从植物内生真菌巴西附龙中分离的两个新的佛手柑烷型倍半萜类化合物。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-03-20 DOI:10.1080/10286020.2025.2477631

Ying Shi, Ling Liu

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引用次数: 0

摘要

从植物内生真菌Paraconiothynium brasiliense Verkley粗提物中分离得到1个新的佛手柑烷型倍半萜内酯型brasilactam A(1)和1个新的佛手柑烷型倍半萜内酯型brasilketolide A(2)，以及2个已知化合物壶胆素(3)和异壶胆素(4)。新化合物的结构在广泛的二维核磁共振技术的基础上得到了阐明。通过13C核磁共振和电子圆二色性（ECD）计算确定了1和2的绝对构型。此外，化合物1 ~ 4对四种人类癌细胞进行了细胞毒性试验。

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Two new bergamotane-type sesquiterpeniods from the plant endophytic fungus Paraconiothyrium brasiliense.

One new bergamotane-type sesquiterpeniod lactam brasilactam A (1) and one new bergamotane-type sesquiterpeniod spiroketal lactone brasiketalolide A (2), along with two known compounds ampullicin (3) and isoampullicin (4) were isolated from the crude extract of the plant endophytic fungus Paraconiothynium brasiliense Verkley. The structures of the new compounds were elucidated on the basis of extensive 2D NMR techniques. The absolute configurations of 1 and 2 were assigned by ¹³C NMR and electronic circular dichroism (ECD) calculations. Furthermore, compounds 1 - 4 were tested for their cytotoxicity against four human cancer cell lines.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.