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Journal of Asian Natural Products Research最新文献

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Ecdysteroid-enriched fraction of Cyathula officinalis suppresses synovial proliferation and inflammation to ameliorate RA by inhibiting the AKT/PI3K/mTOR signaling pathway. Cyathula officinalis富含表皮甾体激素的部位通过抑制AKT/PI3K/mTOR信号通路抑制滑膜增生和炎症，改善RA。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-04-21 DOI: 10.1080/10286020.2025.2492357
Yue-Hui Huang, Lu Qiu, Yi Peng, Rui Cai, Qing-Qing Xiao, Mei-Chen Li, Li-Jia Xu, Qiang Fu
{"title":"Ecdysteroid-enriched fraction of <i>Cyathula officinalis</i> suppresses synovial proliferation and inflammation to ameliorate RA by inhibiting the AKT/PI3K/mTOR signaling pathway.","authors":"Yue-Hui Huang, Lu Qiu, Yi Peng, Rui Cai, Qing-Qing Xiao, Mei-Chen Li, Li-Jia Xu, Qiang Fu","doi":"10.1080/10286020.2025.2492357","DOIUrl":"https://doi.org/10.1080/10286020.2025.2492357","url":null,"abstract":"<p><p>This study investigated the chemical compositions isolated from <i>Cyathula officinalis</i> (CES) and elucidated its anti-RA effects and potential mechanisms. <i>In vitro</i> results revealed that CES suppressed interleukin (IL)-1β-stimulated proliferation, migration, and invasion of MH7A cells in a concentration-dependent manner. <i>In vivo</i> results indicated that CES could reduce the arthritis score, paw swelling, and improve histopathological deterioration. The levels of inflammatory factors, matrix metalloproteinases, and proteins expressed in rat synovial tissue were suppressed after treatment with CES. These findings illustrate that CES is involved in the PI3K/AKT/mTOR/SREBP1/SCD-1/GPX4 axis-mediated ferroptosis and anti-inflammation, exerting its protective effects against the progression of RA.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-23"},"PeriodicalIF":1.3,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polyprenylated acylphloroglucinols from Hypericum attenuatum and their antidepressant activities. 金丝桃中聚丙烯化酰基间苯三酚及其抗抑郁活性。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-04-21 DOI: 10.1080/10286020.2025.2492351
En-Hui Zhang, Dan Liu, Yong Xiang
{"title":"Polyprenylated acylphloroglucinols from <i>Hypericum attenuatum</i> and their antidepressant activities.","authors":"En-Hui Zhang, Dan Liu, Yong Xiang","doi":"10.1080/10286020.2025.2492351","DOIUrl":"https://doi.org/10.1080/10286020.2025.2492351","url":null,"abstract":"<p><p>Three new polycyclic polyprenylated acylphloroglucinols, attenuatumines A-C (<b>1-3</b>), were ioslated from the 90% EtOH extract of the air dried aerial parts of <i>Hypericum attenuatum</i>. Structural elucidation of all the compounds was performed by spectral methods such as 1D and 2D (<sup>1</sup>H-<sup>1</sup>H COSY, HMQC, and HMBC) NMR spectroscopy. All the isolated compounds were evaluated for their antidepressant activity by inhibiting reuptake of tritiated serotonin ([<sup>3</sup>H]-5-HT) and noradrenalinet ([<sup>3</sup>H]-NE) in rat brain synaptosomes. Compounds <b>2</b> exhibited some antidepressant activities in the [<sup>3</sup>H]-5-HT mode.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.3,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rhamnocitrin induces apoptosis of human nasopharyngeal carcinoma by inhibiting IGF-1R signaling pathway in vitro. 鼠李柠檬素通过抑制IGF-1R信号通路诱导鼻咽癌细胞凋亡。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-04-21 DOI: 10.1080/10286020.2025.2491611
Yan-Yuan Zhou, Ya-Zhou Li, Zhi-Qiang Liu, Xiao-Hui Qin, Ya-Qi Wu, Chao-Jie Chong, Liang Lyu, Cheng-Xue Pan
