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Journal of Asian Natural Products Research最新文献

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Diterpenoid alkaloids from Aconitum liaotungenses. 辽东乌头的二萜类生物碱。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-08-18 DOI: 10.1080/10286020.2025.2539163
Li-Li Ye, Mei-Zhen Ye, Qiao Long, Ying-Ying Fei, Ting-Ting Li, Lin Chen, Shuai Huang, Xian-Li Zhou
{"title":"Diterpenoid alkaloids from <i>Aconitum liaotungenses</i>.","authors":"Li-Li Ye, Mei-Zhen Ye, Qiao Long, Ying-Ying Fei, Ting-Ting Li, Lin Chen, Shuai Huang, Xian-Li Zhou","doi":"10.1080/10286020.2025.2539163","DOIUrl":"https://doi.org/10.1080/10286020.2025.2539163","url":null,"abstract":"<p><p>Four new diterpenoid alkaloids, namely liaotungenses A-D, along with twenty known constituents, were isolated from the roots of <i>Aconitum liaotungense</i> Nakai (Ranunculaceae). Liaotungensines A and B are rare franchetine-type C<sub>19</sub>-diterpenoid alkaloids characterized by their unique dual hydroxylation pattern at C-13 and C-15. Liaotungense D is identified as the third documented example of 8,15-seco diterpenoid alkaloids in this structural class. Structural characterization was achieved through integrated spectroscopic analysis employing IR, HR-ESI-MS, and comprehensive 1D/2D NMR techniques. All isolated compounds underwent evaluation for anti-inflammatory potential via nitric oxide (NO) production inhibition assays, but none demonstrated marked inhibitory activity in this pharmacological assessment.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.3,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting epithelial-mesenchymal transition: breviscapine, a promising natural product in cancer and organ fibrosis treatment. 靶向上皮-间质转化：灯盏花素，一种在癌症和器官纤维化治疗中有前景的天然产物。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-08-08 DOI: 10.1080/10286020.2025.2539162
Yu-Xuan Wang, Xiu-Hong Zhong
{"title":"Targeting epithelial-mesenchymal transition: breviscapine, a promising natural product in cancer and organ fibrosis treatment.","authors":"Yu-Xuan Wang, Xiu-Hong Zhong","doi":"10.1080/10286020.2025.2539162","DOIUrl":"https://doi.org/10.1080/10286020.2025.2539162","url":null,"abstract":"<p><p>In recent years, more and more studies have shown that breviscapine and its main active component scutellarin can play an inhibitory role in EMT of different types of tumors and organs, thus interfering with the malignant process of tumor and organ fibrosis. Based on Web of Science, PubMed and CNKI databases, this paper comprehensively reviewed the <i>in vitro</i> and <i>in vivo</i> research results of breviscapine targeting EMT against tumor and organ fibrosis, including the regulation of EMT-related signaling pathways, in order to provide reference for further research and clinical application of breviscapine in the treatment of related diseases.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-23"},"PeriodicalIF":1.3,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The mechanism of Yizhi Qingxin formula to improve neuroinflammation in Alzheimer's disease by regulating the TLR4/NF‑κB/NLRP3 pathway. 益智清心方通过调节TLR4/NF - κB/NLRP3通路改善阿尔茨海默病神经炎症的机制
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-08-04 DOI: 10.1080/10286020.2025.2539987
Wen-Xuan Chen, Qiao-Yi Huang, Jia-Hui Sun, Xin-Yu Yang, Hui Pei, Yu Cao, Hao Li, Li-Na Ma
