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Journal of Asian Natural Products Research最新文献

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Evaluation of the potential anti-arthritic effects and evaluation of acute oral toxicity of the active fraction of Eclipta prostrata leaves in rat model 在大鼠模型中评估 Eclipta prostrata 叶子活性成分的潜在抗关节炎作用和急性口服毒性。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-11-12 DOI: 10.1080/10286020.2024.2422974
Anjoo Kamboj , Hitesh Malhotra , Himanshu Mukhija , Arockia Babu
{"title":"Evaluation of the potential anti-arthritic effects and evaluation of acute oral toxicity of the active fraction of Eclipta prostrata leaves in rat model","authors":"Anjoo Kamboj ,&nbsp;Hitesh Malhotra ,&nbsp;Himanshu Mukhija ,&nbsp;Arockia Babu","doi":"10.1080/10286020.2024.2422974","DOIUrl":"10.1080/10286020.2024.2422974","url":null,"abstract":"<div><div>The primary goal of this research was to isolate and assess the bioactive compounds within <em>Eclipta prostrata</em> Linn’s chloroform extract, with a focus on their potential to combat arthritis, validating its traditional use. Initially, antioxidant characteristics were evaluated, followed by fractionation through column chromatography. The <em>in-vivo</em> safety assessment, following OECD TG 425 Guidelines, showed no mortality at doses up to 2000 mg/kg, confirming the fraction’s safety. Subsequently, the active fraction was assessed in a complete Freund’s adjuvant-induced arthritis model. It demonstrated a dose-dependent inhibitory effect on inflammation and improved various parameters, including thermal latency time, dorsal flexion, motility, and motor coordination. Active bio constituents like rutin, stigmasterol, quercetin, and beta-sitosterol were estimated in the active fraction. The findings provide validation for the traditional use of <em>E. prostrata</em> as a potential plant with anti-arthritic properties, suggesting its potential suitability for rheumatoid arthritis treatment.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 4","pages":"Pages 591-614"},"PeriodicalIF":1.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two new glycosides and a new flavone from Gerbera delavayi 来自非洲菊的两种新苷和一种新黄酮。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-11-09 DOI: 10.1080/10286020.2024.2420613
Yu-Shuang Wen , Li Jiang , Yang Wang , Ying-Jie Xu , Chun-Hua Liu , Yong Huang , Xue Ma , Yong-Jun Li
{"title":"Two new glycosides and a new flavone from Gerbera delavayi","authors":"Yu-Shuang Wen ,&nbsp;Li Jiang ,&nbsp;Yang Wang ,&nbsp;Ying-Jie Xu ,&nbsp;Chun-Hua Liu ,&nbsp;Yong Huang ,&nbsp;Xue Ma ,&nbsp;Yong-Jun Li","doi":"10.1080/10286020.2024.2420613","DOIUrl":"10.1080/10286020.2024.2420613","url":null,"abstract":"<div><div>Three new compounds, including two glycosides, named gerbelavinsides E/G (<strong>1</strong>/<strong>2</strong>), and a flavone, named gerbelavin G (<strong>3</strong>), were isolated from 50% ethanol extract of <em>Gerbera delavayi</em>. Their structures were elucidated based on HR-ESI-MS, IR, UV and NMR spectral data, and the absolute configurations of <strong>1</strong> and <strong>3</strong> were determined by ECD spectra. Three compounds were tested for their inhibition effect against LPS-induced NO production in RAW 264.7 cells. They exhibited different degrees of inhibition activities with rates of 40.55 ± 1.65%, 70.13 ± 0.55%, 56.74 ± 1.15%, respectively.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 4","pages":"Pages 548-555"},"PeriodicalIF":1.3,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Taxifolin ameliorates the D-galactose-induced aging of mouse hippocampal neurons HT-22 cells through modulating SIRT1/p53 and PI3K/AKT signaling pathways 紫杉叶素通过调节SIRT1/p53和PI3K/AKT信号通路改善D-半乳糖诱导的小鼠海马神经元HT-22细胞衰老。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-10-30 DOI: 10.1080/10286020.2024.2421925
Xing-Long Liu , Shuang Zu , Hao· Yue , An-Ning Li , Ping-Ping Sun , Jian-Guo Li , Li Yan , Li-Na Ma , Shuai Zhang
