Design, synthesis, and biological evaluation of bergapten derivatives as potent anti-pancreatic cancer agents.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-06-18 DOI:10.1080/10286020.2025.2514692

Ying Yue, Jia-Rong Liu, Nan Wang, Xing-Rong Wang, Jun-Yi Ma, Jun-Li Yang

引用次数: 0

Abstract

Bergapten, a natural product from Zanthoxylum bungeanum Maxim., exhibits anticancer, antibacterial, anti-inflammatory, and hypolipidemic effects. A derivative, FSG-Y5 showed potent activity against pancreatic cancer cells PANC-1 (IC₅₀ = 2.31 ± 0.25 µM) and CFPAC-1 (IC₅₀ = 4.41 ± 0.47 µM), inhibiting their survival, migration, and invasion while inducing apoptosis via Bax and Cleaved caspase-3 regulation. FSG-Y5 also suppressed pancreatic cancer organoids and zebrafish tumor growth in a concentration and time-dependent manner. These findings highlight bergapten derivatives as promising anticancer candidates, with FSG-Y5 as a potential anti-pancreatic cancer agent for further study.

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bergapten衍生物作为有效的抗胰腺癌药物的设计、合成和生物学评价。

花椒藤，花椒属植物的天然产物。具有抗癌、抗菌、抗炎和降血脂的作用。其衍生物fgs - y5对胰腺癌细胞PANC-1 （IC50 = 2.31±0.25µM）和CFPAC-1 （IC50 = 4.41±0.47µM）具有抑制其生存、迁移和侵袭的活性，同时通过Bax和Cleaved caspase-3调控诱导细胞凋亡。FSG-Y5还以浓度和时间依赖的方式抑制胰腺癌类器官和斑马鱼肿瘤的生长。这些发现突出了bergapten衍生物作为有前途的抗癌候选药物，FSG-Y5作为潜在的抗胰腺癌药物有待进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.