{"title":"The mechanism of Yizhi Qingxin formula to improve neuroinflammation in Alzheimer's disease by regulating the TLR4/NF‑κB/NLRP3 pathway.","authors":"Wen-Xuan Chen, Qiao-Yi Huang, Jia-Hui Sun, Xin-Yu Yang, Hui Pei, Yu Cao, Hao Li, Li-Na Ma","doi":"10.1080/10286020.2025.2539987","DOIUrl":"https://doi.org/10.1080/10286020.2025.2539987","url":null,"abstract":"<p><p>Yizhi Qingxin formula (YQF) is a traditional Chinese medicine for the treatment of Alzheimer's disease (AD). This study explored the mechanism of YQF to improve AD-related neuroinflammation <i>in vivo</i> and <i>in vitro</i>. The behavioral tests, immunohistochemical analysis and Western blot were performed. The present results showed that YQF ameliorated cognitive deficits, reduced hippocampal Aβ deposition, and decreased the number of GFAP and Iba1-positive cells. The results also indicated that YQF suppressed neuroinflammatory cytokines (TNF-α, IL-1β, IL-6) by inhibiting TLR4/NF-κB/NLRP3 pathway. In summary, YQF provides a multi-targeted strategy for AD-related neuroinflammation, which may address limitations of single-pathway therapies.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-19"},"PeriodicalIF":1.3,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pandanus tectorius fruits attenuated cell injury and oxidative stress in high glucose-induced Schwann cells by activating Nrf2/Keap1 signaling pathway. 香豆果通过激活Nrf2/Keap1信号通路减轻高糖诱导的雪旺细胞损伤和氧化应激。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-08-01 Epub Date: 2025-01-31 DOI: 10.1080/10286020.2025.2451340
Jin-Gui Zhang, Jin-Ping Cai, Yu-Xia Wu, Jia-Liang Guo, Yu-Qing Li, Chao Wang
{"title":"Pandanus tectorius fruits attenuated cell injury and oxidative stress in high glucose-induced Schwann cells by activating Nrf2/Keap1 signaling pathway.","authors":"Jin-Gui Zhang, Jin-Ping Cai, Yu-Xia Wu, Jia-Liang Guo, Yu-Qing Li, Chao Wang","doi":"10.1080/10286020.2025.2451340","DOIUrl":"10.1080/10286020.2025.2451340","url":null,"abstract":"<p><p>We studied the protective effects of Pandanus tectorius fruits (PTF) on Schwann cells and sciatic nerve damage in diabetic peripheral neuropathy (DPN) rats. PTF improved RSC96 cell viability and increased Nrf2, Keap1, HO-1, and NQO1 expression. PTF reduced apoptosis and ROS in high glucose-treated cells, which was reversed by Nrf2 siRNA. Co-treatment with SFN further decreased apoptosis and ROS. PTF increased SOD, GSH-Px, NGF, IGF-1, and VEGF activities, reduced by Nrf2 knockdown but restored with SFN. MDA levels showed opposite trends. In DPN rats, PTF reduced pain and prevented nerve damage, suggesting it alleviates DPN by activating the Nrf2/Keap1 pathway.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1188-1204"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel pyrrolidine alkaloid and a novel isoflavone with anti-inflammatory activity from the tubers of Arisaema franchetianum. 从鸢尾块茎中分离出具有抗炎活性的新型吡咯烷类生物碱和新型异黄酮。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-08-01 Epub Date: 2025-06-21 DOI: 10.1080/10286020.2025.2514687
Wan-Qi Yang, Meng-Yuan Cui, Yun-Peng Qin, Kai-Dong Liu, Yong Xu, Ying-Ying Dong, Jing Qu
{"title":"A novel pyrrolidine alkaloid and a novel isoflavone with anti-inflammatory activity from the tubers of <i>Arisaema franchetianum</i>.","authors":"Wan-Qi Yang, Meng-Yuan Cui, Yun-Peng Qin, Kai-Dong Liu, Yong Xu, Ying-Ying Dong, Jing Qu","doi":"10.1080/10286020.2025.2514687","DOIUrl":"10.1080/10286020.2025.2514687","url":null,"abstract":"<p><p>Solanpyrrole B (<b>1</b>), a new pyrrolidine alkaloid and 5,7,4',5'-tetrahydroxy-6, 3'-dimethoxyisoflavone (<b>2</b>), a new isoflavone, along with 12 known compounds (<b>3</b>-<b>14</b>), were isolated from the tubers of <i>Arisaema franchetianum</i>. The chemical structures of these compounds were identified by using spectroscopic analysis (NMR, UV, IR, HR-ESI-MS). Compounds <b>1</b> and <b>2</b> (10 <i>μ</i>M) exhibited anti-inflammatory activities in inhibiting the NF-κB signaling pathway, reducing the release of NO from RAW264.7 macrophages and BV2 microglia induced by LPS. Compounds <b>1</b>, <b>2</b> and <b>11</b> exhibited significant cytotoxic activity against HCT116 cells (IC<sub>50</sub> = 9.16 ± 1.59 <i>μ</i>M), HGC27 cells (IC<sub>50</sub> = 7.98 ± 1.07 <i>μ</i>M), U87MG (IC<sub>50</sub> = 2.81 ± 0.18 <i>μ</i>M), respectively.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1128-1137"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cynatroside B2, a new anti-inflammatory C21 steroid from the roots and rhizomes of Vincetoxicum atratum. Cynatroside B2，一种新的抗炎甾体C21，从白花长春花根和根茎中提取。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-08-01 Epub Date: 2025-01-10 DOI: 10.1080/10286020.2024.2446302
