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Journal of Asian Natural Products Research最新文献

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Celochalcoside, a new quinochalcone C-glycoside from Celosia trigyna 三棱青藤中一种新的醌查尔酮C-糖苷。
IF 1.7 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-05-03 DOI: 10.1080/10286020.2023.2269528
Samy K. El-Desouky
{"title":"Celochalcoside, a new quinochalcone C-glycoside from Celosia trigyna","authors":"Samy K. El-Desouky","doi":"10.1080/10286020.2023.2269528","DOIUrl":"10.1080/10286020.2023.2269528","url":null,"abstract":"<div><p>A new quinochalcone <em>C</em>-glycoside featuring a unique quinonoid moiety, named celochalcoside (<strong>1</strong>), was isolated from the <em>n</em>-butanol extract of the aerial parts of <em>Celosia trigyna</em> L. The structure was determined by extensive spectroscopic analysis as well as mass spectrometric data. Compound <strong>1</strong> showed moderate cytotoxic activities against breast cancer cell lines (MCF-7), colon cancer cell lines (HT-29) and hepatocellular carcinoma cell lines (HepG2) with IC<sub>50</sub> values of 23.16, 37.05 and 18.35 μg/ml, respectively.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41235537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acetylcholinesterase inhibition studies of alkaloid components from Crinum asiaticum var. sinicum: in vitro assessments by molecular docking and molecular dynamics simulations 积雪草生物碱成分的乙酰胆碱酯酶抑制研究：分子对接和分子动力学模拟的体外评估。
IF 1.7 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-05-03 DOI: 10.1080/10286020.2023.2269541
Ngo Viet Duc , Vu Thi Trang , Hoang Le Tuan Anh , Le Ba Vinh , Nguyen Viet Phong , Tran Quang Thuan , Ngo Van Hieu , Nguyen Tien Dat , Le Van Nhan , Do Thanh Tuan , Le Tuan Anh , Do Thi Thao , Bui Huu Tai , Nguyen Cao Cuong , Le Quynh Lien , Seo Young Yang
{"title":"Acetylcholinesterase inhibition studies of alkaloid components from Crinum asiaticum var. sinicum: in vitro assessments by molecular docking and molecular dynamics simulations","authors":"Ngo Viet Duc ,&nbsp;Vu Thi Trang ,&nbsp;Hoang Le Tuan Anh ,&nbsp;Le Ba Vinh ,&nbsp;Nguyen Viet Phong ,&nbsp;Tran Quang Thuan ,&nbsp;Ngo Van Hieu ,&nbsp;Nguyen Tien Dat ,&nbsp;Le Van Nhan ,&nbsp;Do Thanh Tuan ,&nbsp;Le Tuan Anh ,&nbsp;Do Thi Thao ,&nbsp;Bui Huu Tai ,&nbsp;Nguyen Cao Cuong ,&nbsp;Le Quynh Lien ,&nbsp;Seo Young Yang","doi":"10.1080/10286020.2023.2269541","DOIUrl":"10.1080/10286020.2023.2269541","url":null,"abstract":"<div><p>Alkaloids are among the most important and best-known secondary metabolites as sources of new drugs from medicinal plants and marine organisms. A phytochemical investigation of the whole plant of <em>Crinum asiaticum</em> var. <em>sinicum</em> resulted in the isolation of seven alkaloids (<strong>1</strong>–<strong>7</strong>), including one new dimeric compound, bis-(-)-8-demethylmaritidine (<strong>1</strong>). Their structures were elucidated using NMR and HR-ESI-MS. The absolute configuration of new compound <strong>1</strong> was established by circular dichroism spectroscopy. All isolated compounds were evaluated for their inhibitory effects on acetylcholinesterase (AChE) activity <em>in vitro</em>. Among them, compound <strong>1</strong> exhibited the most potent AChE inhibition. Moreover, molecular docking and molecular dynamics simulations were carried out for the most active compound to investigate their binding interactions and dynamics behavior of the AChE protein-ligand complex. Therefore, compound <strong>1</strong> may be a potential candidate for effectively treating Alzheimer’s disease.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54229222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibacterial oxygenated ergostane-type steroids produced by the marine sponge-derived fungus Aspergillus sp. 海洋海绵真菌曲霉产生的抗菌含氧麦角固醇类固醇
