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Research progress on anti-tumor mechanisms of scutellarin 黄芩苷抗肿瘤机制的研究进展。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-05-19 DOI: 10.1080/10286020.2024.2362375
{"title":"Research progress on anti-tumor mechanisms of scutellarin","authors":"","doi":"10.1080/10286020.2024.2362375","DOIUrl":"10.1080/10286020.2024.2362375","url":null,"abstract":"<div><div>Scutellarin, one of natural flavonoids from <em>Scutellaria barbata D. Don</em> and <em>Erigeron breviscapus (vant) Hand.-Mazz</em>. Modern pharmacological studies have shown that scutellarin has a good anti-tumor effect. According to the literature review at home and abroad, scutellarin can inhibit the growth and metastasis of tumor cells, block the cell cycle at various stages, induce apoptosis and autophagy, interfere with tumor metabolism, reverse drug resistance of tumor cells and enhance the sensitivity of chemotherapy drugs. In this paper, the anti-tumor mechanism of scutellarin was reviewed, and the shortcomings of current studies and future research directions were analyzed, so as to provide a basis for further exploration of the anti-tumor potential of scutellarin and its further development and utilization.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 11","pages":"Pages 1261-1275"},"PeriodicalIF":1.3,"publicationDate":"2024-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glycoside constituents from Cayratia geniculata 来自 Cayratia geniculata 的糖苷成分。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-05-16 DOI: 10.1080/10286020.2024.2347521
{"title":"Glycoside constituents from Cayratia geniculata","authors":"","doi":"10.1080/10286020.2024.2347521","DOIUrl":"10.1080/10286020.2024.2347521","url":null,"abstract":"<div><p>Using various chromatographic separations, six glycoside derivatives (<strong>1–6</strong>), including one new <em>ent</em>-labdane glucoside named cayratioside (<strong>1</strong>), were isolated from the methanol extract of <em>Cayratia geniculata</em> stems and leaves. Their structures were elucidated by detailed analysis of the 1D, 2D NMR, and HRESIQTOF mass spectra. The inhibitory effect of <strong>1–6</strong> on LPS-induced NO production in RAW264.7 cells was also evaluated. Among isolated compounds, <strong>1</strong> exhibited moderate activity with an IC<sub>50</sub> value of 59.65 ± 1.85 µM.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 9","pages":"Pages 1130-1137"},"PeriodicalIF":1.3,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140957609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macrophorins H and L, two new HMG-conjugate macrophorins from rihzospheric Penicillium sp. NX-05-G-3 来自日光层青霉 NX-05-G-3 的两种新的 HMG 结合型巨噬细胞蛋白 H 和 L。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-05-16 DOI: 10.1080/10286020.2024.2347530
{"title":"Macrophorins H and L, two new HMG-conjugate macrophorins from rihzospheric Penicillium sp. NX-05-G-3","authors":"","doi":"10.1080/10286020.2024.2347530","DOIUrl":"10.1080/10286020.2024.2347530","url":null,"abstract":"<div><p>Macrophorins H (<strong>4</strong>) and L (<strong>5</strong>), two rare HMG-conjugate macrophorins along with three known macrophorins (<strong>1</strong>-<strong>3</strong>), three DMOA-derived meroterpenoids (<strong>6</strong>-<strong>8</strong>) and two ergosterol derivates (<strong>9</strong>-<strong>10</strong>) were isolated from sterilized rice medium cultured <em>Penicillium</em> sp. NX-05-G-3. Their structures were elucidated by 1D and 2D NMR. The cytotoxicities of all compounds were evaluated, and compounds <strong>1</strong> and <strong>2</strong> showed extensive cytotoxicity against human cancer cell lines Hela, SCC15, MDA-MB-453 and A549, with IC<sub>50</sub> values ranging from 17.6 to 32.8 µM.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 9","pages":"Pages 1041-1048"},"PeriodicalIF":1.3,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140957611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of psoralidin on the expression of glutamate decarboxylases and inhibitory synapse development 补骨脂素对谷氨酸脱羧酶表达和抑制性突触发育的影响
