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Journal of Asian Natural Products Research最新文献

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Schisandrin A can promote the anti-tumor effect of 5-Fu by reversing the immunosuppressive state of the body in rat 五味子甲素可以通过逆转大鼠体内的免疫抑制状态来促进 5-Fu 的抗肿瘤作用。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-01 DOI: 10.1080/10286020.2024.2375291
Xiao-Hui Wang , Peng-Fei Dong , Feng Wang , Lin Zhou
{"title":"Schisandrin A can promote the anti-tumor effect of 5-Fu by reversing the immunosuppressive state of the body in rat","authors":"Xiao-Hui Wang ,&nbsp;Peng-Fei Dong ,&nbsp;Feng Wang ,&nbsp;Lin Zhou","doi":"10.1080/10286020.2024.2375291","DOIUrl":"10.1080/10286020.2024.2375291","url":null,"abstract":"<div><div>In this study, based on Walker 256 in vitro experiments, CCK-8 assay, clone formation assay, wound healing assay, and flow cytometry were used to detect cell apoptosis and cell cycle. It was found that schisandrin may have significant anti-tumor effects in vitro by inhibiting TGF-β/Smad signaling pathway. In addition, in vivo experiments, immunohistochemistry was used to observe the expression of HIF-1α, VEGF and VEGFR-2 in tumor tissues. It was found that schisandrin could significantly improve the immunosuppression induced by 5-Fu and enhance the antitumor effect of 5-Fu. The mechanism may be related to the inhibition of Wnt-1/β-catenin signaling pathway.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 2","pages":"Pages 231-248"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141558838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diterpenoid alkaloids from Delphinium sherriffii Delphinium sherriffii 的二萜生物碱。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-01 DOI: 10.1080/10286020.2024.2376244
Guo-Qing Sun , Cheng-En Fu , Yang Yang , Xiao-Jian Li , Jia-Yi Ma , Shuai Huang , Xian-Li Zhou , Lin Chen
{"title":"Diterpenoid alkaloids from Delphinium sherriffii","authors":"Guo-Qing Sun ,&nbsp;Cheng-En Fu ,&nbsp;Yang Yang ,&nbsp;Xiao-Jian Li ,&nbsp;Jia-Yi Ma ,&nbsp;Shuai Huang ,&nbsp;Xian-Li Zhou ,&nbsp;Lin Chen","doi":"10.1080/10286020.2024.2376244","DOIUrl":"10.1080/10286020.2024.2376244","url":null,"abstract":"<div><div>Three new diterpenoid alkaloids (<strong>1</strong>, <strong>2</strong>, <strong>3</strong>) and seventeen known (<strong>4–20</strong>) compounds were isolated from the whole plant of <em>Delphinium sherriffii</em> Munz (Ranunculaceae). Their structures were elucidated by various spectroscopic analyses, including IR, HR-ESI-MS, 1D and 2D NMR spectra. All compounds were evaluated for the inhibitory activity of Sf9 cells and compound <strong>5</strong> exhibited the strongest cytotoxicity (IC<sub>50</sub> = 8.97 μM) against Sf9 cell line.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 2","pages":"Pages 143-152"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141599920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two new diterpenoid alkaloids from the roots of Aconitum nagarum and their cytotoxic activity 从 Aconitum nagarum 的根中提取的两种新的二萜生物碱及其细胞毒性活性。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-01 DOI: 10.1080/10286020.2024.2373326
Jiang Hu , Ren Ji , Guang-Rong Yang , Tao Lv , Qiang Li , Feng Gao
{"title":"Two new diterpenoid alkaloids from the roots of Aconitum nagarum and their cytotoxic activity","authors":"Jiang Hu ,&nbsp;Ren Ji ,&nbsp;Guang-Rong Yang ,&nbsp;Tao Lv ,&nbsp;Qiang Li ,&nbsp;Feng Gao","doi":"10.1080/10286020.2024.2373326","DOIUrl":"10.1080/10286020.2024.2373326","url":null,"abstract":"<div><div>A chemical investigation on the roots of <em>Aconitum nagarum</em> afforded two undescribed C<sub>19</sub>-diterpenoid alkaloids nagarumines D and E (<strong>1</strong> and <strong>2</strong>). The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (<sup>1</sup>H-<sup>1</sup>H COSY, HMQC, and HMBC) NMR spectroscopy, as well as HR-ESI-MS. The two isolated alkaloids were tested <em>in vitro</em> for cytotoxic activity against five gastric tumor cell lines. Consequently, compound <strong>2</strong> exhibited some cytotoxicities against several human cancer cell lines with IC<sub>50</sub> value less than 20.0 μM.