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Journal of Asian Natural Products Research最新文献

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Network pharmacology approach and experimental verification of Manzufei decoction in the treatment of chronic obstructive pulmonary disease. 曼祖肺汤治疗慢性阻塞性肺疾病的网络药理学方法及实验验证。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-07-01 Epub Date: 2025-09-11 DOI: 10.1080/10286020.2025.2558646
Xin Liu, Chun-Ye Hu, Zheng-Huan Li, Hong-Mei Yang, Cheng-Xin Zhang, Hong Li, Guo-Ming Tang, Yang Chen
{"title":"Network pharmacology approach and experimental verification of Manzufei decoction in the treatment of chronic obstructive pulmonary disease.","authors":"Xin Liu, Chun-Ye Hu, Zheng-Huan Li, Hong-Mei Yang, Cheng-Xin Zhang, Hong Li, Guo-Ming Tang, Yang Chen","doi":"10.1080/10286020.2025.2558646","DOIUrl":"10.1080/10286020.2025.2558646","url":null,"abstract":"<p><p>Manzufei decoction (MZFD) effectively treats COPD, but its mechanisms are unclear. Combining network pharmacology and experimental validation, we identified 168 bioactive components in MZFD and 265 potential targets. Network analysis pinpointed 4 core compounds. Comparing 1167 COPD-related targets revealed 114 overlapping therapeutic targets. Enrichment analysis implicated key pathways, notably AKT signaling. Molecular docking confirmed strong binding of quercetin to AKT and MUC5AC. Animal studies demonstrated that MZFD inhibits AKT signaling pathway activation, reduces MUC5AC protein expression in lung tissue and lung inflammation, thereby alleviating lung injury in AECOPD model rats.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1066-1090"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and biological evaluation of aconitine-type derivatives as potential cardiotonic agents. 潜在强心剂乌头碱类衍生物的合成及生物学评价。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-07-01 DOI: 10.1080/10286020.2026.2691912
Wen-Rong Qu, Xue Wen, Ling-Feng Tian, Hong Wang, Qin He, Xian-Li Zhou, Xi Wang, Shuai Huang
{"title":"Synthesis and biological evaluation of aconitine-type derivatives as potential cardiotonic agents.","authors":"Wen-Rong Qu, Xue Wen, Ling-Feng Tian, Hong Wang, Qin He, Xian-Li Zhou, Xi Wang, Shuai Huang","doi":"10.1080/10286020.2026.2691912","DOIUrl":"https://doi.org/10.1080/10286020.2026.2691912","url":null,"abstract":"<p><p>Eighteen C<sub>19</sub> aconitine-type derivatives were designed and syn-thesized with the modification of core active and strong toxicity components, such as yunaconitine (YA), mesaconitine (MA), and hypaconitine (HA) in Fuzi through hydrolysis and demethylation reactions. Their structures were confirmed by MS,<sup>1</sup>H NMR and <sup>13</sup>C NMR. Isolated frog heart perfusion assay demonstrated that compound <b>18</b> exhibited excellent anti-heart failure activity with a cardiotonic rate of 103.14%. Its cardiotonic effect could be completely antagonized by nonselective calcium channel blockers, suggesting that the pharmacological effect of this compound is closely related to the calcium ion influx mechanism.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-22"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148368321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comprehensive review on phytosomes as an emerging technology for delivering herbal medicines. 磷脂体作为一种新兴的给药技术的综述。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-07-01 Epub Date: 2025-10-08 DOI: 10.1080/10286020.2025.2564401
Preeti Aneja, Rajender Guleria, Shivali Aneja, Dev Prakash Dahiya, Ankush Goyal, Dipan Roy, Jitender Singh, Naresh Kumar Rangra
