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Journal of Asian Natural Products Research最新文献

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A new biflavanol from bark of Nothotsuga longibracteata 从长苞木杉树皮中分离出一种新的双黄烷醇。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-03 DOI: 10.1080/10286020.2024.2446282
Yi-Lin Wu , Min-Jian Dong , Cheng-Xin Sun , Mao-Sheng Zhang , Shi-Ji Xiao
{"title":"A new biflavanol from bark of Nothotsuga longibracteata","authors":"Yi-Lin Wu ,&nbsp;Min-Jian Dong ,&nbsp;Cheng-Xin Sun ,&nbsp;Mao-Sheng Zhang ,&nbsp;Shi-Ji Xiao","doi":"10.1080/10286020.2024.2446282","DOIUrl":"10.1080/10286020.2024.2446282","url":null,"abstract":"<div><div>Seven flavanol derivatives, including three biflavanoids (<strong>1</strong>–<strong>3</strong>), two flavonoids (<strong>4</strong> and <strong>5</strong>), and two spirobiflavonoids (<strong>6</strong> and <strong>7</strong>), were isolated from the bark of <em>Nothotsuga longibracteata</em>. The structure of the undescribed compound <strong>1</strong> was elucidated based on HR-ESIMS, NMR spectroscopy, and electronic circular dichroism (ECD) calculations. All isolated flavanol derivatives were screened for their antioxidant capacity to scavenge DPPH and ABTS<sup>+</sup>.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 7","pages":"Pages 1080-1086"},"PeriodicalIF":1.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simultaneous determination of nine compounds from the roots of Euphorbia fischeriana, Euphorbia ebracteolata and Stellera chamaejasme and their anti-tumor activities 同时测定大戟、大戟和狼毒根中9种化合物的抗肿瘤活性
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-03 DOI: 10.1080/10286020.2024.2442444
Lin-Mei Zhang , Yu Yan , Fan Zhang , Kang Ding , Jia Zhang , Hua Yang , Wei-Ku Zhang , Jun He , Jie-Kun Xu
{"title":"Simultaneous determination of nine compounds from the roots of Euphorbia fischeriana, Euphorbia ebracteolata and Stellera chamaejasme and their anti-tumor activities","authors":"Lin-Mei Zhang ,&nbsp;Yu Yan ,&nbsp;Fan Zhang ,&nbsp;Kang Ding ,&nbsp;Jia Zhang ,&nbsp;Hua Yang ,&nbsp;Wei-Ku Zhang ,&nbsp;Jun He ,&nbsp;Jie-Kun Xu","doi":"10.1080/10286020.2024.2442444","DOIUrl":"10.1080/10286020.2024.2442444","url":null,"abstract":"<div><div>Langdu is generally considered as the roots of <em>Euphorbia fischeriana</em>, <em>Euphorbia ebracteolata</em> and <em>Stellera chamaejasme</em>. However, whether these three plants can substitute for one another has always been a concern. This article aims to clarify the differences among the three Langdu species in chemical constituents and anti-tumor effects. This study provides a qualitative and quantitative analysis of eight diterpenoids and one flavonoid in Langdu samples and IC<sub>50</sub> curves for these compounds, which can serve as a basis for identification and usage.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 7","pages":"Pages 1013-1024"},"PeriodicalIF":1.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploration and computational assessment of ochrocephalamine G from Oxytropis ochrocephala as an anti-HBV candidate 赭棘豆中赭脑胺G作为抗hbv候选物的探索和计算评估。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-03 DOI: 10.1080/10286020.2024.2441773
Ya-Kun Zhang , Zhan Xue , Jian-Bo Tong , Jing Tan , Min Yang , Yan-Rong Zeng , Cheng-Jian Tan
