A network pharmacological target mendelian randomization study on the neuroprotective effects of active ingredients in mahuang fuzi xixin decoction for multiple sclerosis.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-04-21 DOI:10.1080/10286020.2025.2491612

Wei-Jie Li, Chong-Lian Feng, Zhao-Yuan Nie, Ling-Yun Li, Jian-Hui Guo, Xiang-Yu Liu, Yang-Hao Su, Shan-Shan Liu, Zhi-Zhong Cui

引用次数: 0

Abstract

Mahuang Fuzi Xixin Decoction (MFX), a traditional Chinese medicine containing 44 volatile components (97.36% total oil), includes key compounds like α-terpenol (13.34%) and 1,2,3-trimethoxy-5-methyl-benzene (22.64%). Using network pharmacology and Mendelian randomization, 24 active compounds were identified targeting MS-related pathways (NF-κB, NLRP3, Toll-like receptor). Genetic variants in CYP450, GSK3B, CYBB, and PON1 correlated with reduced MS risk. In EAE mice, MFX decreased spinal GSK-3B expression (immunofluorescence) and pro-inflammatory factors (ELISA), demonstrating neuroprotection via anti-inflammatory, antioxidative mechanisms and restored GSK-3B levels, highlighting therapeutic potential for MS.

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麻黄附子西心汤有效成分对多发性硬化症神经保护作用的网络药理靶点孟德尔随机化研究。

中药麻黄附子西心汤含有44种挥发性成分（占总油的97.36%），主要成分为α-萜酚（13.34%）和1,2,3-三甲氧基-5-甲基苯（22.64%）。采用网络药理学和孟德尔随机化方法，鉴定出24种靶向ms相关通路（NF-κB、NLRP3、toll样受体）的活性化合物。CYP450、GSK3B、CYBB和PON1基因变异与MS风险降低相关。在EAE小鼠中，MFX降低脊髓GSK-3B表达（免疫荧光）和促炎因子（ELISA），通过抗炎、抗氧化机制显示神经保护作用，并恢复GSK-3B水平，突出了MS的治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.