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Journal of Asian Natural Products Research最新文献

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Prenylated flavones with potential antiproliferative activities from the stems and leaves of Mycetia hainanensis. 海南菌丝体茎叶中具有潜在抗增殖活性的烯丙基黄酮。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-28 DOI: 10.1080/10286020.2025.2507729
Shu-Ri Li, Lin-Xuan Li, Tian-Yu Wang, Yu-Shan Wang, Long-Cheng Cui, Jia-Yi Hu, Ye-Ping Liu, Yan-Ping Liu, Yan-Hui Fu
{"title":"Prenylated flavones with potential antiproliferative activities from the stems and leaves of <i>Mycetia hainanensis</i>.","authors":"Shu-Ri Li, Lin-Xuan Li, Tian-Yu Wang, Yu-Shan Wang, Long-Cheng Cui, Jia-Yi Hu, Ye-Ping Liu, Yan-Ping Liu, Yan-Hui Fu","doi":"10.1080/10286020.2025.2507729","DOIUrl":"https://doi.org/10.1080/10286020.2025.2507729","url":null,"abstract":"<p><p>A phytochemical study on the stems and leaves of <i>Mycetia hainanensis</i> led to the isolation and identification of a new prenylated flavone, mycehainanone (<b>1</b>), as well as seven known analogs (<b>2 </b>-<b> 8</b>). The chemical structure of <b>1</b> was determined using comprehensive spectroscopic analyses and the known compounds were identified by comparison of their spectroscopic data with those reported in the literature. The antiproliferative activities against five human cancer cell lines (JeKo-1, A549, SMMC-7721, SW480, and MCF-7 cell lines) of all isolated prenylated flavones (<b>1 </b>-<b> 8</b>) were evaluated <i>in vitro</i>. Compounds <b>1 </b>-<b> 8</b> exhibited notable antiproliferative effects against various human cancer cell lines with IC<sub>50</sub> values in range of 0.67 ± 0.02 to 38.92 ± 0.23 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two new abietane diterpenoids from Pinus massoniana. 马尾松中两个新枞烷二萜。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-28 DOI: 10.1080/10286020.2025.2509768
Xue Ma, Zhi-Long He, Bao Zhang, Li Jiang, Yong Huang, Yue-Ting Li, Yong-Jun Li
{"title":"Two new abietane diterpenoids from <i>Pinus massoniana</i>.","authors":"Xue Ma, Zhi-Long He, Bao Zhang, Li Jiang, Yong Huang, Yue-Ting Li, Yong-Jun Li","doi":"10.1080/10286020.2025.2509768","DOIUrl":"https://doi.org/10.1080/10286020.2025.2509768","url":null,"abstract":"<p><p>Two new abietane diterpenoids, massonianene A (<b>1</b>) and massonianene B (<b>2</b>), were isolated from the extract of <i>Pinus massoniana</i>. Their structures were elucidated based on HR-ESI-MS, IR, UV, NMR, ECD and X-ray diffraction analysis. Compound <b>2</b> exhibited significant inhibitory effect against LPS-induced NO production in RAW 264.7 cells, with an IC<sub>50</sub> value of 7.00 ± 1.73 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chlorogenic acid targets SLC37A2 to inhibit macrophage activation via ER-dependent NF-κB and NLRP3 signaling pathways against sepsis-induced acute lung injury. 绿原酸靶向SLC37A2，通过er依赖性NF-κB和NLRP3信号通路抑制巨噬细胞活化，对抗败血症诱导的急性肺损伤。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-27 DOI: 10.1080/10286020.2025.2506181
Yang Chen, Xiao-Wen Zhang, Mei-Mei Zhao, Ling Li, Yang Liu, Tian-Tian Wei, Wei Yu, Bo Han, Zheng-Ping Liu, Ke-Wu Zeng
