Da-Min Jung , Sangsoo Lee , Eun-Mi Kim , Chong Won Choi , Kee K. Kim
{"title":"Mangiferin, a component of Mangifera indica leaf extracts, inhibits lipid synthesis in human sebocytes","authors":"Da-Min Jung , Sangsoo Lee , Eun-Mi Kim , Chong Won Choi , Kee K. Kim","doi":"10.1080/10286020.2024.2369279","DOIUrl":"10.1080/10286020.2024.2369279","url":null,"abstract":"<div><div>Inhibition of lipid synthesis in sebocytes is essential for acne treatments. The effects of natural product-derived substances on lipid synthesis are unknown. This study investigated the effects of water extract of <em>Mangifera indica</em> leaves (WEML) on lipid synthesis in human sebocytes. Sebocyte differentiation in low serum conditions increased lipid accumulation and proliferator-activated receptor γ expression. WEML treatment significantly inhibited lipid accumulation and adipogenic mRNA expression in sebocytes. Mangiferin, a bioactive compound in WEML, also reduced lipid accumulation and adipogenic mRNA expression via the AKT pathway. Thus, WEML and mangiferin effectively inhibit lipid synthesis in sebocytes, showing promise for acne treatment.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 12","pages":"Pages 1489-1501"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Survey of natural products reported by Asian research groups in 2023","authors":"Yan-Fei Liu , Shi-Shan Yu","doi":"10.1080/10286020.2024.2412762","DOIUrl":"10.1080/10286020.2024.2412762","url":null,"abstract":"<div><div>The new natural products reported in 2023 in peer-reviewed articles in journals with good reputations were reviewed and analyzed. The advances made by Asian research groups in the field of natural products chemistry in 2023 were summarized. Compounds with unique structural features and/or promising bioactivities originating from Asian natural sources were discussed based on their structural classification.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 12","pages":"Pages 1389-1404"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Han Qiu , Sheng-Nan Zhao , Jin-Ling Han , Miao Yu , Ruo-Di Wang , Jing-Ru Fang , Yan-Zhu Luo , Ling-Juan Zhu , Xin-Sheng Yao
{"title":"Exploring the mechanism of Si-Miao-Yong-An decoction on heart failure based on molecular docking and network pharmacology","authors":"Han Qiu , Sheng-Nan Zhao , Jin-Ling Han , Miao Yu , Ruo-Di Wang , Jing-Ru Fang , Yan-Zhu Luo , Ling-Juan Zhu , Xin-Sheng Yao","doi":"10.1080/10286020.2024.2370409","DOIUrl":"10.1080/10286020.2024.2370409","url":null,"abstract":"<div><div>The SwissTargetPrediction was employed to predict the potential drug targets of the active component of Si-Miao-Yong-An decoction (SMYAD). The therapeutic targets for HF were searched in the Genecard database, and Cytoscape3.9.1 software was used to construct the \"drug-component-target-disease network\" diagram. In addition, the String platform was used to construct Protein-Protein Interaction (PPI) network, and the DAVID database was used for GO and KEGG analysis. AutoDockTools-1.5.6 software was used for molecular docking verification. Network pharmacology studies have shown that AKT 1, ALB, and CASP 3 are the key targets of action of SMYAD against heart failure. The active compounds are quercetin and kaempferol.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 12","pages":"Pages 1502-1529"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhang Hui , Wang Lai-Fa , Wang Xue-Qin , Deng Ling , He Bin-Sheng , Jian-Ming Li
{"title":"Mechanisms and therapeutic potential of chinonin in nervous system diseases","authors":"Zhang Hui , Wang Lai-Fa , Wang Xue-Qin , Deng Ling , He Bin-Sheng , Jian-Ming Li","doi":"10.1080/10286020.2024.2371040","DOIUrl":"10.1080/10286020.2024.2371040","url":null,"abstract":"<div><div>The flavonoid compound chinonin is one of the main active components of <em>Rhizoma anemarrhena</em> with multiple activities, including anti-inflammatory and antioxidant properties, protection of mitochondrial function and regulation of immunity. In this paper, we reviewed recent research progress on the protective effect of chinonin on brain injury in neurological diseases. “Chinonin” OR “Mangiferin” AND “Nervous system diseases” OR “Neuroprotection” was used as the terms for search in PumMed. After discarding duplicated and irrelevant articles, a total of 23 articles relevant to chinonin published between 2012 and 2023 were identified in our study.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 12","pages":"Pages 1405-1420"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natthaphitcha Khunsantiphong , May Thazin Thant , Chattarika Pengdee , Thanarat Salahong , Hnin Ei Ei Khine , Pithi Chanvorachote , Chatchai Chaotham , Boonchoo Sritularak
