Qian Wang, Xiao-Ying Wang, Jin Tao, Jin-Tao Nie, Yi-Han Zhou, Jing Huang, Jia-Yuan Zhao, Ya-Nan Wang
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Exploring the potential anticancer targets and mechanistic pathways of Elsholtzia densa essential oil based on network pharmacology.
This study aimed to assess the composition of Elsholtzia densa essential oil (EBE) and identify potential targets for inhibiting human hepatocellular carcinoma cell proliferation. The plants were collected from four regions: Jiuzhi, Qinghai; Ruoergai, Sichuan; Aba, Sichuan; and Jiulong, Sichuan. Four EBEs (named No. 1 to No. 4) were analyzed by gas chromatograph-mass spectrometer. EBEs significantly inhibited human hepatocellular carcinoma cells. The EBE collected from Jiuzhi exhibited the most potent inhibitory effect. Core targets identified included MAPK3, EGFR, ESR1, CASP3, PTGS2, BCL2L1, and MAPK14. Notably, the four EBEs prevented hepatocellular carcinoma cell proliferation via neuroactive ligand-receptor interactions and apoptosis pathways.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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