resolving resonance overlap in structurally related QAs.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-16"},"PeriodicalIF":1.3,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147645437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Design, synthesis and biological evaluation of asiatic acid derivatives as survivin inhibitors.","authors":"Liang-Feng Zhang, Yong-Hu Qiu, Dong-Ping Xu, Zan Wang, Xin-Ru Yu, Yan-Qiu Meng","doi":"10.1080/10286020.2026.2649836","DOIUrl":"https://doi.org/10.1080/10286020.2026.2649836","url":null,"abstract":"<p><p>Targeting Survivin with small molecules is a validated oncological strategy. Fourteen novel asiatic acid (<b>AA</b>) derivatives incorporating phosphate ester pharmacophores were designed and synthesized guided by the principles of fragment-based drug discovery and informed by the essential pharmacophoric features of known potent Survivin inhibitors. In <i>vitro</i> evaluation revealed that these compounds, particularly compound <b>II<sub>6</sub></b>, effectively inhibited the proliferation of MCF-7, A549 and HeLa cells. Molecular docking indicated that the designed compounds interact with key residues of Survivin through covalent and non-covalent interactions. The selected compound may suppress tumor proliferation via Survivin inhibition, constituting a potential lead for cancer therapy.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-19"},"PeriodicalIF":1.3,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147645440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rui-Han Zhang, Yan Dong, Yi Sun, Yi-Hui Yang, Chang Li
{"title":"Two new polyketides isolated from the endophytic fungus <i>Phomopsis heveicola</i> POH-zhi and its antifungal activity.","authors":"Rui-Han Zhang, Yan Dong, Yi Sun, Yi-Hui Yang, Chang Li","doi":"10.1080/10286020.2026.2649829","DOIUrl":"https://doi.org/10.1080/10286020.2026.2649829","url":null,"abstract":"<p><p>Two new polyketides, demethyl-epiremisporine B (<b>1</b>) and demethyl-coniochaetone A (<b>2</b>), together with four known polyketide compounds including diaportheone A (<b>3</b>), vertixanthone (<b>4</b>), peniphenone (<b>5</b>) and 3,8-dihydroxy-1-propylanthraquinone (<b>6</b>), were isolated from the endophytic fungus <i>Phomopsis heveicola</i> obtained from <i>Sterculia lychnophora</i>. The structures of the new metabolites were elucidated by NMR and HRESIMS analysis, and the absolute configuration of compound <b>1</b> was established by ECD spectroscopy. These compounds were evaluated for their antifungal activity against <i>Candida albicans</i> CMCC 98001 and <i>Aspergillus niger</i> R330. Compounds <b>4</b> and <b>6</b> showed significant antifungal activity on <i>C. Albicans</i> CMCC 98001, with the MIC of 3.125 μg/ml.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147645397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optimization and development of lycopene-loaded hydrogel for breast cancer using Box-Behnken design.","authors":"Suman Khurana, Parveen Kumar Goyal, Shrestha Sharma","doi":"10.1080/10286020.2026.2647195","DOIUrl":"https://doi.org/10.1080/10286020.2026.2647195","url":null,"abstract":"<p><p>The aim of this study was to optimize, formulate, and evaluate a hydrogel composed of chitosan and β-glycerophosphate (β-GP) for the delivery of lycopene in the treatment of breast cancer. Box-Behnken design (BBD) was employed to optimize the formulation, where chitosan concentration (A), β-GP concentration (B) as critical material attributes (CMAs), and stirring speed (C) as critical process parameter (CPP) were selected. The hydrogel was optimized based on gelation time and swelling ratio. The optimized formulation exhibited a gelation time of 145 ± 1.2s, and a swelling ratio of 130.57 ± 2.4%. <i>In Vitro</i> drug release studies demonstrated lycopene release over 24 h. Cytotoxicity studies against breast cancer cell lines demonstrated IC<sub>50</sub> values of 95.45 μg/mL for MCF-7 and 91.16 μg/mL for MDA-MB-231 cells under <i>in vitro</i> conditions. These results suggested that the optimized hydrogel may serve as a feasible platform for localized drug delivery against breast cancer.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-19"},"PeriodicalIF":1.3,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147645465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}