{"title":"Talarindigotin A: a cytotoxic indigotin derivative, from the mangrove endophytic fungus <i>Talaromyces amestolkiae</i> SCNU-F0041.","authors":"Jia-Lin Li, Ling-Ling Liu, Zi-Rong Lin, Hai-Qi Zeng, Zhe Zhou, Yu-Hua Long","doi":"10.1080/10286020.2024.2428228","DOIUrl":"https://doi.org/10.1080/10286020.2024.2428228","url":null,"abstract":"<p><p>A new indigotin alkaloid, named talarindigotin A (<b>1</b>), along with the analogue 5H, 6H-quinindolin-11-one (<b>2</b>) were isolated from the mangrove endophytic fungus <i>Talaromyces amestolkiae</i> SCNU-F0041. Their structures were assigned on the basis of NMR, HRMS, and single-crystal X-ray diffraction analysis. In the cytotoxic bioassay, compound <b>1</b> showed great cytotoxicity against HepG2, Hela, HCT116, and Huh7 human cancer cell lines with IC<sub>50</sub> values ranging from 2.08 to 4.58 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.3,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"<i>Garcinia cowa</i> bark extract induces oxidative stress mediated cellular apoptosis in <i>Leishmania donovani</i> parasite modulated by its active phytosterol constituent.","authors":"Nibedita Pyne, Ishita Bhattacharya, Santanu Paul","doi":"10.1080/10286020.2024.2429145","DOIUrl":"https://doi.org/10.1080/10286020.2024.2429145","url":null,"abstract":"<p><p>Visceral leishmaniasis still remains a leading cause of parasitic deaths, with modern pentavalent antimonials showing limited efficacy and health risks. The methanolic bark extract of the Northeastern Indian plant, <i>Garcinia cowa</i>, demonstrated potent leishmanicidal effects against the parasite <i>Leishmania donovani</i>, demonstrating IC<sub>50</sub> values of 20-36 µg/ml, with selective toxicity for parasites over healthy cells. It induced parasite death through elevated oxidative and nitrosative stress elements, reduced arginase activity, nuclear fragmentation, cell cycle arrest, and apoptosis. A GC-MS study and molecular docking identified stigmasterol as a primary component, an antileishmanial compound that inhibits <i>Leishmania donovani</i> parasite efficiently.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-23"},"PeriodicalIF":1.3,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"New 3-acyl derivatives of glaucocalyxin A: designed, synthesis and <i>in vitro</i> antibacterial activities.","authors":"Wei-Xian Yang, Wei-Qing Zhang, Mei-Qi Wei, Mei-Hui Duan, Xian-Ji Liu, Chen Yan","doi":"10.1080/10286020.2024.2429136","DOIUrl":"https://doi.org/10.1080/10286020.2024.2429136","url":null,"abstract":"<p><p>To discover novel antimicrobial drug, 22 novel acylated derivatives were synthesized by A-ring modification of glaucocalyxin A. The structures of these derivatives were confirmed by NMR and MS data. <i>In vitro</i> antimicrobial activity of these compounds was evaluated against <i>E. faecium</i>, <i>E. faecalis</i>, MRSA, <i>E. coli</i>, <i>A. baumannii</i> and <i>K. pneumoniae</i>. The results showed compound <b>3d</b> against <i>E. faecium</i>, <i>E. faecalis</i> and MRSA with a minimum inhibitory concentration of 4 μg/ml. And further molecular docking revealed that compound <b>3d</b> has a higher binding affinity. In conclusion, compound <b>3d</b> has the potential to develop into a new drug against drug-resistant bacteria.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.3,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Atefeh Jalali , Maryam Kabiri , Shima Hashemi , Alireza Abdi Ardekani , Mohammad M. Zarshenas
