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Journal of Asian Natural Products Research最新文献

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Enhancement of aqueous solubility of hesperidin and naringenin utilizing hydrotropic solubilization technique: characterization and in vitro evaluation 利用水力增溶技术提高橙皮甙和柚皮甙的水溶性：特征描述和体外评估。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-06-26 DOI: 10.1080/10286020.2024.2358831
{"title":"Enhancement of aqueous solubility of hesperidin and naringenin utilizing hydrotropic solubilization technique: characterization and in vitro evaluation","authors":"","doi":"10.1080/10286020.2024.2358831","DOIUrl":"10.1080/10286020.2024.2358831","url":null,"abstract":"<div><p>The therapeutic potential of two important flavonoids, i.e. hesperidin and naringenin, remains unutilized due to pharmacokinetics issues, especially poor aqueous solubility. Hydrotropic solid dispersions with different agents like sodium salicylate, niacinamide, benzoic acid, and urea etc. can change the solubility profile of poorly soluble drugs. The current study investigated the potential of different hydrotropic agents in improving the solubility of both natural bioactives. The hydrotropic solid dispersion in 1:3 w/w drug: sodium salicylate ratio showed maximum solubility and dissolution amongst all the tested hydrotropes. This novel and economical approach could be explored for other poorly soluble pharmaceuticals.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 10","pages":"Pages 1207-1218"},"PeriodicalIF":1.3,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytotoxic iridoid glycosides from the leaves of Paederia scandens 从Paederia scandens叶子中提取的具有细胞毒性的鸢尾甙。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-06-26 DOI: 10.1080/10286020.2024.2358820
{"title":"Cytotoxic iridoid glycosides from the leaves of Paederia scandens","authors":"","doi":"10.1080/10286020.2024.2358820","DOIUrl":"10.1080/10286020.2024.2358820","url":null,"abstract":"<div><p>A phytochemical investigation on the 80% EtOH extract of the leaves of <em>Paederia scandens</em> (Lour.) Merr. resulted into the isolation of three undescribed iridoid glycosides, 10-<em>O</em>-<em>trans</em>-<em>p</em>-coumaroyl-(4<em>R</em>,6<em>R</em>)-3,4-dihydro-3<em>α</em>-methylthiopaederoside (<strong>1</strong>), 10-<em>O</em>-<em>trans</em>-feruloyl-(4<em>S</em>,6<em>R</em>)-3,4-dihydro-2′-<em>O</em>-3<em>α</em>-paederoside (<strong>2</strong>), and 10-<em>O</em>-<em>trans</em>-caffeoyl-paederosidic acid ethyl ester (<strong>3</strong>). The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (<sup>1</sup>H-<sup>1</sup>H COSY, HMQC, and HMBC) NMR spectroscopy, as well as high resolution mass spectrometry. The isolated compounds were tested <em>in vitro</em> for cytotoxic activity against five endocrine tumor cell lines. As a result, compound <strong>1</strong> exhibited some cytotoxicities against all the tested tumor cell lines with IC<sub>50</sub> value less than 20.0 μM.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 10","pages":"Pages 1139-1146"},"PeriodicalIF":1.3,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141457061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization and identification of major flavonoids of bamboo leaf extract by HPLC/ESI-QTOF-MS/MS 利用 HPLC/ESI-QTOF-MS/MS 对竹叶提取物中的主要黄酮类化合物进行表征和鉴定。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-06-26 DOI: 10.1080/10286020.2024.2360039
{"title":"Characterization and identification of major flavonoids of bamboo leaf extract by HPLC/ESI-QTOF-MS/MS","authors":"","doi":"10.1080/10286020.2024.2360039","DOIUrl":"10.1080/10286020.2024.2360039","url":null,"abstract":"<div><p>Bamboo leaf extract (BLE) is a pale brown powder extracted from bamboo leaves, and it is listed in the Chinese Standard GB-2760 as a legal and safe food additive. The present study aims to identify and characterize the major flavonoids in BLE. The identification of major flavonoids was carried out using ultra performance liquid chromatography combined with electrospray ionization quadruple time-of-flight tandem mass spectrometry (HPLC/ESI-QTOF-MS/MS). A total of 31 flavonoid compounds were identified and tentatively characterized base on reference standards and MS dissociation mechanisms. HPLC/ESI-QTOF-MS can serve as an important analytical platform to identification structure of bamboo leaf flavonoids (BLF).</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 10","pages":"Pages 1147-1159"},"PeriodicalIF":1.3,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new 3,4-dinorsteroid from the marine sponge Cliona sp. 海洋海绵 Cliona sp.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-06-26 DOI: 10.1080/10286020.2024.2360114