{"title":"Chlorogenic acid targets SLC37A2 to inhibit macrophage activation via ER-dependent NF-κB and NLRP3 signaling pathways against sepsis-induced acute lung injury.","authors":"Yang Chen, Xiao-Wen Zhang, Mei-Mei Zhao, Ling Li, Yang Liu, Tian-Tian Wei, Wei Yu, Bo Han, Zheng-Ping Liu, Ke-Wu Zeng","doi":"10.1080/10286020.2025.2506181","DOIUrl":"https://doi.org/10.1080/10286020.2025.2506181","url":null,"abstract":"<p><p>Sepsis-induced acute lung injury (SI-ALI) requires urgent treatment due to severe inflammation. Our study found chlorogenic acid (CGA) suppressed LPS-induced macrophage activation by lowering NO, TNF-α, and IL-6. TPP-based strategies identified SLC37A2 as the direct target of CGA, validated by CETSA/MST. Molecular docking indicated CGA-SLC37A2 hydrogen bonding. CGA alleviated endoplasmic reticulum stress via SLC37A2, inhibiting TLR4/NF-κB and NLRP3 pathways to reduce inflammation. In SI-ALI mice and zebrafish models, CGA mitigated lung injury through these mechanisms taken together. This work highlights the therapeutic potential of CGA for SI-ALI and the critical role of SLC37A2 in combating infectious pneumonia.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-22"},"PeriodicalIF":1.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monoterpene derivatives from the fruits of Illicium simonsii 淫羊藿果实中的单萜衍生物。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-23 DOI: 10.1080/10286020.2025.2504964
Mi Li , Guo-Zhu Su , Hai-Qiang Wang , Xiao-Jing Wang , Li Li , Yu-Huan Li , Shuang-Gang Ma , Shi-Shan Yu
{"title":"Monoterpene derivatives from the fruits of Illicium simonsii","authors":"Mi Li ,&nbsp;Guo-Zhu Su ,&nbsp;Hai-Qiang Wang ,&nbsp;Xiao-Jing Wang ,&nbsp;Li Li ,&nbsp;Yu-Huan Li ,&nbsp;Shuang-Gang Ma ,&nbsp;Shi-Shan Yu","doi":"10.1080/10286020.2025.2504964","DOIUrl":"10.1080/10286020.2025.2504964","url":null,"abstract":"<div><div>Three previously undescribed monoterpene derivatives, illisimoncins A–C (<strong>1</strong>–<strong>3</strong>) and one undescribed 2-formylpyrrole alkaloid (<strong>4</strong>) were isolated from the fruits of <em>Illicium simonsii</em> together with five known monoterpenes (<strong>5</strong>-<strong>9</strong>). Structural elucidation of compounds <strong>1</strong>-<strong>4</strong> was elucidated through comprehensive spectroscopic analyses and their absolute configurations were determined by the dimolybdenum tetraacetate [Mo<sub>2</sub>(AcO)<sub>4</sub>]-induced ICD experiment and modified Mosher’s method. Compounds <strong>2</strong> and <strong>7</strong> showed antiviral activities against Coxsackievirus B3 with IC<sub>50</sub> values of 57.74 and 23.24 µM, respectively.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 6","pages":"Pages 834-843"},"PeriodicalIF":1.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biotransformation and activity identification of icariin in human intestinal fungus Pichia occidentalis. 西毕赤酵母中淫羊藿苷的生物转化及活性鉴定。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-21 DOI: 10.1080/10286020.2025.2493937
Jia-Shuo Li, Ru-Xin Yao, Qing Lv, Gang Wang, Xue Wang, Yu-Fei Wang, Fang-Yu Yang, Guo-Biao Liang, Zhuang Miao
{"title":"Biotransformation and activity identification of icariin in human intestinal fungus <i>Pichia occidentalis</i>.","authors":"Jia-Shuo Li, Ru-Xin Yao, Qing Lv, Gang Wang, Xue Wang, Yu-Fei Wang, Fang-Yu Yang, Guo-Biao Liang, Zhuang Miao","doi":"10.1080/10286020.2025.2493937","DOIUrl":"https://doi.org/10.1080/10286020.2025.2493937","url":null,"abstract":"<p><p>Compared to icariin, icariside II demonstrates superior absorption and metabolic properties along with enhanced bioactivity. In this study, using DXM-Glc fluorescence assay, <i>Pichia occidentalis</i> was identified as an intestinal fungus expressing functional glucosidase, which could efficiently convert icariin to icariside II via glycosidic bond hydrolysis, revealing the fungus-mediated intestinal glycoside metabolism pathway and determining the optimal conditions for the conversion, including temperature, drug loading, pH and reaction time. Meanwhile, icariside II exhibited anti-glioma activity, and its mechanism of action involved the inhibition of the activation of NF-κB signaling pathway in glioma cells.