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Journal of Asian Natural Products Research最新文献

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Characterization of metabolic profile of Dazhu Hongjingtian and evaluation of its anti-hypoxic constituents 大竹红景天代谢谱特征及抗缺氧成分评价。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-04 DOI: 10.1080/10286020.2024.2434550
Chun-Yan Ou , Xia Gao , Jia-Jia Wang , Xia-Lin Chen , Liang Cao , Zhen-Zhong Wang , Chen-Feng Zhang , Wei Xiao
{"title":"Characterization of metabolic profile of Dazhu Hongjingtian and evaluation of its anti-hypoxic constituents","authors":"Chun-Yan Ou ,&nbsp;Xia Gao ,&nbsp;Jia-Jia Wang ,&nbsp;Xia-Lin Chen ,&nbsp;Liang Cao ,&nbsp;Zhen-Zhong Wang ,&nbsp;Chen-Feng Zhang ,&nbsp;Wei Xiao","doi":"10.1080/10286020.2024.2434550","DOIUrl":"10.1080/10286020.2024.2434550","url":null,"abstract":"<div><div>Dazhu Hongjingtian (DZ) is renowned for its diverse pharmacological activities, yet its metabolic pathways remain to be fully elucidated. In this study, the metabolic profile after oral administration of DZ extract (DZE) in rats was systematically identified by the UPLC/Q-TOF-MS/MS method for the first time. A total of 94 components, including 32 prototypes and 62 metabolites, were tentatively characterized in rat plasma and various tissues samples. Furthermore, 6 constituents (salidroside, quercetin, 4-hydroxycinnamic acid, 5-hydroxymethylfurfural, <em>p</em>-tyrosol, and gallic acid) derived from plasma prototypes were identified as bioactive by assessing cell viabilities of OGD-injured RSC96 cells.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 5","pages":"Pages 690-708"},"PeriodicalIF":1.3,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rosmarinic acid suppresses the progression of COPD via Syk by modulating airway inflammation and epithelial apoptosis in vivo and in vitro 迷迭香酸在体内和体外通过调节气道炎症和上皮细胞凋亡，通过 Syk 抑制慢性阻塞性肺病的发展。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-04 DOI: 10.1080/10286020.2024.2403617
Ji-Qiao Yuan , Xu-Yu Li , Yan-Nan Fan , Nan Fang , Ping Li , Xin-Zhu Wen , Qi Hou , Zi-Qian Zhang , Ming-Bao Lin
{"title":"Rosmarinic acid suppresses the progression of COPD via Syk by modulating airway inflammation and epithelial apoptosis in vivo and in vitro","authors":"Ji-Qiao Yuan ,&nbsp;Xu-Yu Li ,&nbsp;Yan-Nan Fan ,&nbsp;Nan Fang ,&nbsp;Ping Li ,&nbsp;Xin-Zhu Wen ,&nbsp;Qi Hou ,&nbsp;Zi-Qian Zhang ,&nbsp;Ming-Bao Lin","doi":"10.1080/10286020.2024.2403617","DOIUrl":"10.1080/10286020.2024.2403617","url":null,"abstract":"<div><div>Rosmarinic acid (RosA), a hydrophilic phenolic compound found in various plants, has several biological effects such as anti-inflammatory and anti-apoptosis activities. However, its potential impact on chronic obstructive pulmonary disease (COPD) and its underlying mechanism has not been investigated. In this study, we explored the potential therapeutic effects and mechanism of RosA on COPD airway inflammation and alveolar epithelial apoptosis <em>in vivo</em> and <em>in vitro</em>. Our data suggested that RosA may be a therapeutic candidate for COPD with low toxicity. The corresponding mechanism lies in its anti-inflammatory effect on macrophage and bronchial epithelial cells, as well as protective effect on lung epithelial apoptosis via the jointly cross-target spleen tyrosine kinase (Syk).</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 5","pages":"Pages 732-746"},"PeriodicalIF":1.3,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meroterpenoids from Rhododendron racemosum and their anti-inflammatory activities 总状杜鹃花中萜类化合物及其抗炎活性。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-04 DOI: 10.1080/10286020.2024.2431813
Si-Xuan Liu , Si-Yang Dai , Yong-Fu Lu , Chun-Lin Guo , Chang Li , Yi-Hui Yang , Yue-Hu Pei
