Two new polymethoxyflavones with fully substituted A-ring from the peels of Citrus reticulata "dahongpao".

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-10-08 DOI:10.1080/10286020.2025.2567403

Juan Li, Yang-He Liu, Hao-Yuan Zheng, Qiang Zhan, Bin Xiao, Ding Liu, Chun-Lei Zhang

引用次数: 0

Abstract

Phytochemical investigation of the peels of Citrus reticulata "Dahongpao" resulted in the isolation and characterization of six polymethoxyflavones. Their structures were elucidated as 5,6,7,3'-tetrahydroxy-8,4'-dimethoxyflavone (1), 5,6,7-trihydroxy-8,3',4'-trimethoxyflavone (2), 5,7,8-trihydroxy-6,3',4'-trimethoxyflavone (3), 5,8-dihydroxy -6,7,3',4'-tetramethoxyflavone (4), 5,6,7,8-tetrahydroxy-3',4'-dimethoxyflavone (5), and nobiletin (6) by analysis of their spectroscopic data. They feature a characteristic fully substituted A-ring and a 3',4'-disubstituted B-ring, analogous to nobiletin. Among them, compounds 1 and 2 are new compounds. Full assignment of NMR data for compounds 3 and 5 is presented here for the first time. Furthermore, the discrepancies in the previously reported NMR spectroscopic data of compound 4 are discussed.

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从大红袍柑桔果皮中分离出两个新的具有全取代a环的多甲氧基黄酮。

对大红袍柑桔果皮进行了植物化学研究，分离并鉴定了6种多甲氧基黄酮。通过对它们的波谱分析，分别鉴定为5,6,7,3′-四羟基-8,4′-二甲氧基黄酮(1)、5,6,7-三羟基-8,3′，4′-三甲氧基黄酮(2)、5,7,8-三羟基-6,3′，4′-三甲氧基黄酮(3)、5,8-二羟基-6,7,3′，4′-四甲基甲氧基黄酮(4)、5,6,7,8-四羟基-3′，4′-二甲氧基黄酮(5)和皂素(6)。它们具有一个典型的全取代a环和一个3',4'-双取代b环，类似于诺比列素。其中化合物1和2为新化合物。本文首次对化合物3和5的核磁共振数据进行了完整的赋值。此外，还讨论了先前报道的化合物4的核磁共振光谱数据的差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.