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Journal of Asian Natural Products Research最新文献

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Two new diterpenoid alkaloids from the roots of Aconitum nagarum and their cytotoxic activity. 从 Aconitum nagarum 的根中提取的两种新的二萜生物碱及其细胞毒性活性。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-07-08 DOI: 10.1080/10286020.2024.2373326
Jiang Hu, Ren Ji, Guang-Rong Yang, Tao Lv, Qiang Li, Feng Gao
{"title":"Two new diterpenoid alkaloids from the roots of <i>Aconitum nagarum</i> and their cytotoxic activity.","authors":"Jiang Hu, Ren Ji, Guang-Rong Yang, Tao Lv, Qiang Li, Feng Gao","doi":"10.1080/10286020.2024.2373326","DOIUrl":"https://doi.org/10.1080/10286020.2024.2373326","url":null,"abstract":"<p><p>A chemical investigation on the roots of <i>Aconitum nagarum</i> afforded two undescribed C<sub>19</sub>-diterpenoid alkaloids nagarumines D and E (<b>1</b> and <b>2</b>). The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (<sup>1</sup>H-<sup>1</sup>H COSY, HMQC, and HMBC) NMR spectroscopy, as well as HR-ESI-MS. The two isolated alkaloids were tested <i>in vitro</i> for cytotoxic activity against five gastric tumor cell lines. Consequently, compound <b>2</b> exhibited some cytotoxicities against several human cancer cell lines with IC<sub>50</sub> value less than 20.0 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two new cucurbitane-type triterpenoid saponins from the fruit of Citrullus colocynthis 从秋刀鱼果实中提取的两种新葫芦烷类三萜皂甙
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-07-04 DOI: 10.1080/10286020.2024.2364908
{"title":"Two new cucurbitane-type triterpenoid saponins from the fruit of Citrullus colocynthis","authors":"","doi":"10.1080/10286020.2024.2364908","DOIUrl":"10.1080/10286020.2024.2364908","url":null,"abstract":"<div><div>Two new cucurbitane-type triterpenoid saponins, 2,20<em>β</em>,22<em>β</em>-trihydroxy-16<em>α</em>,23(<em>R</em>)-epoxycucurbita-1,5,24-triene-3,11-dione 2-<em>O</em>-<em>β</em>-D-glucopyranoside (<strong>1</strong>), 2,20<em>β</em>,22<em>α</em>-trihydroxy-16<em>α</em>,23(<em>S</em>)-epoxycucurbita-1,5,11,24-tetraene-3-one 2-<em>O</em>-<em>β</em>-D-glucopyranoside (<strong>2</strong>) were isolated from the fruit of <em>Citrullus colocynthis</em> (L.) Schrad. Their structures were elucidated by mass spectrometry, IR, 1D, and 2D NMR spectroscopy, etc. Besides, both of the compounds showed significant hepatoprotective activities at 10 <em>μ</em>M against paracetamol-induced HepG2 cell damage.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141503000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fuzheng Huayu recipe inhibits bleomycin-induced pulmonary fibrosis in rats by inhibiting M2 polarization of macrophages via the oxidative phosphorylation pathway. 扶正化瘀方通过氧化磷酸化途径抑制巨噬细胞的M2极化，从而抑制博莱霉素诱导的大鼠肺纤维化。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-07-03 DOI: 10.1080/10286020.2024.2371050
Xing-Hua Yuan, Su-Fang Zhang, Yu Hang, Yan-Hua Shen, Shan-Fang Zhang, Wei-Ling Huang, Jing-Yi Huang, Ye-Chang Qian, Xiu-Lian Zhang, Qiu-Hong Li, Li Li
{"title":"Fuzheng Huayu recipe inhibits bleomycin-induced pulmonary fibrosis in rats by inhibiting M2 polarization of macrophages via the oxidative phosphorylation pathway.","authors":"Xing-Hua Yuan, Su-Fang Zhang, Yu Hang, Yan-Hua Shen, Shan-Fang Zhang, Wei-Ling Huang, Jing-Yi Huang, Ye-Chang Qian, Xiu-Lian Zhang, Qiu-Hong Li, Li Li","doi":"10.1080/10286020.2024.2371050","DOIUrl":"10.1080/10286020.2024.2371050","url":null,"abstract":"<p><p>Fuzheng Huayu recipe (FZHYR) is a Chinese patent medicine for the treatment of fibrosis. The effects of FZHYR on pulmonary fibrosis and macrophage polarization were investigated <i>in vitro</i>. FZHYR inhibited pulmonary inflammation and fibrosis and M2 polarization of macrophages in bleomycin-induced pulmonary fibrosis (BPF) of rat model. Differentially expressed genes were screened by high-throughput mRNA sequencing and GSEA showed that oxidative phosphorylation (OXPHOS) was correlated with BPF. FZHYR inhibited expressions of <i>Ndufa2</i> and <i>Ndufa6</i> in lung tissues of BPF rats. These findings suggest that OXPHOS pathway serves as a possible target for pulmonary fibrosis therapy by FZHYR.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New cembranoid with potent anti-inflammatory effect isolated from Boswellia sacra by inactivating the NF-κB signaling pathway. 通过使 NF-κB 信号通路失活，从乳香中分离出具有强效抗炎作用的新型cembranoid。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-07-02 DOI: 10.1080/10286020.2024.2372390