Jing-Yu Zhang, Yi-Nuo Shi, Sheng Dong, Chen Ji, Yang Yu, Jiu-Zhi Yuan, Chong-Ning Lv, Jin-Cai Lu
{"title":"Cynatroside B<sub>2</sub>, a new anti-inflammatory C<sub>21</sub> steroid from the roots and rhizomes of <i>Vincetoxicum atratum</i>.","authors":"Jing-Yu Zhang, Yi-Nuo Shi, Sheng Dong, Chen Ji, Yang Yu, Jiu-Zhi Yuan, Chong-Ning Lv, Jin-Cai Lu","doi":"10.1080/10286020.2024.2446302","DOIUrl":"10.1080/10286020.2024.2446302","url":null,"abstract":"<p><p>A series of C<sub>21</sub> steroidal glycosides were isolated from the roots and rhizomes of <i>Vincetoxicum atratum</i> (Bunge) C. Morren et Decne., including a new compound, cynatroside B<sub>2</sub> (<b>1</b>), and seven known compounds (<b>2</b>-<b>8</b>). Their structures were identified by comprehensive spectroscopic analyses, including NMR and HR-ESI-MS spectral data. The isolated steroids were evaluated for their anti-inflammatory activity against lipopolysaccharide-induced mouse macrophage RAW264.7 cells. Compound <b>1</b> displayed a significant inhibitory effect on NO, TNF-<i>α</i> and IL-1<i>β</i>.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1205-1214"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new steroid from Penicillium brocae G2131. 从西兰花青霉菌G2131中分离出一个新的甾体。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-08-01 Epub Date: 2025-01-31 DOI: 10.1080/10286020.2025.2451332
Jie-Yi Zhou, Chen-Yang Cui, Li-Na Mao, Qun Zhou, Zhi-Ping Wang
{"title":"A new steroid from <i>Penicillium brocae</i> G2131.","authors":"Jie-Yi Zhou, Chen-Yang Cui, Li-Na Mao, Qun Zhou, Zhi-Ping Wang","doi":"10.1080/10286020.2025.2451332","DOIUrl":"10.1080/10286020.2025.2451332","url":null,"abstract":"<p><p>A comprehensive study was carried out on <i>Penicillium brocae</i> G2131, which originated from Yunnan Menghai Pu'er tea. This study resulted in the identification of five compounds, one of which is a newly discovered compound: (5aR)-6-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-5a-methyl-5,5a,6,7,8,8a-hexa hydro-2H-indeno[5,4-b]furan-2-one (<b>1</b>), four known compounds: demethylincisterol A<sub>3</sub> (<b>2</b>), (22<i>E</i>, 24 <i>R</i>)-ergosta-7,9(11),22-trien-3<i>β</i>-ol (<b>3</b>), (22<i>E</i>,24<i>R</i>)-5<i>α</i>,8<i>α</i>-epidixyer-gosta-6,22-dien-3<i>β</i>-ol (<b>4</b>) and <i>p</i>- hydroxybenzaldehyde (<b>5</b>). The structure of compound <b>1</b> was determined using a variety of spectroscopic methods such as <sup>1</sup>H spectrum,<sup>13</sup>C spectrum, HMBC, HSQC,<sup>1</sup>H-<sup>1</sup>H COSY, LC-MS, UV, IR and comparison of their NMR data with literature. The absolute configuration of compound <b>1</b> was established by comparing the experimental and ECD spectra. All compounds were tested for their anti-acetylcholine activity, however, none of them demonstrated any anti-acetylcholine activity.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1215-1221"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and biological evaluation of oleanolic acid derivatives as potential c-kit inhibitors. 齐墩果酸衍生物作为潜在c-kit抑制剂的合成及生物学评价。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-08-01 Epub Date: 2025-01-31 DOI: 10.1080/10286020.2025.2451336
Zhen-Yu Kuai, Zheng-Fei Zhu, Xuan Zeng, Yan-Qiu Meng
