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Journal of Asian Natural Products Research最新文献

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A new biflavanol from bark of Nothotsuga longibracteata. 从长苞木杉树皮中分离出一种新的双黄烷醇。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-01-01 DOI: 10.1080/10286020.2024.2446282
Yi-Lin Wu, Min-Jian Dong, Cheng-Xin Sun, Mao-Sheng Zhang, Shi-Ji Xiao
{"title":"A new biflavanol from bark of <i>Nothotsuga longibracteata</i>.","authors":"Yi-Lin Wu, Min-Jian Dong, Cheng-Xin Sun, Mao-Sheng Zhang, Shi-Ji Xiao","doi":"10.1080/10286020.2024.2446282","DOIUrl":"https://doi.org/10.1080/10286020.2024.2446282","url":null,"abstract":"<p><p>Seven flavanol derivatives, including three biflavanoids (<b>1</b>-<b>3</b>), two flavonoids (<b>4</b> and <b>5</b>), and two spirobiflavonoids (<b>6</b> and <b>7</b>), were isolated from the bark of <i>Nothotsuga longibracteata</i>. The structure of the undescribed compound <b>1</b> was elucidated based on HR-ESIMS, NMR spectroscopy, and electronic circular dichroism (ECD) calculations. All isolated flavanol derivatives were screened for their antioxidant capacity to scavenge DPPH and ABTS<sup>+</sup>.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Compound FLZ attenuates neuroinflammation through inhibiting Src/PTEN/Akt signaling pathway. 化合物FLZ通过抑制Src/PTEN/Akt信号通路减轻神经炎症。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-01-01 DOI: 10.1080/10286020.2024.2435981
Fang-Fang Li, Yuan-Peng Zheng, Gen Li, Yang Yang, Jing-Wei Ma, Cai-Xia Zang, Deng Tao, Li Li, Xiu-Qi Bao, Dan Zhang
{"title":"Compound FLZ attenuates neuroinflammation through inhibiting Src/PTEN/Akt signaling pathway.","authors":"Fang-Fang Li, Yuan-Peng Zheng, Gen Li, Yang Yang, Jing-Wei Ma, Cai-Xia Zang, Deng Tao, Li Li, Xiu-Qi Bao, Dan Zhang","doi":"10.1080/10286020.2024.2435981","DOIUrl":"https://doi.org/10.1080/10286020.2024.2435981","url":null,"abstract":"<p><p>Compound FLZ has neuroprotective effects on Parkinson's disease (PD), while the precise mechanism remains unclear. In this study, we found that FLZ decreased PTEN/Akt activity in LPS-challenged BV2 cells. Neuroinflammatory responses suppressed by FLZ were abolished when PTEN or Src was inhibited. Additionally, FLZ weakened the interactions of Src and PTEN, and attenuated Src phosphorylation once PETN was inhibited, but failed to decrease PTEN phosphorylation when Src was silenced. Eventually, we elaborated that FLZ bound to Src directly and inhibited its activity. Collectively, FLZ attenuated neuroinflammation through inhibiting Src/PTEN/Akt pathway, paving the way for clinical use of FLZ to treat PD.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-17"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three new terpenoid derivatives from the deep-sea-derived fungus Aspergillus sydowii DFFSCS007. 深海来源真菌西多曲霉DFFSCS007的三个新的萜类衍生物。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-12-28 DOI: 10.1080/10286020.2024.2443086
Xu-Meng Ren, Ke-Yue Wu, Shu-Hua Qi
{"title":"Three new terpenoid derivatives from the deep-sea-derived fungus <i>Aspergillus sydowii</i> DFFSCS007.","authors":"Xu-Meng Ren, Ke-Yue Wu, Shu-Hua Qi","doi":"10.1080/10286020.2024.2443086","DOIUrl":"https://doi.org/10.1080/10286020.2024.2443086","url":null,"abstract":"<p><p>Three new terpenoid derivatives (1<i>S</i>,6<i>R</i>,7<i>S</i>)-hydrobenzosydowic acid (<b>1</b>), (1 <i>R</i>,6<i>S</i>,7<i>S</i>)-hydrobenzosydowic acid (<b>2</b>), and (7 <i>R</i>,10<i>R</i>)-11-dehydroxy-iso-10-hydroxysydowic acid (<b>3</b>), along with the known analogues (<i>S</i>)-2-(1-(4-nitrobenzoyl)pyrrolidine-2-carboxamido)benzoic acid (<b>4</b>) and trihydroxybutyl ester of 4-carboxydiorcinol (<b>5</b>) were isolated from the deep-sea-derived fungus <i>Aspergillus sydowii</i> DFFSCS007. Their structures were determined by spectroscopic analysis. Compound <b>4</b> with a nitrobenzene group was isolated from nature for the first time. The antibacterial activities of <b>1</b>-<b>5</b> and cytotoxicity of <b>1</b>-<b>3</b> were also evaluated.