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Journal of Asian Natural Products Research最新文献

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Study on the chemical composition of the stems and leaves of Phytolacca americana. 美洲植物茎叶化学成分的研究。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-10-06 DOI: 10.1080/10286020.2026.2740775
Yang Wang, Hui-Ying Ma, Hui-Chun Geng, Jing-Ya Yang, Yi-Ming Zhai
{"title":"Study on the chemical composition of the stems and leaves of <i>Phytolacca americana</i>.","authors":"Yang Wang, Hui-Ying Ma, Hui-Chun Geng, Jing-Ya Yang, Yi-Ming Zhai","doi":"10.1080/10286020.2026.2740775","DOIUrl":"https://doi.org/10.1080/10286020.2026.2740775","url":null,"abstract":"<p><p>The stems and leaves of <i>Phytolacca americana</i> were phytochemically investigated, leading to the isolation and identification of nine compounds. Two new compounds, 6,7-dimethoxy-4<i>β</i>-hydroxypeltogynane (<b>1</b>) and phytolaccamide A (<b>2</b>) were characterized, with compound <b>1</b> assigned an absolute configuration of 2<i>R</i>, 3<i>S</i>, 4<i>S</i>. Compounds <b>1</b>, <b>3</b> and <b>4</b> represrent rare peltogynane-type structures. Preliminary <i>in vitro</i> antibacterial and antifungal screening showed no obvious inhibitory activity against <i>Staphylococcus aureus</i> subsp. <i>aureus</i> ATCC 29213 or <i>Candida albicans</i> ATCC 10231 at 100 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.6,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery and semisynthesis of coniochaetones N-P: antimicrobial and antioxidant heterocyclics from an Antarctic-derived fungus Penicillium sp. S2014503. 从南极真菌青霉菌sp. S2014503中发现和半合成coniochaetones N-P：抗菌和抗氧化杂环。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-10-05 DOI: 10.1080/10286020.2026.2740154
Hai-Bo Zhang, Imran Khan, Wen-Yu Cheng, Kumar Saurav, Fazli Sattar, Wei Liu, Li-Ping Zhang, Yin-Yue Deng, Fang Peng, Wen-Jun Zhang, Chang-Sheng Zhang
{"title":"Discovery and semisynthesis of coniochaetones N-P: antimicrobial and antioxidant heterocyclics from an Antarctic-derived fungus <i>Penicillium</i> sp. S2014503.","authors":"Hai-Bo Zhang, Imran Khan, Wen-Yu Cheng, Kumar Saurav, Fazli Sattar, Wei Liu, Li-Ping Zhang, Yin-Yue Deng, Fang Peng, Wen-Jun Zhang, Chang-Sheng Zhang","doi":"10.1080/10286020.2026.2740154","DOIUrl":"https://doi.org/10.1080/10286020.2026.2740154","url":null,"abstract":"<p><p><i>Penicillium</i> sp. S2014503 is a fungus found in the Antarctic. Herein, we report a new heterocyclic (<b>1</b>) and two semi-synthesized ones (<b>2</b>-<b>3</b>) derived from citrinin (<b>4</b>), the main product of S2014503. Absolute configurations of <b>1</b> and <b>4</b> were deduced by single crystal X-ray diffraction analyses. Compound <b>2</b> was analyzed to be a diastereomeric mixture. The structure of compound <b>3</b> was determined by NMR and X-ray diffraction analyses. Compounds <b>2</b> and <b>3</b> showed strong antibacterial activity. Furthermore, compounds <b>1</b>-<b>4</b> exhibited excellent synergistic effects against <i>Candida albicans</i> SC5314 by inhibiting its mycelia formation. Compound <b>3</b> also displayed significant antioxidant activities.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.6,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antimelanogenesis and antioxidant activity of Broussonetia papyrifera leaf extract fermentation broth. 纸莎草叶提取物发酵液的抗黑色素生成及抗氧化活性。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-10-01 Epub Date: 2026-01-19 DOI: 10.1080/10286020.2026.2613432
Bo Dou, Rui-Qi Wu, Xiao-Lai Ma, Xiao-Qun Duan
