Pandanus tectorius fruits attenuated cell injury and oxidative stress in high glucose-induced Schwann cells by activating Nrf2/Keap1 signaling pathway.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-01-31 DOI:10.1080/10286020.2025.2451340

Jin-Gui Zhang, Jin-Ping Cai, Yu-Xia Wu, Jia-Liang Guo, Yu-Qing Li, Chao Wang

引用次数: 0

Abstract

We studied the protective effects of Pandanus tectorius fruits (PTF) on Schwann cells and sciatic nerve damage in diabetic peripheral neuropathy (DPN) rats. PTF improved RSC96 cell viability and increased Nrf2, Keap1, HO-1, and NQO1 expression. PTF reduced apoptosis and ROS in high glucose-treated cells, which was reversed by Nrf2 siRNA. Co-treatment with SFN further decreased apoptosis and ROS. PTF increased SOD, GSH-Px, NGF, IGF-1, and VEGF activities, reduced by Nrf2 knockdown but restored with SFN. MDA levels showed opposite trends. In DPN rats, PTF reduced pain and prevented nerve damage, suggesting it alleviates DPN by activating the Nrf2/Keap1 pathway.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.