IF 1.7 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-05-03 DOI: 10.1080/10286020.2023.2259317
Hui-Min Wen , Ya-Wen Zhang , Fang-Jian Feng , Guo-Bao Huang , Yu-Han Lv , Zou-Yan Zhang , Li-Jian Ding
{"title":"Antibacterial oxygenated ergostane-type steroids produced by the marine sponge-derived fungus Aspergillus sp.","authors":"Hui-Min Wen ,&nbsp;Ya-Wen Zhang ,&nbsp;Fang-Jian Feng ,&nbsp;Guo-Bao Huang ,&nbsp;Yu-Han Lv ,&nbsp;Zou-Yan Zhang ,&nbsp;Li-Jian Ding","doi":"10.1080/10286020.2023.2259317","DOIUrl":"10.1080/10286020.2023.2259317","url":null,"abstract":"<div><p>Two oxygenated ergostane-type steroids including one new compound, 3<em>β</em>-hydroxy-5<em>α</em>,6<em>β</em>-methoxyergosta-7,22-dien-15-one (<strong>1</strong>) along with a known analogue ergosta-6,22-dien-3<em>β</em>,5<em>α</em>,8<em>α</em>-triol (<strong>2</strong>) were isolated from the crude extracts of the marine sponge-derived fungus <em>Aspergillus</em> sp. Their structures were elucidated on the basis of combined NMR and MS spectroscopic methods. Compound <strong>1</strong> was a marine ergostane-type steroid with two methoxy groups at C-5 and C-6, respectively. These oxygenated ergostane-type steroids were evaluated for their antibacterial activities against human or aquatic pathogens. Among them, compound <strong>1</strong> exhibited antibacterial activity against <em>Staphylococcus aureus.</em></p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10247596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cordycepin, a bioactive compound from Cordyceps spp., moderates Alzheimer’s disease-associated pathology via anti-oxidative stress and autophagy activation 虫草素是一种来自虫草属的生物活性化合物，通过抗氧化应激和自噬激活调节阿尔茨海默病相关病理。
IF 1.7 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-05-03 DOI: 10.1080/10286020.2023.2258797
Natchadaporn Soraksa , Nudjanad Heebkaew , Wilasinee Promjantuek , Phongsakorn Kunhorm , Palakorn Kaokean , Nipha Chaicharoenaudomung , Parinya Noisa
{"title":"Cordycepin, a bioactive compound from Cordyceps spp., moderates Alzheimer’s disease-associated pathology via anti-oxidative stress and autophagy activation","authors":"Natchadaporn Soraksa ,&nbsp;Nudjanad Heebkaew ,&nbsp;Wilasinee Promjantuek ,&nbsp;Phongsakorn Kunhorm ,&nbsp;Palakorn Kaokean ,&nbsp;Nipha Chaicharoenaudomung ,&nbsp;Parinya Noisa","doi":"10.1080/10286020.2023.2258797","DOIUrl":"10.1080/10286020.2023.2258797","url":null,"abstract":"<div><p>Alzheimer’s causes cognitive dysfunction. This study investigated the neuro-promoting effects of cordycepin on amyloid-beta precursor protein (APP) synthesis in human neuroblastoma SH-SY5Y cells. Cordycepin was found to boost SH-SY5Y cell proliferation and decreased AD pathology. APP, PS1, and PS2 were downregulated whereas <em>ADAM10</em> and <em>SIRT1</em> were upregulated by cordycepin. Cordycepin also reduced APP secretion in a dose-dependent manner. Cordycepin alleviated oxidative stress by the upregulation of <em>GPX</em> and <em>SOD</em>, as well as autophagy genes (<em>LC3</em>, <em>ATG5</em>, and <em>ATG12</em>). Cordycepin activity was also found to be SIRT1-dependent. Therefore, cordycepin may relieve the neuronal degeneration caused by APP overproduction, and oxidative stress.