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progress in the study of curcumin metabolism in vivo. 姜黄素体内代谢的研究进展。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-12-18 DOI: 10.1080/10286020.2024.2420619
Shi-Jie Zhong, Ya-Dong Xing, Lu-Yao Dong, Yi Chen, Nan Liu, Zeng-Ming Wang, Hui Zhang, Ai-Ping Zheng
{"title":"Progress in the study of curcumin metabolism <i>in vivo</i>.","authors":"Shi-Jie Zhong, Ya-Dong Xing, Lu-Yao Dong, Yi Chen, Nan Liu, Zeng-Ming Wang, Hui Zhang, Ai-Ping Zheng","doi":"10.1080/10286020.2024.2420619","DOIUrl":"https://doi.org/10.1080/10286020.2024.2420619","url":null,"abstract":"<p><p>Curcumin has diverse biological functions, especially antioxidant and anti-inflammatory properties, but clinical trials have been hindered by its low bioavailability and pharmacokinetic properties. To achieve therapeutic efficacy, understanding curcumin's <i>in vivo</i> metabolism is crucial. We reviewed current research on curcumin metabolism in PubMed, Google Scholar, and CNKI. This article outlines curcumin's metabolic processes in the body via oral and intravenous injection. It suggests that upon entering the human body, curcumin may undergo oxidation, reduction, binding, and microbial community influence.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-19"},"PeriodicalIF":1.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meroterpenoids from Rhododendron racemosum and their anti-inflammatory activities. 总状杜鹃花中萜类化合物及其抗炎活性。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-12-18 DOI: 10.1080/10286020.2024.2431813
Si-Xuan Liu, Si-Yang Dai, Yong-Fu Lu, Chun-Lin Guo, Chang Li, Yi-Hui Yang, Yue-Hu Pei
{"title":"Meroterpenoids from <i>Rhododendron racemosum</i> and their anti-inflammatory activities.","authors":"Si-Xuan Liu, Si-Yang Dai, Yong-Fu Lu, Chun-Lin Guo, Chang Li, Yi-Hui Yang, Yue-Hu Pei","doi":"10.1080/10286020.2024.2431813","DOIUrl":"https://doi.org/10.1080/10286020.2024.2431813","url":null,"abstract":"<p><p>Three meroterpenoids, including one new compound, ranhuadujuanine E (<b>1</b>), one new natural product, methyl (<i>E</i>)-3-(3,7-dimethylocta-2,6-dien-1-yl)-2,4-dihydroxy-6-methylbenzoate (<b>2</b>), and one known compound, ranhuadujuanine D (<b>3</b>), along with two known sesquiterpenoids (<b>4</b>-<b>5</b>) were isolated from <i>Rhododendron racemosum</i>. Their structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configuration of C-6' in compound <b>1</b> was assigned by using Snatzke's method. Compounds <b>1</b>-<b>3</b> had inhibitory effects on LPS-induced NO release in RAW264.7 cells.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the therapeutic potential of Annona reticulata extract: molecular docking, dynamics, and ADMET properties for cancer treatment and anti-inflammatory activity. 探索网纹花提取物的治疗潜力：用于癌症治疗和抗炎活性的分子对接、动力学和 ADMET 特性。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-12-13 DOI: 10.1080/10286020.2024.2435983
Pratheep Thangaraj, Ekambaram Gayathiri, Palanisamy Prakash, Dhivya Viswanathan, Mostafizur Rahaman, Saravanan Pandiaraj, Nagarajan S, Rekha Anantharaman, Rajakumar Govindasamy
