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Journal of Asian Natural Products Research最新文献

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Two undescribed bisabolane-type sesquiterpenoids from the endophytic fungus Penicillium herquei. 来自内生真菌青霉菌的两个未描述的双abolane型倍半萜类。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-07-16 DOI: 10.1080/10286020.2026.2701131
Yi-Yang Xiong, Lin-Lin Li, Jing Huang, Meng-Yi Deng, Xian-Li Zhou
{"title":"Two undescribed bisabolane-type sesquiterpenoids from the endophytic fungus <i>Penicillium herquei</i>.","authors":"Yi-Yang Xiong, Lin-Lin Li, Jing Huang, Meng-Yi Deng, Xian-Li Zhou","doi":"10.1080/10286020.2026.2701131","DOIUrl":"https://doi.org/10.1080/10286020.2026.2701131","url":null,"abstract":"<p><p>Sixteen compounds, including two undescribed bisabolane-type sesquiterpenoids (<b>1</b>, <b>2</b>), four aromatic derivatives (<b>3</b>-<b>6</b>), two cyclopeptides (<b>7</b>, <b>8</b>), two acyclic sesquiterpenes (<b>9</b>-<b>10</b>), four fatty acid esters (<b>11</b>-<b>14</b>) and two fatty acids (<b>15</b>-<b>16</b>), were separated from the endophytic fungus <i>Penicillium herquei</i>. Their structures were established by analysis of spectroscopic data, HRESIMS spectra, NMR data and comparison with data in relevant literature. It is the first time that all of these compounds were isolated from <i>P. herquei</i>. The <i>in vitro</i> cytotoxicity of all isolated was evaluated against four tumor cell lines (HCT116, A549, HeLa, and Hepg2 cells) by the MTT assay, and compounds <b>1</b>, <b>2</b>, <b>4</b>, <b>7</b> and <b>8</b> exhibited cytotoxicity with IC<sub>50</sub> values ranging from 9.7 ± 0.8 to 37.4 ± 2.5 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148455928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three new steroidal alkaloids from the whole plants of Sarcococca ruscifolia. 三种新甾体生物碱的全株提取。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-07-15 DOI: 10.1080/10286020.2026.2697865
Yong-Jin Ye, Xiao-Hui Sun, Gang Ke, Pu-Zhao Zhang, Ya-Mei Zhang
{"title":"Three new steroidal alkaloids from the whole plants of <i>Sarcococca ruscifolia</i>.","authors":"Yong-Jin Ye, Xiao-Hui Sun, Gang Ke, Pu-Zhao Zhang, Ya-Mei Zhang","doi":"10.1080/10286020.2026.2697865","DOIUrl":"https://doi.org/10.1080/10286020.2026.2697865","url":null,"abstract":"<p><p>ABETRACTThree previously undescribed steroidal alkaloids, 20<i>α-N,N-</i>dimethylamino<i>-</i>2<i>β-</i>hydroxy<i>-</i>3<i>α-</i>senecioylamino<i>-</i>5<i>α-</i>pregnane (<b>1</b>), 20<i>α-N,N-</i>dimethylamino<i>-</i>2<i>β,</i>4<i>α-</i>dihydroxy<i>-</i>3<i>α-</i>senecioylamino<i>-</i>5<i>α-</i>pregnane (<b>2</b>) and 20<i>α-N,N-</i>dimethylamino-2<i>β</i>,15<i>α</i>-dihydroxy-3<i>α</i>-senecioylamino-5<i>α</i>-pregn-16-ene (<b>3</b>), were isolated from the whole plants of <i>Sarcococca ruscifolia</i>. Their structures were determined through the analysis of physiochemical properties and spectroscopic data. Compound <b>1</b> showed a certain inhibitory effect on human glioma U251 cells with an IC<sub>50</sub> value of 13.51 <i>μ</i>M.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148446874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breviscapine alleviates liver fibrosis by inhibiting epithelial-mesenchymal transition via TGF-beta1/Smad3 pathway. 灯盏花素通过tgf - β 1/Smad3途径抑制上皮-间质转化，减轻肝纤维化。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-07-14 DOI: 10.1080/10286020.2026.2697867
Xiu-Hong Zhong, Yao Li, Yu-Kun Song, Yan-Mei Sun, Dong-Fang Zhang, Hai-Chao Ge, Ying-Li He
