{"title":"Exploring the therapeutic potential of <i>Annona reticulata</i> extract: molecular docking, dynamics, and ADMET properties for cancer treatment and anti-inflammatory activity.","authors":"Pratheep Thangaraj, Ekambaram Gayathiri, Palanisamy Prakash, Dhivya Viswanathan, Mostafizur Rahaman, Saravanan Pandiaraj, Nagarajan S, Rekha Anantharaman, Rajakumar Govindasamy","doi":"10.1080/10286020.2024.2435983","DOIUrl":"10.1080/10286020.2024.2435983","url":null,"abstract":"<p><p>Colorectal cancer remains a global health challenge, prompting the exploration of natural compounds for treatment. <i>Annona reticulata</i> shows promise as a source of activity biomolecules. This study analyzed the dynamics, molecular docking and ADMET properties of the extract, highlighting interaction with inflammatory protein. Key findings include compounds with binding energies of -9.61 and -9.01 kcal/mol for 5fia and 7cx2 receptors. Simulations over 100 ns assessed RMSD, RMSF, SASA, and H-bonding, confirming stability and favorable ADME/toxicity profiles. These results highlight <i>A. reticulata</i> as a promising candidate for developing anti-inflammatory and anticancer drugs.[Figure: see text].</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-23"},"PeriodicalIF":1.3,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wulipan Tuohudaali, Teng-Fei Ji, Wan-Ting Ding, Chen-Yang Li, Jian-Shen Bianba, Ren Ci, Jun Zhao
{"title":"Urolithin B inhibits LPS-induced macrophage M1 polarization via miR155-5p mediated MAPK/NF-кB pathway.","authors":"Wulipan Tuohudaali, Teng-Fei Ji, Wan-Ting Ding, Chen-Yang Li, Jian-Shen Bianba, Ren Ci, Jun Zhao","doi":"10.1080/10286020.2024.2435984","DOIUrl":"https://doi.org/10.1080/10286020.2024.2435984","url":null,"abstract":"<p><p>This study investigated inhibiting mechanisms of Urolithin B (Uro B) on macrophage M1 polarization. Uro B (50 μM) could inhibit the PGE2, COX-2, NO, iNOS, TNF-α, IL-1β and IL-6 levels compared with model group (<i>P</i> < 0.05) as well as the CD86 and F4/80 expression. The miR155-5p overexpression could increase the p38 MAPK, JNK, ERK mRNA activities (<i>P</i> < 0.05), Uro B (50 μM) could reverse changes in these indicators (<i>P</i> < 0.05). Moreover, Uro B (50 μM) could inhibit the TLR4, Src, IκBα, NF-κBp65 and their phosphorylated protein expression (<i>P</i> < 0.05). Therefore, Uro B may inhibit macrophage M1 polarization via miR155-5p mediated MAPK/NF-кB pathway.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.3,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pei-You Ren, Jian-Ying Zhang, Lei Zhao, Xiang-Jun Sun
{"title":"<i>Tripterygium wilfordii</i> polyglycoside tablets attenuated the progression of hepatocellular carcinoma by targeting IL-6 and downstream signaling pathways in a multi-target manner.","authors":"Pei-You Ren, Jian-Ying Zhang, Lei Zhao, Xiang-Jun Sun","doi":"10.1080/10286020.2024.2435992","DOIUrl":"https://doi.org/10.1080/10286020.2024.2435992","url":null,"abstract":"<p><p><i>Tripterygium wilfordii</i> polyglycoside tablets (TWPT) have traditionally been used to treat certain inflammatory diseases. This study validated TWPT as a novel application in hepatocellular carcinoma treatment through multiple targets, thereby expanding its clinical medication scope. TWPT exhibited a low toxicity and a significantly antihepatoma effects <i>in vitro</i> and <i>in vivo</i>. Through network pharmacology analysis, we found TWPT attenuated the progression of hepatocellular carcinoma by multi-targeting, including IL-6, MMP9, TNF-α and VEGFA. Additionally, TWPT targeted IL-6 to regulate downstream pathways, including the PI3K/Akt, JAK2/STAT3, and MAPK signaling pathways. Thus, TWPT could be developed as a potential therapeutic drug for hepatocellular carcinoma.