{"title":"Exploring the therapeutic potential of <i>Annona reticulata</i> extract: molecular docking, dynamics, and ADMET properties for cancer treatment and anti-inflammatory activity.","authors":"Pratheep Thangaraj, Ekambaram Gayathiri, Palanisamy Prakash, Dhivya Viswanathan, Mostafizur Rahaman, Saravanan Pandiaraj, Nagarajan S, Rekha Anantharaman, Rajakumar Govindasamy","doi":"10.1080/10286020.2024.2435983","DOIUrl":"10.1080/10286020.2024.2435983","url":null,"abstract":"<p><p>Colorectal cancer remains a global health challenge, prompting the exploration of natural compounds for treatment. <i>Annona reticulata</i> shows promise as a source of activity biomolecules. This study analyzed the dynamics, molecular docking and ADMET properties of the extract, highlighting interaction with inflammatory protein. Key findings include compounds with binding energies of -9.61 and -9.01 kcal/mol for 5fia and 7cx2 receptors. Simulations over 100 ns assessed RMSD, RMSF, SASA, and H-bonding, confirming stability and favorable ADME/toxicity profiles. These results highlight <i>A. reticulata</i> as a promising candidate for developing anti-inflammatory and anticancer drugs.[Figure: see text].</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-23"},"PeriodicalIF":1.3,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urolithin B inhibits LPS-induced macrophage M1 polarization via miR155-5p mediated MAPK/NF-кB pathway. 尿素B通过miR155-5p介导的MAPK/NF-кB途径抑制lps诱导的巨噬细胞M1极化。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-12-13 DOI: 10.1080/10286020.2024.2435984
Wulipan Tuohudaali, Teng-Fei Ji, Wan-Ting Ding, Chen-Yang Li, Jian-Shen Bianba, Ren Ci, Jun Zhao
{"title":"Urolithin B inhibits LPS-induced macrophage M1 polarization via miR155-5p mediated MAPK/NF-кB pathway.","authors":"Wulipan Tuohudaali, Teng-Fei Ji, Wan-Ting Ding, Chen-Yang Li, Jian-Shen Bianba, Ren Ci, Jun Zhao","doi":"10.1080/10286020.2024.2435984","DOIUrl":"https://doi.org/10.1080/10286020.2024.2435984","url":null,"abstract":"<p><p>This study investigated inhibiting mechanisms of Urolithin B (Uro B) on macrophage M1 polarization. Uro B (50 μM) could inhibit the PGE2, COX-2, NO, iNOS, TNF-α, IL-1β and IL-6 levels compared with model group (<i>P</i> < 0.05) as well as the CD86 and F4/80 expression. The miR155-5p overexpression could increase the p38 MAPK, JNK, ERK mRNA activities (<i>P</i> < 0.05), Uro B (50 μM) could reverse changes in these indicators (<i>P</i> < 0.05). Moreover, Uro B (50 μM) could inhibit the TLR4, Src, IκBα, NF-κBp65 and their phosphorylated protein expression (<i>P</i> < 0.05). Therefore, Uro B may inhibit macrophage M1 polarization via miR155-5p mediated MAPK/NF-кB pathway.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.3,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tripterygium wilfordii polyglycoside tablets attenuated the progression of hepatocellular carcinoma by targeting IL-6 and downstream signaling pathways in a multi-target manner. 雷公藤多苷片通过多靶点靶向IL-6及下游信号通路，减缓了肝癌的进展。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-12-13 DOI: 10.1080/10286020.2024.2435992
Pei-You Ren, Jian-Ying Zhang, Lei Zhao, Xiang-Jun Sun
{"title":"<i>Tripterygium wilfordii</i> polyglycoside tablets attenuated the progression of hepatocellular carcinoma by targeting IL-6 and downstream signaling pathways in a multi-target manner.","authors":"Pei-You Ren, Jian-Ying Zhang, Lei Zhao, Xiang-Jun Sun","doi":"10.1080/10286020.2024.2435992","DOIUrl":"https://doi.org/10.1080/10286020.2024.2435992","url":null,"abstract":"<p><p><i>Tripterygium wilfordii</i> polyglycoside tablets (TWPT) have traditionally been used to treat certain inflammatory diseases. This study validated TWPT as a novel application in hepatocellular carcinoma