C₁₉-Diterpenoid alkaloids from two plants of Aconitum sinoaxillare and Aconitum chasmanthum.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-06-11 DOI:10.1080/10286020.2025.2513492

Ling-Feng Tian, Mei-Zhen Ye, Ting-Ting Li, Qiao Long, Shu Wang, Min Zhang, Lin Chen, Shuai Huang, Xian-Li Zhou

引用次数: 0

Abstract

Five new compounds (1-5) were isolated from the whole plants of two species of Aconitum, including two aconitine-type C₁₉-diterpenoid alkaloids, sinoaxidines A (1) and B (2) and a franchetine-type C₁₉-diterpenoid alkaloid, sinoaxidine C (3) from Aconitum sinoaxillare W. T. Wang. Two aconitine-type C₁₉-diterpenoid alkaloids, chasmanthumines A (4) and B (5) from Aconitum chasmanthum Stapf, and forty known diterpenoid alkaloids were also isolated. The structures of all compounds were identified based on extensive IR, 1D, 2D NMR and HR-ESI-MS data analysis. Compound 6 exhibited potent inhibitory effects on the production of NO in RAW 264.7 cells with IC₅₀ of 29.60 μM respectively.

查看原文本刊更多论文

从乌头和乌头两种植物中提取c19 -二萜类生物碱。

从两种乌头属植物中分离得到5个新化合物（1 ~ 5），包括乌头碱型c19 -二萜生物碱A(1)和B(2)和乌头碱型c19 -二萜生物碱C(3)。从乌头中分离到2种乌头碱型c19 -二萜生物碱A(4)和B(5)，以及40种已知的二萜生物碱。所有化合物的结构都是基于广泛的IR， 1D， 2D NMR和HR-ESI-MS数据分析确定的。化合物6对RAW 264.7细胞NO的生成有较强的抑制作用，IC50分别为29.60 μM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.

C19-Diterpenoid alkaloids from two plants of Aconitum sinoaxillare and Aconitum chasmanthum.

Abstract

C₁₉-Diterpenoid alkaloids from two plants of Aconitum sinoaxillare and Aconitum chasmanthum.