Cannabinoid receptor ligands with potential therapeutic applications and mechanisms of action: a versatile natural therapeutic agent.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-07-02 DOI:10.1080/10286020.2025.2522396

Shivendra Mani Tripathi, Sharda Sambhakar, Sudhanshu Mishra, Rishabha Malviya, Sathvik Belagodu Sridhar

引用次数: 0

Abstract

The endocannabinoid system (ECS) is a complex signaling network essential for regulating various physiological processes in the body. Selective cannabinoid receptor ligands have been developed to modulate specific ECS signaling pathways, offering potential therapeutic benefits. These ligands, with high selectivity and affinity for cannabinoid receptors, demonstrate potential in managing diverse medical conditions. Standardizing dosing is crucial to ensure reliable therapeutic effects, as cannabinoids may exhibit biphasic effects. Combination strategies involving both CB1 and CB2 receptor modulation show promise in managing complex conditions, including chronic pain, autoimmune disorders, and neurodegenerative diseases.

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具有潜在治疗应用和作用机制的大麻素受体配体：一种多功能天然治疗剂。

内源性大麻素系统（ECS）是一个复杂的信号网络，对调节人体各种生理过程至关重要。选择性大麻素受体配体已被开发用于调节特定的ECS信号通路，提供潜在的治疗益处。这些配体对大麻素受体具有高选择性和亲和力，在管理各种医疗条件方面表现出潜力。标准化剂量对于确保可靠的治疗效果至关重要，因为大麻素可能表现出双相效应。涉及CB1和CB2受体调节的联合策略在治疗复杂疾病，包括慢性疼痛、自身免疫性疾病和神经退行性疾病方面显示出希望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.