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-05-15 DOI: 10.1080/10286020.2024.2346297
{"title":"Effects of psoralidin on the expression of glutamate decarboxylases and inhibitory synapse development","authors":"","doi":"10.1080/10286020.2024.2346297","DOIUrl":"10.1080/10286020.2024.2346297","url":null,"abstract":"<div><p>Gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter required for excitation/inhibition balance is synthesized by the glutamic acid decarboxylases (GADs) in GABAergic neurons. The levels and activity of GADs are strongly correlated with GABA and neural transmission. Dysregulation of GADs and GABA is associated with various neurological disorders. The study used psoralidin, found in the seeds of <em>Psoralea corylifolia</em>, to investigate its effect on GAD levels and regulatory mechanisms in primary cortical neurons. Psoralidin reduced GAD67 through transcriptional regulation. The reduction was not mediated by the N-methyl-D-aspartate receptor. Additionally, psoralidin attenuated the formation of inhibitory synapses in primary hippocampal neurons.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 9","pages":"Pages 1106-1114"},"PeriodicalIF":1.3,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140957608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two new jatrophane diterpenoids from Euphorbia helioscopia with activity towards autophagic flux 大戟科植物 helioscopia 中两种新的麻风烷二萜类化合物对自噬通量具有活性。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-05-15 DOI: 10.1080/10286020.2024.2345181
Ming-You Peng , Xiong Zhang , Qin-Dan Li , En-Ming Feng , Lu Chen , Hu-Cheng Yang , Bing Guo , Ying-Tong Di , Lei Tang , Rong-Can Luo , Ying Yan
{"title":"Two new jatrophane diterpenoids from Euphorbia helioscopia with activity towards autophagic flux","authors":"Ming-You Peng ,&nbsp;Xiong Zhang ,&nbsp;Qin-Dan Li ,&nbsp;En-Ming Feng ,&nbsp;Lu Chen ,&nbsp;Hu-Cheng Yang ,&nbsp;Bing Guo ,&nbsp;Ying-Tong Di ,&nbsp;Lei Tang ,&nbsp;Rong-Can Luo ,&nbsp;Ying Yan","doi":"10.1080/10286020.2024.2345181","DOIUrl":"10.1080/10286020.2024.2345181","url":null,"abstract":"<div><p>Nine jatrophane diterpenoids were isolated from the whole plant <em>Euphorbia helioscopia</em>, including two new ones, helioscopnins A (<strong>1</strong>) and B (<strong>2</strong>). Comprehensive spectroscopic data analysis and ECD calculations elucidated their structures, including absolute configurations. All compounds were evaluated for bioactivity towards autophagic flux by flow cytometry using HM mCherry-GFP-LC3 cells. Compounds <strong>1</strong>, <strong>3</strong>, <strong>4</strong>, <strong>5</strong>, <strong>8</strong>, and <strong>9</strong> significantly increased autophagic flux.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 8","pages":"Pages 900-909"},"PeriodicalIF":1.3,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140957615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of natural perfume as potential fungicide candidates: construction and biological evaluation of vanillin analogs bearing the 1,3,4-oxadiazole/1,3-thiazolidin-4-one fragments 开发天然香水作为潜在的杀真菌剂候选物：含有 1,3,4-oxadiazole/1,3-thiazolidin-4-one 片段的香兰素类似物的构建和生物学评价。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-05-15 DOI: 10.1080/10286020.2024.2346636
{"title":"Development of natural perfume as potential fungicide candidates: construction and biological evaluation of vanillin analogs bearing the 1,3,4-oxadiazole/1,3-thiazolidin-4-one fragments","authors":"","doi":"10.1080/10286020.2024.2346636","DOIUrl":"10.1080/10286020.2024.2346636","url":null,"abstract":"<div><p>Two series of vanillin derivatives containing 1,3,4-oxadiazole and 1,3-thiazolidin-4-one scaffolds were prepared and evaluated for their antifungal activity. The results revealed that compounds <strong>6j</strong> (29.73 μg/ml) and <strong>7a</strong> (38.15 μg/ml) displayed excellent inhibitory activity against the spore of <em>Fusarium solani</em>. The inhibitory activity of compound <strong>7d</strong> (10.53 μg/ml) against the spore of <em>Alternaria solani</em> was more than 42-fold that of vanillin. Compound <strong>7a</strong> (37.54 μg/ml) showed better antifungal activity against the spore of <em>B. cinerea</em> than positive controls. The cytotoxicity assay confirmed that compounds <strong>6k</strong>, <strong>7a</strong>, and <strong>7d</strong> showed good selectivity and less toxicity to normal mammalian cells.