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Journal of Asian Natural Products Research最新文献

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Potential benefits of marine-derived compounds for slowing the advancement of Alzheimer's disease. 海洋萃取化合物对延缓阿尔茨海默氏症发展的潜在益处。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-10-07 DOI: 10.1080/10286020.2024.2409869
Aditya Malan, Manjusha Choudhary, Prabhjeet Kaur Bamrah, Dipender Kumari
{"title":"Potential benefits of marine-derived compounds for slowing the advancement of Alzheimer's disease.","authors":"Aditya Malan, Manjusha Choudhary, Prabhjeet Kaur Bamrah, Dipender Kumari","doi":"10.1080/10286020.2024.2409869","DOIUrl":"https://doi.org/10.1080/10286020.2024.2409869","url":null,"abstract":"<p><p>The incidence of Alzheimer's is increasing and poses a significant social and economic burden. The pathogenesis involved in the expansion of AD includes neuronal oxidative damage, tau phosphorylation, amyloid beta aggregation, neuroinflammation, etc. Despite enormous efforts, there is currently no effective treatment or cure for this condition in the allopathic system. Marine compounds are appealing options and have a strong neuroprotective impact. Marine-derived compounds from sponges, algae, and marine invertebrates can be used for neuroprotection, with fewer adverse effects than synthetic drugs. Various compounds such as bryostatin-1, docosahexaenoic acid, spirolides, and astaxanthin, GV-971, have demonstrated outstanding activity and bioavailability.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-26"},"PeriodicalIF":1.3,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, characterization and anticancer, antibacterial activities of pentacyclic triterpenoid glycoside derivatives 五环三萜苷衍生物的合成、表征和抗癌、抗菌活性。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-09-24 DOI: 10.1080/10286020.2024.2405224
Pan-Pan Wang , Yan-Dan Liu , Lan-Tian Cui , Gao Li , Long-Xuan Zhao , Mei Jin
{"title":"Synthesis, characterization and anticancer, antibacterial activities of pentacyclic triterpenoid glycoside derivatives","authors":"Pan-Pan Wang ,&nbsp;Yan-Dan Liu ,&nbsp;Lan-Tian Cui ,&nbsp;Gao Li ,&nbsp;Long-Xuan Zhao ,&nbsp;Mei Jin","doi":"10.1080/10286020.2024.2405224","DOIUrl":"10.1080/10286020.2024.2405224","url":null,"abstract":"<div><div>As a kind of glycoside, pentacyclic triterpenoid saponins have good biological activities, such as anticancer, antibacterial, antiviral and hypoglycemic effects [<span><span>1</span></span>]. In this paper, twenty-four pentacyclic triterpenoid derivatives, including twelve monosaccharide derivatives, were designed and synthesized. The anticancer effect and antibacterial activities of all compounds were evaluated. It is noteworthy that compound <strong>UA-2b</strong> has the strongest inhibitory effect on the growth of A549, Hela and HepG2 cancer cells (IC<sub>50</sub> = 5.37 ± 0.22 µM, 5.82 ± 0.25 µM and 5.47 ± 0.06 µM, respectively). Compounds <strong>OA-2b</strong>, <strong>OA-6a</strong>, <strong>OA-6b</strong>, <strong>UA-2b</strong> and <strong>UA-6a</strong> have the best activity against <em>Escherichia coli</em> 1924 (MIC = 16 μg/ml).</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 3","pages":"Pages 323-339"},"PeriodicalIF":1.3,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rosmarinic acid suppresses the progression of COPD via Syk by modulating airway inflammation and epithelial apoptosis in vivo and in vitro. 迷迭香酸在体内和体外通过调节气道炎症和上皮细胞凋亡，通过 Syk 抑制慢性阻塞性肺病的发展。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-09-23 DOI: 10.1080/10286020.2024.2403617
Ji-Qiao Yuan, Xu-Yu Li, Yan-Nan Fan, Nan Fang, Ping Li, Xin-Zhu Wen, Qi Hou, Zi-Qian Zhang, Ming-Bao Lin