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 2","pages":"Pages 169-175"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chromomycins from soil-derived Streptomyces sp. inhibit the growth of human non-small cell lung cancer cells by targeting c-FLIP 源自土壤的链霉菌的色霉素通过靶向 c-FLIP 抑制人类非小细胞肺癌细胞的生长。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-01 DOI: 10.1080/10286020.2024.2375288
Gao-Jie Li , Chen Wang , Wen-Die Wang , Yue Shang , Chao-Yang Zeng , Ai-Min Wang , Jing-Lin Bai , Jing Su , Ling Su , Shu-Yi Si , Li-Yan Yu , Mao-Luo Gan , Shu-Zhen Chen
{"title":"Chromomycins from soil-derived Streptomyces sp. inhibit the growth of human non-small cell lung cancer cells by targeting c-FLIP","authors":"Gao-Jie Li ,&nbsp;Chen Wang ,&nbsp;Wen-Die Wang ,&nbsp;Yue Shang ,&nbsp;Chao-Yang Zeng ,&nbsp;Ai-Min Wang ,&nbsp;Jing-Lin Bai ,&nbsp;Jing Su ,&nbsp;Ling Su ,&nbsp;Shu-Yi Si ,&nbsp;Li-Yan Yu ,&nbsp;Mao-Luo Gan ,&nbsp;Shu-Zhen Chen","doi":"10.1080/10286020.2024.2375288","DOIUrl":"10.1080/10286020.2024.2375288","url":null,"abstract":"<div><div>Three chromomycin derivatives, chromomycins A<sub>3</sub> (<strong>1,</strong> CA<sub>3</sub>), A<sub>5</sub> (<strong>2,</strong> CA<sub>5</sub>), and monodeacetylchromomycin A<sub>3</sub> (<strong>3,</strong> MDA-CA<sub>3</sub>), were identified from the soil-derived <em>Streptomyces</em> sp. CGMCC 26516. A reinvestigation of the structure of CA<sub>5</sub> is reported, of which the absolute configuration was unambiguously determined for the first time to be identical with that of CA<sub>3</sub> based on nuclear magnetic resonance (NMR) data analysis as well as NMR and electronic circular dichroism calculations. Compounds <strong>1–3</strong> showed potent cytotoxicity against the non-small-cell lung cancer (NSCLC) cells (A549, H460, H157-c-FLIP, and H157-LacZ) and down-regulated the protein expression of c-FLIP in A549 cells. The IC<sub>50</sub> values of chromomycins in H157-c-FLIP were higher than that in H157-LacZ. Furthermore, si-c-FLIP promoted anti-proliferation effect of chromomycins in NSCLC cells. In nude mice xenograft model, <strong>1</strong> and <strong>2</strong> both showed more potent inhibition on the growth of H157-lacZ xenografts than that of H157-c-FLIP xenografts. These results verify that c-FLIP mediates the anticancer effects of chromomycins in NSCLC.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 2","pages":"Pages 153-168"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polyprenylated acylphloroglucinols from Hypericum sampsonii with cytotoxicity against pancreatic carcinomas 对胰腺癌具有细胞毒性的金丝桃中的多烯酰化酰基氯葡萄糖醇。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-01 DOI: 10.1080/10286020.2024.2380744
Xin-Pei Wang , Xue-Hua Li , Jian-Jun Lei , Yu-Wei Xiao , Yang Chi , Qian Sun , He Zhang
{"title":"Polyprenylated acylphloroglucinols from Hypericum sampsonii with cytotoxicity against pancreatic carcinomas","authors":"Xin-Pei Wang ,&nbsp;Xue-Hua Li ,&nbsp;Jian-Jun Lei ,&nbsp;Yu-Wei Xiao ,&nbsp;Yang Chi ,&nbsp;Qian Sun ,&nbsp;He Zhang","doi":"10.1080/10286020.2024.2380744","DOIUrl":"10.1080/10286020.2024.2380744","url":null,"abstract":"<div><div>Chemical investigation on the 80% EtOH extract of the air dried aerial parts of <em>Hypericum sampsonii</em> resulted in the isolation of two new polycyclic polyprenylated derivatives, hypersampines A and B (<strong>1</strong> and <strong>2</strong>). The structures of the new compounds were elucidated by spectroscopic data (NMR, IR, and UV) and high resolution mass analysis. The two isolated polyprenylated acylphloroglucinols were tested <em>in vitro</em> for cytotoxic activities against 6 pancreatic cell lines. As a result, compounds <strong>1</strong> and <strong>2</strong> possessed modest cytotoxic activities against all the tested tumor cell lines with IC<sub>50</sub> values less than 40 μM.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 2","pages":"Pages 136-142"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacterial metabolomics: current applications for human welfare and future aspects 细菌代谢组学：人类福祉的当前应用和未来方面。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-01 DOI: 10.1080/10286020.2024.2385365