{"title":"Antimelanogenesis and antioxidant activity of <i>Broussonetia papyrifera</i> leaf extract fermentation broth.","authors":"Bo Dou, Rui-Qi Wu, Xiao-Lai Ma, Xiao-Qun Duan","doi":"10.1080/10286020.2026.2613432","DOIUrl":"10.1080/10286020.2026.2613432","url":null,"abstract":"<p><p><i>Broussonetia papyrifera</i> leaves are a medicinal plant rich in bioactive substances. This study utilized microbial fermentation of <i>B. papyrifera</i> leaf extract (BLE) to screen out <i>Lactobacillus rhamnosus</i> and <i>Bifidobacterium papyrifera</i> as the most suitable fermentation strains. The total phenols, total flavonoids, total tannins and total triterpenoids content increased after fermentation. The fermentation broth of <i>L. rhamnosus</i> and BLE (BLFs) could inhibit the tyrosinase, melanin production and related protein expression of mouse melanoma cell B16-F10. The fermentation broth of <i>B. bifidum</i> and BLE (BBFs) exhibited significant antioxidant effects. It indicates that the fermented BLE has great application potential in the fields of medicine, cosmetics and related areas.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1514-1537"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146003569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Steroidal glycosides from Tylophora ovata with anti-inflammatory and radical scavenging activities. 具有抗炎和清除自由基活性的卵形霉甾体苷。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-10-01 Epub Date: 2026-01-24 DOI: 10.1080/10286020.2025.2608815
Bing Shao, Hui Wang, Yu Miao, Qing-Jie Zhao, Jie Ren
{"title":"Steroidal glycosides from <i>Tylophora ovata</i> with anti-inflammatory and radical scavenging activities.","authors":"Bing Shao, Hui Wang, Yu Miao, Qing-Jie Zhao, Jie Ren","doi":"10.1080/10286020.2025.2608815","DOIUrl":"10.1080/10286020.2025.2608815","url":null,"abstract":"<p><p>A chemical investigation on 80% ethanol extract from the whole plants of <i>Tylophora ovata</i> afforded two new C<sub>21</sub> steroidal glycosides, ovatacosides A and B (<b>1</b> and <b>2</b>). Structural elucidation of both compounds were performed by spectral methods such as 1D and 2D (<sup>1</sup>H-<sup>1</sup>H COSY, HMQC, and HMBC) NMR spectroscopy and high resolution mass spectrometry. The isolated components were evaluated <i>in vitro</i> for anti-inflammatory activities against COX-1 and COX-2 and radical scavenging potential using DPPH test. Consequently, <b>1</b> exhibited modest selective inhibition on COX-1 (61.9%) at the concentration of 100 μM and significant DPPH scavenging activity (IC<sub>50</sub> = 42.9 μM) comparable with positive control Trolox (IC<sub>50</sub> = 44.2 μM).</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1472-1479"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunohistochemical and metabolomic analysis of Tibetan medicine triphala in response to pancreatic tissues of diabetic rats. 藏药三联对糖尿病大鼠胰腺组织的免疫组化和代谢组学分析。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-10-01 Epub Date: 2026-01-06 DOI: 10.1080/10286020.2025.2607494
Xue-Yan Li, Xiao-Mei Long, Tao Liu, Shuang Guo, Jian-Xing Gu, Fang-Fang Chen, Yi-Dan Fan, Hai-Peng Liu, Yuan Fan, Zhu-Sheng Tang
{"title":"Immunohistochemical and metabolomic analysis of Tibetan medicine triphala in response to pancreatic tissues of diabetic rats.","authors":"Xue-Yan Li, Xiao-Mei Long, Tao Liu, Shuang Guo, Jian-Xing Gu, Fang-Fang Chen, Yi-Dan Fan, Hai-Peng Liu, Yuan Fan, Zhu-Sheng Tang","doi":"10.1080/10286020.2025.2607494","DOIUrl":"10.1080/10286020.2025.2607494","url":null,"abstract":"<p><p>Tibetan Medicine Triphala (THL), consisting of Emblica officinalis, Terminalia bellerica, and Terminalia chebula, is a traditional Tibetan remedy for diabetes mellitus (DM). This study investigated THL's pancreatic metabolomic effects and impacts on paracrine factors (glucagon, insulin, somatostatin, pancreatic polypeptide) in diabetic rats. Rats were divided into six groups, gavaged for 8 weeks, with weekly blood glucose/body weight monitoring. THL reduced serum glucagon, somatostatin, pancreatic polypeptide, elevated insulin, restored pancreatic β-cell function, downregulated α/δ/pp cell expressions, normalized 5 key differential metabolites, and modulated four core metabolic pathways, exerting antidiabetic effects.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1495-1513"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145911677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Signal pathway and active compounds of Penicillium griseofulvum against triple-negative breast cancer. 灰黄青霉菌抗三阴性乳腺癌的信号通路及活性物质研究。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-10-01 Epub Date: 2026-01-23 DOI: 10.1080/10286020.2026.2615671
