Journal of Asian Natural Products Research最新文献

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Pandanus tectorius fruits attenuated cell injury and oxidative stress in high glucose-induced Schwann cells by activating Nrf2/Keap1 signaling pathway.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-01-31 DOI: 10.1080/10286020.2025.2451340
Jin-Gui Zhang, Jin-Ping Cai, Yu-Xia Wu, Jia-Liang Guo, Yu-Qing Li, Chao Wang
{"title":"Pandanus tectorius fruits attenuated cell injury and oxidative stress in high glucose-induced Schwann cells by activating Nrf2/Keap1 signaling pathway.","authors":"Jin-Gui Zhang, Jin-Ping Cai, Yu-Xia Wu, Jia-Liang Guo, Yu-Qing Li, Chao Wang","doi":"10.1080/10286020.2025.2451340","DOIUrl":"https://doi.org/10.1080/10286020.2025.2451340","url":null,"abstract":"<p><p>We studied the protective effects of Pandanus tectorius fruits (PTF) on Schwann cells and sciatic nerve damage in diabetic peripheral neuropathy (DPN) rats. PTF improved RSC96 cell viability and increased Nrf2, Keap1, HO-1, and NQO1 expression. PTF reduced apoptosis and ROS in high glucose-treated cells, which was reversed by Nrf2 siRNA. Co-treatment with SFN further decreased apoptosis and ROS. PTF increased SOD, GSH-Px, NGF, IGF-1, and VEGF activities, reduced by Nrf2 knockdown but restored with SFN. MDA levels showed opposite trends. In DPN rats, PTF reduced pain and prevented nerve damage, suggesting it alleviates DPN by activating the Nrf2/Keap1 pathway.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-17"},"PeriodicalIF":1.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new steroid from Penicillium brocae G2131.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-01-31 DOI: 10.1080/10286020.2025.2451332
Jie-Yi Zhou, Chen-Yang Cui, Li-Na Mao, Qun Zhou, Zhi-Ping Wang
{"title":"A new steroid from <i>Penicillium brocae</i> G2131.","authors":"Jie-Yi Zhou, Chen-Yang Cui, Li-Na Mao, Qun Zhou, Zhi-Ping Wang","doi":"10.1080/10286020.2025.2451332","DOIUrl":"https://doi.org/10.1080/10286020.2025.2451332","url":null,"abstract":"<p><p>A comprehensive study was carried out on <i>Penicillium brocae</i> G2131, which originated from Yunnan Menghai Pu'er tea. This study resulted in the identification of five compounds, one of which is a newly discovered compound: (5aR)-6-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-5a-methyl-5,5a,6,7,8,8a-hexa hydro-2H-indeno[5,4-b]furan-2-one (<b>1</b>), four known compounds: demethylincisterol A<sub>3</sub> (<b>2</b>), (22<i>E</i>, 24 <i>R</i>)-ergosta-7,9(11),22-trien-3<i>β</i>-ol (<b>3</b>), (22<i>E</i>,24<i>R</i>)-5<i>α</i>,8<i>α</i>-epidixyer-gosta-6,22-dien-3<i>β</i>-ol (<b>4</b>) and <i>p</i>- hydroxybenzaldehyde (<b>5</b>). The structure of compound <b>1</b> was determined using a variety of spectroscopic methods such as <sup>1</sup>H spectrum,<sup>13</sup>C spectrum, HMBC, HSQC,<sup>1</sup>H-<sup>1</sup>H COSY, LC-MS, UV, IR and comparison of their NMR data with literature. The absolute configuration of compound <b>1</b> was established by comparing the experimental and ECD spectra. All compounds were tested for their anti-acetylcholine activity, however, none of them demonstrated any anti-acetylcholine activity.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and biological evaluation of oleanolic acid derivatives as potential c-kit inhibitors.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-01-31 DOI: 10.1080/10286020.2025.2451336
Zhen-Yu Kuai, Zheng-Fei Zhu, Xuan Zeng, Yan-Qiu Meng
