Cynatroside B2，一种新的抗炎甾体C21，从白花长春花根和根茎中提取。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-01-10 DOI:10.1080/10286020.2024.2446302

Jing-Yu Zhang, Yi-Nuo Shi, Sheng Dong, Chen Ji, Yang Yu, Jiu-Zhi Yuan, Chong-Ning Lv, Jin-Cai Lu

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引用次数: 0

摘要

从白花长春花（Vincetoxicum atratum (Bunge) C. Morren et Decne）的根和根茎中分离到一系列C21甾体苷。，包括一个新的化合物，cynatroside B2(1)和七个已知的化合物（2-8）。通过NMR和HR-ESI-MS光谱数据对其结构进行了鉴定。研究了分离的类固醇对脂多糖诱导的小鼠巨噬细胞RAW264.7细胞的抗炎活性。化合物1对NO、TNF-α、IL-1β均有明显抑制作用。

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Cynatroside B₂, a new anti-inflammatory C₂₁ steroid from the roots and rhizomes of Vincetoxicum atratum.

A series of C₂₁ steroidal glycosides were isolated from the roots and rhizomes of Vincetoxicum atratum (Bunge) C. Morren et Decne., including a new compound, cynatroside B₂ (1), and seven known compounds (2-8). Their structures were identified by comprehensive spectroscopic analyses, including NMR and HR-ESI-MS spectral data. The isolated steroids were evaluated for their anti-inflammatory activity against lipopolysaccharide-induced mouse macrophage RAW264.7 cells. Compound 1 displayed a significant inhibitory effect on NO, TNF-α and IL-1β.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.