{"title":"Taxifolin ameliorates the D-galactose-induced aging of mouse hippocampal neurons HT-22 cells through modulating SIRT1/p53 and PI3K/AKT signaling pathways","authors":"Xing-Long Liu ,&nbsp;Shuang Zu ,&nbsp;Hao· Yue ,&nbsp;An-Ning Li ,&nbsp;Ping-Ping Sun ,&nbsp;Jian-Guo Li ,&nbsp;Li Yan ,&nbsp;Li-Na Ma ,&nbsp;Shuai Zhang","doi":"10.1080/10286020.2024.2421925","DOIUrl":"10.1080/10286020.2024.2421925","url":null,"abstract":"<div><div>By establishing an <em>in vitro</em> model of D-Gal-induced brain neuronal cell (HT-22) senescence, it was found that TAX treatment significantly increased the activities of SOD and GSH, while decreasing MDA levels in aging HT-22 cells, indicating that TAX effectively restored the total antioxidant capacity and antioxidant enzyme activity of aging HT-22 cells induced by D-Gal, and attenuated cellular oxidative stress injury. In addition, taxifolin could also protect HT-22 cells from aging by up-regulating SIRT1 while reducing the expression of Ac-p53, indicating that TAX may be an active substance that can effectively delay cell aging.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 4","pages":"Pages 615-631"},"PeriodicalIF":1.3,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in natural products and derivatives with antiviral activity against respiratory syncytial virus (RSV) 具有抗呼吸道合胞病毒（RSV）病毒活性的天然产品和衍生物的最新进展。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-10-19 DOI: 10.1080/10286020.2024.2417211
Ameena Tur Rasool , Erguang Li , Ahsan Nazir
{"title":"Recent advances in natural products and derivatives with antiviral activity against respiratory syncytial virus (RSV)","authors":"Ameena Tur Rasool ,&nbsp;Erguang Li ,&nbsp;Ahsan Nazir","doi":"10.1080/10286020.2024.2417211","DOIUrl":"10.1080/10286020.2024.2417211","url":null,"abstract":"<div><div>Respiratory syncytial virus (RSV) is a widespread viral infection that causes millions of high-risk illnesses annually. Medicinal herbs such as ginseng root, echinacea purpurea, and radix astragali have a positive effect on antiviral activity by preventing viral adhesion, syncytial development, inhibiting viral internalization, relieving respiratory inflammation, strengthening the immune system, and stimulating the release of interferons. The potential benefits of natural products in terms of lower costs, better patient outcomes, and fewer adverse effects are discussed. This review examines the current evidence on the prevention and control of RSV with natural ingredients and the challenges and opportunities in clinical practice.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 4","pages":"Pages 505-528"},"PeriodicalIF":1.3,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Caenorhabditis elegans as in vivo model for the screening of natural plants-derived novel anti-aging compounds: a short introduction 作为体内模型筛选天然植物提取的新型抗衰老化合物的草履虫：简短介绍。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-10-15 DOI: 10.1080/10286020.2024.2414189
Samah H. O. Zarroug
{"title":"Caenorhabditis elegans as in vivo model for the screening of natural plants-derived novel anti-aging compounds: a short introduction","authors":"Samah H. O. Zarroug","doi":"10.1080/10286020.2024.2414189","DOIUrl":"10.1080/10286020.2024.2414189","url":null,"abstract":"<div><div>The global aging population highlights the need for effective anti-aging treatments. Natural products show promise, but thorough evaluation requires <em>in vivo</em> models due to the complexity of aging. Ethical concerns are driving a shift from traditional models like rabbits and mice to alternatives such as <em>Caenorhabditis elegans</em>. This microscopic nematode, with its short life cycle, genetic similarities to humans, and cost-effectiveness, is ideal for testing anti-aging compounds. We review studies using <em>C. elegans</em> to assess natural products, suggesting it could serve as a primary model for ­evaluating the safety and efficacy of plant-derived anti-aging compounds.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 4","pages":"Pages 577-590"},"PeriodicalIF":1.3,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A regio-specific 4’-O-methyltransferase from Epimedium pseudowushanense regiospecifically catalyzing 8-prenylkeampferol to icaritin 一种来自淫羊藿的区域特异性 4'-O-甲基转移酶，可将 8-异戊烯基莰菲醇催化为冰片苷。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-10-07 DOI: 10.1080/10286020.2024.2411710