{"title":"Exploration and computational assessment of ochrocephalamine G from Oxytropis ochrocephala as an anti-HBV candidate","authors":"Ya-Kun Zhang ,&nbsp;Zhan Xue ,&nbsp;Jian-Bo Tong ,&nbsp;Jing Tan ,&nbsp;Min Yang ,&nbsp;Yan-Rong Zeng ,&nbsp;Cheng-Jian Tan","doi":"10.1080/10286020.2024.2441773","DOIUrl":"10.1080/10286020.2024.2441773","url":null,"abstract":"<div><div>Three compounds, including a novel quinolizidine alkaloid, ochrocephalamine G (<strong>1</strong>), were isolated from <em>Oxytropis ochrocephala</em>. Structural elucidation was achieved through spectroscopic analysis and electronic circular dichroism. Biological assays showed that ochrocephalamine G (100 μM) inhibited HBsAg and HBeAg by 8.28% and 16.17%, respectively. Computational studies, including molecular docking and dynamics simulations, revealed its binding mode with HBV core protein, providing a solid foundation for developing <em>O. ochrocephala</em> as an anti-HBV therapeutic agent.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 7","pages":"Pages 1058-1071"},"PeriodicalIF":1.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatoprotective diterpenes from the nodes of Pinus massoniana 马尾松结中保肝二萜的研究。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-03 DOI: 10.1080/10286020.2025.2506527
Jia-Qi Chen , Ling-Zhi Zhang , Jie Ma , Chuang-Jun Li , Ying-Da Zang , Hua Sun , Dong-Ming Zhang
{"title":"Hepatoprotective diterpenes from the nodes of Pinus massoniana","authors":"Jia-Qi Chen ,&nbsp;Ling-Zhi Zhang ,&nbsp;Jie Ma ,&nbsp;Chuang-Jun Li ,&nbsp;Ying-Da Zang ,&nbsp;Hua Sun ,&nbsp;Dong-Ming Zhang","doi":"10.1080/10286020.2025.2506527","DOIUrl":"10.1080/10286020.2025.2506527","url":null,"abstract":"<div><div>Three new diterpenes, named pinusins D-F (<strong>1</strong>-<strong>3</strong>), were isolated from the Chinese medicine “<em>Pini Lignum Nodi</em>” (the dried tuberculate or branched nodes of <em>Pinus massoniana</em>), along with twelve known diterpenes. The structures of these new compounds were determined using detailed spectroscopic methods and ECD calculations. Compounds <strong>4</strong>-<strong>15</strong> displayed moderate hepatoprotective activity against H<sub>2</sub>O<sub>2</sub>-induced oxidative damage in HepG2 cells, while compounds <strong>5</strong>-<strong>15</strong> exhibited markedly enhanced efficacy ­surpassing that of bicyclol (positive control).</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 7","pages":"Pages 995-1004"},"PeriodicalIF":1.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pachyphyllanone, a new cycloartane triterpenoid isolated from Aglaia pachyphylla and its cytotoxic activity 厚叶木酮：一种从厚叶木中分离得到的新的环ar烷类三萜及其细胞毒活性。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-03 DOI: 10.1080/10286020.2024.2446280
Wahyu Safriansyah , Endang Juliansyah ,  Rustaman , Al Arofatus Naini , Kindi Farabi , Mohamad Nurul Azmi , Mohamad Azlan Nafiah , Hadi Kuncoro , Unang Supratman , Sofa Fajriah , Desi Harneti
{"title":"Pachyphyllanone, a new cycloartane triterpenoid isolated from Aglaia pachyphylla and its cytotoxic activity","authors":"Wahyu Safriansyah ,&nbsp;Endang Juliansyah ,&nbsp; Rustaman ,&nbsp;Al Arofatus Naini ,&nbsp;Kindi Farabi ,&nbsp;Mohamad Nurul Azmi ,&nbsp;Mohamad Azlan Nafiah ,&nbsp;Hadi Kuncoro ,&nbsp;Unang Supratman ,&nbsp;Sofa Fajriah ,&nbsp;Desi Harneti","doi":"10.1080/10286020.2024.2446280","DOIUrl":"10.1080/10286020.2024.2446280","url":null,"abstract":"<div><div><em>Aglaia pachyphylla</em> is a species from the <em>Aglaia</em> genus (Meliaceae) and the chemical constituent has not been widely explored. A new cycloartane-type triterpenoid, pachyphyllanone (<strong>1</strong>), along with four known compounds (<strong>2</strong>-<strong>5</strong>) were isolated from <em>Aglaia pachyphylla</em> Miq. Furthermore, the structure of the new compound was elucidated by the interpretation of spectroscopic data, including 1D and 2D-NMR, as well as ECD and NMR calculations (DP4+ analysis). Compounds <strong>1</strong>-<strong>5</strong> showed cytotoxic activities against MCF-7 with IC<sub>50</sub> values ranging from 160.74 to 299.75 μM.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 7","pages":"Pages 1072-1079"},"PeriodicalIF":1.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Five new phenolics from the red resin of Dracaena cochinchinensis 龙珠红树脂中5个新酚类物质。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-03 DOI: 10.1080/10286020.2025.2497279