{"title":"A new phenanthrene with a spirolactone ring from Dendrobium ochreatum","authors":"Natthaphitcha Khunsantiphong , May Thazin Thant , Chattarika Pengdee , Thanarat Salahong , Hnin Ei Ei Khine , Pithi Chanvorachote , Chatchai Chaotham , Boonchoo Sritularak","doi":"10.1080/10286020.2024.2368831","DOIUrl":"10.1080/10286020.2024.2368831","url":null,"abstract":"<div><div>Dendroochreatene (<strong>1</strong>), a new phenanthrene derivative with a spirolactone ring, was isolated from the whole <em>Dendrobium ochreatum</em> plant together with 11 known compounds (<strong>2</strong>–<strong>12</strong>). The structure of the new compound was elucidated spectroscopically and phenolic compounds were firstly reported from <em>D. ochreatum.</em> Moscatilin (<strong>4</strong>), major compound isolated from <em>D. ochreatum,</em> was found to be cytotoxic toward H460 lung-cancer cells, with an IC<sub>50</sub> value of 147.3 ± 0.9 µM, while loddigesiinol C (<strong>7</strong>), C-<em>α</em>-methoxy derivative was inactive.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 12","pages":"Pages 1543-1550"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141432046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jing-Rong Li , Ling-Yu Li , Hai-Xin Zhang , Ming-Qin Zhong , Zhong-Mei Zou
{"title":"Atramacronoid A induces the PANoptosis-like cell death of human breast cancer cells through the CASP-3/PARP-GSDMD-MLKL pathways","authors":"Jing-Rong Li , Ling-Yu Li , Hai-Xin Zhang , Ming-Qin Zhong , Zhong-Mei Zou","doi":"10.1080/10286020.2024.2368841","DOIUrl":"10.1080/10286020.2024.2368841","url":null,"abstract":"<div><div>Breast cancer is the most common malignant tumor and a major cause of mortality among women worldwide. Atramacronoid A (AM-A) is a unique natural sesquiterpene lactone isolated from the rhizome of <em>Atractylodes macrocephala</em> Koidz (known as Baizhu in Chinese). Our study demonstrated that AM-A triggers a specific form of cell death resembling PANoptosis-like cell death. Further analysis indicated that AM-A-induced PANoptosis-like cell death is associated with the CASP-3/PARP-GSDMD-MLKL pathways, which are mediated by mitochondrial dysfunction. These results suggest the potential of AM-A as a lead compound and offer insights for the development of therapeutic agents for breast cancer from natural products.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 12","pages":"Pages 1475-1488"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bao Zhang , Hai-Hua Yuan , Jia Sun , Hang Xun , Jie Wang , Feng Qiu , Jian-Jun Wang , Xi Yao , Jin Wang , Wei Fan , Feng Tang
{"title":"Five new glycosides from the culms of Phyllostachys nigra var. henonis","authors":"Bao Zhang , Hai-Hua Yuan , Jia Sun , Hang Xun , Jie Wang , Feng Qiu , Jian-Jun Wang , Xi Yao , Jin Wang , Wei Fan , Feng Tang","doi":"10.1080/10286020.2024.2366450","DOIUrl":"10.1080/10286020.2024.2366450","url":null,"abstract":"<div><div>Five new glycosides, namely methyl 3-methoxybenzoate-4,5-di-<em>O</em>-<em>β</em>-D-glucopyranoside <strong>(1)</strong>, (1a<em>S</em>,3a<em>S</em>,3<em>R</em>)-3-(4’-<em>O</em>-<em>β</em>-D-glucopyranosyl-3’-methoxyphenyl)-5,6-dioxa-bicyclo[3.3.0]octane-1-one <strong>(2)</strong>, quinolin-4(1<em>H</em>)-one-3-<em>O</em>-<em>β</em>-D-glucopyranoside <strong>(3)</strong>, 3-methoxy-propiophenone 4-<em>O</em>-(6’-<em>β</em>-D-xylopyranosyl)-<em>β</em>-D-glucopyranoside <strong>(4)</strong>, methyl 3-methoxybenzoate 4-<em>O</em>-(6’-<em>β</em>-D-xylopyranosyl)-<em>β</em>-D-glucopyranoside <strong>(5)</strong>, and one known compound, bambulignan B <strong>(6)</strong> were isolated from the culms of <em>Phyllostachys nigra</em> var<em>. henonis</em>. Their structures were determined using spectroscopic analysis. All compounds were evaluated for their DPPH radical scavenging activity. Compound <strong>6</strong> exhibited antioxidant activity with IC<sub>50</sub> value of 59.5 μM (positive control, L-ascorbic acid, IC<sub>50</sub> = 12.4 μM; 2,6-ditertbutyl-4-methyl phenol, IC<sub>50</sub> = 11.8 μM).