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synergistic effect and biochemical evaluation of kolaviron and quercetin on rat-model benign prostate hyperplasia. 克拉维铁与槲皮素对大鼠良性前列腺增生模型的协同作用及生化评价。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-17 DOI: 10.1080/10286020.2025.2501022
Ujong P Ujong, Mbang E Ibor, Iwara A Iwara, Mbeh U Eteng
{"title":"Synergistic effect and biochemical evaluation of kolaviron and quercetin on rat-model benign prostate hyperplasia.","authors":"Ujong P Ujong, Mbang E Ibor, Iwara A Iwara, Mbeh U Eteng","doi":"10.1080/10286020.2025.2501022","DOIUrl":"https://doi.org/10.1080/10286020.2025.2501022","url":null,"abstract":"<p><p>This study examined the effects of kolaviron and quercetin, individually and combined, on biochemical and histopathological changes in testosterone-induced benign prostatic hyperplasia (BPH) in male Wistar rats. Forty-two rats were divided into six groups, with BPH induced in all but the control group. Treatments included kolaviron, quercetin, their combination, and finasteride. BPH increased PSA, 5-α reductase, DHT, kidney and liver function markers, and altered lipid profiles. Treatments reduced these elevations and improved testosterone and HDL-c levels. Findings suggest that kolaviron and quercetin effectively ameliorate BPH, indicating their potential as affordable, non-invasive options for BPH management.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-16"},"PeriodicalIF":1.3,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytotoxic limonoids from the barks of Chisocheton siamensis. 猕猴桃树皮的细胞毒性类柠檬素。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-16 DOI: 10.1080/10286020.2025.2501020
Xue-Hua Li, Jian-Jun Lei, Yang Chi, Xin-Pei Wang, Yu-Wei Xiao, Qian Sun, He Zhang
{"title":"Cytotoxic limonoids from the barks of <i>Chisocheton siamensis</i>.","authors":"Xue-Hua Li, Jian-Jun Lei, Yang Chi, Xin-Pei Wang, Yu-Wei Xiao, Qian Sun, He Zhang","doi":"10.1080/10286020.2025.2501020","DOIUrl":"https://doi.org/10.1080/10286020.2025.2501020","url":null,"abstract":"<p><p>A phytochemical study of 90% methanol extract of the barks of <i>Chisocheton siamensis</i> afforded three undescribed limonoids, siamensisines A-C (<b>1</b>-<b>3</b>). The structures of the new compounds were elucidated by spectroscopic analysis (NMR, IR, UV, and MS). The isolated limonoids were tested <i>in vitro</i> for cytotoxic activities against 5 pancreatic cell lines. As a result, limonoid <b>3</b> exhibited some cytotoxic activities against all the tested tumor cell lines with IC<sub>50</sub> values less than 20 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolation and characterization of a new diketopiperazine from Cephalotrichum sp. RD-ZLM03 isolated in Jinlun cave. 金仑洞头菌RD-ZLM03中一种新型二酮哌嗪的分离与表征。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-15 DOI: 10.1080/10286020.2025.2497284
Yi Hao, Pei-Hai Li, Rong-Xiang Wu, Cai-Xia Wei, Ting Shu, Fan-Dong Kong, Pei Wang, Li-Man Zhou
