Pachyphyllanone, a new cycloartane triterpenoid isolated from Aglaia pachyphylla and its cytotoxic activity.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-01-10 DOI:10.1080/10286020.2024.2446280

Wahyu Safriansyah, Endang Juliansyah, Rustaman, Al Arofatus Naini, Kindi Farabi, Mohamad Nurul Azmi, Mohamad Azlan Nafiah, Hadi Kuncoro, Unang Supratman, Sofa Fajriah, Desi Harneti

引用次数: 0

Abstract

Aglaia pachyphylla is a species from the Aglaia genus (Meliaceae) and the chemical constituent has not been widely explored. A new cycloartane-type triterpenoid, pachyphyllanone (1), along with four known compounds (2-5) were isolated from Aglaia pachyphylla Miq. Furthermore, the structure of the new compound was elucidated by the interpretation of spectroscopic data, including 1D and 2D-NMR, as well as ECD and NMR calculations (DP4+ analysis). Compounds 1-5 showed cytotoxic activities against MCF-7 with IC₅₀ values ranging from 160.74 to 299.75 μM.

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厚叶木酮：一种从厚叶木中分离得到的新的环ar烷类三萜及其细胞毒活性。

厚叶木兰花是木兰花属（Meliaceae）的一种，其化学成分尚未被广泛研究。从厚叶木香中分离到一个新的环artan型三萜化合物厚叶木香酮(1)和4个已知化合物（2-5）。此外，通过光谱数据的解释，包括1D和2D-NMR，以及ECD和NMR计算（DP4+分析），阐明了新化合物的结构。化合物1 ~ 5对MCF-7具有细胞毒活性，IC50值在160.74 ~ 299.75 μM之间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.