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Journal of Asian Natural Products Research最新文献

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Sesquiterpenes with anti-inflammatory activity from the stems and branches of Melicope patulinervia 山核桃茎、枝中具有抗炎活性的倍半萜素。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-03 DOI: 10.1080/10286020.2025.2508874
Sai Li , En-Lian Du , Qi Gong , Fei Chen , Jun-Jie Tan , Shi-Jin Qu , Hai-Yan Zhang , Chang-Heng Tan
{"title":"Sesquiterpenes with anti-inflammatory activity from the stems and branches of Melicope patulinervia","authors":"Sai Li ,&nbsp;En-Lian Du ,&nbsp;Qi Gong ,&nbsp;Fei Chen ,&nbsp;Jun-Jie Tan ,&nbsp;Shi-Jin Qu ,&nbsp;Hai-Yan Zhang ,&nbsp;Chang-Heng Tan","doi":"10.1080/10286020.2025.2508874","DOIUrl":"10.1080/10286020.2025.2508874","url":null,"abstract":"<div><div>Five new sesquiterpenes comprising three zieranes, melicopatulones A–C (<strong>1</strong>–<strong>3</strong>) and two guaianes, melicopatulones D–E (<strong>5</strong>–<strong>6</strong>), were isolated from the stems and branches of <em>Melicope patulinervia</em>, together with melicodenones B (<strong>4</strong>), C (<strong>7</strong>) and D (<strong>8</strong>). Their structures with absolute configurations were elucidated on the basis of analysis of MS, NMR, and TDDFT-ECD calculations. Sesquiterpenes <strong>1</strong>, <strong>2</strong> and <strong>6</strong> exhibited significant inhibitory effect at 10 µM on lipopolysaccharide-induced NO production in BV-2 microglial cells.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 7","pages":"Pages 977-982"},"PeriodicalIF":1.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cannabinoid receptor ligands with potential therapeutic applications and mechanisms of action: a versatile natural therapeutic agent. 具有潜在治疗应用和作用机制的大麻素受体配体：一种多功能天然治疗剂。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-02 DOI: 10.1080/10286020.2025.2522396
Shivendra Mani Tripathi, Sharda Sambhakar, Sudhanshu Mishra, Rishabha Malviya, Sathvik Belagodu Sridhar
{"title":"Cannabinoid receptor ligands with potential therapeutic applications and mechanisms of action: a versatile natural therapeutic agent.","authors":"Shivendra Mani Tripathi, Sharda Sambhakar, Sudhanshu Mishra, Rishabha Malviya, Sathvik Belagodu Sridhar","doi":"10.1080/10286020.2025.2522396","DOIUrl":"https://doi.org/10.1080/10286020.2025.2522396","url":null,"abstract":"<p><p>The endocannabinoid system (ECS) is a complex signaling network essential for regulating various physiological processes in the body. Selective cannabinoid receptor ligands have been developed to modulate specific ECS signaling pathways, offering potential therapeutic benefits. These ligands, with high selectivity and affinity for cannabinoid receptors, demonstrate potential in managing diverse medical conditions. Standardizing dosing is crucial to ensure reliable therapeutic effects, as cannabinoids may exhibit biphasic effects. Combination strategies involving both CB1 and CB2 receptor modulation show promise in managing complex conditions, including chronic pain, autoimmune disorders, and neurodegenerative diseases.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-20"},"PeriodicalIF":1.3,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ginseng: a traditional medicine and food homologous plant. 人参：一种传统医药和食品同源植物。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-06-28 DOI: 10.1080/10286020.2025.2514689
Xiao-Xue Song, En-Lin Liu, Xiao-Wei Du