{"title":"Rhamnocitrin induces apoptosis of human nasopharyngeal carcinoma by inhibiting IGF-1R signaling pathway <i>in vitro</i>.","authors":"Yan-Yuan Zhou, Ya-Zhou Li, Zhi-Qiang Liu, Xiao-Hui Qin, Ya-Qi Wu, Chao-Jie Chong, Liang Lyu, Cheng-Xue Pan","doi":"10.1080/10286020.2025.2491611","DOIUrl":"https://doi.org/10.1080/10286020.2025.2491611","url":null,"abstract":"<p><p>This study explored rhamnocitrin's apoptotic effects on human nasopharyngeal carcinoma cell lines (CNE-2/C666-1) and underlying mechanisms. Following treatment with varying concentrations, cell proliferation, apoptosis, and protein expression were analyzed using MTT assay, Hoechst/Annexin V-FITC/PI staining, and western blot. Results showed rhamnocitrin inhibited cell proliferation, induced apoptosis, downregulated IGF-1R, Erk1/2, and Akt phosphorylation, and activated caspase 3, caspase 8, caspase 9, and Bax while inhibiting survivin, Bcl-2, and Mcl-1. In conclusion, rhamnocitrin induces apoptosis in nasopharyngeal carcinoma cells by inhibiting the IGF-1R signaling pathway and its downstream effectors Akt and Erk1/2.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-16"},"PeriodicalIF":1.3,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Four new phenolic compounds from stems and leaves of Hemerocallis citrina (Daylily). 黄花萱草茎叶中4个新的酚类化合物。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-04-16 DOI: 10.1080/10286020.2025.2483806
Xiao-Xue Li, Han Yu, Shang-Hong Song, Xiao-Hua Liu, Yu-Ning Zheng, Zhao-Hui Li, Jia-Mei Chen, Chun-Xin Xing, Xiao-Feng He, Guang-Hua Lu
{"title":"Four new phenolic compounds from stems and leaves of <i>Hemerocallis citrina</i> (Daylily).","authors":"Xiao-Xue Li, Han Yu, Shang-Hong Song, Xiao-Hua Liu, Yu-Ning Zheng, Zhao-Hui Li, Jia-Mei Chen, Chun-Xin Xing, Xiao-Feng He, Guang-Hua Lu","doi":"10.1080/10286020.2025.2483806","DOIUrl":"https://doi.org/10.1080/10286020.2025.2483806","url":null,"abstract":"<p><p>Four new phenolic compounds, hemerodiphenylethanes A-D (<b>1-4</b>), along with eight known compounds methyl 2,4-dihydroxy-6-[2-(4-hydroxyphenyl) ethyl] benzoate (<b>5</b>), methyl 2,4-dihydroxy-6-(4-hydroxyphenethyl)-3-methylbenzoate (<b>6</b>), neochlorogenic acid (<b>7</b>), isoquercetin (<b>8</b>), isorhamnetin-3-O-β-D-galactoside (<b>9</b>), velutin (<b>10</b>), rutin (<b>11</b>), and (+)-syringaresinol (<b>12</b>), were isolated from the stems and leaves of <i>Hemerocallis citrina</i> Baroni (Daylily). Their structures were elucidated based on HR-ESI-MS, 1D- and 2D-NMR spectra, and ECD calculations. Among them, both compounds <b>10</b> and <b>12</b> were isolated from the genus <i>Hemerocallis</i>, and compounds <b>5</b> and <b>6</b> were isolated from this plant species for the first time. These compounds showed antioxidant activity as determined by IC<sub>50</sub> values of DPPH and ABTS<sup>+</sup> in a radical scavenging experiment.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Iridoid glycosides from the leaves of Paederia foetida and their antinociceptive activities. 黄连叶环烯醚萜苷类化合物及其抗伤活性研究。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-04-15 DOI: 10.1080/10286020.2025.2490108
Yu-Feng Chen, Wei Gong, Xue Sun
{"title":"Iridoid glycosides from the leaves of <i>Paederia foetida</i> and their antinociceptive activities.","authors":"Yu-Feng Chen, Wei Gong, Xue Sun","doi":"10.1080/10286020.2025.2490108","DOIUrl":"https://doi.org/10.1080/10286020.2025.2490108","url":null,"abstract":"<p><p>A chemical investigation on the leaves of <i>Paederia Foetida</i> resulted into the isolation of two new iridoid glycosides, paefoetines A and B (<b>1</b> and <b>2</b>). Structural elucidation of all the compounds was performed by spectral methods such as 1D and 2D (<sup>1</sup>H<i>-</i><sup>1</sup>H COSY, HMQC, and HMBC) NMR spectroscopy. The two isolated iridoid glycosides were tested <i>in vivo</i> for their antinociceptive properties. As a result, <b>1</b> exhibited potent antinociceptive activity and its ED<sub>50</sub> value (49.2 μmol/kg) was twofold less than those of the positive control drugs aspirin.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.3,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three new limonoids with high oxidation from the fruits of Aglaia edulis. 从菖蒲果实中提取三种新的高氧化类柠檬素。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-04-11 DOI: 10.1080/10286020.2025.2482075
