化合物FLZ通过抑制Src/PTEN/Akt信号通路减轻神经炎症。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-01-01 DOI:10.1080/10286020.2024.2435981

Fang-Fang Li, Yuan-Peng Zheng, Gen Li, Yang Yang, Jing-Wei Ma, Cai-Xia Zang, Deng Tao, Li Li, Xiu-Qi Bao, Dan Zhang

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引用次数: 0

摘要

化合物FLZ对帕金森病（PD）具有神经保护作用，但其确切机制尚不清楚。在本研究中，我们发现FLZ降低了lps刺激的BV2细胞中PTEN/Akt的活性。当PTEN或Src被抑制时，FLZ抑制的神经炎症反应被消除。此外，FLZ减弱了Src和PTEN的相互作用，当PETN被抑制时，FLZ减弱了Src的磷酸化，但当Src被沉默时，FLZ未能降低PTEN的磷酸化。最后，我们阐述了FLZ直接与Src结合并抑制其活性。综上所述，FLZ通过抑制Src/PTEN/Akt通路减轻神经炎症，为临床应用FLZ治疗PD铺平了道路。

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Compound FLZ attenuates neuroinflammation through inhibiting Src/PTEN/Akt signaling pathway.

Compound FLZ has neuroprotective effects on Parkinson's disease (PD), while the precise mechanism remains unclear. In this study, we found that FLZ decreased PTEN/Akt activity in LPS-challenged BV2 cells. Neuroinflammatory responses suppressed by FLZ were abolished when PTEN or Src was inhibited. Additionally, FLZ weakened the interactions of Src and PTEN, and attenuated Src phosphorylation once PETN was inhibited, but failed to decrease PTEN phosphorylation when Src was silenced. Eventually, we elaborated that FLZ bound to Src directly and inhibited its activity. Collectively, FLZ attenuated neuroinflammation through inhibiting Src/PTEN/Akt pathway, paving the way for clinical use of FLZ to treat PD.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.