{"title":"Ginseng: a traditional medicine and food homologous plant.","authors":"Xiao-Xue Song, En-Lin Liu, Xiao-Wei Du","doi":"10.1080/10286020.2025.2514689","DOIUrl":"https://doi.org/10.1080/10286020.2025.2514689","url":null,"abstract":"<p><p>Ginseng (<i>Panax ginseng</i> CA Meyer), a perennial herb belonging to the Araliaceae family, has been cultivated and used in China for over 2,000 years. Ginseng, a renowned medicinal plant, is highly valued for its health benefits and is among the top herbal medicines in traditional Chinese medicine. Its roots, leaves, and stems are utilized for medicinal and edible purposes. This paper reviews the cultivation history, chemical constituents, and pharmacological activities of ginseng, which is rich in ginsenosides and other bioactive compounds. It provides a reference for the comprehensive development and utilization of this medicinal plant.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.3,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on the synthesis, structural characterization, and anti-hepatoma cell proliferation effects of sulfated alfalfa polysaccharides. 硫酸酸化紫花苜蓿多糖的合成、结构表征及抗肝癌细胞增殖作用研究。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-06-27 DOI: 10.1080/10286020.2025.2521824
Lang Qiu, Jia-Yi Wang, Dan-Qi Li, Xue-Gui Liu, Pin-Yi Gao
{"title":"Study on the synthesis, structural characterization, and anti-hepatoma cell proliferation effects of sulfated alfalfa polysaccharides.","authors":"Lang Qiu, Jia-Yi Wang, Dan-Qi Li, Xue-Gui Liu, Pin-Yi Gao","doi":"10.1080/10286020.2025.2521824","DOIUrl":"https://doi.org/10.1080/10286020.2025.2521824","url":null,"abstract":"<p><p>A water-soluble polysaccharide (APS) from <i>Medicago Sativa</i> L. (alfalfa) stems was sulfated via the chlorosulfonic acid (CSA)-pyridine (Pyr) method under three conditions, yielding SAPS-1, SAPS-2, and SAPS-3. Structural characterization (HPGPC, NMR, FT-IR, SEM) confirmed successful sulfation and increased water solubility. SAPSs 1-3 exhibited superior scavenging of DPPH, ABTS, and OH radicals compared to APS. Both APS and SAPSs 1-3 inhibited hepatoma cell (HepG2, Hep3B) proliferation <i>in vitro</i>. Cell cycle analysis showed APS-induced G0/G1 arrest, while SAPS-3 exhibited biphasic regulation by maintaining G0/G1 arrest and stimulating S-phase accumulation. The CSA-Pyr technique enhanced the inhibitory effects, offering promise for developing bioactive compounds from alfalfa biomass.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-18"},"PeriodicalIF":1.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New modified silybin derivatives: design, synthesis, and preliminary evaluation of antitumor activity. 新型改性水飞蓟宾衍生物：设计、合成及抗肿瘤活性初步评价。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-06-18 DOI: 10.1080/10286020.2025.2515257
Yan-Qiu Meng, Chao-Hui Zhang, Dong-Ping Xu, Lei Gao, Yan Li
{"title":"New modified silybin derivatives: design, synthesis, and preliminary evaluation of antitumor activity.","authors":"Yan-Qiu Meng, Chao-Hui Zhang, Dong-Ping Xu, Lei Gao, Yan Li","doi":"10.1080/10286020.2025.2515257","DOIUrl":"https://doi.org/10.1080/10286020.2025.2515257","url":null,"abstract":"<p><p>Based on the molecular docking of Epidermal Growth Factor Receptor inhibitors and known small molecules, key amino acid fragments and active groups were analyzed through computer-aided drug design techniques. Subsequently, these active functional groups were introduced at positions C-23 and C-7 of silybin to design and synthesize 12 novel silybin derivatives. The structures of these innovative silybin analogues were confirmed by nuclear magnetic resonance and mass spectrometry. Moreover, the antitumor activities of these novel analogues were evaluated by MTT assay. As a result, compounds <b>I<sub>2</sub></b> and <b>I<sub>8</sub></b> exhibited greater cytotoxicity against tumor cells compared to silybin and positive control drugs such as gefitinib. In conclusion, our study synthesized 12 novel silybin derivatives and identified compounds <b>I<sub>2</sub></b> and <b>I<sub>8</sub></b> as potential candidates or cancer therapy.