Jie-Yi Zhou, Chen-Yang Cui, Li-Na Mao, Qun Zhou, Zhi-Ping Wang
{"title":"从西兰花青霉菌G2131中分离出一个新的甾体。","authors":"Jie-Yi Zhou, Chen-Yang Cui, Li-Na Mao, Qun Zhou, Zhi-Ping Wang","doi":"10.1080/10286020.2025.2451332","DOIUrl":null,"url":null,"abstract":"<p><p>A comprehensive study was carried out on <i>Penicillium brocae</i> G2131, which originated from Yunnan Menghai Pu'er tea. This study resulted in the identification of five compounds, one of which is a newly discovered compound: (5aR)-6-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-5a-methyl-5,5a,6,7,8,8a-hexa hydro-2H-indeno[5,4-b]furan-2-one (<b>1</b>), four known compounds: demethylincisterol A<sub>3</sub> (<b>2</b>), (22<i>E</i>, 24 <i>R</i>)-ergosta-7,9(11),22-trien-3<i>β</i>-ol (<b>3</b>), (22<i>E</i>,24<i>R</i>)-5<i>α</i>,8<i>α</i>-epidixyer-gosta-6,22-dien-3<i>β</i>-ol (<b>4</b>) and <i>p</i>- hydroxybenzaldehyde (<b>5</b>). The structure of compound <b>1</b> was determined using a variety of spectroscopic methods such as <sup>1</sup>H spectrum,<sup>13</sup>C spectrum, HMBC, HSQC,<sup>1</sup>H-<sup>1</sup>H COSY, LC-MS, UV, IR and comparison of their NMR data with literature. The absolute configuration of compound <b>1</b> was established by comparing the experimental and ECD spectra. All compounds were tested for their anti-acetylcholine activity, however, none of them demonstrated any anti-acetylcholine activity.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1215-1221"},"PeriodicalIF":1.3000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A new steroid from <i>Penicillium brocae</i> G2131.\",\"authors\":\"Jie-Yi Zhou, Chen-Yang Cui, Li-Na Mao, Qun Zhou, Zhi-Ping Wang\",\"doi\":\"10.1080/10286020.2025.2451332\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A comprehensive study was carried out on <i>Penicillium brocae</i> G2131, which originated from Yunnan Menghai Pu'er tea. This study resulted in the identification of five compounds, one of which is a newly discovered compound: (5aR)-6-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-5a-methyl-5,5a,6,7,8,8a-hexa hydro-2H-indeno[5,4-b]furan-2-one (<b>1</b>), four known compounds: demethylincisterol A<sub>3</sub> (<b>2</b>), (22<i>E</i>, 24 <i>R</i>)-ergosta-7,9(11),22-trien-3<i>β</i>-ol (<b>3</b>), (22<i>E</i>,24<i>R</i>)-5<i>α</i>,8<i>α</i>-epidixyer-gosta-6,22-dien-3<i>β</i>-ol (<b>4</b>) and <i>p</i>- hydroxybenzaldehyde (<b>5</b>). The structure of compound <b>1</b> was determined using a variety of spectroscopic methods such as <sup>1</sup>H spectrum,<sup>13</sup>C spectrum, HMBC, HSQC,<sup>1</sup>H-<sup>1</sup>H COSY, LC-MS, UV, IR and comparison of their NMR data with literature. The absolute configuration of compound <b>1</b> was established by comparing the experimental and ECD spectra. All compounds were tested for their anti-acetylcholine activity, however, none of them demonstrated any anti-acetylcholine activity.</p>\",\"PeriodicalId\":15180,\"journal\":{\"name\":\"Journal of Asian Natural Products Research\",\"volume\":\" \",\"pages\":\"1215-1221\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Asian Natural Products Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/10286020.2025.2451332\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/31 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asian Natural Products Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/10286020.2025.2451332","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/31 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
A comprehensive study was carried out on Penicillium brocae G2131, which originated from Yunnan Menghai Pu'er tea. This study resulted in the identification of five compounds, one of which is a newly discovered compound: (5aR)-6-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-5a-methyl-5,5a,6,7,8,8a-hexa hydro-2H-indeno[5,4-b]furan-2-one (1), four known compounds: demethylincisterol A3 (2), (22E, 24 R)-ergosta-7,9(11),22-trien-3β-ol (3), (22E,24R)-5α,8α-epidixyer-gosta-6,22-dien-3β-ol (4) and p- hydroxybenzaldehyde (5). The structure of compound 1 was determined using a variety of spectroscopic methods such as 1H spectrum,13C spectrum, HMBC, HSQC,1H-1H COSY, LC-MS, UV, IR and comparison of their NMR data with literature. The absolute configuration of compound 1 was established by comparing the experimental and ECD spectra. All compounds were tested for their anti-acetylcholine activity, however, none of them demonstrated any anti-acetylcholine activity.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