{"title":"Synthesis and biological evaluation of oleanolic acid derivatives as potential c-kit inhibitors.","authors":"Zhen-Yu Kuai, Zheng-Fei Zhu, Xuan Zeng, Yan-Qiu Meng","doi":"10.1080/10286020.2025.2451336","DOIUrl":"https://doi.org/10.1080/10286020.2025.2451336","url":null,"abstract":"<p><p>The 3-O-(4'-imidazole)-12-en-olean-28-amide derivatives <b>7-1</b> to <b>7-11</b> through modification the C-3 and C-28 of the natural product oleanolic acid were prepared, and their structures were confirmed by MS,<sup>1</sup>H NMR and <sup>13</sup>C NMR. The antitumor activities of these compounds against breast cancer MCF-7 and gastric cancer SGC7901 cells <i>in vitro</i> were determined by MTT assay. Cell tests showed that the antitumor activities of compound <b>7-10</b> exhibited significant antitumor activity which was equivalent to the positive control drug nilotinib, and the affinity was verified by molecular dynamics experiment <i>in vitro</i>. Molecular docking showed that compound <b>7-10</b> have high binding ability with c-kit. Therefore, compound <b>7-10</b> has the potential to become a new c-kit inhibitor, which deserves further research.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analytical method development and validation for monosaccharide profiling in Lignosus rhinocerotis using rP-HPLC.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-01-31 DOI: 10.1080/10286020.2025.2453852
Solehah Mohd Rosdan Bushra, Ruzilawati Abu Bakar, Asma Abdullah Nurul
{"title":"Analytical method development and validation for monosaccharide profiling in <i>Lignosus rhinocerotis</i> using rP-HPLC.","authors":"Solehah Mohd Rosdan Bushra, Ruzilawati Abu Bakar, Asma Abdullah Nurul","doi":"10.1080/10286020.2025.2453852","DOIUrl":"https://doi.org/10.1080/10286020.2025.2453852","url":null,"abstract":"<p><p><i>Lignosus rhinocerotis</i> is rich in polysaccharide with diverse -bioactivities. This study developed a pre-column derivatization reversed-phase high-performance liquid chromatography (RP-HPLC) method for analyzing monosaccharides in <i>Lignosus rhinocerotis</i> polysaccharides (LRP). LRP underwent hydrolysis, derivatization, and separation on a Cosmosil 5C18-MS-II column at 254 nm. Baseline separation of eight standard monosaccharides was achieved within 45 min. Calibration curves, precision, and accuracy were validated. Quantitative analysis revealed LRP as a heteropolysaccharide containing mannose, ribose, rhamnose, glucose, galactose, xylose, and arabinose, with 100.28-111.02% recovery. This optimized RP-HPLC offers a simple, reproducible, and accurate tool for LRP monosaccharides analysis, facilitating in understanding its structure-function relationship.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the potential anticancer targets and mechanistic pathways of Elsholtzia densa essential oil based on network pharmacology. 基于网络药理学的密枝精油潜在抗癌靶点及作用机制探讨。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-01-10 DOI: 10.1080/10286020.2024.2446294
Qian Wang, Xiao-Ying Wang, Jin Tao, Jin-Tao Nie, Yi-Han Zhou, Jing Huang, Jia-Yuan Zhao, Ya-Nan Wang
{"title":"Exploring the potential anticancer targets and mechanistic pathways of <i>Elsholtzia densa</i> essential oil based on network pharmacology.","authors":"Qian Wang, Xiao-Ying Wang, Jin Tao, Jin-Tao Nie, Yi-Han Zhou, Jing Huang, Jia-Yuan Zhao, Ya-Nan Wang","doi":"10.1080/10286020.2024.2446294","DOIUrl":"https://doi.org/10.1080/10286020.2024.2446294","url":null,"abstract":"<p><p>This study aimed to assess the composition of <i>Elsholtzia densa</i> essential oil (EBE) and identify potential targets for inhibiting human hepatocellular carcinoma cell proliferation. The plants were collected from four regions: Jiuzhi, Qinghai; Ruoergai, Sichuan; Aba, Sichuan; and Jiulong, Sichuan. Four EBEs (named No. 1 to No. 4) were analyzed by gas chromatograph-mass spectrometer. EBEs significantly inhibited human hepatocellular carcinoma cells. The EBE collected from Jiuzhi exhibited the most potent inhibitory effect. Core targets identified included MAPK3, EGFR, ESR1, CASP3, PTGS2, BCL2L1, and MAPK14. Notably, the four EBEs prevented hepatocellular carcinoma cell proliferation via neuroactive ligand-receptor interactions and apoptosis pathways.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-20"},"PeriodicalIF":1.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of intestinal bacterial carboxylesterase-mediated metabolites and the potential antitumour molecular mechanism of angoroside C. 肠道细菌羧酸酯酶代谢产物及赤霉素C潜在的抗肿瘤分子机制分析。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-01-10 DOI: 10.1080/10286020.2024.2441823
