Apoptotic effect of carvacrol on different cancer cells and its potential as an active medicine ingredient.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-06-18 DOI:10.1080/10286020.2025.2517669

Müge Musmula, Senem Akkoc

引用次数: 0

Abstract

Apoptosis is the programmed death of cells that have lost their function, have been damaged, or are no longer needed in the organism. Genes that control this process are overexpressed in some tumors. Carvacrol, a terpenoid, has been shown to inhibit tumor growth and induce apoptosis in cancerous cells, increasing caspase activity, DNA fragmentation, and the expression of the Bax protein, while decreasing Bcl-2 expression. In this review, the effects of carvacrol on various cancers and its potential as a drug are summarized.

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香芹酚对不同肿瘤细胞的凋亡作用及其作为活性药物成分的潜力。

细胞凋亡是指失去功能、受损或机体不再需要的细胞的程序性死亡。控制这一过程的基因在某些肿瘤中过度表达。Carvacrol是一种萜类化合物，已被证明可以抑制肿瘤生长并诱导癌细胞凋亡，增加caspase活性、DNA片段化和Bax蛋白的表达，同时降低Bcl-2的表达。本文综述了香芹酚对多种癌症的作用及其作为一种药物的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.