Xiao-Rong Yin, Zhen Yuan, Wei-Feng Wang, Bing-Yang Zhang, Lu-Qiong Wang, Feng Qiu, Feng Zhao
{"title":"New cembranoid with potent anti-inflammatory effect isolated from <i>Boswellia sacra</i> by inactivating the NF-κB signaling pathway.","authors":"Xiao-Rong Yin, Zhen Yuan, Wei-Feng Wang, Bing-Yang Zhang, Lu-Qiong Wang, Feng Qiu, Feng Zhao","doi":"10.1080/10286020.2024.2372390","DOIUrl":"https://doi.org/10.1080/10286020.2024.2372390","url":null,"abstract":"<p><p><i>Boswellia sacra</i> has the properties of activating blood circulation, fixing pain, subduing swelling and promoting muscle growth. However, the anti-inflammatory active ingredients and molecular mechanisms of <i>Boswellia sacra</i> are still not clearly explored. <i>Boswellia sacra</i> was grounded and extracted using 95% ethanol, the extracts were separated by column chromatography preparation to give compounds. Spectral analysis and quantum calculations confirmed the structures of compounds and identified compound <b>1</b> as a new compound. Compounds <b>1</b>-<b>3</b> showed potent inhibitory activities and their effects on inflammatory mediator NO and inflammatory cytokines were examined by ELISA assay. Furthermore, their modulatory mechanism on inflammatory signal pathways was explored.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction. 更正。
IF 1.7 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-07-01 Epub Date: 2024-03-28 DOI: 10.1080/10286020.2024.2334547
{"title":"Correction.","authors":"","doi":"10.1080/10286020.2024.2334547","DOIUrl":"10.1080/10286020.2024.2334547","url":null,"abstract":"","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140305781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new cassane diterpenoid from the seed of Caesalpinia sappan. 从 Caesalpinia sappan 种子中提取的一种新的决明二萜。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-06-30 DOI: 10.1080/10286020.2024.2360640
Yue-Lin Zhao, Yue Jin, Zi-Ying Han, Wen-Han Song, Hui-Lin Zhu, Jian Zhang, Qian Wang, Miao Wang, Xiao-Wen Jiang, Hui-Yuan Gao
{"title":"A new cassane diterpenoid from the seed of <i>Caesalpinia sappan</i>.","authors":"Yue-Lin Zhao, Yue Jin, Zi-Ying Han, Wen-Han Song, Hui-Lin Zhu, Jian Zhang, Qian Wang, Miao Wang, Xiao-Wen Jiang, Hui-Yuan Gao","doi":"10.1080/10286020.2024.2360640","DOIUrl":"https://doi.org/10.1080/10286020.2024.2360640","url":null,"abstract":"<p><p>In this study, a previously undescribed cassane diterpenoid, named caesalpinin JF (<b>1</b>), along with two known cassane diterpenoids caesanine C (<b>2</b>) and tomocinol B (<b>3</b>), was isolated from 95% EtOH extract of the seeds of <i>Caesalpinia sappan</i> Linn. Additionally, three known compounds including pulcherrin R (<b>4</b>), syringaresinol-4'-<i>O</i>-<i>β</i>-D-glucopyranoside (<b>5</b>) and kaempferol (<b>6</b>) were also identified. The structures of the isolated compounds were elucidated by comprehensive 1D and 2D NMR spectroscopic analyses. Additionally, electronic circular dichroism (ECD) calculation was used to identify the absolute structure of compound <b>1</b>. Among the isolated compounds, compound <b>1</b> displayed a potent anti-neuroinflammation with an IC<sub>50</sub> value of 9.87 ± 1.71 <i>μ</i>M.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bis-piperidine alkaloids from the peels of Areca catechu. 从Areca catechu果皮中提取的双哌啶生物碱。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-06-30 DOI: 10.1080/10286020.2024.2372383
Xia Zhang, Fang-Xin Wang, Zi-Wei Li, Song Wang, Shi-Qing Zhang, Min Song, Xiao-Qi Zhang
{"title":"Bis-piperidine alkaloids from the peels of <i>Areca catechu</i>.","authors":"Xia Zhang, Fang-Xin Wang, Zi-Wei Li, Song Wang, Shi-Qing Zhang, Min Song, Xiao-Qi Zhang","doi":"10.1080/10286020.2024.2372383","DOIUrl":"https://doi.org/10.1080/10286020.2024.2372383","url":null,"abstract":"<p><p>Four new alkaloids, arecatines A-D (<b>1</b>-<b>4</b>), were isolated from the peels of <i>Areca catechu</i>. Compound <b>1</b> is an unusual piperidine-pyridine hybrid alkaloid, whereas compounds <b>2</b>-<b>4</b> feature bis-piperidine alkaloids. Their structures were elucidated by UV, IR, HRESIMS, and NMR spectra analysis. The molecular docking analysis indicated that compound <b>3</b> exhibited the best binding affinity with the GABA<sub>A</sub> receptor, indicating its potential anti-epilepsy activity.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new canthinone glycoside isolated from the root barks of Ailanthus altissima with NO inhibitory activity 从具有 NO 抑制活性的 Ailanthus altissima 根皮中分离出一种新的 canthinone 苷。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-06-28 DOI: 10.1080/10286020.2024.2360047