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41176283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A derivative of trihydroxynaphthalenone and a pyrone metabolite from the endophytic fungus Talaromyces purpurpgenus 来自内生真菌 Talaromyces purpurpgenus 的一种三羟基萘酮衍生物和一种吡喃酮代谢物。
IF 1.7 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-05-03 DOI: 10.1080/10286020.2024.2333359
Yang Liu , Ke-Liang Chen , Jing-Yi Zhao , Chen-Yu Yang , Xing-Bao Jia , Yu-Wei Niu , Ya-Nan Tian , Yang Yang , Yun-Bao Liu
{"title":"A derivative of trihydroxynaphthalenone and a pyrone metabolite from the endophytic fungus Talaromyces purpurpgenus","authors":"Yang Liu ,&nbsp;Ke-Liang Chen ,&nbsp;Jing-Yi Zhao ,&nbsp;Chen-Yu Yang ,&nbsp;Xing-Bao Jia ,&nbsp;Yu-Wei Niu ,&nbsp;Ya-Nan Tian ,&nbsp;Yang Yang ,&nbsp;Yun-Bao Liu","doi":"10.1080/10286020.2024.2333359","DOIUrl":"10.1080/10286020.2024.2333359","url":null,"abstract":"<div><p>A newly discovered trihydroxynaphthalenone derivative, epoxynaphthalenone (<strong>1</strong>) involving the condensation of ortho-hydroxyl groups into an epoxy structure, and a novel pyrone metabolite characterized as pyroneaceacid (<strong>2</strong>), were extracted from <em>Talaromyces purpurpgenus</em>, an endophytic fungus residing in <em>Rhododendron molle</em>. The structures of these compounds were elucidated through a comprehensive analysis of their NMR and HRESIMS data. The determination of absolute configurations was accomplished using electronic circular dichroism (ECD) calculations and CD spectra. Notably, these recently identified metabolites exhibited a moderate inhibitory activity against xanthine oxidase (XOD).</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140335684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nicotine improves DSS-induced colitis by inhibiting NLRP3 and altering gut microbiota 尼古丁通过抑制 NLRP3 和改变肠道微生物群来改善 DSS 诱导的结肠炎。
IF 1.7 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-05-03 DOI: 10.1080/10286020.2024.2331773
Yi-Xiang Zhang , Xiao-Qian Chi , Meng Li , Wei Zhang , Ying Guan , Lian-Qiu Wu
{"title":"Nicotine improves DSS-induced colitis by inhibiting NLRP3 and altering gut microbiota","authors":"Yi-Xiang Zhang ,&nbsp;Xiao-Qian Chi ,&nbsp;Meng Li ,&nbsp;Wei Zhang ,&nbsp;Ying Guan ,&nbsp;Lian-Qiu Wu","doi":"10.1080/10286020.2024.2331773","DOIUrl":"10.1080/10286020.2024.2331773","url":null,"abstract":"<div><p>Ulcerative colitis (UC) is a chronic recurrent inflammatory disease affecting the rectum and colon. Numerous epidemiological studies have identified smoking as a protective factor for UC. Dysbiosis of intestinal microbiota and release of inflammatory factors are well-established characteristics associated with UC. Therefore, we have observed that nicotine exhibits the potential to ameliorate colitis symptoms in UC mice. Additionally, it exerts a regulatory effect on colonic microbiota dysbiosis by promoting the growth of beneficial bacteria while suppressing harmful bacteria. Combined <em>in vivo</em> and <em>in vitro</em> investigations demonstrate that nicotine primarily impedes the assembly of NLRP3, subsequently inhibiting downstream IL-1β secretion.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140664954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potent halogenated xanthone derivatives: synthesis, molecular docking and study on antityrosinase activity 强效卤代黄酮衍生物：合成、分子对接及抗酪氨酸酶活性研究。