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design, synthesis, and biological evaluation of bergapten derivatives as potent anti-pancreatic cancer agents. bergapten衍生物作为有效的抗胰腺癌药物的设计、合成和生物学评价。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-06-18 DOI: 10.1080/10286020.2025.2514692
Ying Yue, Jia-Rong Liu, Nan Wang, Xing-Rong Wang, Jun-Yi Ma, Jun-Li Yang
{"title":"Design, synthesis, and biological evaluation of bergapten derivatives as potent anti-pancreatic cancer agents.","authors":"Ying Yue, Jia-Rong Liu, Nan Wang, Xing-Rong Wang, Jun-Yi Ma, Jun-Li Yang","doi":"10.1080/10286020.2025.2514692","DOIUrl":"https://doi.org/10.1080/10286020.2025.2514692","url":null,"abstract":"<p><p>Bergapten, a natural product from <i>Zanthoxylum bungeanum</i> Maxim., exhibits anticancer, antibacterial, anti-inflammatory, and hypolipidemic effects. A derivative, FSG-Y5 showed potent activity against pancreatic cancer cells PANC-1 (IC<sub>50</sub> = 2.31 ± 0.25 µM) and CFPAC-1 (IC<sub>50</sub> = 4.41 ± 0.47 µM), inhibiting their survival, migration, and invasion while inducing apoptosis <i>via</i> Bax and Cleaved caspase-3 regulation. FSG-Y5 also suppressed pancreatic cancer organoids and zebrafish tumor growth in a concentration and time-dependent manner. These findings highlight bergapten derivatives as promising anticancer candidates, with FSG-Y5 as a potential anti-pancreatic cancer agent for further study.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-17"},"PeriodicalIF":1.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design, synthesis and anti-tumor activity of oleanolic acid derivatives targeting EGFR. 靶向EGFR齐墩果酸衍生物的设计、合成及抗肿瘤活性研究。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-06-18 DOI: 10.1080/10286020.2025.2515260
Yan-Qiu Meng, Li-Ming Liu, Dong-Ping Xu, Guo Chen, Tong-Tong Gu
{"title":"Design, synthesis and anti-tumor activity of oleanolic acid derivatives targeting EGFR.","authors":"Yan-Qiu Meng, Li-Ming Liu, Dong-Ping Xu, Guo Chen, Tong-Tong Gu","doi":"10.1080/10286020.2025.2515260","DOIUrl":"https://doi.org/10.1080/10286020.2025.2515260","url":null,"abstract":"<p><p>With computer-aided drug design (CADD) technology, a total of 12 inhibitors of EGFR based on oleanolic acid (<b>OA</b>) derivatives were designed and synthesized with modification at C-3 and C-28 positions of <b>OA</b>. Their structures were confirmed by <sup>1</sup>H-NMR,<sup>13</sup>C-NMR and ESI-MS. The anti-tumor activities of these novel analogues were evaluated by MTT assay, and the results showed that the derivatives <b>I<sub>6</sub></b> and <b>II<sub>2</sub></b> had stronger cytotoxicity on A549 and MCF-7 cancer cells, which may be potential candidate compounds for tumor therapy.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and antitumor activity of silibinin derivatives targeting VEGFR. 靶向VEGFR的水飞蓟宾衍生物的合成及抗肿瘤活性研究。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-06-18 DOI: 10.1080/10286020.2025.2515250
Lei Gao, Liang-Feng Zhang, Yan Li, Chao-Hui Zhang, Yan-Qiu Meng
