类黄酮在慢性疾病中的生物活性和生物利用度研究进展：转运体和酶。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-04-25 DOI:10.1080/10286020.2025.2493925

Li-Sha Ye , Hong-Fei Mu , Bao-Lian Wang

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引用次数: 0

摘要

黄酮类化合物在人类饮食中含量丰富，其治疗生物活性已被广泛研究。近年来的研究对黄酮类化合物的生物学活性的认识有了显著的进展，证明了其对各种慢性疾病的治疗作用。然而，黄酮类化合物普遍较低的生物利用度限制了它们的有效性。因此，对黄酮类化合物的药代动力学进行研究是必要的，尤其要关注转运体和代谢酶的作用。本文综述了近年来黄酮类化合物的生物活性研究，强调了转运体和代谢酶在其药代动力学中的重要性。

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Advances in flavonoid bioactivity in chronic diseases and bioavailability: transporters and enzymes

Flavonoids, abundant in the human diet, have been extensively studied for their therapeutic bioactivities. Recent research has made significantly advances in our understanding of the biological activities of flavonoids, demonstrating their therapeutic effects for various chronic diseases. However, the generally low bioavailability of flavonoids limits their effectiveness. Therefore, it is essential to explore the pharmacokinetics of flavonoids, paying particular attention to the roles of transporters and metabolizing enzymes. This paper reviews recent studies on the bioactivity of flavonoids, highlighting the importance of transporters and metabolic enzymes in their pharmacokinetics.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.