{"title":"Modulation of gut microbiota composition by three traditional mineral medicines in mice.","authors":"Meng-Jie Li, Na Li, Yang-Yang Dong, Ling-Li Wu, Hong-Lin Zhang, Xuan-Chen Chen, Dong-Rui Zhou","doi":"10.1080/10286020.2025.2564412","DOIUrl":null,"url":null,"abstract":"<p><p>Traditional Chinese medicine (TCM) formulations rely on syndrome differentiation and empirical knowledge, lacking modern scientific support. This study examined the modulation of three mineral medicines-Halloysitum Album (HA), Calcaribus Loess Nodus (CLN), and Smectite (SMT)-on murine gut microbiota using 16S rRNA sequencing, to develop TCM formulations targeting specific beneficial bacteria. HA selectively promoted <i>Faecalibacterium rodentium</i>, CLN enhanced the probiotic <i>Lactobacillus reuteri</i>, while SMT specifically stimulated <i>Roseburia</i> proliferation. Mechanistic studies revealed that SMT modulated microbiota via biofilm formation. These findings suggest that formulating TCM compounds targeting beneficial intestinal bacteria could provide new theoretical support for TCM compatibility principles.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-15"},"PeriodicalIF":1.3000,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asian Natural Products Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/10286020.2025.2564412","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Traditional Chinese medicine (TCM) formulations rely on syndrome differentiation and empirical knowledge, lacking modern scientific support. This study examined the modulation of three mineral medicines-Halloysitum Album (HA), Calcaribus Loess Nodus (CLN), and Smectite (SMT)-on murine gut microbiota using 16S rRNA sequencing, to develop TCM formulations targeting specific beneficial bacteria. HA selectively promoted Faecalibacterium rodentium, CLN enhanced the probiotic Lactobacillus reuteri, while SMT specifically stimulated Roseburia proliferation. Mechanistic studies revealed that SMT modulated microbiota via biofilm formation. These findings suggest that formulating TCM compounds targeting beneficial intestinal bacteria could provide new theoretical support for TCM compatibility principles.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