IF 1.7 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-05-03 DOI: 10.1080/10286020.2023.2264784
Fatin Farhana Baharuddin , Nadiah Mad Nasir , Bimo Ario Tejo , Soo Peng Koh , Shuruti Ramakrishnan , Nur Qurratu Ain A. Nordin , Anis Nasuha Adzahar , Pavithren Devakrishnan , Salsabiilaa Mohd Razib
{"title":"Potent halogenated xanthone derivatives: synthesis, molecular docking and study on antityrosinase activity","authors":"Fatin Farhana Baharuddin ,&nbsp;Nadiah Mad Nasir ,&nbsp;Bimo Ario Tejo ,&nbsp;Soo Peng Koh ,&nbsp;Shuruti Ramakrishnan ,&nbsp;Nur Qurratu Ain A. Nordin ,&nbsp;Anis Nasuha Adzahar ,&nbsp;Pavithren Devakrishnan ,&nbsp;Salsabiilaa Mohd Razib","doi":"10.1080/10286020.2023.2264784","DOIUrl":"10.1080/10286020.2023.2264784","url":null,"abstract":"<div><p>Tyrosinase inhibitors can reduce melanin production for skin whitening, but some existing products may harm the skin. This study discovered six compounds that inhibit tyrosinase in the mushroom <em>Agaricus bisporus</em> by over 50%. Compound <strong>11</strong> displayed strong inhibition (<strong>92.2%</strong> and <strong>86.7%)</strong> for L-tyrosine and L-DOPA substrates, while compound <strong>13</strong> showed high inhibition (<strong>96.0%</strong> and <strong>62.0%</strong>) for both substrates. Molecular docking simulations revealed compounds <strong>11</strong> and <strong>13</strong> bind at the allosteric site of the enzyme. Xanthone derivatives, based on these findings, hold potential as safe skin whitening agents and for pigmentation-related diseases in the cosmetic industry.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41128018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Iridoid glycosides from Morinda officinalis induce lysosomal biogenesis and promote autophagic flux to attenuate oxidative stress 巴戟天的Iridoid糖苷诱导溶酶体生物发生并促进自噬流量以减轻氧化应激。
IF 1.7 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-05-03 DOI: 10.1080/10286020.2023.2269370
Yin-Yuan Wang , Jian-Cheng Ni , Yue-Qin Zhao , Xu Yang , Zhen-Peng Niu , Xing-Zhi Yang , Xian-Xiang Dong , Yu-Han Zhao , Xiao-Jiang Hao , Xiao Ding
{"title":"Iridoid glycosides from Morinda officinalis induce lysosomal biogenesis and promote autophagic flux to attenuate oxidative stress","authors":"Yin-Yuan Wang ,&nbsp;Jian-Cheng Ni ,&nbsp;Yue-Qin Zhao ,&nbsp;Xu Yang ,&nbsp;Zhen-Peng Niu ,&nbsp;Xing-Zhi Yang ,&nbsp;Xian-Xiang Dong ,&nbsp;Yu-Han Zhao ,&nbsp;Xiao-Jiang Hao ,&nbsp;Xiao Ding","doi":"10.1080/10286020.2023.2269370","DOIUrl":"10.1080/10286020.2023.2269370","url":null,"abstract":"<div><p><em>Morinda officinalis</em> is a traditional Chinese tonic herb, and have been used in the treatment of multiple diseases. Here, three iridoid glycosides isolated from <em>M. officinalis</em> were evaluated for their roles in the autophagy-lysosomal pathway. All three iridoid glycosides could induce TFEB/TFE3-mediated lysosomal biogenesis and trigger autophagy. Interestingly, they promoted the nuclear import of TFEB/TFE3 without affecting their nuclear export, suggesting their role in the maintenance of lysosomal homeostasis. The results from this study shed light on the identification of autophagy activators from <em>M. officinalis</em> and provide a basis for developing them in the treatment of oxidative stress-involved diseases.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61562798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structure elucidation and NMR spectral assignments of one new dammarane-type triterpenoid saponin from black ginseng 黑人参中一种新的达玛烷类三萜皂苷的结构阐释和核磁共振谱定位