treatment through multiple targets, thereby expanding its clinical medication scope. TWPT exhibited a low toxicity and a significantly antihepatoma effects <i>in vitro</i> and <i>in vivo</i>. Through network pharmacology analysis, we found TWPT attenuated the progression of hepatocellular carcinoma by multi-targeting, including IL-6, MMP9, TNF-α and VEGFA. Additionally, TWPT targeted IL-6 to regulate downstream pathways, including the PI3K/Akt, JAK2/STAT3, and MAPK signaling pathways. Thus, TWPT could be developed as a potential therapeutic drug for hepatocellular carcinoma.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-21"},"PeriodicalIF":1.3,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of metabolic profile of Dazhu Hongjingtian and evaluation of its anti-hypoxic constituents. 大竹红景天代谢谱特征及抗缺氧成分评价。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-12-12 DOI: 10.1080/10286020.2024.2434550
Chun-Yan Ou, Xia Gao, Jia-Jia Wang, Xia-Lin Chen, Liang Cao, Zhen-Zhong Wang, Chen-Feng Zhang, Wei Xiao
{"title":"Characterization of metabolic profile of Dazhu Hongjingtian and evaluation of its anti-hypoxic constituents.","authors":"Chun-Yan Ou, Xia Gao, Jia-Jia Wang, Xia-Lin Chen, Liang Cao, Zhen-Zhong Wang, Chen-Feng Zhang, Wei Xiao","doi":"10.1080/10286020.2024.2434550","DOIUrl":"https://doi.org/10.1080/10286020.2024.2434550","url":null,"abstract":"<p><p>Dazhu Hongjingtian (DZ) is renowned for its diverse pharmacological activities, yet its metabolic pathways remain to be fully elucidated. In this study, the metabolic profile after oral administration of DZ extract (DZE) in rats was systematically identified by the UPLC/Q-TOF-MS/MS method for the first time. A total of 94 components, including 32 prototypes and 62 metabolites, were tentatively characterized in rat plasma and various tissues samples. Furthermore, 6 constituents (salidroside, quercetin, 4-hydroxycinnamic acid, 5-hydroxymethylfurfural, <i>p</i>-tyrosol, and gallic acid) derived from plasma prototypes were identified as bioactive by assessing cell viabilities of OGD-injured RSC96 cells.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-19"},"PeriodicalIF":1.3,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Culcinoside E, a new sulfated steroidal biglycoside from the starfish Culcita novaeguineae. Culcinoside E：一种从新海星Culcita novaeguineae中提取的磺化甾体大糖苷。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-12-03 DOI: 10.1080/10286020.2024.2434564
Le Thi Vien, Tran Thi Hong Hanh, Tran Hong Quang, Nguyen Dang Ngai, Dao Viet Ha, Nguyen Xuan Cuong
{"title":"Culcinoside E, a new sulfated steroidal biglycoside from the starfish <i>Culcita novaeguineae</i>.","authors":"Le Thi Vien, Tran Thi Hong Hanh, Tran Hong Quang, Nguyen Dang Ngai, Dao Viet Ha, Nguyen Xuan Cuong","doi":"10.1080/10286020.2024.2434564","DOIUrl":"https://doi.org/10.1080/10286020.2024.2434564","url":null,"abstract":"<p><p>Using various chromatographic separations, six steroid glycoside derivatives, including one new compound named culcinoside E (<b>1</b>), were isolated from the methanol extract of the starfish <i>Culcita novaeguineae</i>. Their structures were confirmed by detailed analysis of the 1D, 2D NMR, and HR ESI QTOF mass spectra. Among isolated compounds, culcinoside E (<b>1</b>), diplasterioside A (<b>5</b>), and thornasteroside A (<b>6</b>) inhibited growth of <i>Enterococcus faecalis</i>, whereas culcitoside C<sub>1</sub> (<b>3</b>) was active on <i>Candida albicans</i>.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.3,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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