Jian-Ye Song, Xiang Hui, Ru Feng, Yi Zhao, Jia-Chun Hu, Jing-Yu Jin, Jin-Yue Lu, Hui Xu, Jing-Yue Wang, Heng-Tong Zuo, Meng-Liang Ye, Yan Wang
{"title":"Analysis of intestinal bacterial carboxylesterase-mediated metabolites and the potential antitumour molecular mechanism of angoroside C.","authors":"Jian-Ye Song, Xiang Hui, Ru Feng, Yi Zhao, Jia-Chun Hu, Jing-Yu Jin, Jin-Yue Lu, Hui Xu, Jing-Yue Wang, Heng-Tong Zuo, Meng-Liang Ye, Yan Wang","doi":"10.1080/10286020.2024.2441823","DOIUrl":"https://doi.org/10.1080/10286020.2024.2441823","url":null,"abstract":"<p><p>Angoroside C (AgrC) is a compound with many pharmacological properties. However, its antitumour potential has not been well studied. The low bioavailability of AgrC suggests a strong link to gut bacteria. Therefore, we identified and quantified four AgrC metabolites in gut microbiota. Molecular docking and inhibitor-based experiments demonstrated that carboxylesterase played a key role in AgrC metabolism. Both AgrC and its metabolites inhibited the viability of CT-26 cells, and potential antitumour targets were further explored. Additionally, AgrC significantly increased the levels of propionic, butyric, valeric and isovaleric acids. This provides a new insight for the antitumour effects of AgrC.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-18"},"PeriodicalIF":1.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cynatroside B2, a new anti-inflammatory C21 steroid from the roots and rhizomes of Vincetoxicum atratum. Cynatroside B2,一种新的抗炎甾体C21,从白花长春花根和根茎中提取。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-01-10 DOI: 10.1080/10286020.2024.2446302
Jing-Yu Zhang, Yi-Nuo Shi, Sheng Dong, Chen Ji, Yang Yu, Jiu-Zhi Yuan, Chong-Ning Lv, Jin-Cai Lu
{"title":"Cynatroside B<sub>2</sub>, a new anti-inflammatory C<sub>21</sub> steroid from the roots and rhizomes of <i>Vincetoxicum atratum</i>.","authors":"Jing-Yu Zhang, Yi-Nuo Shi, Sheng Dong, Chen Ji, Yang Yu, Jiu-Zhi Yuan, Chong-Ning Lv, Jin-Cai Lu","doi":"10.1080/10286020.2024.2446302","DOIUrl":"https://doi.org/10.1080/10286020.2024.2446302","url":null,"abstract":"<p><p>A series of C<sub>21</sub> steroidal glycosides were isolated from the roots and rhizomes of <i>Vincetoxicum atratum</i> (Bunge) C. Morren et Decne., including a new compound, cynatroside B<sub>2</sub> (<b>1</b>), and seven known compounds (<b>2</b>-<b>8</b>). Their structures were identified by comprehensive spectroscopic analyses, including NMR and HR-ESI-MS spectral data. The isolated steroids were evaluated for their anti-inflammatory activity against lipopolysaccharide-induced mouse macrophage RAW264.7 cells. Compound <b>1</b> displayed a significant inhibitory effect on NO, TNF-<i>α</i> and IL-1<i>β</i>.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploration and computational assessment of ochrocephalamine G from Oxytropis ochrocephala as an anti-HBV candidate. 赭棘豆中赭脑胺G作为抗hbv候选物的探索和计算评估。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-01-10 DOI: 10.1080/10286020.2024.2441773
Ya-Kun Zhang, Zhan Xue, Jian-Bo Tong, Jing Tan, Min Yang, Yan-Rong Zeng, Cheng-Jian Tan