{"title":"Meroterpenoids from Rhododendron racemosum and their anti-inflammatory activities","authors":"Si-Xuan Liu ,&nbsp;Si-Yang Dai ,&nbsp;Yong-Fu Lu ,&nbsp;Chun-Lin Guo ,&nbsp;Chang Li ,&nbsp;Yi-Hui Yang ,&nbsp;Yue-Hu Pei","doi":"10.1080/10286020.2024.2431813","DOIUrl":"10.1080/10286020.2024.2431813","url":null,"abstract":"<div><div>Three meroterpenoids, including one new compound, ranhuadujuanine E (<strong>1</strong>), one new natural product, methyl (<em>E</em>)-3-(3,7-dimethylocta-2,6-dien-1-yl)-2,4-dihydroxy-6-methylbenzoate (<strong>2</strong>), and one known compound, ranhuadujuanine D (<strong>3</strong>), along with two known sesquiterpenoids (<strong>4</strong>-<strong>5</strong>) were isolated from <em>Rhododendron racemosum</em>. Their structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configuration of C-6’ in compound <strong>1</strong> was assigned by using Snatzke’s method. Compounds <strong>1</strong>-<strong>3</strong> had inhibitory effects on LPS-induced NO release in RAW264.7 cells.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 5","pages":"Pages 669-676"},"PeriodicalIF":1.3,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Compound FLZ attenuates neuroinflammation through inhibiting Src/PTEN/Akt signaling pathway 化合物FLZ通过抑制Src/PTEN/Akt信号通路减轻神经炎症。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-04 DOI: 10.1080/10286020.2024.2435981
Fang-Fang Li , Yuan-Peng Zheng , Gen Li , Yang Yang , Jing-Wei Ma , Cai-Xia Zang , Deng Tao , Li Li , Xiu-Qi Bao , Dan Zhang
{"title":"Compound FLZ attenuates neuroinflammation through inhibiting Src/PTEN/Akt signaling pathway","authors":"Fang-Fang Li ,&nbsp;Yuan-Peng Zheng ,&nbsp;Gen Li ,&nbsp;Yang Yang ,&nbsp;Jing-Wei Ma ,&nbsp;Cai-Xia Zang ,&nbsp;Deng Tao ,&nbsp;Li Li ,&nbsp;Xiu-Qi Bao ,&nbsp;Dan Zhang","doi":"10.1080/10286020.2024.2435981","DOIUrl":"10.1080/10286020.2024.2435981","url":null,"abstract":"<div><div>Compound FLZ has neuroprotective effects on Parkinson’s disease (PD), while the precise mechanism remains unclear. In this study, we found that FLZ decreased PTEN/Akt activity in LPS-challenged BV2 cells. Neuroinflammatory responses suppressed by FLZ were abolished when PTEN or Src was inhibited. Additionally, FLZ weakened the interactions of Src and PTEN, and attenuated Src phosphorylation once PETN was inhibited, but failed to decrease PTEN phosphorylation when Src was silenced. Eventually, we elaborated that FLZ bound to Src directly and inhibited its activity. Collectively, FLZ attenuated neuroinflammation through inhibiting Src/PTEN/Akt pathway, paving the way for clinical use of FLZ to treat PD.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 5","pages":"Pages 770-786"},"PeriodicalIF":1.3,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hongjingtian alleviates arsenic-induced hepatocyte injury by inhibiting oxidative stress and endoplasmic reticulum stress. 红景天通过抑制氧化应激和内质网应激减轻砷诱导的肝细胞损伤。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-04-26 DOI: 10.1080/10286020.2025.2481290
Jiang-Tao Cao, Hai-Wen Li, Jia-Qi Chen, Hai-Long Lv, Yu-Feng Jiang
{"title":"Hongjingtian alleviates arsenic-induced hepatocyte injury by inhibiting oxidative stress and endoplasmic reticulum stress.","authors":"Jiang-Tao Cao, Hai-Wen Li, Jia-Qi Chen, Hai-Long Lv, Yu-Feng Jiang","doi":"10.1080/10286020.2025.2481290","DOIUrl":"https://doi.org/10.1080/10286020.2025.2481290","url":null,"abstract":"<p><p>This study explored Hongjingtian's (HJT) protective effects against arsenic-induced hepatotoxicity. NaAsO<sub>2</sub> (8 μM, 24 h)-damaged hepatocytes treated with HJT (50/100 mg/L) showed restored cell viability via CCK-8/LDH assays. HJT reduced arsenic-induced ROS, improved mitochondrial membrane potential, elevated SOD/CAT activity, lowered MDA, and suppressed apoptosis by downregulating Caspase-3/Bax while upregulating Bcl-2. Additionally, HJT alleviated endoplasmic reticulum stress (ERS). Mechanistically, HJT attenuated arsenic-induced hepatocyte apoptosis by mitigating oxidative stress and ERS via ROS reduction.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.3,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytotoxic ent-abietane diterpenoids from the leaves of Croton crassifolius. 巴豆叶中细胞毒性异戊二烯二萜。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-04-25 DOI: 10.1080/10286020.2025.2493929