{"title":"Medicinal plants or bioactive components with antioxidant/anti-apoptotic effects as a potential therapeutic approach in heart failure prevention and management: a literature review","authors":"Atefeh Jalali , Maryam Kabiri , Shima Hashemi , Alireza Abdi Ardekani , Mohammad M. Zarshenas","doi":"10.1080/10286020.2024.2414196","DOIUrl":"10.1080/10286020.2024.2414196","url":null,"abstract":"<div><div>Heart failure is described as a complicated syndrome, which is estimated that 56.2 million people were living with HF globally in 2019. Oxidative stress and apoptosis play a major role on HF development via targeting several signaling pathways in cardiac cells. This study investigated medicinal plants or their bioactive components with positive effects on HF management. In this research, keywords “heart failure,” “plant,” “antioxidant” or “radical scavenging,” “herbal” and “apoptosis” were synchronously searched through popular databases from 1990 up to 2023. Finally, the role of oxidative stress and apoptosis in HF development was searched and related signaling pathways were investigated.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 3","pages":"Pages 275-291"},"PeriodicalIF":1.3,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lin Liang, Xi Yuan, Xiao-Ya Xian, Xian-Li Zhou, Tong-Dong Kuang, Jin-Tao Gao, Li-Sheng Wang, Cheng-Qin Liang
{"title":"Two new quinazolinone alkaloids from <i>Aspergillus udagawae</i>.","authors":"Lin Liang, Xi Yuan, Xiao-Ya Xian, Xian-Li Zhou, Tong-Dong Kuang, Jin-Tao Gao, Li-Sheng Wang, Cheng-Qin Liang","doi":"10.1080/10286020.2024.2424910","DOIUrl":"https://doi.org/10.1080/10286020.2024.2424910","url":null,"abstract":"<p><p>Two new quinazolinone alkaloids, benzomalvin F (<b>1</b>), and quinadoline C (<b>2</b>), along with four known quinazolinones (<b>3</b>-<b>6</b>), were isolated from cultures of the wetland-soil-derived fungus <i>Aspergillus udagawae</i> from the Huixian wetland in Guilin. Their structures were elucidated based on detailed spectroscopic analysis, including 1D, 2D NMR, mass spectrometry, and IR spectra. In addition, the anti-inflammatory results showed that compounds <b>1</b>, <b>2</b>, <b>4</b>, and <b>5</b> had significant inhibitory effects on NO production in RAW264.7 cells activated by lipopolysaccharide (LPS), with IC<sub>50</sub> values of 24.5 ± 0.1, 29.7 ± 0.1, 29.4 ± 0.1, and 31.0 ± 0.1 µM respectively, compared with the positive control indomethacin (IC<sub>50</sub> = 31.6 ± 0.4 μM).</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of the potential anti-arthritic effects and evaluation of acute oral toxicity of the active fraction of <i>Eclipta prostrata</i> leaves in rat model.","authors":"Anjoo Kamboj, Hitesh Malhotra, Himanshu Mukhija, Arockia Babu","doi":"10.1080/10286020.2024.2422974","DOIUrl":"https://doi.org/10.1080/10286020.2024.2422974","url":null,"abstract":"<p><p>The primary goal of this research was to isolate and assess the bioactive compounds within <i>Eclipta prostrata</i> Linn's chloroform extract, with a focus on their potential to combat arthritis, validating its traditional use. Initially, antioxidant characteristics were evaluated, followed by fractionation through column chromatography. The <i>in-vivo</i> safety assessment, following OECD TG 425 Guidelines, showed no mortality at doses up to 2000 mg/kg, confirming the fraction's safety. Subsequently, the active fraction was assessed in a complete Freund's adjuvant-induced arthritis model. It demonstrated a dose-dependent inhibitory effect on inflammation and improved various parameters, including thermal latency time, dorsal flexion, motility, and motor coordination. Active bio constituents like rutin, stigmasterol, quercetin, and beta-sitosterol were estimated in the active fraction. The findings provide validation for the traditional use of <i>E. prostrata</i> as a potential plant with anti-arthritic properties, suggesting its potential suitability for rheumatoid arthritis treatment.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-24"},"PeriodicalIF":1.3,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yu-Shuang Wen, Li Jiang, Yang Wang, Ying-Jie Xu, Chun-Hua Liu, Yong Huang, Xue Ma, Yong-Jun Li