Han-Sheng Lv, Hou-Li Jiang, Yu-Jin Sun, Ping Ying, Qiang Zheng, Ling-Yi Kong, Jun Luo
{"title":"Three new limonoids with high oxidation from the fruits of <i>Aglaia edulis</i>.","authors":"Han-Sheng Lv, Hou-Li Jiang, Yu-Jin Sun, Ping Ying, Qiang Zheng, Ling-Yi Kong, Jun Luo","doi":"10.1080/10286020.2025.2482075","DOIUrl":"https://doi.org/10.1080/10286020.2025.2482075","url":null,"abstract":"<p><p>Agledulines L-N (<b>1 - 3</b>), three previously undescribed limonoids with the A/D-ring-seco structural characteristics and high degree oxidation, along with the three reported compounds (<b>4 - 6</b>), were isolated from the fruits of <i>Aglaia edulis</i>. The structures of <b>1 - 3</b> were elucidated by NMR data, HRESIMS, ECD spectra, and circular dichroism exciton chirality method. The furan rings in <b>1</b> and <b>2</b> were oxidized to <i>γ</i>-hydroxy-butene lactone moiety, and the tautomerism of hemiacetal C-21 contributed to the disappearance of NMR signals in the segments. The biological evaluation showed that <b>1 - 3</b> had no anti-inflammatory activity by inhibiting NO release in LPS-activated RAW264.7 macrophages.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.3,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design and synthesis of a novel β-anhydroicartin derivative targeting tumor cell mitochondria based on the regulation of p16INK4a and its in vitro biological activity evaluation. 基于p16INK4a调控的靶向肿瘤细胞线粒体的β-无氢蛋白衍生物的设计合成及其体外生物活性评价
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-04-10 DOI: 10.1080/10286020.2025.2488322
Hui Shu, Fang-Fei Liu, Feng-Yan Su, Qian Zhang, Yan Zhao, Wei Li, Jia-Hong Han, En-Bo Cai
{"title":"Design and synthesis of a novel β-anhydroicartin derivative targeting tumor cell mitochondria based on the regulation of p16INK4a and its <i>in vitro</i> biological activity evaluation.","authors":"Hui Shu, Fang-Fei Liu, Feng-Yan Su, Qian Zhang, Yan Zhao, Wei Li, Jia-Hong Han, En-Bo Cai","doi":"10.1080/10286020.2025.2488322","DOIUrl":"https://doi.org/10.1080/10286020.2025.2488322","url":null,"abstract":"<p><p>Based on the regulation of β-anhydroicaritin on the stability of p16INK4a encoded by CDKN2A gene, nine novel triphenylphosphine derivatives targeting tumor cell mitochondria were synthesized. Compound <b>13</b> increased the ability to inhibit lung cancer A549 cells by 24 times compared with 5-fluorouracil. Biological studies have shown that compound <b>13</b> significantly promotes early apoptosis and induces mitochondrial dysfunction in A549 cells. Further studies showed that compound <b>13</b> arrested 73% of the cells in the G0/G1 phase, preventing the cells from entering the DNA synthesis phase. In summary, compound <b>13</b> is expected to be developed as a new targeted anti-tumor drug.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-17"},"PeriodicalIF":1.3,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sulfonated and sulfated lignans/neolignans from an aqueous extract of Isatis indigotica roots 从板蓝根的水提取物中提取的磺化和磺化木脂素/新木脂素。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-04-10 DOI: 10.1080/10286020.2025.2483810
Jia-Yi Feng , Yu-Feng Liu , Xiao-Qiang Lei , Qing-Lan Guo , Jian-Gong Shi
{"title":"Sulfonated and sulfated lignans/neolignans from an aqueous extract of Isatis indigotica roots","authors":"Jia-Yi Feng ,&nbsp;Yu-Feng Liu ,&nbsp;Xiao-Qiang Lei ,&nbsp;Qing-Lan Guo ,&nbsp;Jian-Gong Shi","doi":"10.1080/10286020.2025.2483810","DOIUrl":"10.1080/10286020.2025.2483810","url":null,"abstract":"<div><div>Five sulfonated and sulfated lignans/neolignans (<strong>1</strong>–<strong>5</strong>), together with a neolignan analogue (<strong>6</strong>), were isolated from an aqueous extract of the <em>Isatis indigotica</em> roots (ban lan gen). Their structures were determined by spectral data analysis in combination with electronic circular dichroism (ECD) and NMR calculations. Among the isolates, <strong>1</strong> and <strong>2</strong> are sulfonated 7,9′-epoxylignans, while <strong>3</strong>–<strong>5</strong> are either sulfated or sulfonated 4′,7-epoxy-8,3′-neolignans. In the preliminary bioassay, <strong>2</strong> and <strong>3</strong> exhibited moderate inhibitory activities against TGF-<em>β</em> induced HSC-T6 cell activation.