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Journal of Asian Natural Products Research最新文献

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Bioactive prenylated c6–c3 derivatives from the roots of Illicium brevistylum 从Illicium brevistylum的根中提取的具有生物活性的前炔基c6-c3衍生物。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-08-14 DOI: 10.1080/10286020.2024.2365437
{"title":"Bioactive prenylated c6–c3 derivatives from the roots of Illicium brevistylum","authors":"","doi":"10.1080/10286020.2024.2365437","DOIUrl":"10.1080/10286020.2024.2365437","url":null,"abstract":"<div><div>Three new prenylated C<sub>6</sub>–C<sub>3</sub> compounds (<strong>1–3</strong>), together with two known prenylated C<sub>6</sub>–C<sub>3</sub> compounds (<strong>4–5</strong>) and one known C<sub>6</sub>–C<sub>3</sub> derivative (<strong>6</strong>), were isolated from the roots of <em>Illicium brevistylum</em> A. C. Smith. The structures of <strong>1–3</strong> were elucidated by spectroscopic methods including 1D and 2D NMR, HRESIMS, CD experiments and ECD calculations. The structure of illibrefunone A (<strong>1</strong>) was confirmed by single-crystal X-ray diffraction analysis. All compounds were evaluated in terms of their anti-inflammatory potential on nitric oxide (NO) generation in lipopolysaccharide-stimulated murine RAW264.7 macrophages and murine BV2 microglial cells, antiviral activity against Coxsackievirus B3 (CVB3) and influenza virus A/Hanfang/359/95 (H3N2). Compounds <strong>3</strong> and <strong>4</strong> exhibited potent inhibitory effects on the production of NO in RAW 264.7 cells with IC<sub>50</sub> values of 20.57 and 12.87 μM respectively, which were greater than those of dexamethasone (positive control). Compounds <strong>1</strong> and <strong>4–6</strong> exhibited weak activity against Coxsackievirus B3, with IC<sub>50</sub> values ranging from 25.87 to 33.33 μM.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 11","pages":"Pages 1292-1304"},"PeriodicalIF":1.3,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141419215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genome mining for ribosomally synthesized and post-translationally modified peptides (RiPPs) in Streptomyces bacteria 链霉菌中核糖体合成和翻译后修饰肽（RiPPs）的基因组挖掘。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-08-13 DOI: 10.1080/10286020.2024.2390510
Abdullah Al Mamun , Khorshed Alam , Farjana Akter Koly , Farjana Showline Chaity , Jannatul Ferdous , Saiful Islam
{"title":"Genome mining for ribosomally synthesized and post-translationally modified peptides (RiPPs) in Streptomyces bacteria","authors":"Abdullah Al Mamun ,&nbsp;Khorshed Alam ,&nbsp;Farjana Akter Koly ,&nbsp;Farjana Showline Chaity ,&nbsp;Jannatul Ferdous ,&nbsp;Saiful Islam","doi":"10.1080/10286020.2024.2390510","DOIUrl":"10.1080/10286020.2024.2390510","url":null,"abstract":"<div><div>Ribosomally synthesized post-translationally modified peptides (RiPPs) are a novel category of bioactive natural products (NPs). <em>Streptomyces</em> bacteria are a potential source of many bioactive NPs. Limited opportunities are available to characterize all the bioactive NP gene clusters. In this study, 410 sequences of <em>Streptomyces</em> were analyzed for RiPPs through genome mining using the National Center for Biotechnology Information (NCBI), by combining BAGEL and anti-SMASH. A total of 4098 RiPPs were found; including both classified (lanthipeptide, RiPP-like, bacteriocin, LAPs, lassopeptide, thiopeptides) and nonclassified RiPPs. Soil was identified as a rich habitat for RiPPs. These data may offer alternative future remedies for various health issues.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 3","pages":"Pages 354-367"},"PeriodicalIF":1.3,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrated ceRNAs regulating relationship and bioinformatics analysis to study the molecular mechanisms of the inhibition of puerarin on bladder cancer cell 综合ceRNAs调控关系和生物信息学分析，研究葛根素抑制膀胱癌细胞的分子机制。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-08-12 DOI: 10.1080/10286020.2024.2390508
