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Journal of Asian Natural Products Research最新文献

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Unraveling the mechanisms of matrine in esophageal cancer treatment: insights from network pharmacology, bioinformatics, and molecular biology experiments. 揭示苦参碱治疗食管癌的机制：来自网络药理学、生物信息学和分子生物学实验的见解。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-08-01 Epub Date: 2025-10-29 DOI: 10.1080/10286020.2025.2576668
Si-Min Wen, Ting Lv, Lei Lei, Liang-Yu Shi
{"title":"Unraveling the mechanisms of matrine in esophageal cancer treatment: insights from network pharmacology, bioinformatics, and molecular biology experiments.","authors":"Si-Min Wen, Ting Lv, Lei Lei, Liang-Yu Shi","doi":"10.1080/10286020.2025.2576668","DOIUrl":"10.1080/10286020.2025.2576668","url":null,"abstract":"<p><p>Matrine, a natural compound from traditional Chinese medicine, demonstrates anti-esophageal cancer (EC) efficacy via multi-target mechanisms. In this study, integrated network pharmacology and WGCNA identified MGLL, EPHX2, and CES2 as key targets for matrine. Clinical nomograms indicated their prognostic value, and bioinformatics analysis confirmed their downregulation in EC, correlating with tumor stage, survival, and immune infiltration. Molecular docking confirmed stable binding between matrine and these targets. In vitro experiments showed matrine upregulates their expressions, concurrently inhibiting EC cell proliferation and inducing apoptosis. In conclusion, matrine treats EC through dual actions-direct antitumor effects and immunomodulation-highlighting its therapeutic potential.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1211-1234"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145400831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two new macrocyclic cembrane diterpenoids from Boswellia seratta gum resin. 两个新的大环膜二萜类化合物的研究。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-08-01 Epub Date: 2025-11-13 DOI: 10.1080/10286020.2025.2583447
Durgaprasad Metta, Raveendra Babu Kothapalli, Ramarao Paidi, Ramakrishna Singuru
{"title":"Two new macrocyclic cembrane diterpenoids from <i>Boswellia seratta</i> gum resin.","authors":"Durgaprasad Metta, Raveendra Babu Kothapalli, Ramarao Paidi, Ramakrishna Singuru","doi":"10.1080/10286020.2025.2583447","DOIUrl":"10.1080/10286020.2025.2583447","url":null,"abstract":"<p><p>Two previously undescribed macrocyclic diterpenoids, cycloserratol (<b>1</b>) and isopapyrifuranol A (<b>2</b>) were isolated from the gum resin of <i>Boswellia seratta.</i> Compound <b>1</b> was confirmed as trihydroxy substituted 12-membered macrocyclic cembrane-type diterpenoid skeleton and <b>2</b> was a new 1,12-oxygen fused trihydroxy cembrane skeleton. The structures of these new metabolites were characterized by HRESIMS, 1D NMR and 2D NMR analysis.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1144-1151"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145504492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scuregeliolides a-C: new neo-clerodane diterpenoids from Scutellaria regeliana and their anti-inflammatory activities. 黄芩内酯a-C：黄芩中新的新氯烷二萜及其抗炎活性。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-08-01 Epub Date: 2025-11-26 DOI: 10.1080/10286020.2025.2587634
De-Wu Zhang, Xi-Dian Yue, Yue Wang, Jia-Huan Liu, Sheng-Jun Dai