Hao Yu, Hong-Ying Chen, Xue-Jun Wang, Xiao-Mei Shen, Bo Sun, Jia-Ge Sun, Bei Hou, Xiao-Yi Zhang, Xue-Rong Ye
{"title":"Cytotoxic <i>ent</i>-abietane diterpenoids from the leaves of <i>Croton crassifolius</i>.","authors":"Hao Yu, Hong-Ying Chen, Xue-Jun Wang, Xiao-Mei Shen, Bo Sun, Jia-Ge Sun, Bei Hou, Xiao-Yi Zhang, Xue-Rong Ye","doi":"10.1080/10286020.2025.2493929","DOIUrl":"https://doi.org/10.1080/10286020.2025.2493929","url":null,"abstract":"<p><p>Two new <i>ent</i>-abietane diterpenoids, 2<i>β</i>,15-dihydroxy-<i>ent</i>-abieta-7,13-dien-3-one (<b>1</b>) and 6<i>β</i>,13<i>α</i>-dihydroxy-<i>ent</i>-abieta-8(14)-en-3-one (<b>2</b>), together a known <i>ent</i>-abietane diterpenoid 3<i>α</i>,7<i>β</i>-dihydroxy-<i>ent</i>-abieta-8,11,13-triene (<b>3</b>), were isolated from the 80% acetone extract of the leaves of <i>Croton crassifolius</i>. The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (<sup>1</sup>H-<sup>1</sup>H COSY, HMQC, and HMBC) NMR spectroscopy, as well as high resolution mass spectrometry. The isolated compounds were tested <i>in vitro</i> for cytotoxic activity against five urologic carcinoma cell lines. Consequently, compound <b>3</b> exhibited some cytotoxicities against all the tested tumor cell lines with IC<sub>50</sub> value less than 20.0 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in flavonoid bioactivity in chronic diseases and bioavailability: transporters and enzymes 类黄酮在慢性疾病中的生物活性和生物利用度研究进展：转运体和酶。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-04-25 DOI: 10.1080/10286020.2025.2493925
Li-Sha Ye , Hong-Fei Mu , Bao-Lian Wang
{"title":"Advances in flavonoid bioactivity in chronic diseases and bioavailability: transporters and enzymes","authors":"Li-Sha Ye ,&nbsp;Hong-Fei Mu ,&nbsp;Bao-Lian Wang","doi":"10.1080/10286020.2025.2493925","DOIUrl":"10.1080/10286020.2025.2493925","url":null,"abstract":"<div><div>Flavonoids, abundant in the human diet, have been extensively studied for their therapeutic bioactivities. Recent research has made significantly advances in our understanding of the biological activities of flavonoids, demonstrating their therapeutic effects for various chronic diseases. However, the generally low bioavailability of flavonoids limits their effectiveness. Therefore, it is essential to explore the pharmacokinetics of flavonoids, paying particular attention to the roles of transporters and metabolizing enzymes. This paper reviews recent studies on the bioactivity of flavonoids, highlighting the importance of transporters and metabolic enzymes in their pharmacokinetics.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 6","pages":"Pages 805-833"},"PeriodicalIF":1.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Withaferin A ameliorates psoriasis-like skin lesions by suppressing oxidative stress in keratinocytes. Withaferin A通过抑制角质形成细胞的氧化应激改善牛皮癣样皮肤病变。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-04-25 DOI: 10.1080/10286020.2025.2492825
Ming-Yi Zhang, Yu-Chang Liu, Xing-Yu Liu, Di-Wei Chen, Chao Han, Xin Shen, You-Xiang Ding, Xiao-Ping Wang, Ai-Ping Shi