{"title":"A new 3,4-dinorsteroid from the marine sponge Cliona sp.","authors":"","doi":"10.1080/10286020.2024.2360114","DOIUrl":"10.1080/10286020.2024.2360114","url":null,"abstract":"<div><p>A new steroid, 2a-oxa-2-oxo-5<em>β</em>-hydroxy-3,4-dinor-24-methylcholesta-22<em>E</em>-ene (<strong>1</strong>), together with 10 known ones (<strong>2–11</strong>), was isolated from the marine sponge <em>Cliona</em> sp. The structures of these compounds were determined by the spectroscopic methods (UV, IR, MS, and NMR) and X-ray diffraction analysis. Compound <strong>1</strong> was the third example of 3,4-dinorsteroid with a hemiketal at C-5 that was isolated from the natural source. In addition, the antibacterial activities of these compounds were also evaluated. However, none of them exhibited significant inhibition effects.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 10","pages":"Pages 1254-1260"},"PeriodicalIF":1.3,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of a collection of nootkatone analogues with diverse skeletons 合成一系列具有不同骨架的诺卡酮类似物。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-06-26 DOI: 10.1080/10286020.2024.2358834
{"title":"Synthesis of a collection of nootkatone analogues with diverse skeletons","authors":"","doi":"10.1080/10286020.2024.2358834","DOIUrl":"10.1080/10286020.2024.2358834","url":null,"abstract":"<div><p>A collection of ring distorted analogue of Nootkatone including 6 CTD (Complex to Diversity) compounds and 9 SAR (Structure Activity Relationship) compounds were synthesized utilizing the carbonyl group as a starting reaction point.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 10","pages":"Pages 1160-1165"},"PeriodicalIF":1.3,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical constituents from the twigs with leaves of Tetradium trichotomum Tetradium trichotomum树枝和树叶中的化学成分。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-06-25 DOI: 10.1080/10286020.2024.2363403
{"title":"Chemical constituents from the twigs with leaves of Tetradium trichotomum","authors":"","doi":"10.1080/10286020.2024.2363403","DOIUrl":"10.1080/10286020.2024.2363403","url":null,"abstract":"<div><div>Twelve compounds, comprising of four new ones, 6<em>β</em>,7α-limondiol (<strong>1</strong>) and ethyl 19-hydroxyisoobacunoate diosphenol (<strong>2</strong>), <em>N</em>-benzoyl 3-prenyltyramine (<strong>9</strong>) and 9-<em>O</em>-methyl integrifoliodiol (<strong>12</strong>), were isolated from the twigs with leaves of <em>Tetradium trichotomum</em>. The structures were elucidated by analysis of MS, NMR, and single-crystal X-ray diffraction. Compounds <strong>1</strong>, <strong>6</strong>, <strong>8</strong>, <strong>9</strong> and <strong>12</strong> exhibited immunosuppressive activities <em>in vitro</em> against the proliferation of ConA-induced T lymphocytes and LPS-induced B cells.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 11","pages":"Pages 1285-1291"},"PeriodicalIF":1.3,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141450594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design, synthesis and biological evaluation of aloperine derivatives as potential anticancer agents 作为潜在抗癌剂的阿洛哌啶衍生物的设计、合成和生物学评价。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-06-21 DOI: 10.1080/10286020.2024.2349660
{"title":"Design, synthesis and biological evaluation of aloperine derivatives as potential anticancer agents","authors":"","doi":"10.1080/10286020.2024.2349660","DOIUrl":"10.1080/10286020.2024.2349660","url":null,"abstract":"<div><p>Modifications at different positions on the aloperine molecule were performed to improve its anticancer activity and develop anticancer drugs. The <em>in vitro</em> anticancer activities of 44 synthesized compounds were evaluated. The effect of modification positions on anticancer activity was discussed and a structure–activity relationship analysis was established. A novel series of compounds with modifications at the <em>N</em>12 position showed much higher cytotoxicity than aloperine. Among them, compound <strong>22</strong> displayed promising <em>in vitro</em> anticancer activity against PC9 cells with a median inhibitory concentration (IC<sub>50</sub>) of 1.43 μM. The mechanism studies indicated that compound <strong>22</strong> induced cell apoptosis and cell cycle arrest in PC9 cells. These results demonstrate the potential of aloperine thiourea derivatives in anticancer activity.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 9","pages":"Pages 1057-1086"},"PeriodicalIF":1.3,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141450595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new coumarin and a new flavonoid from Ochrocarpus longifolius 一种来自 Ochrocarpus longifolius 的新香豆素和一种新黄酮类化合物。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-06-19 DOI: 10.1080/10286020.2024.2363416
