Xin-Yang Liu, Jing-Jing Zhang, Qian-Qian Yin, Yan-Ping Zhang, Chen Zhao, Ming-Xia Fang, Qing-Qi Meng, Yue Hou, Di Zhou, Ning Li
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引用次数: 0
Abstract
Eleven compounds were isolated from the n-butanol extract of Aglaia odorata Lour, including one undescribed lignan, curlignan-4-O-β-D-glucopyranoside (1), and ten known compounds (2-11). Their structures were characterized by comprehensive spectral analysis, nuclear magnetic resonance (1D and 2D NMR), mass spectrometry (MS), and electronic circular dichroism (ECD). The inhibitory effects of these compounds on nitric oxide (NO) production in lipopolysaccharide (LPS) stimulated BV-2 microglia were evaluated. The experimental results indicated that the anti-neuroinflammatory activities of compounds 1, 3, 4, 6, 7, 9 and 10 were significantly better than those of the positive control minocycline (IC50 = 41.34 ± 3.55 μM), with IC50 values ranging from 1.31 to 15.70 μM.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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