Sesquiterpenes with anti-inflammatory activity from the stems and branches of Melicope patulinervia.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-05-28 DOI:10.1080/10286020.2025.2508874

Sai Li, En-Lian Du, Qi Gong, Fei Chen, Jun-Jie Tan, Shi-Jin Qu, Hai-Yan Zhang, Chang-Heng Tan

引用次数: 0

Abstract

Five new sesquiterpenes comprising three zieranes, melicopatulones A-C (1-3) and two guaianes, melicopatulones D-E (5-6), were isolated from the stems and branches of Melicope patulinervia, together with melicodenones B (4), C (7) and D (8). Their structures with absolute configurations were elucidated on the basis of analysis of MS, NMR, and TDDFT-ECD calculations. Sesquiterpenes 1, 2 and 6 exhibited significant inhibitory effect at 10 µM on lipopolysaccharide-induced NO production in BV-2 microglial cells.

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山核桃茎、枝中具有抗炎活性的倍半萜素。

从柳枝和柳枝中分离到5个新的倍半萜类化合物，包括3个齐烷类化合物melicopatulones A-C（1-3）和2个瓜苷类化合物melicopatulones D- e(5-6)，以及melicodenones B(4)、C(7)和D(8)。通过MS、NMR和TDDFT-ECD分析，确定了它们的绝对构型。倍半萜1、2和6对脂多糖诱导的BV-2小胶质细胞NO生成有显著的抑制作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.