{"title":"Scuregeliolides a-C: new <i>neo</i>-clerodane diterpenoids from <i>Scutellaria regeliana</i> and their anti-inflammatory activities.","authors":"De-Wu Zhang, Xi-Dian Yue, Yue Wang, Jia-Huan Liu, Sheng-Jun Dai","doi":"10.1080/10286020.2025.2587634","DOIUrl":"10.1080/10286020.2025.2587634","url":null,"abstract":"<p><p>Three new <i>neo</i>-clerodane diterpenoids, named scuregeliolides A<b>-</b>C (<b>1</b>-<b>3</b>), were isolated from the whole plant of <i>Scutellaria regeliana</i>. Their chemical structures, including absolute stereochemical configurations, were fully elucidated by means of integrated spectroscopic techniques and Electronic Circular Dichroism (ECD) calculations. <i>In vitro</i>, three undescribed <i>neo</i>-clerodane diterpenoids showed significant anti-inflammatory activities due to inhibiting the release of TNF-<i>α</i>, IL-6 and IL-1<i>β</i> in the LPS-induced RAW264.7 cells, as well as preventing the release of <i>β</i>-glucuronidase from the PAF-stimulated PMNs.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1133-1143"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145604219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting GPX4-dependent ferroptosis by natural compounds in multiple sclerosis. 多发性硬化症中天然化合物靶向gpx4依赖性铁下垂。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-08-01 Epub Date: 2025-11-13 DOI: 10.1080/10286020.2025.2576660
Ning Zhou, Yi-Rong Dong, Jin-Rong Wang, Cai-Xia Zang, Jing-Wei Ma, Yang Yang, Qiu-Zhu Chen, Yue-Qi Jiang, Xing Yang, Shou-Peng Cao, Mei-Chuan Zhou, Sen-Xiang Zeng, Fang-Fang Li, Xiu-Qi Bao, Dan Zhang
{"title":"Targeting GPX4-dependent ferroptosis by natural compounds in multiple sclerosis.","authors":"Ning Zhou, Yi-Rong Dong, Jin-Rong Wang, Cai-Xia Zang, Jing-Wei Ma, Yang Yang, Qiu-Zhu Chen, Yue-Qi Jiang, Xing Yang, Shou-Peng Cao, Mei-Chuan Zhou, Sen-Xiang Zeng, Fang-Fang Li, Xiu-Qi Bao, Dan Zhang","doi":"10.1080/10286020.2025.2576660","DOIUrl":"10.1080/10286020.2025.2576660","url":null,"abstract":"<p><p>Multiple sclerosis (MS) is an autoimmune-mediated, heterogeneous, multifactorial central nervous system degenerative disease influenced by genetics and environment. Ferroptosis, an iron-dependent lipid peroxidation/reactive oxygen species-induced programmed cell death, exacerbates MS pathology. Glutathione peroxidase 4 (GPX4) regulates ferroptosis by clearing peroxides to sustain cells. Targeting GPX4-mediated ferroptosis, especially via safe, potent natural compounds, is a promising MS treatment. This review explores GPX4-dependent ferroptosis's role in MS progression and summarizes natural compounds for MS therapy.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1109-1124"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145504501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dihydroagarofuran sesquiterpene derivatives from the roots of Tripterygium wilfordii. 雷公藤根部的二氢呋喃倍半萜衍生物。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-08-01 Epub Date: 2025-11-12 DOI: 10.1080/10286020.2025.2579867
Ya-Lin Hu, Ping-Ting Hong, Yu-Ting Lei, Wen-Jie Chen, Chong Wang, Jia-Li Huang, Zhen Li, Zhi-Jie Li, Wen Li
{"title":"Dihydroagarofuran sesquiterpene derivatives from the roots of <i>Tripterygium wilfordii</i>.","authors":"Ya-Lin Hu, Ping-Ting Hong, Yu-Ting Lei, Wen-Jie Chen, Chong Wang, Jia-Li Huang, Zhen Li, Zhi-Jie Li, Wen Li","doi":"10.1080/10286020.2025.2579867","DOIUrl":"10.1080/10286020.2025.2579867","url":null,"abstract":"<p><p>Two new (<b>1-2</b>) and five known (<b>3-7</b>) dihydro-<i>β</i>-agarofuran derivatives were isolated from the roots of <i>Tripterygium wilfordii</i>. The structures of new compounds were elucidated by spectroscopic techniques, such as UV, IR, HRESIMS and NMR. And the structure of compound <b>1</b> was confirmed by X-ray crystallographic. Cytotoxic activity assays against four human tumor cell lines (SK-MEL-2, HCC1806, HUH-7, PANC-1) were assessed for compounds <b>1-7</b>. Compound <b>2</b> exhibited pronounced cytotoxicity against SK-MEL-2 cells with an IC<sub>50</sub> value of 9.18 μM. Additionally, compound <b>5</b> showed significant cytotoxic effects on SK-MEL-2 and HCC1806 cells with IC<sub>50</sub> values of 4.59 μM and 8.14 μM, respectively.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1159-1168"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145495559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new cyclohexenone and two new phenanthrones from Elatostema tenuicaudatum. 一个新的环己酮和两个新现象。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-08-01 Epub Date: 2025-10-28 DOI: 10.1080/10286020.2025.2577883