Hong Shi , Nan-Pu Lin , Yong-Xian Cheng
{"title":"Five new phenolics from the red resin of Dracaena cochinchinensis","authors":"Hong Shi ,&nbsp;Nan-Pu Lin ,&nbsp;Yong-Xian Cheng","doi":"10.1080/10286020.2025.2497279","DOIUrl":"10.1080/10286020.2025.2497279","url":null,"abstract":"<div><div>Five undescribed phenolics including three new flavonoids (<strong>1</strong>-<strong>3</strong>), one new flavone glycoside (<strong>4</strong>) and one neolignan (<strong>5</strong>), together with seven known compounds were isolated from the resins of <em>Dracaena cochinchinensis</em> (Chinese dragon’s blood). Their structures were elucidated based on detailed spectroscopic analysis, including 1D, 2D NMR, mass spectrometry, and electronic circular dichroism (ECD) data analysis. In addition, biological evaluation of compounds <strong>1</strong>–<strong>5</strong> on anti-renal fibrotic activities were conducted, and the results showed that compounds <strong>1a</strong>, <strong>2</strong>, and <strong>5</strong> display anti-renal fibrotic activities in TFG-<em>β</em> induced NRK-52e cells.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 7","pages":"Pages 966-976"},"PeriodicalIF":1.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three new terpenoid derivatives from the deep-sea-derived fungus Aspergillus sydowii DFFSCS007 深海来源真菌西多曲霉DFFSCS007的三个新的萜类衍生物。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-03 DOI: 10.1080/10286020.2024.2443086
Xu-Meng Ren , Ke-Yue Wu , Shu-Hua Qi
{"title":"Three new terpenoid derivatives from the deep-sea-derived fungus Aspergillus sydowii DFFSCS007","authors":"Xu-Meng Ren ,&nbsp;Ke-Yue Wu ,&nbsp;Shu-Hua Qi","doi":"10.1080/10286020.2024.2443086","DOIUrl":"10.1080/10286020.2024.2443086","url":null,"abstract":"<div><div>Three new terpenoid derivatives (1<em>S</em>,6<em>R</em>,7<em>S</em>)-hydrobenzosydowic acid (<strong>1</strong>), (1 <em>R</em>,6<em>S</em>,7<em>S</em>)-hydrobenzosydowic acid (<strong>2</strong>), and (7 <em>R</em>,10<em>R</em>)-11-dehydroxy-iso-10-hydroxysydowic acid (<strong>3</strong>), along with the known analogues (<em>S</em>)-2-(1-(4-nitrobenzoyl)pyrrolidine-2-carboxamido)benzoic acid (<strong>4</strong>) and trihydroxybutyl ester of 4-carboxydiorcinol (<strong>5</strong>) were isolated from the deep-sea-derived fungus <em>Aspergillus sydowii</em> DFFSCS007. Their structures were determined by spectroscopic analysis. Compound <strong>4</strong> with a nitrobenzene group was isolated from nature for the first time. The antibacterial activities of <strong>1</strong>-<strong>5</strong> and cytotoxicity of <strong>1</strong>-<strong>3</strong> were also evaluated.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 7","pages":"Pages 1005-1012"},"PeriodicalIF":1.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eriodictyol inhibits the proliferation and inflammatory response in keratinocytes in psoriasis through inactivating DYRK1A-mediated endoplasmic reticulum stress 戊二醇通过灭活dyrk1a介导的内质网应激，抑制银屑病中角质形成细胞的增殖和炎症反应。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-03 DOI: 10.1080/10286020.2024.2446301
Rui Yuan , Qi-Chao Sun , Yue-Peng An , Qing Zhang , Qiong Zhang , Yue Li
