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Journal of Asian Natural Products Research最新文献

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Screening of potential α-glucosidase inhibitors from astragalus membranaceus by affinity ultrafiltration screening coupled with UPLC-ESI-Orbitrap-MS method 用 UPLC-ESI-Orbitrap-MS 法结合亲和超滤筛选黄芪中潜在的 α-葡萄糖苷酶抑制剂。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-06-12 DOI: 10.1080/10286020.2024.2366007
{"title":"Screening of potential α-glucosidase inhibitors from astragalus membranaceus by affinity ultrafiltration screening coupled with UPLC-ESI-Orbitrap-MS method","authors":"","doi":"10.1080/10286020.2024.2366007","DOIUrl":"10.1080/10286020.2024.2366007","url":null,"abstract":"<div><div><em>Astragalus membranaceus</em> is a traditional Chinese medicine with multiple pharmacological activities. Modern pharmacological research has found that <em>Astragalus membranaceus</em> extract has an inhibitory effect on α-glucosidase, however, which component can inhibit the activity of α-glucosidase and its degree of inhibition are unknown. To address this issue, this study used affinity ultrafiltration screening combined with UPLC-ESI-Orbitrap-MS technology to screen α-glucosidase inhibitors in <em>Astragalus membranaceus</em>. Using affinity ultrafiltration technology, we obtained the active components, and using UPLC-ESI-Orbitrap-MS technology, we quickly analyzed and identified them. As a result, a total of 8 ingredients were selected as α-glucosidase inhibitors.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three new flavonoids from the roots of Sophora tonkinensis 从越南槐根中提取的三种新黄酮类化合物。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-06-10 DOI: 10.1080/10286020.2024.2364909
{"title":"Three new flavonoids from the roots of Sophora tonkinensis","authors":"","doi":"10.1080/10286020.2024.2364909","DOIUrl":"10.1080/10286020.2024.2364909","url":null,"abstract":"<div><div>Three new flavonoids including two isoflavanones sophortones A and B (<strong>1</strong> and <strong>2</strong>), and one chalcone sophortone C (<strong>3</strong>) were isolated from the roots of <em>Sophora tonkinensis</em>. Their structures were established by UV, IR, HRESIMS, and NMR data. The absolute configurations of <strong>1</strong> and <strong>2</strong> were determined by electronic circular dichroism (ECD) calculations.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lycium barbarum polysaccharides regulate the gut microbiota to modulate metabolites in high-fat diet-induced obese rats 枸杞多糖调节肠道微生物群，从而调节高脂饮食诱导的肥胖大鼠体内的代谢物。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-06-10 DOI: 10.1080/10286020.2024.2355130
{"title":"Lycium barbarum polysaccharides regulate the gut microbiota to modulate metabolites in high-fat diet-induced obese rats","authors":"","doi":"10.1080/10286020.2024.2355130","DOIUrl":"10.1080/10286020.2024.2355130","url":null,"abstract":"<div><p><em>Lycium Barbarum</em> Polysaccharides (LBP) can benefit lipid parameters such as total cholesterol, triglyceride, and high-density lipoprotein levels and upregulate the level of <em>Firmicutes</em>, increase the diversity of gut microbiota and reduce metabolic disorders, finally relieving weight gain of obese rats. But it cannot reverse the outcome of obesity. Over 30 differential metabolites and four pathways are altered by LBP.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Possible mechanism for the protective effect of active ingredients of astragalus membranaceus on diabetes nephropathy 黄芪有效成分对糖尿病肾病的保护作用的可能机制。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-06-10 DOI: 10.1080/10286020.2024.2364350
{"title":"Possible mechanism for the protective effect of active ingredients of astragalus membranaceus on diabetes nephropathy","authors":"","doi":"10.1080/10286020.2024.2364350","DOIUrl":"10.1080/10286020.2024.2364350","url":null,"abstract":"<div><div>Astragali Radix (AR), a common traditional Chinese medicinal herb, exhibits protective effects on diabetic nephropathy (DN) in extensive researches. Aticles focusing on AR in PubMed were collected and reviewed in order to summarize the latest pharmacological effects on DN. The action mechanisms for protectiving effects of AR were associated with regulation of anti-fibrosis, anti-inflammation, anti-oxidative stress, anti-podocyte apoptosis, restoration of mitochondrial function, restoration of endothelial function in diabetes nephropathy experimental models. Consequently, AR hold promise as potential novel therapeutics for the treatment of DN.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design, synthesis, and anti-oomycete activity of 3-acyloxymaltol/ethyl maltol derivatives 3-acyloxymaltol/ethyl maltol 衍生物的设计、合成和抗霉菌活性。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-06-10 DOI: 10.1080/10286020.2024.2355144
{"title":"Design, synthesis, and anti-oomycete activity of 3-acyloxymaltol/ethyl maltol derivatives","authors":"","doi":"10.1080/10286020.2024.2355144","DOIUrl":"10.1080/10286020.2024.2355144","url":null,"abstract":"<div><p>Twenty 3-acyloxymaltol/ethyl maltol derivatives (<strong>7a-j</strong> and <strong>8a-j</strong>) were synthesized and evaluated <em>in vitro</em> for their anti-oomycete activity against <em>Phytophthora capsici</em>, respectively. Among all of twenty derivatives, more than half of the compounds <strong>7f</strong>, <strong>7h</strong>, <strong>8a-h</strong> and <strong>8j</strong> had anti-oomycete activity higher than the positive control zoxamide (EC<sub>50</sub> = 22.23 mg/L), and the EC<sub>50</sub> values of 18.66, 20.32, 12.80, 16.18, 10.59, 14.98, 16.80, 10.36, 15.32, 12.64, and 13.59 mg/L, respectively. Especially, compounds <strong>8c</strong> and <strong>8f</strong> exhibited the best anti-oomycete activity against <em>P. capsici</em> with EC<sub>50</sub> values of 10.59 and 10.36 mg/L, respectively. Overall, hydroxyl group of maltol/ethyl maltol is important active modification site.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modeling and biological evaluation of pegmolesatide, a novel and potent erythropoiesis-stimulating agent 一种新型强效红细胞生成刺激剂 pegmolesatide 的建模和生物学评估。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-06-10 DOI: 10.1080/10286020.2024.2362376