</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 12","pages":"Pages 1421-1429"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hui Li , Wen-Shuo Zhang , Rui Liu , Wei Wang , Li-Li Jiao , Zhi Liu , Wei Wu
{"title":"Impact of radish seeds (Semen Raphani) on the absorption and transportation of ginsenosides in the Caco-2 cell model: a UPLC-ESI-MS analysis","authors":"Hui Li , Wen-Shuo Zhang , Rui Liu , Wei Wang , Li-Li Jiao , Zhi Liu , Wei Wu","doi":"10.1080/10286020.2024.2366008","DOIUrl":"10.1080/10286020.2024.2366008","url":null,"abstract":"<div><div>This study examined the impact of Semen raphani on the absorption of ginsenosides from <em>Panax ginseng</em> C.A. Meyer (ginseng) using a Caco-2 cell model and Ultra-High-Performance Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry (UPLC-ESI-MS). Six primary ginsenosides (Rg1, Re, Rb1, Rb2, Rc, Rd) were quantified. Results showed that Semen Raphani increased the efflux rate of ginsenosides, particularly at higher concentrations, suggesting it inhibits their absorption. The research elucidates the intestinal absorption process of ginsenosides and the antagonistic mechanism of Semen Raphani against ginseng.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 12","pages":"Pages 1430-1444"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Li Liao, Na Wang, Ling Mei, Bin Long, Tong Luo, Meng-Qi Wang, Lan Lu, Hong-Bo Dong
{"title":"Total synthesis and antibacterial evaluation of lupalbigenin and isolupalbigenin.","authors":"Li Liao, Na Wang, Ling Mei, Bin Long, Tong Luo, Meng-Qi Wang, Lan Lu, Hong-Bo Dong","doi":"10.1080/10286020.2024.2428794","DOIUrl":"https://doi.org/10.1080/10286020.2024.2428794","url":null,"abstract":"<p><p>Lupalbigenin (<b>1</b>) is an antibacterial isoflavone isolated from <i>Maclura cochinchinensis</i> (Lour.) Corner (Moraceae). In this study, we achieved the first gram-scale synthesis of lupalbigenin (<b>1</b>) from commercially available genistein (<b>2</b>), with a yield of 47.7%. The key step was a Claisen rearrangement that simultaneously installed two prenyl groups at the C-6 and C-11 positions of lupalbigenin (<b>1</b>). Antimicrobial activity assays revealed that lupalbigenin (<b>1</b>) exhibited rapid bactericidal activity, inhibited α-hemolysin and biofilm formation, and disrupted bacterial cell membranes. These findings suggest that lupalbigenin (<b>1</b>) is a promising candidate for the development of novel antibiotics to combat bacterial infections.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Discovery of two new long chain fatty acid esters of flavonol glycoside from Pollen Typhae Carbonisatus and their protective effects on HBMECs.","authors":"Min-Jie Liu, Dong-Quan Gu, Ren-Zhong Wang, Kai-Di Wang, Si-Yu Wu, Shuang Han, De-Ling Wu, Feng-Qing Xu, Wu-Xi Zhou","doi":"10.1080/10286020.2024.2428238","DOIUrl":"https://doi.org/10.1080/10286020.2024.2428238","url":null,"abstract":"<p><p>ABATRACTTwo new compounds, namely, isorhamnenin-3-<i>O</i>-neohesperidin-6''-linoleic acid ester (<b>1</b>) and isorhamnenin-3-<i>O</i>-neohesperidin-6''-palmitate (<b>2</b>), along with 17 known compounds, were isolated from Pollen Typhae Carbonisatus (PTC). Their structures were elucidated on the basis of one-dimensional (1D)-, two-dimensional (2D)-nuclear magnetic resonance (NMR), and high-resolution electrospray ionization mass spectrometry (HRESIMS) spectroscopic data analyses. The two new compounds (<b>1</b> and <b>2</b>) exhibited a protective effect in a dose-dependent manner and promoted tube generation in the oxygen-glucose deprivation/reoxygenation (OGD/R)-induced human brain microvascular endothelial cells (HBMECs).</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}