{"title":"Eriodictyol inhibits the proliferation and inflammatory response in keratinocytes in psoriasis through inactivating DYRK1A-mediated endoplasmic reticulum stress","authors":"Rui Yuan ,&nbsp;Qi-Chao Sun ,&nbsp;Yue-Peng An ,&nbsp;Qing Zhang ,&nbsp;Qiong Zhang ,&nbsp;Yue Li","doi":"10.1080/10286020.2024.2446301","DOIUrl":"10.1080/10286020.2024.2446301","url":null,"abstract":"<div><div>Our work is conducted to reveal the impacts of eriodictyol on psoriasis. CCK-8 and EdU assays measured HaCaT cell proliferation. ELISA detected the activities of inflammatory cytokines and chemokines. Western blot examined the expressions of proliferation-, inflammation- and ERS-associated proteins. Molecular docking predicted the binding affinity of eriodictyol to DYRK1A. RT-qPCR and Western blot analyzed DYRK1A expression. Eriodictyol inhibited the proliferation and inflammatory response in M5-challenged HaCaT cells. Eriodictyol targeted and down-regulated DYRK1A expression. DYRK1A overexpression abolished the impacts of eriodictyol on M5-stimulated HaCaT cells. Conclusively, eriodictyol might suppress ERS mediated by DYRK1A to elicit anti-psoriasis functions.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 7","pages":"Pages 1025-1037"},"PeriodicalIF":1.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Minor indoloquinolizidine monoterpene alkaloids from an aqueous extract of the hook-bearing stem of Uncaria rhynchophylla 钩钩藤茎水提物中微量吲哚喹啉单萜生物碱。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-03 DOI: 10.1080/10286020.2025.2509764
Jin-Qiu Ren , Xiao-Qiang Lei , Qing-Lan Guo , Jian-Gong Shi
{"title":"Minor indoloquinolizidine monoterpene alkaloids from an aqueous extract of the hook-bearing stem of Uncaria rhynchophylla","authors":"Jin-Qiu Ren ,&nbsp;Xiao-Qiang Lei ,&nbsp;Qing-Lan Guo ,&nbsp;Jian-Gong Shi","doi":"10.1080/10286020.2025.2509764","DOIUrl":"10.1080/10286020.2025.2509764","url":null,"abstract":"<div><div>Six minor undescribed indoloquinolizidine monoterpene alkaloids, uncarrhynchophyllines F − K (<strong>1 </strong>−<strong> 6</strong>), were isolated from an aqueous decoction of the hook-bearing stems of <em>Uncaria rhynchophylla</em> (gou-teng). Their structures were determined by spectroscopic data analysis in combination with electron circular dichroism (ECD) and NMR calculations. Compounds <strong>1 </strong>−<strong> 4</strong> are rare indoloquinolizidine iminium zwitterions, while <strong>5</strong> exhibited protective effects against APAP induced liver cell injury.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 7","pages":"Pages 983-994"},"PeriodicalIF":1.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resveratrol: a potential alternative therapeutic agent for patients suffering from chronic obstructive pulmonary disease (COPD) 白藜芦醇：慢性阻塞性肺疾病（COPD）患者的潜在替代治疗剂。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-03 DOI: 10.1080/10286020.2025.2459597
Ong Yan Ren , Yasmeen Siddiqui , Mohammed Tahir Ansari , Asgar Ali
{"title":"Resveratrol: a potential alternative therapeutic agent for patients suffering from chronic obstructive pulmonary disease (COPD)","authors":"Ong Yan Ren ,&nbsp;Yasmeen Siddiqui ,&nbsp;Mohammed Tahir Ansari ,&nbsp;Asgar Ali","doi":"10.1080/10286020.2025.2459597","DOIUrl":"10.1080/10286020.2025.2459597","url":null,"abstract":"<div><div>This review explores the therapeutic potential of resveratrol, focusing on its molecular and cellular effects on Chronic Obstructive Pulmonary Disease (COPD), bioavailability enhancement strategies, and development challenges for applications in food, pharmaceuticals, and postharvest sectors. Resveratrol protects lungs by activating SIRT1, reducing oxidative stress via ROS regulation through Nrf2-mediated antioxidant enzymes. It shows promise as an alternative to corticosteroids in COPD and cancer treatment. Encapsulation innovations in resveratrol offer opportunities for food fortification, minimizing risks of chemical degradation and isomerization during storage, paving the way for its broader utility in health and nutrition applications.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 7","pages":"Pages 951-965"},"PeriodicalIF":1.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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