Yu-Yang Ma , Wen Gao , Hao Wang , Hao Xu , Deng Pan , Jing-Kai Wang , Peng Xu , Hai-Luo Wang , Kun Pang
{"title":"Integrated ceRNAs regulating relationship and bioinformatics analysis to study the molecular mechanisms of the inhibition of puerarin on bladder cancer cell","authors":"Yu-Yang Ma ,&nbsp;Wen Gao ,&nbsp;Hao Wang ,&nbsp;Hao Xu ,&nbsp;Deng Pan ,&nbsp;Jing-Kai Wang ,&nbsp;Peng Xu ,&nbsp;Hai-Luo Wang ,&nbsp;Kun Pang","doi":"10.1080/10286020.2024.2390508","DOIUrl":"10.1080/10286020.2024.2390508","url":null,"abstract":"<div><div>Based on previous experiments, we demonstrated puerarin inhibited the proliferation of BC T24 cells. To further explore the molecular mechanisms, whole transcriptome sequencing combined with bioinformatics analysis was performed. The results showed puerarin significantly inhibited T24 proliferation and pathway enrichment analysis of differentially expressed RNAs were mainly enriched in Cell cycle, PI3K/AKT, Ras family chromatin remodeling. lncRNAs and circRNAs may regulate miRNAs, thereby regulating the expression of ITGA1, PAK2 and UTRN. The predicted upstream transcription factor ERG and puerarin were well docked, which may be one of the underlying mechanisms by which puerarin inhibiting BC cells.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 3","pages":"Pages 400-420"},"PeriodicalIF":1.3,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141971157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kaempferol inhibited invasion and metastasis of gastric cancer cells by targeting AKT/GSK3β pathway based on network pharmacology and molecular docking 基于网络药理学和分子对接的山奈酚通过靶向AKT/GSK3β通路抑制胃癌细胞的侵袭和转移
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-08-10 DOI: 10.1080/10286020.2024.2387756
Xia-Qing Gao , Hai-Long Li , Meng Wang , Chun-Ting Yang , Rong Su , Li-Hua Shao
{"title":"Kaempferol inhibited invasion and metastasis of gastric cancer cells by targeting AKT/GSK3β pathway based on network pharmacology and molecular docking","authors":"Xia-Qing Gao ,&nbsp;Hai-Long Li ,&nbsp;Meng Wang ,&nbsp;Chun-Ting Yang ,&nbsp;Rong Su ,&nbsp;Li-Hua Shao","doi":"10.1080/10286020.2024.2387756","DOIUrl":"10.1080/10286020.2024.2387756","url":null,"abstract":"<div><div>This study aims to explore the mechanisms of the inhibitory effect of kaempferol on the invasion and metastasis of gastric cancer (GC) cells through network pharmacology prediction and experimental verification. It identifies core targets via PPI network analysis and finds that kaempferol binds to these targets well. <em>In vitro</em> experiments showed that kaempferol could inhibit the proliferation, colony formation, migration and invasion of GC cells. Western blotting indicated kaempferol may reduce AKT and GSK3β phosphorylation, leading to lower expression of invasion-related genes SRC, MMP9, CXCR4, KDR, and MMP2. Overall, kaempferol may prevent migration and invasion of GC cells via the AKT/GSK3β signaling pathway.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 3","pages":"Pages 421-441"},"PeriodicalIF":1.3,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Four new lycoctonine-type C19-diterpenoid alkaloids from the whole plants of Delphinium kamaonense. 从Delphinium kamaonense全株中提取的四种新的莱克多宁型C19-二萜生物碱。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-07-31 DOI: 10.1080/10286020.2024.2385370
Xing-Yao Li, Rui-Sheng Chen, Guo-Chang Li, Kai-Cheng Du, Lan-Tao Lai, Yu-Meng Wang, Da-Li Meng