{"title":"Rosmarinic acid suppresses the progression of COPD <i>via</i> Syk by modulating airway inflammation and epithelial apoptosis <i>in vivo</i> and <i>in vitro</i>.","authors":"Ji-Qiao Yuan, Xu-Yu Li, Yan-Nan Fan, Nan Fang, Ping Li, Xin-Zhu Wen, Qi Hou, Zi-Qian Zhang, Ming-Bao Lin","doi":"10.1080/10286020.2024.2403617","DOIUrl":"https://doi.org/10.1080/10286020.2024.2403617","url":null,"abstract":"<p><p>Rosmarinic acid (RosA), a hydrophilic phenolic compound found in various plants, has several biological effects such as anti-inflammatory and anti-apoptosis activities. However, its potential impact on chronic obstructive pulmonary disease (COPD) and its underlying mechanism has not been investigated. In this study, we explored the potential therapeutic effects and mechanism of RosA on COPD airway inflammation and alveolar epithelial apoptosis <i>in vivo</i> and <i>in vitro</i>. Our data suggested that RosA may be a therapeutic candidate for COPD with low toxicity. The corresponding mechanism lies in its anti-inflammatory effect on macrophage and bronchial epithelial cells, as well as protective effect on lung epithelial apoptosis via the jointly cross-target spleen tyrosine kinase (Syk).</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-15"},"PeriodicalIF":1.3,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on the anti-HBV activity of matrine alkaloids from Oxytropis ochrocephala by MTT, 3d-QSAR, molecular docking and molecular dynamics simulation 通过MTT、3d-QSAR、分子对接和分子动力学模拟研究牛膝草中的马钱子碱的抗HBV活性
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-09-18 DOI: 10.1080/10286020.2024.2402369
Ya-Kun Zhang , Jian-Bo Tong , Jing Tan , Min Yang , Xiao-Yu Xing , Yan-Rong Zeng , Zhan Xue , Cheng-Jian Tan
{"title":"Study on the anti-HBV activity of matrine alkaloids from Oxytropis ochrocephala by MTT, 3d-QSAR, molecular docking and molecular dynamics simulation","authors":"Ya-Kun Zhang ,&nbsp;Jian-Bo Tong ,&nbsp;Jing Tan ,&nbsp;Min Yang ,&nbsp;Xiao-Yu Xing ,&nbsp;Yan-Rong Zeng ,&nbsp;Zhan Xue ,&nbsp;Cheng-Jian Tan","doi":"10.1080/10286020.2024.2402369","DOIUrl":"10.1080/10286020.2024.2402369","url":null,"abstract":"<div><div>To elucidate the structure-activity relationship of 17 matrine alkaloids from <em>Oxytropis ochrocephala</em> Bunge, their effect on hepatitis B surface antigen (HBsAg) secretion was studied using the MTT assay. A 3D-QSAR analysis showed a strong correlation between chemical structures and biological activities (<em>q<sup>2</sup></em> = 0.625, <em>r<sup>2</sup></em> = 0.859). Molecular docking and molecular dynamics simulations revealed that hydrogen bonding and hydrophobic interactions with hepatitis B core protein (PDB:5T2P) are key to inhibiting HBsAg secretion, suggesting potential for developing natural anti-hepatitis B drugs.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 3","pages":"Pages 442-459"},"PeriodicalIF":1.3,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic potential of Cordyceps sinensis targeting oxidative stress and inflammatory response in the treatment of COPD rats: insights from metabolomics analysis 冬虫夏草针对氧化应激和炎症反应治疗慢性阻塞性肺病大鼠的治疗潜力：代谢组学分析的启示。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-09-17 DOI: 10.1080/10286020.2024.2403611
Ying-Ying Liu , Gai-Jie Dou , Yuan-Can Xiao , Xiao-Yi Chen , Li-Xin Wei , Wen-Bin Zhou
{"title":"Therapeutic potential of Cordyceps sinensis targeting oxidative stress and inflammatory response in the treatment of COPD rats: insights from metabolomics analysis","authors":"Ying-Ying Liu ,&nbsp;Gai-Jie Dou ,&nbsp;Yuan-Can Xiao ,&nbsp;Xiao-Yi Chen ,&nbsp;Li-Xin Wei ,&nbsp;Wen-Bin Zhou","doi":"10.1080/10286020.2024.2403611","DOIUrl":"10.1080/10286020.2024.2403611","url":null,"abstract":"<div><div>This study aimed to investigate the effects of wild <em>Cordyceps sinensis</em> on chronic obstructive pulmonary disease (COPD) rats through metabolomics approach, combined with biochemical parameters evaluations. Consequently, <em>C. sinensis</em> exhibited regulatory effects on the lung’s metabolic profiles in COPD rats. Treatment with <em>C. sinensis</em> potentially modulated glycerophospholipid metabolism, glutathione metabolism, and tryptophan metabolism, thereby alleviating oxidative stress (by decreasing MDA and GSSG, while increasing SOD and GSH) and inflammatory response (by inhibiting TNF-α, IL-8, and MMP-9) in COPD rats while improving lung tissue damage.