Hyperwightianols I-N, six new meroterpenoids from Hypericum wightianum.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-10-14 DOI:10.1080/10286020.2025.2567445

Chuan-Lu Fu, Ping Ying, Wei-Ming Huang, Ze Liu, Zi-Wei Jia, Qiang Zheng, You-Jun Wu, Ling-Yi Kong, Wen-Jun Xu

引用次数: 0

Abstract

Six undescribed meroterpenoids, designated as hyperwightianols I-N (1-6), were isolated from the dried whole herb of Hypericum wightianum. The structures of these compounds were elucidated through comprehensive spectroscopic analyses, including high-resolution mass spectrometry (HRMS), 1D & 2D nuclear magnetic resonance spectroscopy (NMR), as well as electronic circular dichroism (ECD). Compounds 1-3 featured a chromone core hybridized with a monoterpene unit (geranyl or geranyl-derived groups), while 4-6 were characterized by benzoic acid or cinnamic acid cores hybridized with a lavandulyl unit. In all cases, the monoterpene fragments were linked to the core structures via C-4 ether bond.

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从金丝桃中提取的6个新萜类化合物-超重醇I-N。

从金丝桃（Hypericum wightianum）全草中分离得到6个未描述的子萜类化合物，命名为高重醇I-N（1-6）。这些化合物的结构通过高分辨率质谱（HRMS）、一维和二维核磁共振谱（NMR）以及电子圆二色性（ECD）等综合光谱分析得以阐明。化合物1-3具有与单萜烯（香叶基或香叶基衍生基团）杂交的色素核，而4-6具有与薰衣草基杂交的苯甲酸或肉桂酸核。在所有情况下，单萜烯片段通过C-4醚键与核心结构相连。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.