{"title":"Four new lycoctonine-type C<sub>19</sub>-diterpenoid alkaloids from the whole plants of <i>Delphinium kamaonense</i>.","authors":"Xing-Yao Li, Rui-Sheng Chen, Guo-Chang Li, Kai-Cheng Du, Lan-Tao Lai, Yu-Meng Wang, Da-Li Meng","doi":"10.1080/10286020.2024.2385370","DOIUrl":"https://doi.org/10.1080/10286020.2024.2385370","url":null,"abstract":"<p><p>Four new lycoctonine-type C<sub>19</sub>-diterpenoid alkaloids kamaonensines H-K (<b>1-4</b>) have been isolated from the whole plants of <i>Delphinium kamaonense</i>, together with 12 known compounds (<b>5-16</b>). Interestingly, kamaonensines <b>1-3</b> contained a rare nitrone (immine N-oxide) moiety, respectively. Their structures were established by spectroscopic analyses. The active evaluation of compounds (<b>1-16</b>) by LPS induced RAW 264.7 macrophages showed that compounds <b>4</b> and <b>8</b> displayed strong anti-inflammatory activities. While compounds <b>11</b> and <b>12</b> also showed strong cytotoxicities by the RAW 264.7 cell viability assay.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.3,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two new cucurbitane-type triterpenoid saponins from the fruit of Citrullus colocynthis 从秋刀鱼果实中提取的两种新葫芦烷类三萜皂甙
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-07-04 DOI: 10.1080/10286020.2024.2364908
{"title":"Two new cucurbitane-type triterpenoid saponins from the fruit of Citrullus colocynthis","authors":"","doi":"10.1080/10286020.2024.2364908","DOIUrl":"10.1080/10286020.2024.2364908","url":null,"abstract":"<div><div>Two new cucurbitane-type triterpenoid saponins, 2,20<em>β</em>,22<em>β</em>-trihydroxy-16<em>α</em>,23(<em>R</em>)-epoxycucurbita-1,5,24-triene-3,11-dione 2-<em>O</em>-<em>β</em>-D-glucopyranoside (<strong>1</strong>), 2,20<em>β</em>,22<em>α</em>-trihydroxy-16<em>α</em>,23(<em>S</em>)-epoxycucurbita-1,5,11,24-tetraene-3-one 2-<em>O</em>-<em>β</em>-D-glucopyranoside (<strong>2</strong>) were isolated from the fruit of <em>Citrullus colocynthis</em> (L.) Schrad. Their structures were elucidated by mass spectrometry, IR, 1D, and 2D NMR spectroscopy, etc. Besides, both of the compounds showed significant hepatoprotective activities at 10 <em>μ</em>M against paracetamol-induced HepG2 cell damage.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 11","pages":"Pages 1320-1327"},"PeriodicalIF":1.3,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141503000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction. 更正。
IF 1.7 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-07-01 Epub Date: 2024-03-28 DOI: 10.1080/10286020.2024.2334547
{"title":"Correction.","authors":"","doi":"10.1080/10286020.2024.2334547","DOIUrl":"10.1080/10286020.2024.2334547","url":null,"abstract":"","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"865"},"PeriodicalIF":1.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140305781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new cassane diterpenoid from the seed of Caesalpinia sappan. 从 Caesalpinia sappan 种子中提取的一种新的决明二萜。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-06-30 DOI: 10.1080/10286020.2024.2360640
Yue-Lin Zhao, Yue Jin, Zi-Ying Han, Wen-Han Song, Hui-Lin Zhu, Jian Zhang, Qian Wang, Miao Wang, Xiao-Wen Jiang, Hui-Yuan Gao