{"title":"Breviscapine alleviates liver fibrosis by inhibiting epithelial-mesenchymal transition via TGF-beta1/Smad3 pathway.","authors":"Xiu-Hong Zhong, Yao Li, Yu-Kun Song, Yan-Mei Sun, Dong-Fang Zhang, Hai-Chao Ge, Ying-Li He","doi":"10.1080/10286020.2026.2697867","DOIUrl":"https://doi.org/10.1080/10286020.2026.2697867","url":null,"abstract":"<p><p>Liver fibrosis may develop into cirrhosis and liver cancer, lacking effective approved treatments. Breviscapine extracted from <i>Erigeron breviscapus</i> possesses low toxicity and favorable pharmacokinetics, yet its anti-fibrotic mechanisms remain unclear. This study verified its protective effects on cell and rat fibrosis models. It suppresses HSC activation and ECM accumulation by inhibiting TGF-β1/Smad3 pathway, reversing EMT. Breviscapine is a promising candidate for hepatic fibrosis therapy.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-24"},"PeriodicalIF":1.6,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148446915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New compounds from the leaves of Coriaria nepalensis. 尼泊尔芫荽叶中的新化合物。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-07-06 DOI: 10.1080/10286020.2026.2687569
Rui Ke, Hai-Qiang Wang, Cheng-Yong Tan, Mi Li, Shi-Shan Yu
{"title":"New compounds from the leaves of <i>Coriaria nepalensis</i>.","authors":"Rui Ke, Hai-Qiang Wang, Cheng-Yong Tan, Mi Li, Shi-Shan Yu","doi":"10.1080/10286020.2026.2687569","DOIUrl":"https://doi.org/10.1080/10286020.2026.2687569","url":null,"abstract":"<p><p>Four undescribed compounds, including one new sesquiterpene lactone (<b>1</b>, coriarilactone A), two new phenylpropanoid glycosides (<b>2</b> and <b>3</b>, corianosides A and B), and one new coumarin (<b>4</b>, coriacoumarin A), together with five known sesquiterpenes, were isolated from the leaves of the toxic medicinal plant <i>Coriaria nepalensis.</i> The structures of <b>1-4</b> were elucidated through a combination of extensive NMR spectroscopic analysis, HRESIMS, and X-ray crystallography. Notably, compounds <b>2-3</b> possess a rare heptose moiety, which were isolated from the Coriariaceae family for the first time. Compound <b>1</b> exhibited potential neuroprotective activity. All compounds showed no convulsant neurotoxicity and no remarkable inhibitory activity toward four human cancer cell lines.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.6,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148390874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concise total synthesis of coerulescine by Cu(I)-catalyzed tandem reaction. Cu(I)催化串联反应简捷全合成蓝胺。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-07-05 DOI: 10.1080/10286020.2026.2695175
Bo-Qin Zi, Qiu-Ting Yang, Tian-Feng Peng, Tao Lv, Yu-Xiang Zhao, Xian-Fu Shen
{"title":"Concise total synthesis of coerulescine by Cu(I)-catalyzed tandem reaction.","authors":"Bo-Qin Zi, Qiu-Ting Yang, Tian-Feng Peng, Tao Lv, Yu-Xiang Zhao, Xian-Fu Shen","doi":"10.1080/10286020.2026.2695175","DOIUrl":"https://doi.org/10.1080/10286020.2026.2695175","url":null,"abstract":"<p><p>Herein, we disclosed a concise total synthesis of indole alkaloid coerulescine via a novel copper(I)-catalyzed tandem reaction of chiral <i>tert</i>-butanesulfinyl amide <i>o</i>-iodoanilide derivative with methyl chloroformate as the electrophile reagent to afford the quaternary carbon stereocenter efficiently, followed by hydrolysis of the <i>tert</i>-butanesulfinyl group and a tandem ammonolysis process to give the key spiro[pyrrolidine-3,3'-oxindole] core of the coerulescine alkaloids.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.6,"publicationDate":"2026-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148390827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of bergapten-loaded long-circulating liposomes on osteogenic differentiation of human dental pulp stem cells. 载bergapten长循环脂质体对人牙髓干细胞成骨分化的影响。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-07-01 Epub Date: 2025-10-29 DOI: 10.1080/10286020.2025.2575989