{"title":"A new coumarin and a new flavonoid from Ochrocarpus longifolius","authors":"","doi":"10.1080/10286020.2024.2363416","DOIUrl":"10.1080/10286020.2024.2363416","url":null,"abstract":"<div><div>A new coumarin (<strong>1</strong>) and a new flavonoid (<strong>2</strong>) were isolated from the air-dried flower buds of <em>Ochrocarpus longifolius</em>, together with ten known compounds (<strong>3</strong>–<strong>12</strong>). The structures of two new compounds were established by 1D and 2D NMR and MS data. In addition, the new compound <strong>2</strong> showed significant proliferation inhibitory activity on Eca-109 and MGC-803 cells. The results of this study may enrich the diversity of compounds from <em>O. longifolius</em> and provide a basis for further research on its natural products and pharmacological activities.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 11","pages":"Pages 1311-1319"},"PeriodicalIF":1.3,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141426941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Secondary metabolites from the fungus Cladosporium xylophilum Cladosporium xylophilum 真菌的次级代谢物。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-06-19 DOI: 10.1080/10286020.2024.2362384
{"title":"Secondary metabolites from the fungus Cladosporium xylophilum","authors":"","doi":"10.1080/10286020.2024.2362384","DOIUrl":"10.1080/10286020.2024.2362384","url":null,"abstract":"<div><div>A new cladosporol derivative xylophilum A (<strong>1</strong>), together with 10 known compounds (<strong>2</strong>–<strong>11</strong>), were isolated from the rice fermentation of the fungus <em>Cladosporium xylophilum</em>. Their structures were established by extensive spectroscopic methods and comparison of their NMR data with literatures. The antimicrobial activity of compound <strong>1</strong> against 11 kinds of pathogenic microbial was evaluated, but no significant activity was found (MIC &gt;100 μg/ml).</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 11","pages":"Pages 1374-1380"},"PeriodicalIF":1.3,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141426942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protective effects of bioactive components targeting β2-adrenergic receptors and muscarinic-3 acetylcholine receptor in Zhisou San on ovalbumin-induced allergic asthma 知寿散中针对β2-肾上腺素能受体和毒蕈碱-3乙酰胆碱受体的生物活性成分对卵清蛋白诱发的过敏性哮喘的保护作用
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-06-14 DOI: 10.1080/10286020.2024.2365442
{"title":"Protective effects of bioactive components targeting β2-adrenergic receptors and muscarinic-3 acetylcholine receptor in Zhisou San on ovalbumin-induced allergic asthma","authors":"","doi":"10.1080/10286020.2024.2365442","DOIUrl":"10.1080/10286020.2024.2365442","url":null,"abstract":"<div><div>One promising approach to overcome drug resistance in asthma treatments involves dual-target therapy, specifically targeting the β2 adrenergic receptor (β<sub>2</sub>-AR) and muscarinic-3 acetylcholine receptor (M<sub>3</sub>R). This study investigated the anti-asthma effects and dual-target mechanisms of glycyrrhizic acid, hesperidin, and platycodin D (GHP) from Zhisou San. GHP administration effectively attenuated OVA-induced inflammatory infiltration and overproduction of mucus in asthmatic mice. Additionally, GHP treatment significantly suppressed M<sub>3</sub>R and promoted β<sub>2</sub>-AR activation, resulting in the relaxation of tracheal smooth muscle. These findings concluded that GHP mitigated asthma by targeting β<sub>2</sub>-AR and M<sub>3</sub>R to ameliorate airway inflammation and modulate airway smooth muscle relaxation.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 11","pages":"Pages 1358-1373"},"PeriodicalIF":1.3,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141317447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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