{"title":"A new cassane diterpenoid from the seed of <i>Caesalpinia sappan</i>.","authors":"Yue-Lin Zhao, Yue Jin, Zi-Ying Han, Wen-Han Song, Hui-Lin Zhu, Jian Zhang, Qian Wang, Miao Wang, Xiao-Wen Jiang, Hui-Yuan Gao","doi":"10.1080/10286020.2024.2360640","DOIUrl":"https://doi.org/10.1080/10286020.2024.2360640","url":null,"abstract":"<p><p>In this study, a previously undescribed cassane diterpenoid, named caesalpinin JF (<b>1</b>), along with two known cassane diterpenoids caesanine C (<b>2</b>) and tomocinol B (<b>3</b>), was isolated from 95% EtOH extract of the seeds of <i>Caesalpinia sappan</i> Linn. Additionally, three known compounds including pulcherrin R (<b>4</b>), syringaresinol-4'-<i>O</i>-<i>β</i>-D-glucopyranoside (<b>5</b>) and kaempferol (<b>6</b>) were also identified. The structures of the isolated compounds were elucidated by comprehensive 1D and 2D NMR spectroscopic analyses. Additionally, electronic circular dichroism (ECD) calculation was used to identify the absolute structure of compound <b>1</b>. Among the isolated compounds, compound <b>1</b> displayed a potent anti-neuroinflammation with an IC<sub>50</sub> value of 9.87 ± 1.71 <i>μ</i>M.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.3,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new canthinone glycoside isolated from the root barks of Ailanthus altissima with NO inhibitory activity 从具有 NO 抑制活性的 Ailanthus altissima 根皮中分离出一种新的 canthinone 苷。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-06-28 DOI: 10.1080/10286020.2024.2360047
{"title":"A new canthinone glycoside isolated from the root barks of Ailanthus altissima with NO inhibitory activity","authors":"","doi":"10.1080/10286020.2024.2360047","DOIUrl":"10.1080/10286020.2024.2360047","url":null,"abstract":"<div><p>One new canthinone glycoside (<strong>1</strong>), together with six known compounds (<strong>2</strong>–<strong>7</strong>) including three lignans (<strong>2</strong>–<strong>4</strong>), two coumarins (<strong>5</strong>–<strong>6)</strong> and one phenol (<strong>7)</strong> was isolated from the root barks of <em>Ailanthus altissima</em>. The structure of new compound <strong>1</strong> was established by the interpretation of UV, IR, MS and NMR data, while its absolute configuration was determined by acid hydrolysis and GIAO NMR calculations with DP4+ probability analysis. The inhibitory effects of all compounds on Nitric oxide (NO) production were investigated in lipopolysaccharide (LPS)-induced RAW 264.7 cells. Results showed that compounds <strong>2</strong> and <strong>5</strong> displayed NO production inhibitory activity with IC<sub>50</sub> values of 30.1 and 15.3 <em>μ</em>M, respectively.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 10","pages":"Pages 1247-1253"},"PeriodicalIF":1.3,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design, synthesis and biological activity of oxyevodiamine-based histone deacetylase 6 inhibitors 基于氧代乙二胺的组蛋白去乙酰化酶 6 抑制剂的设计、合成和生物活性。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-06-26 DOI: 10.1080/10286020.2024.2362383
{"title":"Design, synthesis and biological activity of oxyevodiamine-based histone deacetylase 6 inhibitors","authors":"","doi":"10.1080/10286020.2024.2362383","DOIUrl":"10.1080/10286020.2024.2362383","url":null,"abstract":"<div><div>Histone deacetylase 6 (HDAC6) was a potential target for Alzheimer’s disease (AD). In this study, a series of novel oxyevodiamine-based HDAC6 inhibitors with a variety of linker moieties were designed, synthesized and evaluated. Compound <strong>12</strong> with a benzyl linker was identified as a high potent and selective HDAC6 inhibitor. It inhibited HDAC6 with an IC<sub>50</sub> value of 6.2 nM and was more than 200 fold selectivity over HDAC1. It also had lower cytotoxicity and higher anti-H<sub>2</sub>O<sub>2</sub> activity <em>in vitro</em> comparing with other derivatives. Compound <strong>12</strong> might be a good lead as novel HDAC6 inhibitor for the treatment of AD.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 11","pages":"Pages 1328-1338"},"PeriodicalIF":1.3,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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