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-21"},"PeriodicalIF":1.3,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Characterization of metabolic profile of Dazhu Hongjingtian and evaluation of its anti-hypoxic constituents.","authors":"Chun-Yan Ou, Xia Gao, Jia-Jia Wang, Xia-Lin Chen, Liang Cao, Zhen-Zhong Wang, Chen-Feng Zhang, Wei Xiao","doi":"10.1080/10286020.2024.2434550","DOIUrl":"https://doi.org/10.1080/10286020.2024.2434550","url":null,"abstract":"<p><p>Dazhu Hongjingtian (DZ) is renowned for its diverse pharmacological activities, yet its metabolic pathways remain to be fully elucidated. In this study, the metabolic profile after oral administration of DZ extract (DZE) in rats was systematically identified by the UPLC/Q-TOF-MS/MS method for the first time. A total of 94 components, including 32 prototypes and 62 metabolites, were tentatively characterized in rat plasma and various tissues samples. Furthermore, 6 constituents (salidroside, quercetin, 4-hydroxycinnamic acid, 5-hydroxymethylfurfural, <i>p</i>-tyrosol, and gallic acid) derived from plasma prototypes were identified as bioactive by assessing cell viabilities of OGD-injured RSC96 cells.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-19"},"PeriodicalIF":1.3,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Le Thi Vien, Tran Thi Hong Hanh, Tran Hong Quang, Nguyen Dang Ngai, Dao Viet Ha, Nguyen Xuan Cuong
{"title":"Culcinoside E, a new sulfated steroidal biglycoside from the starfish <i>Culcita novaeguineae</i>.","authors":"Le Thi Vien, Tran Thi Hong Hanh, Tran Hong Quang, Nguyen Dang Ngai, Dao Viet Ha, Nguyen Xuan Cuong","doi":"10.1080/10286020.2024.2434564","DOIUrl":"https://doi.org/10.1080/10286020.2024.2434564","url":null,"abstract":"<p><p>Using various chromatographic separations, six steroid glycoside derivatives, including one new compound named culcinoside E (<b>1</b>), were isolated from the methanol extract of the starfish <i>Culcita novaeguineae</i>. Their structures were confirmed by detailed analysis of the 1D, 2D NMR, and HR ESI QTOF mass spectra. Among isolated compounds, culcinoside E (<b>1</b>), diplasterioside A (<b>5</b>), and thornasteroside A (<b>6</b>) inhibited growth of <i>Enterococcus faecalis</i>, whereas culcitoside C<sub>1</sub> (<b>3</b>) was active on <i>Candida albicans</i>.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.3,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ST Shukla , Anu Kaushik , Samiullah Allahbaksh Auti , Dinesh Kumar , Supriya Kumar Das
{"title":"Preclinical determination of wound-healing activity of halibut oil cream in rat model of burn wound","authors":"ST Shukla , Anu Kaushik , Samiullah Allahbaksh Auti , Dinesh Kumar , Supriya Kumar Das","doi":"10.1080/10286020.2024.2368835","DOIUrl":"10.1080/10286020.2024.2368835","url":null,"abstract":"<div><div>This study investigated the effects of halibut oil cream, containing omega-3 fatty acids, vitamins A and D, and hydroxyproline, on burn wound healing in rats. Acute dermal toxicity tests confirmed its nontoxicity. Wistar rats were divided into five groups: a control, a positive control treated with silver sulfadiazine 1% (SSD), and three groups treated with 3%, 9%, and 27% halibut oil cream Formulation (HBOF). The SSD and HBOF groups showed significant healing improvements compared to the control. Histopathological analysis indicated increased collagen production in the HBOF groups, suggesting halibut oil cream’s potential as a topical treatment for burn wounds.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 12","pages":"Pages 1455-1474"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cai-Wen Fan , Li Luo , Mei-Shan Li , Yun-Qiong Gu , Yi-Lin Fang , Feng Qin , Heng-Shan Wang
{"title":"Sesquilignans PD from Zanthoxylum nitidum var. tomentosum exerts antitumor effects via the ROS/MAPK pathway in liver cancer cells","authors":"Cai-Wen Fan , Li Luo , Mei-Shan Li , Yun-Qiong Gu , Yi-Lin Fang , Feng Qin , Heng-Shan Wang","doi":"10.1080/10286020.2024.2371032","DOIUrl":"10.1080/10286020.2024.2371032","url":null,"abstract":"<div><div>Sesquilignans <strong>PD</strong> is a natural phenylpropanoid compound that was isolated from <em>Zanthoxylum nitidum</em> var. <em>tomentosum</em>. In this study, we assessed the antitumor effect of <strong>PD</strong> on SK-Hep-1 and HepG2 cells and the underlying molecular mechanisms. The results revealed that <strong>PD</strong> markedly inhibited the proliferation and migration of both liver cancer cells. Moreover, <strong>PD</strong> induced apoptosis, autophagy, and reactive oxygen species (ROS) production in liver cancer cells. Notably, <strong>PD</strong> increased the protein levels of p-p38 MAPK and p-ERK1/2 in liver cancer cells. This is the first report on the anticancer effect of <strong>PD</strong>, which is mediated <em>via</em> increased ROS production and MAPK signaling activation.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 12","pages":"Pages 1530-1542"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhao Zhai , Jie Fu , Meng-Liang Ye , Jing-Yue Wang , Hao-Jian Zhang , Hang Yu , Xin-Yu Yang , Hui Xu , Jia-Chun Hu , Jin-Yue Lu , Heng-Tong Zuo , Yi Zhao , Jian-Ye Song , Yong Zhang , Yan Wang , Nian-Zeng Xing