Dao Duc Thien, Nguyen Hoang Sa, Le Quoc Thang, Nguyen Thanh Tam
{"title":"A new cyclohexenone and two new phenanthrones from <i>Elatostema tenuicaudatum</i>.","authors":"Dao Duc Thien, Nguyen Hoang Sa, Le Quoc Thang, Nguyen Thanh Tam","doi":"10.1080/10286020.2025.2577883","DOIUrl":"10.1080/10286020.2025.2577883","url":null,"abstract":"<p><p>A new cyclohexenone, 5<i>S</i>-(3,4-dihydroxyphenethyl)cyclohex-2-en-1-one (<b>1</b>), along with two new phenanthrones, (4a<i>S</i>,10a<i>S</i>)- 1,9,10,10a -tetrahydro-4a,6,7-trihydroxy-4(4a<i>H</i>)-phenanthrone (<b>2</b>) and (4a<i>S</i>,10a<i>S</i>)-4a-hydroxy-7-methoxy-1,9,10,10a-tetrahydro-4(4a<i>H</i>)-phenanthrone 6-O-<i>β</i>-D-glucopyranoside (<b>3</b>) were isolated from the whole plant of <i>Elatostema tenuicaudatum.</i> The structures were determined by spectroscopic methods including 1D, 2D NMR and HR-ESI-MS. The absolute configurations of compounds <b>1-3</b> were determined by their experimental and calculated ECD spectral data. The isolates were evaluated for inhibitory activity on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophage cells, and compound <b>2</b> showed the strongest activity with an IC<sub>50</sub> value of 9.5 ± 1.2 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1125-1132"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145377592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new verrucosane diterpenoid from the Vietnamese liverwort Plagiochila bantamensis. 越南板蓝藻中一个新的疣胞烷二萜。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-08-01 Epub Date: 2025-11-03 DOI: 10.1080/10286020.2025.2577286
Le Thi-Kim-Dung, Nguyen Thi-Nhu-Quynh, Le Thanh-Nguyen, Tram Nguyen-Khanh-Trinh, Nguyen Thi-Phuong, Thi-Hoai-Thu Nguyen, Ngoc-Hong Nguyen, Jirapast Sichaem, Thuc-Huy Duong
{"title":"A new verrucosane diterpenoid from the Vietnamese liverwort <i>Plagiochila bantamensis</i>.","authors":"Le Thi-Kim-Dung, Nguyen Thi-Nhu-Quynh, Le Thanh-Nguyen, Tram Nguyen-Khanh-Trinh, Nguyen Thi-Phuong, Thi-Hoai-Thu Nguyen, Ngoc-Hong Nguyen, Jirapast Sichaem, Thuc-Huy Duong","doi":"10.1080/10286020.2025.2577286","DOIUrl":"10.1080/10286020.2025.2577286","url":null,"abstract":"<p><p>A new verrucosane-type diterpenoid, bantamenside (<b>1</b>), along with six known compounds (<b>2-7</b>), was isolated from the Vietnamese liverwort <i>Plagiochila bantamensis</i>. The structure of the new compound was determined using comprehensive spectroscopic methods, including 1D and 2D NMR techniques as well as high-resolution mass spectrometry. Furthermore, all isolated compounds were evaluated for their ability to inhibit nitric oxide (NO) production. Compounds <b>1-3</b> and <b>6-7</b> demonstrated notable NO inhibitory activity, with IC<sub>50</sub> values ranging from 12.85 to 51.37 µM, outperforming or comparable to that of the positive control L-NMMA (IC<sub>50</sub> 41.30 ± 6.60 µM).</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1235-1243"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145437977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The guardian that guides: cinnamic acid enhances oral bioavailability of diverse TCM components by reinforcing rather than disrupting intestinal barrier integrity. 指导的守护者：肉桂酸通过增强而不是破坏肠道屏障的完整性来提高多种中药成分的口服生物利用度。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-07-31 DOI: 10.1080/10286020.2026.2707134
Fang-Fang Fan, Meng-Yao Cui, Rui-Han Guo, Kun Pan, Hong-Ye Xu, Xiao-Qin Chu