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 6","pages":"Pages 844-853"},"PeriodicalIF":1.3,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrated meta-analysis, network pharmacology, computational biology, and in vitro experimental verification to reveal the anti-fatigue mechanism of Lycium barbarum. 综合meta分析、网络药理学、计算生物学、体外实验验证等方法，揭示枸杞抗疲劳作用机制。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-04-10 DOI: 10.1080/10286020.2025.2488316
Teng-Teng Huang, Xiao-Ling Chen, Dai-Wen Chen, Bing Yu, Ping Zheng, Hui Yan, Jun He, Zhi-Qing Huang
{"title":"Integrated meta-analysis, network pharmacology, computational biology, and <i>in vitro</i> experimental verification to reveal the anti-fatigue mechanism of <i>Lycium barbarum</i>.","authors":"Teng-Teng Huang, Xiao-Ling Chen, Dai-Wen Chen, Bing Yu, Ping Zheng, Hui Yan, Jun He, Zhi-Qing Huang","doi":"10.1080/10286020.2025.2488316","DOIUrl":"https://doi.org/10.1080/10286020.2025.2488316","url":null,"abstract":"<p><p>This study aims to elucidate <i>Lycium barbarum</i> (LB)'s anti-fatigue mechanisms. Meta-analysis confirmed LB's anti-fatigue capacity, while network pharmacology, molecular docking, and molecular dynamics simulations identified key targets (SRC, HSP90AA1, EGFR, PRKACA, MAPK1). Furthermore, validation experiments in C2C12 cells demonstrated that LB mitigates H<sub>2</sub>O<sub>2</sub>-induced reactive oxygen species (ROS) accumulation and restores cell viability. qPCR analysis further revealed that LB downregulates the mRNA expression of <i>CAT</i>, <i>IL-6</i> and <i>TNF-α</i>, while modulating the expression of these target genes. In summary, our data confirm the anti-fatigue effects of LB and elucidate that LB exerts multi-component, multi-target, and multi-pathway mechanisms in combating fatigue.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.3,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical constituents from artemisia annua with potential anti-inflammatory activities. 黄花蒿具有潜在抗炎活性的化学成分。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-04-10 DOI: 10.1080/10286020.2025.2490115
Qi-Guo Wu, Si-Meng Li, Ye-Qing Hu, Fu Cao, Yong-Li Wang, Gui-Xin Chou
{"title":"Chemical constituents from <i>artemisia annua</i> with potential anti-inflammatory activities.","authors":"Qi-Guo Wu, Si-Meng Li, Ye-Qing Hu, Fu Cao, Yong-Li Wang, Gui-Xin Chou","doi":"10.1080/10286020.2025.2490115","DOIUrl":"https://doi.org/10.1080/10286020.2025.2490115","url":null,"abstract":"<p><p>Phytochemical analysis of <i>Artemisia annua</i> aerial parts revealed three novel lignan glycosides (arteannuoside A-B, annusesquilignanoside) and 18 known compounds (<b>4</b>-<b>21</b>), including spanning megastigmanes (<b>4-13</b>), coumarin (<b>14</b>), nitrogen-containing compound (<b>15</b>), phenylethanol glycoside (<b>16</b>), and phenolic compounds (<b>17</b>-<b>21</b>). Compounds (<b>4, 6, 10, 12, 15-18)</b> were first isolated from this species. Structural characterization employed NMR spectroscopy and literature comparison. The new compounds demonstrated concentration-dependent IL-6 inhibition in LPS-activated macrophages. At 100 μM, compounds <b>1</b> (68.75%), <b>2</b> (71.89%) and <b>3</b> (61.34%) showed strong activity, while at 50 μM yielded 33.45%, 39.37%, and 45.36% inhibition respectively.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.3,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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