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 3","pages":"Pages 460-477"},"PeriodicalIF":1.3,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proteomic analysis of two novel peptides from the Odontobuthus doriae scorpion venom 对来自 Odontobuthus doriae 蝎毒的两种新型多肽的蛋白质组分析。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-09-17 DOI: 10.1080/10286020.2024.2403612
Jamil Zargan , Ehsan Jahangirian , Haider A. Khan , Shakir Ali
{"title":"Proteomic analysis of two novel peptides from the Odontobuthus doriae scorpion venom","authors":"Jamil Zargan ,&nbsp;Ehsan Jahangirian ,&nbsp;Haider A. Khan ,&nbsp;Shakir Ali","doi":"10.1080/10286020.2024.2403612","DOIUrl":"10.1080/10286020.2024.2403612","url":null,"abstract":"<div><div>The venom of the <em>Odontobuthus doriae</em> scorpion, prevalent in East Asia and Iran, has not been fully characterized. This study provides the first proteomic profile of <em>O. doriae</em> venom to explore its potential as a medical. 2D-PAGE analysis revealed 96 protein spots with isoelectric points from 3 to 9 and molecular weights between 6.6 to 205 kDa. Fourteen toxin fractions were isolated via HPLC, and SDS-PAGE showed seven protein bands ranging from 3.8 to 182 kDa. MALDI-TOF MS identified Peptide 1 and Peptide 2, resembling Hemoglobin beta-2 chain and Chaperonin HSP60 and suggest potential therapeutic applications for P1 and P2.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 3","pages":"Pages 301-322"},"PeriodicalIF":1.3,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical constituents from the endophytic fungus Aspergillus sp. S3 of Hibiscus tiliaceus 木槿内生真菌黑曲霉 S3 的化学成分
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-09-14 DOI: 10.1080/10286020.2024.2399572
Wen-Feng Chen , Meng-Meng Wang , Jing Tian , Bo-Heng Hu , Ya-Nan Lu , Chun-Mei Yang , Han-Qiao Liang , Rui-Zhang Feng
{"title":"Chemical constituents from the endophytic fungus Aspergillus sp. S3 of Hibiscus tiliaceus","authors":"Wen-Feng Chen ,&nbsp;Meng-Meng Wang ,&nbsp;Jing Tian ,&nbsp;Bo-Heng Hu ,&nbsp;Ya-Nan Lu ,&nbsp;Chun-Mei Yang ,&nbsp;Han-Qiao Liang ,&nbsp;Rui-Zhang Feng","doi":"10.1080/10286020.2024.2399572","DOIUrl":"10.1080/10286020.2024.2399572","url":null,"abstract":"<div><div>A new sterol, aspersterol E (<strong>1</strong>), a newly discovered alkaloid, asperginine A (<strong>2</strong>), and five known compounds (<strong>3–7</strong>) were obtained from the endophytic fungus <em>Aspergillus</em> sp. S3 of <em>Hibiscus tiliaceus</em> Linn. The compounds were extracted from their fermentation products using silica gel, ODS C18, and semi-preparative HPLC. The structure of each compound was determined through spectroscopic analysis. All the obtained compounds (<strong>1–7</strong>) were evaluated for their cytotoxic activity against the mouse pre-gastric cancer cell line MFC by using the MTT assay. The IC<sub>50</sub> values of compounds <strong>1</strong>, <strong>2</strong>, <strong>3,</strong> and <strong>5</strong> were found to be 153.43 μM, 61.25 μM, 73.19 μM, and 181.69 μM respectively.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 3","pages":"Pages 292-300"},"PeriodicalIF":1.3,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic potential of xtr-miR-22-3p from Plastrum testudinis in acute promyelocytic leukemia Plastrum testudinis 中的 xtr-miR-22-3p 对急性早幼粒细胞白血病的治疗潜力
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-08-30 DOI: 10.1080/10286020.2024.2395566
Ming-Yang Chen , Meng Li , Qing-Yi Xu , Shu-Wang Zhang , Guang-Xi Ren , Chun-Sheng Liu