IF 1.7 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-05-03 DOI: 10.1080/10286020.2023.2253153
Xue-Ting Zhao , De-Qiang Dou , Yang Qu , Guo-Gang Zhang
{"title":"Structure elucidation and NMR spectral assignments of one new dammarane-type triterpenoid saponin from black ginseng","authors":"Xue-Ting Zhao ,&nbsp;De-Qiang Dou ,&nbsp;Yang Qu ,&nbsp;Guo-Gang Zhang","doi":"10.1080/10286020.2023.2253153","DOIUrl":"10.1080/10286020.2023.2253153","url":null,"abstract":"<div><p>New dammarane-type triterpenoid saponin, named 22(<em>R</em>)-notoginsenoside Ab1 (<strong>1</strong>), together with thirteen known dammarane-type triterpenoid saponins (<strong>2</strong>-<strong>14</strong>) was isolated from the EtOH extract of black ginseng and their structures were elucidated on the basis of one- and two-dimensional NMR (including <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, HSQC, HMBC, ROESY) and calculated ECD. Among them, compounds <strong>1-2</strong> and <strong>6</strong>-<strong>8</strong> were isolated for the first time from ginseng and black ginseng. Besides, the absolute structure of 22(<em>R</em>)- and 22(<em>S</em>)- notoginsenoside Ab1 were distinguished by ECD for the first time.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10183985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect and mechanism of gomisin D on the isoproterenol induced myocardial injury in H9C2 cells and mice 戈米辛 D 对异丙肾上腺素诱导的 H9C2 细胞和小鼠心肌损伤的影响和机制
IF 1.7 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-05-03 DOI: 10.1080/10286020.2024.2336152
Zi-Han Chen , Yan-Xin Liu , Zhi-Wei Chen , Mo-Di Lin , Jin-Lan Zhang , Zhe Wang , Hua Sun
{"title":"Effect and mechanism of gomisin D on the isoproterenol induced myocardial injury in H9C2 cells and mice","authors":"Zi-Han Chen ,&nbsp;Yan-Xin Liu ,&nbsp;Zhi-Wei Chen ,&nbsp;Mo-Di Lin ,&nbsp;Jin-Lan Zhang ,&nbsp;Zhe Wang ,&nbsp;Hua Sun","doi":"10.1080/10286020.2024.2336152","DOIUrl":"10.1080/10286020.2024.2336152","url":null,"abstract":"<div><p>We established myocardial injury models <em>in vivo</em> and <em>in vitro</em> to investigate the cardioprotective effect of gomisin D obtained from <em>Schisandra chinensis</em>. Gomisin D significantly inhibited isoproterenol-induced apoptosis and hypertrophy in H9C2 cells. Gomisin D decreased serum BNP, ANP, CK-MB, cTn-T levels and histopathological alterations, and inhibited myocardial hypertrophy in mice. In mechanisms research, gomisin D reversed ISO-induced accumulation of intracellular ROS and Ca<sup>2+</sup>. Gomisin D further improved mitochondrial energy metabolism disorders by regulating the TCA cycle. These results demonstrated that gomisin D had a significant effect on isoproterenol-induced myocardial injury by inhibiting oxidative stress, calcium overload and improving mitochondrial energy metabolism.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140613127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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