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 9","pages":"Pages 1094-1105"},"PeriodicalIF":1.3,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140957607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Secofumitremorgins C and D, a pair of atropisomers from saltern-derived fungus Aspergillus fumigatus GXIMD00544 盐生曲霉 GXIMD00544 中的一对阿托异构体 Secofumitremorgins C 和 D。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-05-15 DOI: 10.1080/10286020.2024.2349664
{"title":"Secofumitremorgins C and D, a pair of atropisomers from saltern-derived fungus Aspergillus fumigatus GXIMD00544","authors":"","doi":"10.1080/10286020.2024.2349664","DOIUrl":"10.1080/10286020.2024.2349664","url":null,"abstract":"<div><p>A pair of atropisomers secofumitremorgins C (<strong>1a</strong>) and D (<strong>1b</strong>), together with fifteen known alkaloids (<strong>2-16</strong>), were isolated from a saltern-derived fungus <em>Aspergillus fumigatus</em> GXIMD00544. The structures of atropisomers <strong>1a</strong> and <strong>1b</strong> were elucidated by the detailed spectroscopic data, chemical reaction and quantum chemical calculations. Compounds <strong>1</strong> and <strong>8</strong> displayed antifungal spore germination effects against plant pathogenic fungus associated with sugarcane <em>Fusarium</em> sp. with inhibitory rates of 53% and 77% at the concentration of 100 µM, repectively. Atropisomers <strong>1</strong> also exhibited antifouling potential against <em>Balanus amphitrite</em> larval settlement with an inhibitory rate of 96% at the concentration of 100 µM.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 9","pages":"Pages 1049-1056"},"PeriodicalIF":1.3,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140957613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two new oleanane triterpenes from Maytenus hookeri 来自 Maytenus hookeri 的两种新的齐墩果烷三萜。
IF 1.7 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-05-08 DOI: 10.1080/10286020.2024.2340073
Quan-Yu Yang , Song-Xue Yang , Qiong Wei , Yan-Zi Ma , Bo Li , Xue-Wen Wu , Rui-Han Zhang , Xing-Jie Zhang , Xiao-Li Li , Wei-Lie Xiao
{"title":"Two new oleanane triterpenes from Maytenus hookeri","authors":"Quan-Yu Yang ,&nbsp;Song-Xue Yang ,&nbsp;Qiong Wei ,&nbsp;Yan-Zi Ma ,&nbsp;Bo Li ,&nbsp;Xue-Wen Wu ,&nbsp;Rui-Han Zhang ,&nbsp;Xing-Jie Zhang ,&nbsp;Xiao-Li Li ,&nbsp;Wei-Lie Xiao","doi":"10.1080/10286020.2024.2340073","DOIUrl":"10.1080/10286020.2024.2340073","url":null,"abstract":"<div><p>Two new triterpenes mayteneri A (<strong>1</strong>), mayteneri B (<strong>2</strong>), and seven known compounds (<strong>3-9</strong>) were isolated from stems of <em>Maytenus hookeri</em> Loes. The chemical structures of compounds <strong>1</strong> and <strong>2</strong> were established by 1D, 2D NMR, HRESIMS analysis, and calculating electronic circular dichroism (ECD). The structures of known compounds <strong>3</strong>-<strong>9</strong> were determined by comparison of their spectral with those reported. Compounds <strong>4</strong>-<strong>7</strong> showed significant inhibitory activity for NLRP3 inflammasome, with the IC<sub>50</sub> values of 2.36–3.44 <em>μ</em>M.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 7","pages":"Pages 803-811"},"PeriodicalIF":1.7,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140891523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acetylcholinesterase inhibition studies of alkaloid components from Crinum asiaticum var. sinicum: in vitro assessments by molecular docking and molecular dynamics simulations 积雪草生物碱成分的乙酰胆碱酯酶抑制研究：分子对接和分子动力学模拟的体外评估。
IF 1.7 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-05-03 DOI: 10.1080/10286020.2023.2269541