Di Li, Jun-Guo Huang, Cheng-Yun Huang, Bai-Hui Lu, Jing Li, Wen-Jing Wang, Xiao-Long Yang
{"title":"Signal pathway and active compounds of <i>Penicillium griseofulvum</i> against triple-negative breast cancer.","authors":"Di Li, Jun-Guo Huang, Cheng-Yun Huang, Bai-Hui Lu, Jing Li, Wen-Jing Wang, Xiao-Long Yang","doi":"10.1080/10286020.2026.2615671","DOIUrl":"10.1080/10286020.2026.2615671","url":null,"abstract":"<p><p>Triple-negative breast cancer (TNBC) is a type of breast cancer that has a high rate of growth and metastasis. In this study, the liquid fermentation product (EX-9) of <i>Penicillium griseofulvum</i>, an endophytic fungus derived from the medicinal plant <i>Delphinium grandiflorum</i> L., has exhibited significant anti-cancer activity against TNBC. We investigated the therapeutic effects and potential mechanisms of EX-9 on TNBC both <i>in vivo</i> and <i>in vitro</i>. Our findings demonstrated that EX-9 exhibited remarkable efficacy against TNBC both <i>in vivo</i> and <i>in vitro</i>, while showing negligible toxicity. The potential mechanism for its anti-TNBC effect involved the inhibition of the PI3K/Akt signaling pathway. Additionally, we employed liquid chromatography-mass spectrometry (LC-MS) technology and network pharmacology methods to uncover the potential pharmacological substance basis of EX-9 in combating TNBC.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1480-1494"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146029755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New alkaloids from the twigs and leaves of tabernaemontana divaricata and their neuroprotective effects. 小红花嫩枝和叶中的新生物碱及其神经保护作用。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-10-01 Epub Date: 2026-01-06 DOI: 10.1080/10286020.2025.2608814
Dong-Hao Lu, Fei-Yan Wu, Nan Zhou, Xia Zhang, Zhen-Hua Li, Song Wang, Min Song, Zi-Wei Li, Xiao-Qi Zhang
{"title":"New alkaloids from the twigs and leaves of <i>tabernaemontana divaricata</i> and their neuroprotective effects.","authors":"Dong-Hao Lu, Fei-Yan Wu, Nan Zhou, Xia Zhang, Zhen-Hua Li, Song Wang, Min Song, Zi-Wei Li, Xiao-Qi Zhang","doi":"10.1080/10286020.2025.2608814","DOIUrl":"10.1080/10286020.2025.2608814","url":null,"abstract":"<p><p>Two novel monoterpenoid quinoline alkaloids, tabernacatines A and B (<b>1</b> and <b>2</b>), and a new monoterpenoid indole alkaloid, tabernacatine C (<b>3</b>), along with three known alkaloids (<b>4 </b>-<b> 6</b>), were isolated from the twigs and leaves of <i>Tabernaemontana divaricata</i>. Their structures were elucidated based on UV, IR, HR-ESI-MS, NMR spectra analysis, X-ray diffraction, and ECD calculation methods. Compounds <b>1 - 6</b> were evaluated for their neuroprotective effects in glutamate-induced HT22 cells, and compounds <b>4</b>-<b>6</b> exhibited potent neuroprotective effects.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1448-1456"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145911655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methyl jasmonate protects liver and pancreas tissues of adult diabetic rats from STZ-induced oxidative stress damage. 茉莉酸甲酯可保护成年糖尿病大鼠肝脏和胰腺组织免受stz诱导的氧化应激损伤。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-10-01 Epub Date: 2026-01-12 DOI: 10.1080/10286020.2025.2611910
Marjan Shabazi, Seifollah Bahramikia, Razieh Kooshki