{"title":"Synthesis and antitumor activity of silibinin derivatives targeting VEGFR.","authors":"Lei Gao, Liang-Feng Zhang, Yan Li, Chao-Hui Zhang, Yan-Qiu Meng","doi":"10.1080/10286020.2025.2515250","DOIUrl":"https://doi.org/10.1080/10286020.2025.2515250","url":null,"abstract":"<p><p>Totally 10 inhibitors of VEGFR based on silibinin derivatives were designed and synthesized with the modification on the hydroxyl group at C-3 and C-7 positions of silibinin through acylation, selective aminolysis, alkylation, oxidation, and dehydrogenation reactions. Their structures were confirmed by MS, <sup>1</sup>H NMR, and <sup>13</sup>C NMR. <i>In vitro</i> activity assay showed that these compounds can inhibit cell proliferation of A549 and SGC7901 cells, especially compounds <b>I<sub>3</sub></b> and <b>I<sub>8</sub></b> showed better inhibitory activity on these tumor cells, and similar to the positive control drug lapatinib, which may be potential candidate compounds for tumor therapy.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Apoptotic effect of carvacrol on different cancer cells and its potential as an active medicine ingredient. 香芹酚对不同肿瘤细胞的凋亡作用及其作为活性药物成分的潜力。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-06-18 DOI: 10.1080/10286020.2025.2517669
Müge Musmula, Senem Akkoc
{"title":"Apoptotic effect of carvacrol on different cancer cells and its potential as an active medicine ingredient.","authors":"Müge Musmula, Senem Akkoc","doi":"10.1080/10286020.2025.2517669","DOIUrl":"https://doi.org/10.1080/10286020.2025.2517669","url":null,"abstract":"<p><p>Apoptosis is the programmed death of cells that have lost their function, have been damaged, or are no longer needed in the organism. Genes that control this process are overexpressed in some tumors. Carvacrol, a terpenoid, has been shown to inhibit tumor growth and induce apoptosis in cancerous cells, increasing caspase activity, DNA fragmentation, and the expression of the Bax protein, while decreasing Bcl-2 expression. In this review, the effects of carvacrol on various cancers and its potential as a drug are summarized.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-18"},"PeriodicalIF":1.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
C19-Diterpenoid alkaloids from two plants of Aconitum sinoaxillare and Aconitum chasmanthum. 从乌头和乌头两种植物中提取c19 -二萜类生物碱。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-06-11 DOI: 10.1080/10286020.2025.2513492
Ling-Feng Tian, Mei-Zhen Ye, Ting-Ting Li, Qiao Long, Shu Wang, Min Zhang, Lin Chen, Shuai Huang, Xian-Li Zhou
{"title":"C<sub>19</sub>-Diterpenoid alkaloids from two plants of <i>Aconitum sinoaxillare</i> and <i>Aconitum chasmanthum</i>.","authors":"Ling-Feng Tian, Mei-Zhen Ye, Ting-Ting Li, Qiao Long, Shu Wang, Min Zhang, Lin Chen, Shuai Huang, Xian-Li Zhou","doi":"10.1080/10286020.2025.2513492","DOIUrl":"https://doi.org/10.1080/10286020.2025.2513492","url":null,"abstract":"<p><p>Five new compounds (<b>1</b>-<b>5</b>) were isolated from the whole plants of two species of <i>Aconitum</i>, including two aconitine-type C<sub>19</sub>-diterpenoid alkaloids, sinoaxidines A (<b>1</b>) and B (<b>2</b>) and a franchetine-type C<sub>19</sub>-diterpenoid alkaloid, sinoaxidine C (<b>3</b>) from <i>Aconitum sinoaxillare</i> W. T. Wang. Two aconitine-type C<sub>19</sub>-diterpenoid alkaloids, chasmanthumines A (<b>4</b>) and B (<b>5</b>) from <i>Aconitum chasmanthum</i> Stapf, and forty known diterpenoid alkaloids were also isolated. The structures of all compounds were identified based on extensive IR, 1D, 2D NMR and HR-ESI-MS data analysis. Compound <b>6</b> exhibited potent inhibitory effects on the production of NO in RAW 264.7 cells with IC<sub>50</sub> of 29.60 <i>μ</i>M respectively.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.3,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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