Qazi Mohammad Sajid Jamal , Varish Ahmad
{"title":"Bacterial metabolomics: current applications for human welfare and future aspects","authors":"Qazi Mohammad Sajid Jamal ,&nbsp;Varish Ahmad","doi":"10.1080/10286020.2024.2385365","DOIUrl":"10.1080/10286020.2024.2385365","url":null,"abstract":"<div><div>An imbalanced microbiome is linked to several diseases, such as cancer, inflammatory bowel disease, obesity, and even neurological disorders. Bacteria and their by-products are used for various industrial and clinical purposes. The metabolites under discussion were chosen based on their biological impacts on host and gut microbiota interactions as established by metabolome research. The separation of bacterial metabolites by using statistics and machine learning analysis creates new opportunities for applications of bacteria and their metabolites in the environmental and medical sciences. Thus, the metabolite production strategies, methodologies, and importance of bacterial metabolites for human well-being are discussed in this review.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 2","pages":"Pages 207-230"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Four new homoisoflavonoids from Caesalpinia pulcherrima 从 Caesalpinia pulcherrima 中提取的四种新的同异黄酮。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-01 DOI: 10.1080/10286020.2024.2387307
Yu-Cheng Zheng , Wen-Jian Gu , Ren-Geng Shu , Pu-Zhao Zhang
{"title":"Four new homoisoflavonoids from Caesalpinia pulcherrima","authors":"Yu-Cheng Zheng ,&nbsp;Wen-Jian Gu ,&nbsp;Ren-Geng Shu ,&nbsp;Pu-Zhao Zhang","doi":"10.1080/10286020.2024.2387307","DOIUrl":"10.1080/10286020.2024.2387307","url":null,"abstract":"<div><div>Four new homoisoflavonoids, 7-hydroxy-3-[hydroxy(4′-methoxyphenyl)methyl]-benzopyran-4-one (<strong>1</strong>), (3<em>R</em>)<strong><em>-</em></strong>7, 8-dihydroxy-3-(4′-methoxybenzyl)-chroman-4-one (<strong>2</strong>), 7-hydroxy-3-(2′-hydroxy-4′-methoxybenzyl)-chroman-4-one (<strong>3</strong>), and 7-hydroxy-3-(2′-hydroxy-4′-methoxybenzyl)-benzopyran-4-one (<strong>4</strong>), were isolated from the seeds of <em>Caesalpinia pulcherrima</em>. The structures of new compounds were elucidated by MS and NMR spectra. Their absolute configurations were assigned using electronic circular dichroism spectrum. Compounds <strong>2</strong> and <strong>4</strong> exhibited cytotoxic effects on MCF-7/TAM cells with the IC<sub>50</sub> values of 101.4 ± 0.03 and 93.02 ± 0.03 <em>μ</em>M, respectively.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 2","pages":"Pages 126-135"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of scaberol C amino acid ester derivatives with anti-cancer activity 具有抗癌活性的葶苈醇 C 氨基酸酯衍生物的合成
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-01 DOI: 10.1080/10286020.2024.2380737
Cheng-Long Li , Zheng Han , Dong-Ya Luo , Hui Ren , Li Ye , Guo-Dong Yao , Qing-Bo Liu