{"title":"A comprehensive review on phytosomes as an emerging technology for delivering herbal medicines.","authors":"Preeti Aneja, Rajender Guleria, Shivali Aneja, Dev Prakash Dahiya, Ankush Goyal, Dipan Roy, Jitender Singh, Naresh Kumar Rangra","doi":"10.1080/10286020.2025.2564401","DOIUrl":"10.1080/10286020.2025.2564401","url":null,"abstract":"<p><p>A \"novel drug delivery system\" is a new and effective alternative pathway to administer drugs that evade the limitations of traditional methods. The natural medications can be a good approach for delivering the active ingredients to the target-specific area. However, many plant extracts and compounds face challenges like poor solubility and poor absorption. To overcome these issues, the emergence of \"phytosomes\" has been developed. Phytosomes are advanced herbal delivery systems that improve the absorption and effectiveness of plant extracts. This review highlights the key advancements in phytosomal technology, their practical benefits, and cost-effectiveness.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"965-983"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulatory mechanisms and therapeutic potential of natural microglia inhibitors in Parkinson's disease. 天然小胶质细胞抑制剂在帕金森病中的调节机制和治疗潜力。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-07-01 Epub Date: 2025-08-28 DOI: 10.1080/10286020.2025.2544148
Ting-Ting Jin, Rui-Zhen Shi, Jian-Wen Shi, Fei Liu, Yong-Xin Liang
{"title":"Regulatory mechanisms and therapeutic potential of natural microglia inhibitors in Parkinson's disease.","authors":"Ting-Ting Jin, Rui-Zhen Shi, Jian-Wen Shi, Fei Liu, Yong-Xin Liang","doi":"10.1080/10286020.2025.2544148","DOIUrl":"10.1080/10286020.2025.2544148","url":null,"abstract":"<p><p>Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases affecting the central nervous system. The pathogenesis of PD is complex, and its etiology remains poorly understood. Recently, it has been suggested that neuroinflammation caused by overactivated microglia plays a significant role in the occurrence and development of PD. The use of anti-inflammatory medication to delay or prevent the occurrence and progression of PD has become a hot topic of research in this field. This review introduces the inflammatory mechanism of PD, the related inflammatory factors, and the progress of using natural anti-inflammatory drugs for PD prevention and treatment.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"943-964"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyrtiosin, a novel pyridinium-conjugated indole derivative from vietnamese marine sponge hyrtios erectus. hytiosin：一种新型吡啶共轭吲哚衍生物。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-07-01 Epub Date: 2025-10-03 DOI: 10.1080/10286020.2025.2565343
Le Viet Ha Tran, Huu Canh Vo, Vinh Han La, Quoc Tuan Le, Minh Canh Nguyen, Duc Trung Le, Thi Thu Hien Do, Huynh Nguyen Khanh Tran
{"title":"Hyrtiosin, a novel pyridinium-conjugated indole derivative from vietnamese marine sponge <i>hyrtios erectus</i>.","authors":"Le Viet Ha Tran, Huu Canh Vo, Vinh Han La, Quoc Tuan Le, Minh Canh Nguyen, Duc Trung Le, Thi Thu Hien Do, Huynh Nguyen Khanh Tran","doi":"10.1080/10286020.2025.2565343","DOIUrl":"10.1080/10286020.2025.2565343","url":null,"abstract":"<p><p>The present phytochemical investigation of methanol extract from Vietnamese marine sponge, <i>Hyrtios erectus</i>, resulted to the isolation and structure elucidation of five compounds consisting of a new pyridinium-conjugated indole derivative (hyrtiosin, <b>1</b>), together with four known alkaloids identified as gramine (<b>2</b>), indole-3-carboxaldehyde (<b>3</b>), 3-(methoxymethyl)indole (<b>4</b>) and <i>N</i>-methylnicotinic acid or trigonelline (<b>5</b>). Chemical structures of isolated compounds were established using modern spectroscopic methods including NMR (<sup>1</sup>H,<sup>13</sup>C, COSY, HSQC, HMBC), HR-ESIMS, UV and IR. Compound <b>1</b> is rare occurrence of natural products with an acetyl moiety linked to <i>N</i>-1. The isolated compounds were tested with inhibitory activity of NO production and growth of bacterial strains. Among them, only compound <b>1</b> displayed the weak inhibition of nitric oxide production with an IC<sub>50</sub> value of 38.2 μM, others unfortunately have no activity in both of assays. All of them are first report both of isolation, structural elucidation and bioactivities from specie <i>H. erectus.</i></p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1100-1107"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and anti-Candida albicans activity of oleanolic acid derivatives. 齐墩果酸衍生物的合成及抗白色念珠菌活性研究。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-07-01 Epub Date: 2025-10-27 DOI: 10.1080/10286020.2025.2572087
