{"title":"海南菌丝体茎叶中具有潜在抗增殖活性的烯丙基黄酮。","authors":"Shu-Ri Li, Lin-Xuan Li, Tian-Yu Wang, Yu-Shan Wang, Long-Cheng Cui, Jia-Yi Hu, Ye-Ping Liu, Yan-Ping Liu, Yan-Hui Fu","doi":"10.1080/10286020.2025.2507729","DOIUrl":null,"url":null,"abstract":"<p><p>A phytochemical study on the stems and leaves of <i>Mycetia hainanensis</i> led to the isolation and identification of a new prenylated flavone, mycehainanone (<b>1</b>), as well as seven known analogs (<b>2 </b>-<b> 8</b>). The chemical structure of <b>1</b> was determined using comprehensive spectroscopic analyses and the known compounds were identified by comparison of their spectroscopic data with those reported in the literature. The antiproliferative activities against five human cancer cell lines (JeKo-1, A549, SMMC-7721, SW480, and MCF-7 cell lines) of all isolated prenylated flavones (<b>1 </b>-<b> 8</b>) were evaluated <i>in vitro</i>. Compounds <b>1 </b>-<b> 8</b> exhibited notable antiproliferative effects against various human cancer cell lines with IC<sub>50</sub> values in range of 0.67 ± 0.02 to 38.92 ± 0.23 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3000,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prenylated flavones with potential antiproliferative activities from the stems and leaves of <i>Mycetia hainanensis</i>.\",\"authors\":\"Shu-Ri Li, Lin-Xuan Li, Tian-Yu Wang, Yu-Shan Wang, Long-Cheng Cui, Jia-Yi Hu, Ye-Ping Liu, Yan-Ping Liu, Yan-Hui Fu\",\"doi\":\"10.1080/10286020.2025.2507729\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A phytochemical study on the stems and leaves of <i>Mycetia hainanensis</i> led to the isolation and identification of a new prenylated flavone, mycehainanone (<b>1</b>), as well as seven known analogs (<b>2 </b>-<b> 8</b>). The chemical structure of <b>1</b> was determined using comprehensive spectroscopic analyses and the known compounds were identified by comparison of their spectroscopic data with those reported in the literature. The antiproliferative activities against five human cancer cell lines (JeKo-1, A549, SMMC-7721, SW480, and MCF-7 cell lines) of all isolated prenylated flavones (<b>1 </b>-<b> 8</b>) were evaluated <i>in vitro</i>. Compounds <b>1 </b>-<b> 8</b> exhibited notable antiproliferative effects against various human cancer cell lines with IC<sub>50</sub> values in range of 0.67 ± 0.02 to 38.92 ± 0.23 μM.</p>\",\"PeriodicalId\":15180,\"journal\":{\"name\":\"Journal of Asian Natural Products Research\",\"volume\":\" \",\"pages\":\"1-8\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-05-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Asian Natural Products Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/10286020.2025.2507729\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asian Natural Products Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/10286020.2025.2507729","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Prenylated flavones with potential antiproliferative activities from the stems and leaves of Mycetia hainanensis.
A phytochemical study on the stems and leaves of Mycetia hainanensis led to the isolation and identification of a new prenylated flavone, mycehainanone (1), as well as seven known analogs (2 - 8). The chemical structure of 1 was determined using comprehensive spectroscopic analyses and the known compounds were identified by comparison of their spectroscopic data with those reported in the literature. The antiproliferative activities against five human cancer cell lines (JeKo-1, A549, SMMC-7721, SW480, and MCF-7 cell lines) of all isolated prenylated flavones (1 - 8) were evaluated in vitro. Compounds 1 - 8 exhibited notable antiproliferative effects against various human cancer cell lines with IC50 values in range of 0.67 ± 0.02 to 38.92 ± 0.23 μM.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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