{"title":"Withaferin A ameliorates psoriasis-like skin lesions by suppressing oxidative stress in keratinocytes.","authors":"Ming-Yi Zhang, Yu-Chang Liu, Xing-Yu Liu, Di-Wei Chen, Chao Han, Xin Shen, You-Xiang Ding, Xiao-Ping Wang, Ai-Ping Shi","doi":"10.1080/10286020.2025.2492825","DOIUrl":"https://doi.org/10.1080/10286020.2025.2492825","url":null,"abstract":"<p><p>Psoriasis is a chronic disease with elusive pathogenesis linked to genetic, and immune factors. Studies have shown most patients have experienced high levels of oxidative stress, which can lead to inflammation or damage. Withaferin A is a natural product with multiple pharmacological activities, including anti-tumor and anti-inflammatory effects. We investigated the effects of WA in treating Imiquimod (IMQ)-induced psoriasis mice. The epidermal pathology of mice was significantly improved after treatment. WA inhibited inflammation by decreasing the production of IL-1β, IL-6, and IFN-γ, which were induced by epidermal oxidative stress. Additionally, WA can shift the macrophage status from pro-inflammatory to anti-inflammatory.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Natural anti-neuroinflammatory inhibitors from Aglaia odorata. 天然抗神经炎抑制剂，从香木莲。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-04-21 DOI: 10.1080/10286020.2025.2492355
Xin-Yang Liu, Jing-Jing Zhang, Qian-Qian Yin, Yan-Ping Zhang, Chen Zhao, Ming-Xia Fang, Qing-Qi Meng, Yue Hou, Di Zhou, Ning Li
{"title":"Natural anti-neuroinflammatory inhibitors from <i>Aglaia odorata</i>.","authors":"Xin-Yang Liu, Jing-Jing Zhang, Qian-Qian Yin, Yan-Ping Zhang, Chen Zhao, Ming-Xia Fang, Qing-Qi Meng, Yue Hou, Di Zhou, Ning Li","doi":"10.1080/10286020.2025.2492355","DOIUrl":"https://doi.org/10.1080/10286020.2025.2492355","url":null,"abstract":"<p><p>Eleven compounds were isolated from the <i>n</i>-butanol extract of <i>Aglaia odorata</i> Lour, including one undescribed lignan, curlignan-4-<i>O</i>-<i>β</i>-D-glucopyranoside (<b>1</b>), and ten known compounds (<b>2-11</b>). Their structures were characterized by comprehensive spectral analysis, nuclear magnetic resonance (1D and 2D NMR), mass spectrometry (MS), and electronic circular dichroism (ECD). The inhibitory effects of these compounds on nitric oxide (NO) production in lipopolysaccharide (LPS) stimulated BV-2 microglia were evaluated. The experimental results indicated that the anti-neuroinflammatory activities of compounds <b>1, 3, 4, 6, 7, 9</b> and <b>10</b> were significantly better than those of the positive control minocycline (IC<sub>50</sub> = 41.34 ± 3.55 μM), with IC<sub>50</sub> values ranging from 1.31 to 15.70 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A network pharmacological target mendelian randomization study on the neuroprotective effects of active ingredients in mahuang fuzi xixin decoction for multiple sclerosis. 麻黄附子西心汤有效成分对多发性硬化症神经保护作用的网络药理靶点孟德尔随机化研究。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-04-21 DOI: 10.1080/10286020.2025.2491612
Wei-Jie Li, Chong-Lian Feng, Zhao-Yuan Nie, Ling-Yun Li, Jian-Hui Guo, Xiang-Yu Liu, Yang-Hao Su, Shan-Shan Liu, Zhi-Zhong Cui
{"title":"A network pharmacological target mendelian randomization study on the neuroprotective effects of active ingredients in mahuang fuzi xixin decoction for multiple sclerosis.","authors":"Wei-Jie Li, Chong-Lian Feng, Zhao-Yuan Nie, Ling-Yun Li, Jian-Hui Guo, Xiang-Yu Liu, Yang-Hao Su, Shan-Shan Liu, Zhi-Zhong Cui","doi":"10.1080/10286020.2025.2491612","DOIUrl":"https://doi.org/10.1080/10286020.2025.2491612","url":null,"abstract":"<p><p>Mahuang Fuzi Xixin Decoction (MFX), a traditional Chinese medicine containing 44 volatile components (97.36% total oil), includes key compounds like α-terpenol (13.34%) and 1,2,3-trimethoxy-5-methyl-benzene (22.64%). Using network pharmacology and Mendelian randomization, 24 active compounds were identified targeting MS-related pathways (NF-κB, NLRP3, Toll-like receptor). Genetic variants in CYP450, GSK3B, CYBB, and PON1 correlated with reduced MS risk. In EAE mice, MFX decreased spinal GSK-3B expression (immunofluorescence) and pro-inflammatory factors (ELISA), demonstrating neuroprotection via anti-inflammatory, antioxidative mechanisms and restored GSK-3B levels, highlighting therapeutic potential for MS.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-21"},"PeriodicalIF":1.3,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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