{"title":"Therapeutic potential of xtr-miR-22-3p from Plastrum testudinis in acute promyelocytic leukemia","authors":"Ming-Yang Chen ,&nbsp;Meng Li ,&nbsp;Qing-Yi Xu ,&nbsp;Shu-Wang Zhang ,&nbsp;Guang-Xi Ren ,&nbsp;Chun-Sheng Liu","doi":"10.1080/10286020.2024.2395566","DOIUrl":"10.1080/10286020.2024.2395566","url":null,"abstract":"<div><div>Acute promyelocytic leukemia (APL) is marked by a block at the promyelocyte stage. Treatments like ATRA and ATO face resistance and relapse issues. <em>Plastrum testudinis</em>, a traditional Chinese medicine, may offer therapeutic potential. This study investigated xtr-miR-22-3p from <em>P. testudinis</em> for treating APL. High expression of xtr-miR-22-3p was confirmed, with target prediction indicating interactions with key genes, including PML. xtr-miR-22-3p reduced HL-60 leukemia cell growth, altered the cell cycle, and selectively inhibited HL-60 proliferation while promoting BMSC growth, suggesting its potential as a targeted APL therapy.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 3","pages":"Pages 387-399"},"PeriodicalIF":1.3,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142195443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation analysis between potential hepatotoxicity and ingredient content of polygoni multiflori caulis 潜在肝毒性与何首乌成分含量的相关性分析
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-08-17 DOI: 10.1080/10286020.2024.2391472
Ze-Ye Tan , Gui Zhou , Yi-Ming Feng , Nan Xiang , Shan-Ni Li , Rui-Fang Xie , Xin Zhou
{"title":"Correlation analysis between potential hepatotoxicity and ingredient content of polygoni multiflori caulis","authors":"Ze-Ye Tan ,&nbsp;Gui Zhou ,&nbsp;Yi-Ming Feng ,&nbsp;Nan Xiang ,&nbsp;Shan-Ni Li ,&nbsp;Rui-Fang Xie ,&nbsp;Xin Zhou","doi":"10.1080/10286020.2024.2391472","DOIUrl":"10.1080/10286020.2024.2391472","url":null,"abstract":"<div><div><em>Polygoni Multiflori Caulis</em> (PMC) is commonly used in clinical practice. While the adverse reactions of <em>Polygoni Multiflori Radix</em> (RPM) are well-known, the potential adverse reactions of PMC are often neglected. This article aims to clarify the relationship between hepatotoxic components in PMC and its various producing areas. This study provides a qualitative and quantitative analysis of PMC from various regions, which can serve as a basis for safe usage.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 3","pages":"Pages 340-353"},"PeriodicalIF":1.3,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantitative predictive model for screening optimal processing methods of Polygonati rhizoma 筛选何首乌最佳加工方法的定量预测模型。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-08-16 DOI: 10.1080/10286020.2024.2390496
Shi-Jie Bi , An-Lei Yuan , Zi-Jun Chen , Yue Ren , Kai-Yang Liu , Chao-Qun Liu , Zhen-Zhen Xu , Ze-Wen Wang , Yan-Ling Zhang
{"title":"Quantitative predictive model for screening optimal processing methods of Polygonati rhizoma","authors":"Shi-Jie Bi ,&nbsp;An-Lei Yuan ,&nbsp;Zi-Jun Chen ,&nbsp;Yue Ren ,&nbsp;Kai-Yang Liu ,&nbsp;Chao-Qun Liu ,&nbsp;Zhen-Zhen Xu ,&nbsp;Ze-Wen Wang ,&nbsp;Yan-Ling Zhang","doi":"10.1080/10286020.2024.2390496","DOIUrl":"10.1080/10286020.2024.2390496","url":null,"abstract":"<div><div><em>Polygonati</em> rhizoma (Huangjing in Chinese) is a common clinical tonic with the traditional effects of tonifying Qi, nourishing Yin. However, the lack of precise control of processing parameters has led to the uneven quality of processed Huangjing. A prediction model using the CRITIC method optimizes processing by correlating method, component contents, and biological activity, ensuring consistent quality and efficacy.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 3","pages":"Pages 368-386"},"PeriodicalIF":1.3,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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