Hao-Nan Ding, Xu-Wen Wang, Yu-Xin Qian, Ke Liu, Lei Jin
{"title":"Effects of bergapten-loaded long-circulating liposomes on osteogenic differentiation of human dental pulp stem cells.","authors":"Hao-Nan Ding, Xu-Wen Wang, Yu-Xin Qian, Ke Liu, Lei Jin","doi":"10.1080/10286020.2025.2575989","DOIUrl":"10.1080/10286020.2025.2575989","url":null,"abstract":"<p><p>Bergapten is a natural compound with the potential to regenerate bone. However, its poor solubility and instability hinder its clinical use. We developed bergapten-loaded long-circulating liposomes (BP-LCL) to overcome these challenges. The liposomes were spherical, stable, and highly effective at delivering bergapten. We found that BP-LCL were biocompatible and enhanced the osteogenic differentiation of human dental pulp stem cells. It did this by increasing key markers like RUNX2, COL1, and OCN, and by activating the Wnt/β-catenin signaling pathway. This study suggested that BP-LCL could be a promising new approach for bone regeneration settings.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1033-1050"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145400794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modulation of gut microbiota composition by three traditional mineral medicines in mice. 三种传统矿质药对小鼠肠道菌群组成的调节作用。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-07-01 Epub Date: 2025-10-08 DOI: 10.1080/10286020.2025.2564412
Meng-Jie Li, Na Li, Yang-Yang Dong, Ling-Li Wu, Hong-Lin Zhang, Xuan-Chen Chen, Dong-Rui Zhou
{"title":"Modulation of gut microbiota composition by three traditional mineral medicines in mice.","authors":"Meng-Jie Li, Na Li, Yang-Yang Dong, Ling-Li Wu, Hong-Lin Zhang, Xuan-Chen Chen, Dong-Rui Zhou","doi":"10.1080/10286020.2025.2564412","DOIUrl":"10.1080/10286020.2025.2564412","url":null,"abstract":"<p><p>Traditional Chinese medicine (TCM) formulations rely on syndrome differentiation and empirical knowledge, lacking modern scientific support. This study examined the modulation of three mineral medicines-Halloysitum Album (HA), Calcaribus Loess Nodus (CLN), and Smectite (SMT)-on murine gut microbiota using 16S rRNA sequencing, to develop TCM formulations targeting specific beneficial bacteria. HA selectively promoted <i>Faecalibacterium rodentium</i>, CLN enhanced the probiotic <i>Lactobacillus reuteri</i>, while SMT specifically stimulated <i>Roseburia</i> proliferation. Mechanistic studies revealed that SMT modulated microbiota via biofilm formation. These findings suggest that formulating TCM compounds targeting beneficial intestinal bacteria could provide new theoretical support for TCM compatibility principles.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1051-1065"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolation and structural characterization of an iridoid glycoside and a pyridine derivative, both previously undescribed, from the flowers of Rhododendron decorum. 从杜鹃（Rhododendron decorum）花中分离出一种环烯醚萜苷和一种吡啶衍生物并进行结构表征。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-07-01 Epub Date: 2025-10-29 DOI: 10.1080/10286020.2025.2577288
Zhang Hou-Run, Cheng Qi, Dong-Bao Hu, Ji-Ai Wang, Xiu Chen, Bi Xiao-Xu, Jiang-Bo He, Ying Wang