{"title":"The guardian that guides: cinnamic acid enhances oral bioavailability of diverse TCM components by reinforcing rather than disrupting intestinal barrier integrity.","authors":"Fang-Fang Fan, Meng-Yao Cui, Rui-Han Guo, Kun Pan, Hong-Ye Xu, Xiao-Qin Chu","doi":"10.1080/10286020.2026.2707134","DOIUrl":"https://doi.org/10.1080/10286020.2026.2707134","url":null,"abstract":"<p><p>This study established a Caco-2/HT29 co-culture intestinal epithelial model to systematically investigate the intestinal absorption and transport mechanisms of cinnamic acid (CA). The results indicate that CA enhances intestinal barrier integrity by regulating the expression of tight junction proteins and promoting the secretion of neutral mucus, and significantly increases the intestinal absorption rates of alkaloids (sinomenine hydrochloride, SH), monoterpenes (paeoniflorin, PF), saponins (glycyrrhizic acid, GA), and flavonoids (liquiritin, LQ). These findings provide experimental evidence supporting the use of CA as a natural permeation enhancer to improve oral bioavailability.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-25"},"PeriodicalIF":1.6,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148630517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two undescribed bisabolane-type sesquiterpenoids from the endophytic fungus Penicillium herquei. 来自内生真菌青霉菌的两个未描述的双abolane型倍半萜类。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-07-16 DOI: 10.1080/10286020.2026.2701131
Yi-Yang Xiong, Lin-Lin Li, Jing Huang, Meng-Yi Deng, Xian-Li Zhou
{"title":"Two undescribed bisabolane-type sesquiterpenoids from the endophytic fungus <i>Penicillium herquei</i>.","authors":"Yi-Yang Xiong, Lin-Lin Li, Jing Huang, Meng-Yi Deng, Xian-Li Zhou","doi":"10.1080/10286020.2026.2701131","DOIUrl":"https://doi.org/10.1080/10286020.2026.2701131","url":null,"abstract":"<p><p>Sixteen compounds, including two undescribed bisabolane-type sesquiterpenoids (<b>1</b>, <b>2</b>), four aromatic derivatives (<b>3</b>-<b>6</b>), two cyclopeptides (<b>7</b>, <b>8</b>), two acyclic sesquiterpenes (<b>9</b>-<b>10</b>), four fatty acid esters (<b>11</b>-<b>14</b>) and two fatty acids (<b>15</b>-<b>16</b>), were separated from the endophytic fungus <i>Penicillium herquei</i>. Their structures were established by analysis of spectroscopic data, HRESIMS spectra, NMR data and comparison with data in relevant literature. It is the first time that all of these compounds were isolated from <i>P. herquei</i>. The <i>in vitro</i> cytotoxicity of all isolated was evaluated against four tumor cell lines (HCT116, A549, HeLa, and Hepg2 cells) by the MTT assay, and compounds <b>1</b>, <b>2</b>, <b>4</b>, <b>7</b> and <b>8</b> exhibited cytotoxicity with IC<sub>50</sub> values ranging from 9.7 ± 0.8 to 37.4 ± 2.5 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148455928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three new steroidal alkaloids from the whole plants of Sarcococca ruscifolia. 三种新甾体生物碱的全株提取。
IF 1.6 3区 医学
Journal of Asian Natural Products Research Pub Date : 2026-07-15 DOI: 10.1080/10286020.2026.2697865
Yong-Jin Ye, Xiao-Hui Sun, Gang Ke, Pu-Zhao Zhang, Ya-Mei Zhang
{"title":"Three new steroidal alkaloids from the whole plants of <i>Sarcococca ruscifolia</i>.","authors":"Yong-Jin Ye, Xiao-Hui Sun, Gang Ke, Pu-Zhao Zhang, Ya-Mei Zhang","doi":"10.1080/10286020.2026.2697865","DOIUrl":"https://doi.org/10.1080/10286020.2026.2697865","url":null,"abstract":"<p><p>ABETRACTThree previously undescribed steroidal alkaloids, 20<i>α-N,N-</i>dimethylamino<i>-</i>2<i>β-</i>hydroxy<i>-</i>3<i>α-</i>senecioylamino<i>-</i>5<i>α-</i>pregnane (<b>1</b>), 20<i>α-N,N-</i>dimethylamino<i>-</i>2<i>β,</i>4<i>α-</i>dihydroxy<i>-</i>3<i>α-</i>senecioylamino<i>-</i>5<i>α-</i>pregnane (<b>2</b>) and 20<i>α-N,N-</i>dimethylamino-2<i>β</i>,15<i>α</i>-dihydroxy-3<i>α</i>-senecioylamino-5<i>α</i>-pregn-16-ene (<b>3</b>), were isolated from the whole plants of <i>Sarcococca ruscifolia</i>. Their structures were determined through the analysis of physiochemical properties and spectroscopic data. Compound <b>1</b> showed a certain inhibitory effect on human glioma U251 cells with an IC<sub>50</sub> value of 13.51 <i>μ</i>M.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148446874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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