Ke-Ping Feng , Ji-Mei Liu , Ri-Dao Chen , Qiao-Man Fei , Ke-Bo Xie , Da-Wei Chen , Jun-Gui Dai
{"title":"A regio-specific 4’-O-methyltransferase from Epimedium pseudowushanense regiospecifically catalyzing 8-prenylkeampferol to icaritin","authors":"Ke-Ping Feng ,&nbsp;Ji-Mei Liu ,&nbsp;Ri-Dao Chen ,&nbsp;Qiao-Man Fei ,&nbsp;Ke-Bo Xie ,&nbsp;Da-Wei Chen ,&nbsp;Jun-Gui Dai","doi":"10.1080/10286020.2024.2411710","DOIUrl":"10.1080/10286020.2024.2411710","url":null,"abstract":"<div><div><em>Epimedium</em> is widely used in traditional Chinese medicine and contains rich bioactive compounds. These compounds often have a methyl group at their 4’-OH position catalyzed by methyltransferases. Therefore, studying methyltransferases in <em>Epimedium</em> plants is of great significance. In this study, a flavonol methyltransferase, EpOMT4, was isolated from <em>Epimedium pseudowushanense</em> B.L. Guo. The recombinant enzyme regiospecifically transferred a methyl group to the 4’-OH position of 8-prenylkaempferol forming icaritin. The study demonstrates that enzymatic methylation of flavonoids in <em>Epimedium</em> plants holds significant potential and could provide a promising alternative method for the biosynthetic production of bioactive methylated prenylflavonoids.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 4","pages":"Pages 568-576"},"PeriodicalIF":1.3,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential benefits of marine-derived compounds for slowing the advancement of Alzheimer’s disease 海洋萃取化合物对延缓阿尔茨海默氏症发展的潜在益处。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-10-05 DOI: 10.1080/10286020.2024.2409869
Aditya Malan , Manjusha Choudhary , Prabhjeet Kaur Bamrah , Dipender Kumari
{"title":"Potential benefits of marine-derived compounds for slowing the advancement of Alzheimer’s disease","authors":"Aditya Malan ,&nbsp;Manjusha Choudhary ,&nbsp;Prabhjeet Kaur Bamrah ,&nbsp;Dipender Kumari","doi":"10.1080/10286020.2024.2409869","DOIUrl":"10.1080/10286020.2024.2409869","url":null,"abstract":"<div><div>The incidence of Alzheimer’s is increasing and poses a significant social and economic burden. The pathogenesis involved in the expansion of AD includes neuronal oxidative damage, tau phosphorylation, amyloid beta aggregation, neuroinflammation, etc. Despite enormous efforts, there is currently no effective treatment or cure for this condition in the allopathic system. Marine compounds are appealing options and have a strong neuroprotective impact. Marine-derived compounds from sponges, algae, and marine invertebrates can be used for neuroprotection, with fewer adverse effects than synthetic drugs. Various compounds such as bryostatin-1, docosahexaenoic acid, spirolides, and astaxanthin, GV-971, have demonstrated outstanding activity and bioavailability.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 4","pages":"Pages 479-504"},"PeriodicalIF":1.3,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, characterization and anticancer, antibacterial activities of pentacyclic triterpenoid glycoside derivatives 五环三萜苷衍生物的合成、表征和抗癌、抗菌活性。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-09-24 DOI: 10.1080/10286020.2024.2405224
Pan-Pan Wang , Yan-Dan Liu , Lan-Tian Cui , Gao Li , Long-Xuan Zhao , Mei Jin
{"title":"Synthesis, characterization and anticancer, antibacterial activities of pentacyclic triterpenoid glycoside derivatives","authors":"Pan-Pan Wang ,&nbsp;Yan-Dan Liu ,&nbsp;Lan-Tian Cui ,&nbsp;Gao Li ,&nbsp;Long-Xuan Zhao ,&nbsp;Mei Jin","doi":"10.1080/10286020.2024.2405224","DOIUrl":"10.1080/10286020.2024.2405224","url":null,"abstract":"<div><div>As a kind of glycoside, pentacyclic triterpenoid saponins have good biological activities, such as anticancer, antibacterial, antiviral and hypoglycemic effects [<span><span>1</span></span>]. In this paper, twenty-four pentacyclic triterpenoid derivatives, including twelve monosaccharide derivatives, were designed and synthesized. The anticancer effect and antibacterial activities of all compounds were evaluated. It is noteworthy that compound <strong>UA-2b</strong> has the strongest inhibitory effect on the growth of A549, Hela and HepG2 cancer cells (IC<sub>50</sub> = 5.37 ± 0.22 µM, 5.82 ± 0.25 µM and 5.47 ± 0.06 µM, respectively). Compounds <strong>OA-2b</strong>, <strong>OA-6a</strong>, <strong>OA-6b</strong>, <strong>UA-2b</strong> and <strong>UA-6a</strong> have the best activity against <em>Escherichia coli</em> 1924 (MIC = 16 μg/ml).