{"title":"Two new glycosides and a new flavone from <i>Gerbera delavayi</i>.","authors":"Yu-Shuang Wen, Li Jiang, Yang Wang, Ying-Jie Xu, Chun-Hua Liu, Yong Huang, Xue Ma, Yong-Jun Li","doi":"10.1080/10286020.2024.2420613","DOIUrl":"https://doi.org/10.1080/10286020.2024.2420613","url":null,"abstract":"<p><p>Three new compounds, including two glycosides, named gerbelavinsides E/G (<b>1</b>/<b>2</b>), and a flavone, named gerbelavin G (<b>3</b>), were isolated from 50% ethanol extract of <i>Gerbera delavayi</i>. Their structures were elucidated based on HR-ESI-MS, IR, UV and NMR spectral data, and the absolute configurations of <b>1</b> and <b>3</b> were determined by ECD spectra. Three compounds were tested for their inhibition effect against LPS-induced NO production in RAW 264.7 cells. They exhibited different degrees of inhibition activities with rates of 40.55 ± 1.65%, 70.13 ± 0.55%, 56.74 ± 1.15%, respectively.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Taxifolin ameliorates the D-galactose-induced aging of mouse hippocampal neurons HT-22 cells through modulating SIRT1/p53 and PI3K/AKT signaling pathways.","authors":"Xing-Long Liu, Shuang Zu, Hao Yue, An-Ning Li, Ping-Ping Sun, Jian-Guo Li, Li Yan, Li-Na Ma, Shuai Zhang","doi":"10.1080/10286020.2024.2421925","DOIUrl":"https://doi.org/10.1080/10286020.2024.2421925","url":null,"abstract":"<p><p>By establishing an <i>in vitro</i> model of D-Gal-induced brain neuronal cell (HT-22) senescence, it was found that TAX treatment significantly increased the activities of SOD and GSH, while decreasing MDA levels in aging HT-22 cells, indicating that TAX effectively restored the total antioxidant capacity and antioxidant enzyme activity of aging HT-22 cells induced by D-Gal, and attenuated cellular oxidative stress injury. In addition, taxifolin could also protect HT-22 cells from aging by up-regulating SIRT1 while reducing the expression of Ac-p53, indicating that TAX may be an active substance that can effectively delay cell aging.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-17"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recent advances in natural products and derivatives with antiviral activity against respiratory syncytial virus (RSV).","authors":"Ameena Tur Rasool, Erguang Li, Ahsan Nazir","doi":"10.1080/10286020.2024.2417211","DOIUrl":"https://doi.org/10.1080/10286020.2024.2417211","url":null,"abstract":"<p><p>Respiratory syncytial virus (RSV) is a widespread viral infection that causes millions of high-risk illnesses annually. Medicinal herbs such as ginseng root, echinacea purpurea, and radix astragali have a positive effect on antiviral activity by preventing viral adhesion, syncytial development, inhibiting viral internalization, relieving respiratory inflammation, strengthening the immune system, and stimulating the release of interferons. The potential benefits of natural products in terms of lower costs, better patient outcomes, and fewer adverse effects are discussed. This review examines the current evidence on the prevention and control of RSV with natural ingredients and the challenges and opportunities in clinical practice.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-24"},"PeriodicalIF":1.3,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"<i>Caenorhabditis elegans</i> as <i>in vivo</i> model for the screening of natural plants-derived novel anti-aging compounds: a short introduction.","authors":"Samah H O Zarroug","doi":"10.1080/10286020.2024.2414189","DOIUrl":"https://doi.org/10.1080/10286020.2024.2414189","url":null,"abstract":"<p><p>The global aging population highlights the need for effective anti-aging treatments. Natural products show promise, but thorough evaluation requires <i>in vivo</i> models due to the complexity of aging. Ethical concerns are driving a shift from traditional models like rabbits and mice to alternatives such as <i>Caenorhabditis elegans</i>. This microscopic nematode, with its short life cycle, genetic similarities to humans, and cost-effectiveness, is ideal for testing anti-aging compounds. We review studies using <i>C. elegans</i> to assess natural products, suggesting it could serve as a primary model for -evaluating the safety and efficacy of plant-derived anti-aging compounds.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.3,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}