Fei Zou, Lu-Yi Jiang, Fei Chen, Ze-Fei Fan, Tian-Yu Zhang, Tian-Yue Yang, Rui-Rui Wang, Guang-Hui Ni
{"title":"Synthesis and anti-<i>Candida albicans</i> activity of oleanolic acid derivatives.","authors":"Fei Zou, Lu-Yi Jiang, Fei Chen, Ze-Fei Fan, Tian-Yu Zhang, Tian-Yue Yang, Rui-Rui Wang, Guang-Hui Ni","doi":"10.1080/10286020.2025.2572087","DOIUrl":"10.1080/10286020.2025.2572087","url":null,"abstract":"<p><p>With the increase incidence of <i>Candida albicans</i> infections and the widespread use of azole drugs, particularly fluconazole, the emergence of drug-resistant strains has become a significant concern. In this study, the derivatives were prepared by nucleophilic substitution at the 3-OH position of oleanolic acid, utilizing the reactivity of triphosgene, and by electrophilic coupling at the 28-COOH position through photoredox reactions. The antifungal activity of all compounds was evaluated, revealing that most derivatives exhibited good synergistic antifungal activity with fluconazole against the drug-resistant <i>Candida albicans</i> strain ATCC14053, with FICI values ranging from 0.45 to 0.14.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1015-1032"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145377675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytotoxic cycloartane-type triterpenoids from the leaves of aglaia shawiana. 沙棘叶的细胞毒性环artan型三萜。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-07-01 Epub Date: 2025-10-03 DOI: 10.1080/10286020.2025.2564409
Ricson Pemimpin Hutagaol, Tjandrawati Mozef, Nurlela, Febi Nurilmala, Gian Primahana, Muhammad Eka Prasetya, Sofa Fajriah, Vionita Ristina
{"title":"Cytotoxic cycloartane-type triterpenoids from the leaves of <i>aglaia shawiana</i>.","authors":"Ricson Pemimpin Hutagaol, Tjandrawati Mozef, Nurlela, Febi Nurilmala, Gian Primahana, Muhammad Eka Prasetya, Sofa Fajriah, Vionita Ristina","doi":"10.1080/10286020.2025.2564409","DOIUrl":"10.1080/10286020.2025.2564409","url":null,"abstract":"<p><p>Three cycloartane-type triterpenoids have been isolated from the leaves of <i>Aglaia shawiana,</i> and the structure was determined as a new compound Shawianin A (<b>1</b>), along with two known compounds cycloartane-3<i>β</i>,29-diol-24-one (<b>2</b>), and (24 <i>R</i>)-cycloartane-3<i>β</i>,24,25- triol (<b>3</b>). Their structures were elucidated on the basis of 1D and 2D-nuclear magnetic resonance (NMR) analysis, as well as high-resolution mass spectrometry (HR-MS), infrared (IR), and ultraviolet (UV). Comparative data analysis was also carried out with appropriate reference journals and through a biosynthesis approach of the cycloartane type of triterpene compound. All of the compounds were evaluated for their cytotoxic effects against MCF-7 breast cancer cells and showed cytotoxicity with IC<sub>50</sub> values of >100 µg/ml.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1091-1099"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A pair of epimeric lignan glycosides from Selaginella tamariscina. 来自卷柏的一对外聚木脂素苷。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-06-27 DOI: 10.1080/10286020.2026.2691910
Shuai-Cong Ni, Hai-Xiao-Lin-Mo Ma, A-Ji Diri, Yuan Liu, Xin-Jia Yan, Jing Wen