Ngo Viet Duc , Vu Thi Trang , Hoang Le Tuan Anh , Le Ba Vinh , Nguyen Viet Phong , Tran Quang Thuan , Ngo Van Hieu , Nguyen Tien Dat , Le Van Nhan , Do Thanh Tuan , Le Tuan Anh , Do Thi Thao , Bui Huu Tai , Nguyen Cao Cuong , Le Quynh Lien , Seo Young Yang
{"title":"Acetylcholinesterase inhibition studies of alkaloid components from Crinum asiaticum var. sinicum: in vitro assessments by molecular docking and molecular dynamics simulations","authors":"Ngo Viet Duc ,&nbsp;Vu Thi Trang ,&nbsp;Hoang Le Tuan Anh ,&nbsp;Le Ba Vinh ,&nbsp;Nguyen Viet Phong ,&nbsp;Tran Quang Thuan ,&nbsp;Ngo Van Hieu ,&nbsp;Nguyen Tien Dat ,&nbsp;Le Van Nhan ,&nbsp;Do Thanh Tuan ,&nbsp;Le Tuan Anh ,&nbsp;Do Thi Thao ,&nbsp;Bui Huu Tai ,&nbsp;Nguyen Cao Cuong ,&nbsp;Le Quynh Lien ,&nbsp;Seo Young Yang","doi":"10.1080/10286020.2023.2269541","DOIUrl":"10.1080/10286020.2023.2269541","url":null,"abstract":"<div><p>Alkaloids are among the most important and best-known secondary metabolites as sources of new drugs from medicinal plants and marine organisms. A phytochemical investigation of the whole plant of <em>Crinum asiaticum</em> var. <em>sinicum</em> resulted in the isolation of seven alkaloids (<strong>1</strong>–<strong>7</strong>), including one new dimeric compound, bis-(-)-8-demethylmaritidine (<strong>1</strong>). Their structures were elucidated using NMR and HR-ESI-MS. The absolute configuration of new compound <strong>1</strong> was established by circular dichroism spectroscopy. All isolated compounds were evaluated for their inhibitory effects on acetylcholinesterase (AChE) activity <em>in vitro</em>. Among them, compound <strong>1</strong> exhibited the most potent AChE inhibition. Moreover, molecular docking and molecular dynamics simulations were carried out for the most active compound to investigate their binding interactions and dynamics behavior of the AChE protein-ligand complex. Therefore, compound <strong>1</strong> may be a potential candidate for effectively treating Alzheimer’s disease.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 5","pages":"Pages 652-662"},"PeriodicalIF":1.7,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54229222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibacterial oxygenated ergostane-type steroids produced by the marine sponge-derived fungus Aspergillus sp. 海洋海绵真菌曲霉产生的抗菌含氧麦角固醇类固醇
IF 1.7 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-05-03 DOI: 10.1080/10286020.2023.2259317
Hui-Min Wen , Ya-Wen Zhang , Fang-Jian Feng , Guo-Bao Huang , Yu-Han Lv , Zou-Yan Zhang , Li-Jian Ding
{"title":"Antibacterial oxygenated ergostane-type steroids produced by the marine sponge-derived fungus Aspergillus sp.","authors":"Hui-Min Wen ,&nbsp;Ya-Wen Zhang ,&nbsp;Fang-Jian Feng ,&nbsp;Guo-Bao Huang ,&nbsp;Yu-Han Lv ,&nbsp;Zou-Yan Zhang ,&nbsp;Li-Jian Ding","doi":"10.1080/10286020.2023.2259317","DOIUrl":"10.1080/10286020.2023.2259317","url":null,"abstract":"<div><p>Two oxygenated ergostane-type steroids including one new compound, 3<em>β</em>-hydroxy-5<em>α</em>,6<em>β</em>-methoxyergosta-7,22-dien-15-one (<strong>1</strong>) along with a known analogue ergosta-6,22-dien-3<em>β</em>,5<em>α</em>,8<em>α</em>-triol (<strong>2</strong>) were isolated from the crude extracts of the marine sponge-derived fungus <em>Aspergillus</em> sp. Their structures were elucidated on the basis of combined NMR and MS spectroscopic methods. Compound <strong>1</strong> was a marine ergostane-type steroid with two methoxy groups at C-5 and C-6, respectively. These oxygenated ergostane-type steroids were evaluated for their antibacterial activities against human or aquatic pathogens. Among them, compound <strong>1</strong> exhibited antibacterial activity against <em>Staphylococcus aureus.</em></p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 5","pages":"Pages 548-554"},"PeriodicalIF":1.7,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10247596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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