</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 3","pages":"Pages 323-339"},"PeriodicalIF":1.3,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rosmarinic acid suppresses the progression of COPD via Syk by modulating airway inflammation and epithelial apoptosis in vivo and in vitro. 迷迭香酸在体内和体外通过调节气道炎症和上皮细胞凋亡，通过 Syk 抑制慢性阻塞性肺病的发展。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-09-23 DOI: 10.1080/10286020.2024.2403617
Ji-Qiao Yuan, Xu-Yu Li, Yan-Nan Fan, Nan Fang, Ping Li, Xin-Zhu Wen, Qi Hou, Zi-Qian Zhang, Ming-Bao Lin
{"title":"Rosmarinic acid suppresses the progression of COPD <i>via</i> Syk by modulating airway inflammation and epithelial apoptosis <i>in vivo</i> and <i>in vitro</i>.","authors":"Ji-Qiao Yuan, Xu-Yu Li, Yan-Nan Fan, Nan Fang, Ping Li, Xin-Zhu Wen, Qi Hou, Zi-Qian Zhang, Ming-Bao Lin","doi":"10.1080/10286020.2024.2403617","DOIUrl":"https://doi.org/10.1080/10286020.2024.2403617","url":null,"abstract":"<p><p>Rosmarinic acid (RosA), a hydrophilic phenolic compound found in various plants, has several biological effects such as anti-inflammatory and anti-apoptosis activities. However, its potential impact on chronic obstructive pulmonary disease (COPD) and its underlying mechanism has not been investigated. In this study, we explored the potential therapeutic effects and mechanism of RosA on COPD airway inflammation and alveolar epithelial apoptosis <i>in vivo</i> and <i>in vitro</i>. Our data suggested that RosA may be a therapeutic candidate for COPD with low toxicity. The corresponding mechanism lies in its anti-inflammatory effect on macrophage and bronchial epithelial cells, as well as protective effect on lung epithelial apoptosis via the jointly cross-target spleen tyrosine kinase (Syk).</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-15"},"PeriodicalIF":1.3,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on the anti-HBV activity of matrine alkaloids from Oxytropis ochrocephala by MTT, 3d-QSAR, molecular docking and molecular dynamics simulation 通过MTT、3d-QSAR、分子对接和分子动力学模拟研究牛膝草中的马钱子碱的抗HBV活性
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-09-18 DOI: 10.1080/10286020.2024.2402369
Ya-Kun Zhang , Jian-Bo Tong , Jing Tan , Min Yang , Xiao-Yu Xing , Yan-Rong Zeng , Zhan Xue , Cheng-Jian Tan
{"title":"Study on the anti-HBV activity of matrine alkaloids from Oxytropis ochrocephala by MTT, 3d-QSAR, molecular docking and molecular dynamics simulation","authors":"Ya-Kun Zhang ,&nbsp;Jian-Bo Tong ,&nbsp;Jing Tan ,&nbsp;Min Yang ,&nbsp;Xiao-Yu Xing ,&nbsp;Yan-Rong Zeng ,&nbsp;Zhan Xue ,&nbsp;Cheng-Jian Tan","doi":"10.1080/10286020.2024.2402369","DOIUrl":"10.1080/10286020.2024.2402369","url":null,"abstract":"<div><div>To elucidate the structure-activity relationship of 17 matrine alkaloids from <em>Oxytropis ochrocephala</em> Bunge, their effect on hepatitis B surface antigen (HBsAg) secretion was studied using the MTT assay. A 3D-QSAR analysis showed a strong correlation between chemical structures and biological activities (<em>q<sup>2</sup></em> = 0.625, <em>r<sup>2</sup></em> = 0.859). Molecular docking and molecular dynamics simulations revealed that hydrogen bonding and hydrophobic interactions with hepatitis B core protein (PDB:5T2P) are key to inhibiting HBsAg secretion, suggesting potential for developing natural anti-hepatitis B drugs.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 3","pages":"Pages 442-459"},"PeriodicalIF":1.3,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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