{"title":"Synthesis and biological evaluation of oleanolic acid derivatives as potential c-kit inhibitors.","authors":"Zhen-Yu Kuai, Zheng-Fei Zhu, Xuan Zeng, Yan-Qiu Meng","doi":"10.1080/10286020.2025.2451336","DOIUrl":"10.1080/10286020.2025.2451336","url":null,"abstract":"<p><p>The 3-O-(4'-imidazole)-12-en-olean-28-amide derivatives <b>7-1</b> to <b>7-11</b> through modification the C-3 and C-28 of the natural product oleanolic acid were prepared, and their structures were confirmed by MS,<sup>1</sup>H NMR and <sup>13</sup>C NMR. The antitumor activities of these compounds against breast cancer MCF-7 and gastric cancer SGC7901 cells <i>in vitro</i> were determined by MTT assay. Cell tests showed that the antitumor activities of compound <b>7-10</b> exhibited significant antitumor activity which was equivalent to the positive control drug nilotinib, and the affinity was verified by molecular dynamics experiment <i>in vitro</i>. Molecular docking showed that compound <b>7-10</b> have high binding ability with c-kit. Therefore, compound <b>7-10</b> has the potential to become a new c-kit inhibitor, which deserves further research.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1161-1173"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Baicalin: an active natural product with potential medicinal values. 黄芩苷：一种具有潜在药用价值的活性天然产物。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-08-01 Epub Date: 2025-04-03 DOI: 10.1080/10286020.2025.2482054
Yong-Qiang Wen, Ya-Zhou Wang, Chen-Xu Zhao, Bao-Yu Zhao, Jian-Guo Wang
{"title":"Baicalin: an active natural product with potential medicinal values.","authors":"Yong-Qiang Wen, Ya-Zhou Wang, Chen-Xu Zhao, Bao-Yu Zhao, Jian-Guo Wang","doi":"10.1080/10286020.2025.2482054","DOIUrl":"10.1080/10286020.2025.2482054","url":null,"abstract":"<p><p>Baicalin, a flavonoid derived from the dicotyledonous plant <i>Scutellaria baicalensis</i> Georgi (SBG), is applied to treat various -disorders due to its various pharmacological effects such as anti-inflammatory, antiviral, antibacterial, liver-protecting, lipid-lowering, and neuroprotection. However, baicalin's limited solubility hampers absorption. This article reviews baicalin's pharmacological properties, including pharmacokinetics, cytotoxicity, drug interactions, and therapeutic potential, especially for cardiovascular diseases, obesity, and liver-lipid disorders, aiming to promote its development in medicine, dairy and livestock feed, nutritional health products and cosmetics for humans and other fields.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1087-1111"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel antimicrobial defensin peptides from different coleopteran insects (Coleoptera: Insecta): identification, characterisation and antimicrobial properties. 来自不同鞘翅目昆虫（鞘翅目：昆虫科）的新型抗菌防御肽：鉴定、表征和抗菌特性。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-08-01 Epub Date: 2025-01-09 DOI: 10.1080/10286020.2024.2448011
Ayşe Nur Pektaş, Ertan Mahir Korkmaz
{"title":"Novel antimicrobial defensin peptides from different coleopteran insects (Coleoptera: Insecta): identification, characterisation and antimicrobial properties.","authors":"Ayşe Nur Pektaş, Ertan Mahir Korkmaz","doi":"10.1080/10286020.2024.2448011","DOIUrl":"10.1080/10286020.2024.2448011","url":null,"abstract":"<p><p>Antimicrobial peptides are crucial components of the immune systems of both vertebrates and invertebrates. Here, defensins, the most studied class of antimicrobial molecules in arthropods were investigated in four coleopteran insect species: <i>Harpalus rufipes</i> (DeGeer, 1774), <i>Mylabris quadripunctata</i> (Linnaeus, 1767), <i>Sphaeridium marginatum</i> (Linnaeus, 1758), and <i>Ocypus mus</i> (Brullé, 1832). The peptides synthesized with over 95% purity and their antimicrobial activities were evaluated by MIC test method. As a result, it was determined that <i>Mylabris quadripunctata</i> defensin (MqDef) showed high antimicrobial activity against <i>Staphylococcus aureus</i> and MRSA, whereas <i>Sphaeridium marginatum</i> (SmDef) and <i>Harpalus rufipes</i> (HrDef) defensins against <i>Candida tropicalis</i>.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1146-1160"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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