{"title":"Isolation and characterization of a new diketopiperazine from <i>Cephalotrichum</i> sp. RD-ZLM03 isolated in Jinlun cave.","authors":"Yi Hao, Pei-Hai Li, Rong-Xiang Wu, Cai-Xia Wei, Ting Shu, Fan-Dong Kong, Pei Wang, Li-Man Zhou","doi":"10.1080/10286020.2025.2497284","DOIUrl":"https://doi.org/10.1080/10286020.2025.2497284","url":null,"abstract":"<p><p>A new diketopiperazine, spirotryprostatin C (<b>1</b>), as well as nine known compounds (<b>2</b>-<b>10</b>), were isolated from the fermentation broth of the karst cave derived fungus <i>Cephalotrichum</i> sp. RD-ZLM03. Their structures were determined based on spectroscopic and X-ray diffraction analysis. Compounds <b>2</b>, <b>4</b>, <b>5</b>, <b>6</b>, <b>8</b>, <b>9</b>, and <b>10</b> showed significant proangiogenic activities at the concentration of 25 μM in the zebrafish model.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroprotective effects of Morus alba ethanolic extract against rotenone-induced neurodegeneration and motor impairments in mouse model. 桑乙醇提取物对鱼藤酮诱导的小鼠神经变性和运动损伤的神经保护作用。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-15 DOI: 10.1080/10286020.2025.2501024
Rabia Anjum, Chand Raza, Mehwish Faheem
{"title":"Neuroprotective effects of <i>Morus alba</i> ethanolic extract against rotenone-induced neurodegeneration and motor impairments in mouse model.","authors":"Rabia Anjum, Chand Raza, Mehwish Faheem","doi":"10.1080/10286020.2025.2501024","DOIUrl":"https://doi.org/10.1080/10286020.2025.2501024","url":null,"abstract":"<p><p><i>Morus alba</i> formulations impart neuroprotective properties against dementia, oxidative stress and mitochondrial impairments. The current study aimed to evaluate the neuroprotective potential of ethanolic extract of <i>Morus alba</i> (EMA) on motor impairments. GC-MS characterization of extract revealed active ingredients. Adult mice were exposed to rotenone to induce neurodegeneration and motor dysfunctions. EMA reduced striatal dopamine depletion and motor impairment. Candidate genes for anti-oxidant enzymes, dopamine transmission, synaptogenesis and mitochondrial regulator were significantly modulated in EMA exposed mice. Collectively, EMA imparted preventive action against rotenone-mediated brain damage, augmented antioxidant capabilities and prevented motor dysfunctions. It is suggested that MA as a potential medicinal plant for development of protective strategies in relevant clinical applications.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-19"},"PeriodicalIF":1.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroprotective furanones from a soil-derived fungus Penicillium paxilli ga254. 从土壤真菌青霉paxilli ga254中提取神经保护呋喃酮。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-15 DOI: 10.1080/10286020.2025.2501025
Guang Li, Ya-Jing Wang, Si-Qian Zhou, Xiao-Qian Wu, Jing Li, Wen-Xuan Wang, Hong-Ping Long
{"title":"Neuroprotective furanones from a soil-derived fungus <i>Penicillium paxilli</i> ga254.","authors":"Guang Li, Ya-Jing Wang, Si-Qian Zhou, Xiao-Qian Wu, Jing Li, Wen-Xuan Wang, Hong-Ping Long","doi":"10.1080/10286020.2025.2501025","DOIUrl":"https://doi.org/10.1080/10286020.2025.2501025","url":null,"abstract":"<p><p>Three furanone derivatives (<b>1</b>-<b>3</b>), including one new compound, penicifuranone A (<b>1</b>), and one new natural product (<b>2</b>), along with one known dihydropyranone (<b>4</b>) were isolated from the solid rice medium fermentation of <i>Penicillium paxilli</i> ga254. The structures of these compounds were elucidated using comprehensive NMR spectroscopic analysis. This study represents the first report of these furanone derivatives from this fungus. Additionally, the neuroprotective effects of these compounds against oxygen-glucose deprivation/reperfusion injury in pheochromocytoma-12 cells were investigated.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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