{"title":"The changes of intestinal microbiota and metabolomics during the inhibition of bladder cancer by liquiritigenin","authors":"Zhao Zhai , Jie Fu , Meng-Liang Ye , Jing-Yue Wang , Hao-Jian Zhang , Hang Yu , Xin-Yu Yang , Hui Xu , Jia-Chun Hu , Jin-Yue Lu , Heng-Tong Zuo , Yi Zhao , Jian-Ye Song , Yong Zhang , Yan Wang , Nian-Zeng Xing","doi":"10.1080/10286020.2024.2366010","DOIUrl":"10.1080/10286020.2024.2366010","url":null,"abstract":"<div><div>Liquiritigenin is a natural medicine. However, its inhibitory effect and its potential mechanism on bladder cancer (BCa) remain to be explored. It was found that it could be visualized that the transplanted tumours in the low-dose liquiritigenin -treated group and the high-dose liquiritigenin -treated group were smaller than those in the model group. Liquiritigenin treatment led to alterations in Lachnoclostridium, <em>Escherichia-Shigella, Alistipes</em> and <em>Akkermansia</em>. Non-targeted metabolomics analysis showed that a total of multiple differential metabolites were identified between the model group and the high-dose liquiritigenin-treated group. This provides a new direction and rationale for the antitumour effects of liquiritigenin.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 12","pages":"Pages 1445-1454"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Phosphatidylcholine and ceramide derivatives from white rot fungus Microporus xanthropus PP17-20","authors":"Phongphan Jantaharn , Audomsak Churat , Sirirat Juanan , Ek Sangvichien , Wiyada Mongkolthanaruk , Nuttika Suwannasai , Thanaset Senawong , Sirirath McCloskey","doi":"10.1080/10286020.2024.2368834","DOIUrl":"10.1080/10286020.2024.2368834","url":null,"abstract":"<div><div>The undescribed phosphatidylcholine (<strong>1</strong>), along with twelve known compounds, was isolated from the cultures of white rot fungus <em>Microporus xanthropus</em> PP17-20. In this work the fungus was cultivated in Yeast-Malt extract medium to explore active compound production. The chemical structures were elucidated on the basis of spectroscopic and HRESIMS data. Several isolated compounds were evaluated for anti-proliferative activity against A549 and MCF-7 cancer cell lines.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 12","pages":"Pages 1551-1556"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xian-Sheng Ye , Kuan Lin , Chang-Long Leng , Yu-Ran Gui , Shu-Xiu Zhu , Hui-Ying Liu , Yi-Yuan Xia , Bin-Lian Sun , Wei Liu , Xi-Ji Shu
{"title":"Discovery of sesquiterpene lactones with anti-inflammatory effect from Youngia japonica","authors":"Xian-Sheng Ye , Kuan Lin , Chang-Long Leng , Yu-Ran Gui , Shu-Xiu Zhu , Hui-Ying Liu , Yi-Yuan Xia , Bin-Lian Sun , Wei Liu , Xi-Ji Shu","doi":"10.1080/10286020.2024.2370401","DOIUrl":"10.1080/10286020.2024.2370401","url":null,"abstract":"<div><div>The preliminary study revealed that the ethyl acetate eluate of <em>Youngia japonica</em> (YJ-E) could inhibit the expression of key proteins of p-p65, p-IκBα, p-IKKα/β, and p-AKT in LPS stimulated BV2 cell. Further phytochemical study led to the isolation of eight compounds from YJ-E, including one new sesquiterpene lactone. Their structures were elucidated by several spectroscopic data, and comparing the NMR data of known compound. In addition, all of the isolates were evaluated for the anti-inflammatory effect. As a result, compounds <strong>3</strong> and <strong>4</strong> distinctly attenuated the expressions of p-IκBα, p-p65, and p-AKT in LPS stimulated BV2 cell, respectively.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 12","pages":"Pages 1557-1564"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}