{"title":"Modeling and biological evaluation of pegmolesatide, a novel and potent erythropoiesis-stimulating agent","authors":"","doi":"10.1080/10286020.2024.2362376","DOIUrl":"10.1080/10286020.2024.2362376","url":null,"abstract":"<div><div>Pegmolesatide, a synthetic, polyethylene-glycolylated, peptide-based erythropoiesis-stimulating agent (ESA), has been recently approved in China. Pegmolesatide is derived from the structure of endogenous erythropoietin (EPO), a natural product in mammals. This study compared the <em>in vitro</em> effects and selectivity of pegmolesatide to those of recombinant EPO and carbamylated EPO (CEPO) through computer-aided analyses and biological tests. The findings indicate that pegmolesatide exhibited the same stimulating effect on erythropoiesis as EPO with fewer side effects than EPO and CEPO.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three new antinociceptive diterpenoids from the fruits of Rhododendron molle 杜鹃花果实中的三种新的抗痛觉二萜类化合物。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-06-08 DOI: 10.1080/10286020.2024.2345826
{"title":"Three new antinociceptive diterpenoids from the fruits of Rhododendron molle","authors":"","doi":"10.1080/10286020.2024.2345826","DOIUrl":"10.1080/10286020.2024.2345826","url":null,"abstract":"<div><p>Investigation of the fruits of <em>Rhododendron molle</em> G. Don led to the isolation of three new grayanane-type diterpenoids, rhodomolleins LIV-LVI (<strong>1-3</strong>). The structures and absolute configurations of new compounds were fully elucidated by spectroscopic analysis and single-crystal X-ray diffraction, including HRESIMS, 1 D and 2 D NMR data. Compounds <strong>1</strong>-<strong>3</strong> were evaluated for analgesic activities utilizing an acetic acid-induced writhing test in mice. Compound <strong>1</strong> showed a significant antinociceptive effect with writhe inhibition rates of 72.9% and 100% at doses of 6 mg/kg and 20 mg/kg in mice, respectively. The binding mode of <strong>1</strong> to <em>N</em>-ethylmaleimide-sensitive factor (NSF, PDB: 6IP2) was explored by molecular docking, indicating the presence of hydrogen bond interactions which account for its analgesic activity.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enantioselective formal total synthesis of dihydrospirotryprostatin B 二氢螺前列素 B 的对映体选择性正式全合成。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-06-01 DOI: 10.1080/10286020.2024.2355504
{"title":"Enantioselective formal total synthesis of dihydrospirotryprostatin B","authors":"","doi":"10.1080/10286020.2024.2355504","DOIUrl":"10.1080/10286020.2024.2355504","url":null,"abstract":"<div><p>Spirotryprostatins are representative members of medicinally interesting bioactive molecules of the spirooxindole natural products. In this communication, we present a novel enantioselective total synthesis of the spirooxindole alkaloid dihydrospirotryprostatin B. The synthesis takes advantage of copper-catalyzed tandem reaction of <em>o</em>-iodoanilide chiral sulfinamide derivatives with alkynone to rapidly construct the key quaternary carbon stereocenter of the natural product dihydrospirotryprostatin B.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ionones from cigar tobacco leaves 雪茄烟叶中的酮类化合物
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-05-30 DOI: 10.1080/10286020.2024.2342509
{"title":"Ionones from cigar tobacco leaves","authors":"","doi":"10.1080/10286020.2024.2342509","DOIUrl":"10.1080/10286020.2024.2342509","url":null,"abstract":"<div><p>Phytochemical studies on cigar tobacco leaves led to the isolation of 18 ionone-type compounds, including previously undescribed cigatobanes E (<strong>1</strong>) and F (<strong>2</strong>). Additionally, compounds vomifoliol acetate (<strong>3)</strong>, dehydrovomifoliol (<strong>4)</strong>, 8,9-dihydromegastigmane-4,6-diene-3-one (<strong>5)</strong>, 7<em>α</em>,8<em>α</em>-epoxyblumenol B (<strong>6)</strong>, 3-oxoactinidol (<strong>12</strong>), and loliolide acetate (<strong>15</strong>), 4<em>β</em>-hydroxy-dihydroactinidiolide (<strong>17</strong>), were found in tobacco leaves for the first time. The structural elucidation of all compounds was accomplished through rigorous spectral analysis.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141246778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biotransformation and metabolite activity analysis of flavonoids from propolis in vivo 蜂胶中黄酮类化合物在体内的生物转化和代谢活性分析。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-05-24 DOI: 10.1080/10286020.2024.2355142
{"title":"Biotransformation and metabolite activity analysis of flavonoids from propolis in vivo","authors":"","doi":"10.1080/10286020.2024.2355142","DOIUrl":"10.1080/10286020.2024.2355142","url":null,"abstract":"<div><p>Propolis is a natural resinous compound produced by bees, mixed with their saliva and wax, and has a range of biological benefits, including antioxidant and anti-inflammatory effects. This article reviews the in vivo transformation of propolis flavonoids and their potential influence on drug efficacy. Despite propolis is widely used, there is little research on how the active ingredients of propolis change in the body and how they interact with drugs. Future research will focus on these interactions and the metabolic fate of propolis in vivo.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141093337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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