{"title":"Synthesis of scaberol C amino acid ester derivatives with anti-cancer activity","authors":"Cheng-Long Li ,&nbsp;Zheng Han ,&nbsp;Dong-Ya Luo ,&nbsp;Hui Ren ,&nbsp;Li Ye ,&nbsp;Guo-Dong Yao ,&nbsp;Qing-Bo Liu","doi":"10.1080/10286020.2024.2380737","DOIUrl":"10.1080/10286020.2024.2380737","url":null,"abstract":"<div><div>A series of amino acid ester trifluoroacetate derivatives was synthesized from scaberol C. They were screened for their inhibitory activity against Non-Small Cell Lung Cancer (NSCLC) cells. Among them, compound <strong>2 l</strong> showed significant cytotoxicity against A549 and H460 cells (IC<sub>50</sub>), and was more active than cisplatin (DDP). The epidermal growth factor receptor (EGFR) was overexpressed in NSCLC, which was the target of multiple cancer therapies and a strong prognostic indicator. Our previous studies reported that the target of scaberol C derivatives against NSCLC cells was EGFR. And then molecular docking analysis and molecular dynamics (MD) simulations indicated that <strong>2 l</strong> can stably and covalently bind to the EGFR target protein.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 2","pages":"Pages 189-206"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141785214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A review on phytochemicals as combating weapon for multidrug resistance in cancer 综述植物化学物质作为抗击癌症多药耐药性的武器。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-01 DOI: 10.1080/10286020.2024.2386678
Sharwan Gupta , Anuradha Mehra , Rekha Sangwan
{"title":"A review on phytochemicals as combating weapon for multidrug resistance in cancer","authors":"Sharwan Gupta ,&nbsp;Anuradha Mehra ,&nbsp;Rekha Sangwan","doi":"10.1080/10286020.2024.2386678","DOIUrl":"10.1080/10286020.2024.2386678","url":null,"abstract":"<div><div>One can recognize multidrug resistance (MDR) and residue as a biggest difficulty in cancer specialist. Chemotherapy-resistant cancer may be successfully treated by combining MDR-reversing phytochemicals with anticancer drugs. Though, clinical application of phytochemicals either alone or in conjunction with chemotherapy is still in its early stages or requires more research to determine their safety and efficacy. In this review we highlighted topics related to MDR in cancer, including an introduction to subject, mechanism of action of efflux pump, specific proteins involved in drug resistance, altered drug targets, increased drug metabolism, and potential role of phytochemicals in overcoming drug resistance.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 2","pages":"Pages 107-125"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141909868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening of GLP-1r agonists from natural products using affinity ultrafiltration screening coupled with UPLC-ESI-Orbitrap-MS technology: a case study of Panax ginseng 利用 UPLC-ESI-Orbitrap-MS 技术进行亲和超滤筛选，从天然产品中筛选 GLP-1r 激动剂：三七案例研究。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-01 DOI: 10.1080/10286020.2024.2378821
Hong-Ping Wang , Zhao-Zhou Lin , Qiong Yin , Jing Du
{"title":"Screening of GLP-1r agonists from natural products using affinity ultrafiltration screening coupled with UPLC-ESI-Orbitrap-MS technology: a case study of Panax ginseng","authors":"Hong-Ping Wang ,&nbsp;Zhao-Zhou Lin ,&nbsp;Qiong Yin ,&nbsp;Jing Du","doi":"10.1080/10286020.2024.2378821","DOIUrl":"10.1080/10286020.2024.2378821","url":null,"abstract":"<div><div>In our study, a method based on affinity ultrafiltration screening coupled with UPLC-ESI-Orbitrap-MS technology was established to select Glucagon-like peptide-1 receptor (GLP-1R) agonists from natural products, and as an example, the GLP-1R agonists from <em>Panax ginseng</em> was selected using our established method. As a result, total five GLP-1R agonists were selected from <em>Panax ginseng</em> for the first time. Our results indicated that activating GLP-1R to promote insulin secretion probably was another important hypoglycemia mechanism for ginsenosides in <em>Panax ginseng</em>, which had great influence on the study of the anti-diabetes effect of ginsenosides.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 2","pages":"Pages 176-188"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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