{"title":"A pair of epimeric lignan glycosides from <i>Selaginella tamariscina</i>.","authors":"Shuai-Cong Ni, Hai-Xiao-Lin-Mo Ma, A-Ji Diri, Yuan Liu, Xin-Jia Yan, Jing Wen","doi":"10.1080/10286020.2026.2691910","DOIUrl":"https://doi.org/10.1080/10286020.2026.2691910","url":null,"abstract":"<p><p>To explore the chemical constituents of <i>Selaginella tamariscina</i> and their effects on cancer cells, this study employed multiple chromatographic techniques including polyamide, silica gel, and semi-preparative High-performance liquid chromatography for compound isolation. The structures of the compounds were elucidated based on physicochemical properties and spectroscopic data. A pair of epimeric lignan glycosides, 7'<i>R</i>-tamariscinol U 4-<i>O</i>-<i>β</i>-d-glucopyranoside (<b>1</b>), 7'<i>S</i>-tamariscinol U 4-<i>O</i>-<i>β</i>-d-glucopyranoside (<b>2</b>) were obtained, along with two known compounds 3,5,7-trimethoxyflavone-4'-<i>O</i>-<i>β</i>-d-glucopyranoside (<b>3</b>) and selapeptin B (<b>4</b>). <b>1</b> and <b>2</b> are new, while the spectral data of <b>3</b> and <b>4</b> in methanol-<i>d</i><sub>4</sub> are reported for the first time.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.6,"publicationDate":"2026-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148338653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two new cassane derivatives from the seeds of Hultholia mimosoides. 两种新的藜籽衍生物。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-06-20 DOI: 10.1080/10286020.2026.2690531
Lian Lian, Xin-Xin Zhang, Jun-Yi Ma, Yu-Xin Wu, Miao Wang
{"title":"Two new cassane derivatives from the seeds of <i>Hultholia mimosoides</i>.","authors":"Lian Lian, Xin-Xin Zhang, Jun-Yi Ma, Yu-Xin Wu, Miao Wang","doi":"10.1080/10286020.2026.2690531","DOIUrl":"https://doi.org/10.1080/10286020.2026.2690531","url":null,"abstract":"<p><p>Two previously undescribed cassane diterpenoids, caesmimo C3 (<b>1</b>) and caesmimo C8 (<b>2</b>), were isolated from the seeds of <i>Hultholia mimosoides</i>. Their structures were established by comprehensive spectroscopic analysis, and the absolute configurations were assigned from the electronic circular dichroism spectrum. Bioactively, compounds <b>1</b> and <b>2</b> exhibited significant cytotoxicity, inhibiting the cell viability of NRK-52E cells at a concentration of 50 <i>μ</i>M.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2026-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148295007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protective effects of Angelica dahurica polysaccharide on alleviating hippocampus injury induced by ovariectomized/D-galactose in rats by inhibiting oxidative stress and its serum metabolomics. 白芷多糖通过抑制氧化应激及其血清代谢组学对去卵巢/ d -半乳糖所致大鼠海马损伤的保护作用
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-06-12 DOI: 10.1080/10286020.2026.2683848
Fen Qiu, Xue-Qin He, Yi-Zhang Li, Chun-Feng Wu, Du-Dong Wei, Hao-Yu Liu, Li-Ba Xu
{"title":"Protective effects of <i>Angelica dahurica</i> polysaccharide on alleviating hippocampus injury induced by ovariectomized/D-galactose in rats by inhibiting oxidative stress and its serum metabolomics.","authors":"Fen Qiu, Xue-Qin He, Yi-Zhang Li, Chun-Feng Wu, Du-Dong Wei, Hao-Yu Liu, Li-Ba Xu","doi":"10.1080/10286020.2026.2683848","DOIUrl":"https://doi.org/10.1080/10286020.2026.2683848","url":null,"abstract":"<p><p>We established in vivo models of hippocampal oxidative injury to investigate the protective effect of <i>Angelica dahurica</i> polysaccharide (ADP) on the hippocampus. ADP alleviated ovariectomized/D-Galactose (OVX/D-Gal)-induced hippocampal damage and enhanced antioxidant capacity (increased SOD/GSH-Px, decreased MDA). Additionally, ADP activated the Nrf2 pathway (upregulated Nrf2, downregulated NQO1/HO-1) and inhibited apoptosis (upregulated Bcl-2, downregulated Bax/cleaved caspase-3). Untargeted metabolomics revealed that ADP reversed seven oxidative stress-related metabolites, and pathway analysis implicated glycerophospholipid metabolism in its antioxidant mechanism. These results demonstrated that ADP protects against OVX/D-Gal-induced hippocampal oxidative injury by activating Nrf2, enhancing antioxidant capacity, inhibiting apoptosis, and regulating glycerophospholipid metabolism.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-21"},"PeriodicalIF":1.3,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148225597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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