蓝肉素通过靶向TLR4/MD-2抑制lps诱导的TLR4/NF-κB信号通路炎症。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-10-03 DOI:10.1080/10286020.2025.2469690

Jun-Chao Peng , Wei-Jin Qi , Hong-Ying Wang , Wei Zhou , Xing-Jian Yu , Lu Wang

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引用次数: 0

摘要

TLR4/MD-2是一种识别LPS的蛋白复合物，已成为治疗炎症相关疾病的理想靶点。蓝肉素（blummeatin， BL）是从蓝藻（Blumea balsamifera， L.）中分离得到的。DC在炎症领域的报道很少。本文以TLR4/MD-2复合物为靶点，探讨BL如何调控TLR4/NF-κB炎症信号通路，抑制lps诱导的炎症。BL可以靶向TLR4/MD-2的疏水性口袋，抑制LPS与TLR4/MD-2的结合，抑制TLR4和MD-2的二聚化，抑制TLR4/NF-κB信号通路的激活和下游炎症因子的分泌。BL可能作为TLR4/MD-2的分子靶点用于治疗炎症相关疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Blumeatin inhibits LPS-induced inflammation of TLR4/NF-κB signaling pathway via targeting TLR4/MD-2

TLR4/MD-2, a protein complex to recognize LPS, has become an ideal target for the treatment of inflammation-related diseases. Blumeatin (BL), which is isolated from Blumea balsamifera (L.) DC has rarely been reported in the inflammation field. In this article, we targeted the TLR4/MD-2 complex to explore how BL regulates the TLR4/NF-κB inflammatory signaling pathway and inhibits LPS-induced inflammation. BL can target the hydrophobic pocket of TLR4/MD-2, inhibit the binding of LPS to TLR4/MD-2, the dimerization of TLR4 and MD-2, and the TLR4/NF-κB signaling pathway activation and the secretion of downstream inflammatory factors. BL may be used as a molecular target of TLR4/MD-2 for the treatment of inflammation-related diseases.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.