{"title":"Methyl jasmonate protects liver and pancreas tissues of adult diabetic rats from STZ-induced oxidative stress damage.","authors":"Marjan Shabazi, Seifollah Bahramikia, Razieh Kooshki","doi":"10.1080/10286020.2025.2611910","DOIUrl":"10.1080/10286020.2025.2611910","url":null,"abstract":"<p><p>This study evaluated the potential of methyl jasmonate (MeJA) to modulate oxidative stress damage and hyperglycemia in rats with STZ-induced diabetes. MeJA treatment (5 and 10 mg/kg) improved the destructive effects of STZ-induced oxidative damage, as proved by the decline in ROS formation and lipid peroxidation. In addition, MeJA displayed a substantial upsurge in the level of tissue GSH and activity of CAT and SOD enzymes. Histological analysis confirmed MeJA alleviated liver damage. Given the crucial part oxidative stress plays in the etiology of diabetes, this study offers a novel viewpoint on MeJA's potential as a treatment.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1538-1552"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new nor-28-oleanane glycoside isolated from Syzygium formosum inhibits nitric oxide production in LPS-stimulated RAW264.7 cells. 一种新的正-28-齐墩烷苷可抑制lps刺激RAW264.7细胞中一氧化氮的产生。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-10-01 Epub Date: 2026-01-19 DOI: 10.1080/10286020.2026.2615673
Pham Thi Tham, Pham Thi Thu Giang, Dam Xuan Thang, Vu Thi Thu Hoa, Ngo Thuy Van, Do Thu Chieu, Dao Duy Manh, Pham The Chinh, Bui Huu Tai, Phan Van Kiem
{"title":"A new nor-28-oleanane glycoside isolated from <i>Syzygium formosum</i> inhibits nitric oxide production in LPS-stimulated RAW264.7 cells.","authors":"Pham Thi Tham, Pham Thi Thu Giang, Dam Xuan Thang, Vu Thi Thu Hoa, Ngo Thuy Van, Do Thu Chieu, Dao Duy Manh, Pham The Chinh, Bui Huu Tai, Phan Van Kiem","doi":"10.1080/10286020.2026.2615673","DOIUrl":"10.1080/10286020.2026.2615673","url":null,"abstract":"<p><p>One new nor-28-oleanane glycoside (<b>1</b>) and fifteen known compounds (<b>2 </b>-<b> 16</b>) were separated from a methanol extract of <i>Syzygium formosum</i> leaves. Their structures were elucidated via HRESIMS and NMR spectroscopic analyses. The absolute configuration of <b>1</b> was determined based on ECD spectra calculated using TD-DFT methods. Among the isolates, syringin (<b>11</b>) exhibited significant inhibitory activity against NO production in LPS-stimulated RAW264.7 cells, with an IC<sub>50</sub> value of 18.4 <i>μ</i>M. Compounds <b>1 </b>-<b> 3</b> displayed moderate inhibitory effects, with IC<sub>50</sub> values of 58.4-79.2 <i>μ</i>M.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1566-1574"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145998142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Empirical rules for efficiently determining the structures and configurations of natural compounds via 1D NMR. 通过一维核磁共振有效确定天然化合物结构和构型的经验规则。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-10-01 Epub Date: 2026-04-29 DOI: 10.1080/10286020.2026.2658485
Kuo Xu, Ya-Nan Yang, Pei-Cheng Zhang
{"title":"Empirical rules for efficiently determining the structures and configurations of natural compounds via 1D NMR.","authors":"Kuo Xu, Ya-Nan Yang, Pei-Cheng Zhang","doi":"10.1080/10286020.2026.2658485","DOIUrl":"10.1080/10286020.2026.2658485","url":null,"abstract":"<p><p>Determining the chemical structures and stereochemistry of natural compounds present in trace amounts via derivatization or hydrolysis is a considerable challenge. Nonetheless, when employing conventional deuterated reagents, consistent patterns in the subtle variations in chemical shifts and coupling constants observed in the <sup>1</sup>H or <sup>13</sup>C NMR spectra may provide a straightforward and reliable approach for the structural elucidation in specific cases. Importantly, the 1D NMR-based empirical method presented herein is simple to perform and does not require additional support from other techniques. This mini-review is the first to thoroughly compile these empirical rules by combining our research with existing studies.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1437-1447"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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