{"title":"Exploration and computational assessment of ochrocephalamine G from <i>Oxytropis ochrocephala</i> as an anti-HBV candidate.","authors":"Ya-Kun Zhang, Zhan Xue, Jian-Bo Tong, Jing Tan, Min Yang, Yan-Rong Zeng, Cheng-Jian Tan","doi":"10.1080/10286020.2024.2441773","DOIUrl":"https://doi.org/10.1080/10286020.2024.2441773","url":null,"abstract":"<p><p>Three compounds, including a novel quinolizidine alkaloid, ochrocephalamine G (<b>1</b>), were isolated from <i>Oxytropis ochrocephala</i>. Structural elucidation was achieved through spectroscopic analysis and electronic circular dichroism. Biological assays showed that ochrocephalamine G (100 μM) inhibited HBsAg and HBeAg by 8.28% and 16.17%, respectively. Computational studies, including molecular docking and dynamics simulations, revealed its binding mode with HBV core protein, providing a solid foundation for developing <i>O. ochrocephala</i> as an anti-HBV therapeutic agent.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pachyphyllanone, a new cycloartane triterpenoid isolated from Aglaia pachyphylla and its cytotoxic activity. 厚叶木酮:一种从厚叶木中分离得到的新的环ar烷类三萜及其细胞毒活性。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-01-10 DOI: 10.1080/10286020.2024.2446280
Wahyu Safriansyah, Endang Juliansyah, Rustaman, Al Arofatus Naini, Kindi Farabi, Mohamad Nurul Azmi, Mohamad Azlan Nafiah, Hadi Kuncoro, Unang Supratman, Sofa Fajriah, Desi Harneti
{"title":"Pachyphyllanone, a new cycloartane triterpenoid isolated from <i>Aglaia pachyphylla</i> and its cytotoxic activity.","authors":"Wahyu Safriansyah, Endang Juliansyah, Rustaman, Al Arofatus Naini, Kindi Farabi, Mohamad Nurul Azmi, Mohamad Azlan Nafiah, Hadi Kuncoro, Unang Supratman, Sofa Fajriah, Desi Harneti","doi":"10.1080/10286020.2024.2446280","DOIUrl":"https://doi.org/10.1080/10286020.2024.2446280","url":null,"abstract":"<p><p><i>Aglaia pachyphylla</i> is a species from the <i>Aglaia</i> genus (Meliaceae) and the chemical constituent has not been widely explored. A new cycloartane-type triterpenoid, pachyphyllanone (<b>1</b>), along with four known compounds (<b>2</b>-<b>5</b>) were isolated from <i>Aglaia pachyphylla</i> Miq. Furthermore, the structure of the new compound was elucidated by the interpretation of spectroscopic data, including 1D and 2D-NMR, as well as ECD and NMR calculations (DP4+ analysis). Compounds <b>1</b>-<b>5</b> showed cytotoxic activities against MCF-7 with IC<sub>50</sub> values ranging from 160.74 to 299.75 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel antimicrobial defensin peptides from different coleopteran insects (Coleoptera: Insecta): identification, characterisation and antimicrobial properties. 来自不同鞘翅目昆虫(鞘翅目:昆虫科)的新型抗菌防御肽:鉴定、表征和抗菌特性。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-01-09 DOI: 10.1080/10286020.2024.2448011
Ayşe Nur Pektaş, Ertan Mahir Korkmaz
{"title":"Novel antimicrobial defensin peptides from different coleopteran insects (Coleoptera: Insecta): identification, characterisation and antimicrobial properties.","authors":"Ayşe Nur Pektaş, Ertan Mahir Korkmaz","doi":"10.1080/10286020.2024.2448011","DOIUrl":"https://doi.org/10.1080/10286020.2024.2448011","url":null,"abstract":"<p><p>Antimicrobial peptides are crucial components of the immune systems of both vertebrates and invertebrates. Here, defensins, the most studied class of antimicrobial molecules in arthropods were investigated in four coleopteran insect species: <i>Harpalus rufipes</i> (DeGeer, 1774), <i>Mylabris quadripunctata</i> (Linnaeus, 1767), <i>Sphaeridium marginatum</i> (Linnaeus, 1758), and <i>Ocypus mus</i> (Brullé, 1832). The peptides synthesized with over 95% purity and their antimicrobial activities were evaluated by MIC test method. As a result, it was determined that <i>Mylabris quadripunctata</i> defensin (MqDef) showed high antimicrobial activity against <i>Staphylococcus aureus</i> and MRSA, whereas <i>Sphaeridium marginatum</i> (SmDef) and <i>Harpalus rufipes</i> (HrDef) defensins against <i>Candida tropicalis</i>.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-15"},"PeriodicalIF":1.3,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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