{"title":"Isolation and structural characterization of an iridoid glycoside and a pyridine derivative, both previously undescribed, from the flowers of <i>Rhododendron decorum</i>.","authors":"Zhang Hou-Run, Cheng Qi, Dong-Bao Hu, Ji-Ai Wang, Xiu Chen, Bi Xiao-Xu, Jiang-Bo He, Ying Wang","doi":"10.1080/10286020.2025.2577288","DOIUrl":"10.1080/10286020.2025.2577288","url":null,"abstract":"<p><p>An iridoid glycoside, rhododeoside C (<b>1</b>), and a pyridine derivative, rhododeodine A (<b>2</b>), both previously undescribed, were isolated from the flowers of <i>Rhododendron decorum</i>. The structures were elucidated using 1D and 2D NMR spectroscopy, along with high-resolution electrospray ionization mass spectrometry (HRESIMS). The absolute configurations of both compounds were unambiguously assigned using electronic circular dichroism (ECD) computational methods. Furthermore, all isolated compounds were assessed for their cytotoxic activities against HepG2 and HeLa cell lines.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"997-1006"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145400875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two new polyacetylenes from Bidens parviflora. 两种新聚乙炔来自小花拜登。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-07-01 Epub Date: 2025-11-06 DOI: 10.1080/10286020.2025.2575981
Chuan-Hou Li, Guang-Hui Jiang, Jing-Chun Yao, Hong-Lei Zhou, Hai-Qiang Jiang, Xiao-Jin Liu, Xiao-Qian Ma, Ya-Ning Li, Lian-Guang Huo, Li-Xing Zhang, Tao Shen
{"title":"Two new polyacetylenes from <i>Bidens parviflora</i>.","authors":"Chuan-Hou Li, Guang-Hui Jiang, Jing-Chun Yao, Hong-Lei Zhou, Hai-Qiang Jiang, Xiao-Jin Liu, Xiao-Qian Ma, Ya-Ning Li, Lian-Guang Huo, Li-Xing Zhang, Tao Shen","doi":"10.1080/10286020.2025.2575981","DOIUrl":"10.1080/10286020.2025.2575981","url":null,"abstract":"<p><p>Two novel polyacetylenic compounds were successfully separated from the dichloromethane extract of the aerial parts of <i>Bidens parviflora</i> Willd., known for its ethnomedicinal use in traditional Dai medicine. These compounds were structurally elucidated and identified as (2<i>R</i>)-trideca-3<i>E</i>,5<i>Z</i>,11<i>E</i>-triene-7,9-diyne-1,2,13-triol (<b>1</b>), and (2<i>R</i>)-trideca-11<i>E</i>-ene-5,7,9-triyne-1,2,13-triol (<b>2</b>). Their chemical structures were confirmed through a comprehensive analysis involving ultraviolet (UV) spectroscopy, infrared (IR) spectroscopy, high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), as well as detailed one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopic data, and measurements of specific optical rotation.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1007-1014"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145451795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Secondary metabolites with anti-inflammatory activity isolated from a marine-derived fungus Biscogniauxia sp. 8703. 海洋真菌Biscogniauxia sp. 8703中具有抗炎活性的次级代谢物。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-07-01 Epub Date: 2025-11-09 DOI: 10.1080/10286020.2025.2576000
Li Zheng, Qing-Mei He, Dan He, Sen-Hua Chen, Qi-Lin Wu, Guang-Yuan Luo, Jun Chen, Heng Guo, Zhi-Bo Hu, Li-Tong Chen, Lan Liu, Jing Li
{"title":"Secondary metabolites with anti-inflammatory activity isolated from a marine-derived fungus <i>Biscogniauxia</i> sp. 8703.","authors":"Li Zheng, Qing-Mei He, Dan He, Sen-Hua Chen, Qi-Lin Wu, Guang-Yuan Luo, Jun Chen, Heng Guo, Zhi-Bo Hu, Li-Tong Chen, Lan Liu, Jing Li","doi":"10.1080/10286020.2025.2576000","DOIUrl":"10.1080/10286020.2025.2576000","url":null,"abstract":"<p><p>Four new compounds (<b>1</b>-<b>4</b>), along with 22 known metabolites (<b>5</b>-<b>26</b>), were isolated from the fungus <i>Biscogniauxia</i> sp. 8703. The structures of the new compounds were elucidated based on NMR, MS, and ECD analysis. Compounds <b>1</b> and <b>2</b> were identified as heliannuol D analogs, which exhibited anti-inflammatory activity by inhibiting NO production in LPS-induced RAW 264.7 cell, with IC<sub>50</sub> values of 7.14 and 25.25 <i>μ</i>M, respectively.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"984-996"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145481865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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