{"title":"A new canthinone glycoside isolated from the root barks of Ailanthus altissima with NO inhibitory activity","authors":"","doi":"10.1080/10286020.2024.2360047","DOIUrl":"10.1080/10286020.2024.2360047","url":null,"abstract":"<div><p>One new canthinone glycoside (<strong>1</strong>), together with six known compounds (<strong>2</strong>–<strong>7</strong>) including three lignans (<strong>2</strong>–<strong>4</strong>), two coumarins (<strong>5</strong>–<strong>6)</strong> and one phenol (<strong>7)</strong> was isolated from the root barks of <em>Ailanthus altissima</em>. The structure of new compound <strong>1</strong> was established by the interpretation of UV, IR, MS and NMR data, while its absolute configuration was determined by acid hydrolysis and GIAO NMR calculations with DP4+ probability analysis. The inhibitory effects of all compounds on Nitric oxide (NO) production were investigated in lipopolysaccharide (LPS)-induced RAW 264.7 cells. Results showed that compounds <strong>2</strong> and <strong>5</strong> displayed NO production inhibitory activity with IC<sub>50</sub> values of 30.1 and 15.3 <em>μ</em>M, respectively.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancement of aqueous solubility of hesperidin and naringenin utilizing hydrotropic solubilization technique: characterization and in vitro evaluation 利用水力增溶技术提高橙皮甙和柚皮甙的水溶性：特征描述和体外评估。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-06-26 DOI: 10.1080/10286020.2024.2358831
{"title":"Enhancement of aqueous solubility of hesperidin and naringenin utilizing hydrotropic solubilization technique: characterization and in vitro evaluation","authors":"","doi":"10.1080/10286020.2024.2358831","DOIUrl":"10.1080/10286020.2024.2358831","url":null,"abstract":"<div><p>The therapeutic potential of two important flavonoids, i.e. hesperidin and naringenin, remains unutilized due to pharmacokinetics issues, especially poor aqueous solubility. Hydrotropic solid dispersions with different agents like sodium salicylate, niacinamide, benzoic acid, and urea etc. can change the solubility profile of poorly soluble drugs. The current study investigated the potential of different hydrotropic agents in improving the solubility of both natural bioactives. The hydrotropic solid dispersion in 1:3 w/w drug: sodium salicylate ratio showed maximum solubility and dissolution amongst all the tested hydrotropes. This novel and economical approach could be explored for other poorly soluble pharmaceuticals.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design, synthesis and biological activity of oxyevodiamine-based histone deacetylase 6 inhibitors 基于氧代乙二胺的组蛋白去乙酰化酶 6 抑制剂的设计、合成和生物活性。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-06-26 DOI: 10.1080/10286020.2024.2362383
{"title":"Design, synthesis and biological activity of oxyevodiamine-based histone deacetylase 6 inhibitors","authors":"","doi":"10.1080/10286020.2024.2362383","DOIUrl":"10.1080/10286020.2024.2362383","url":null,"abstract":"<div><div>Histone deacetylase 6 (HDAC6) was a potential target for Alzheimer’s disease (AD). In this study, a series of novel oxyevodiamine-based HDAC6 inhibitors with a variety of linker moieties were designed, synthesized and evaluated. Compound <strong>12</strong> with a benzyl linker was identified as a high potent and selective HDAC6 inhibitor. It inhibited HDAC6 with an IC<sub>50</sub> value of 6.2 nM and was more than 200 fold selectivity over HDAC1. It also had lower cytotoxicity and higher anti-H<sub>2</sub>O<sub>2</sub> activity <em>in vitro</em> comparing with other derivatives. Compound <strong>12</strong> might be a good lead as novel HDAC6 inhibitor for the treatment of AD.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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