香豆果通过激活Nrf2/Keap1信号通路减轻高糖诱导的雪旺细胞损伤和氧化应激。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-01-31 DOI:10.1080/10286020.2025.2451340

Jin-Gui Zhang, Jin-Ping Cai, Yu-Xia Wu, Jia-Liang Guo, Yu-Qing Li, Chao Wang

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引用次数: 0

摘要

我们研究了虎爪果（PTF）对糖尿病周围神经病变（DPN）大鼠雪旺细胞和坐骨神经损伤的保护作用。PTF提高RSC96细胞活力，增加Nrf2、Keap1、HO-1和NQO1的表达。PTF减少高糖处理细胞的凋亡和ROS，这一作用被Nrf2 siRNA逆转。与SFN共处理进一步减少细胞凋亡和ROS。PTF增加SOD、GSH-Px、NGF、IGF-1和VEGF活性，Nrf2敲除使其活性降低，SFN使其活性恢复。MDA水平呈现相反的趋势。在DPN大鼠中，PTF减轻疼痛并防止神经损伤，表明它通过激活Nrf2/Keap1通路减轻DPN。

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Pandanus tectorius fruits attenuated cell injury and oxidative stress in high glucose-induced Schwann cells by activating Nrf2/Keap1 signaling pathway.

We studied the protective effects of Pandanus tectorius fruits (PTF) on Schwann cells and sciatic nerve damage in diabetic peripheral neuropathy (DPN) rats. PTF improved RSC96 cell viability and increased Nrf2, Keap1, HO-1, and NQO1 expression. PTF reduced apoptosis and ROS in high glucose-treated cells, which was reversed by Nrf2 siRNA. Co-treatment with SFN further decreased apoptosis and ROS. PTF increased SOD, GSH-Px, NGF, IGF-1, and VEGF activities, reduced by Nrf2 knockdown but restored with SFN. MDA levels showed opposite trends. In DPN rats, PTF reduced pain and prevented nerve damage, suggesting it alleviates DPN by activating the Nrf2/Keap1 pathway.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.