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Design, synthesis and anti-tumor activity of oleanolic acid derivatives targeting EGFR. 靶向EGFR齐墩果酸衍生物的设计、合成及抗肿瘤活性研究。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-06-18 DOI: 10.1080/10286020.2025.2515260
Yan-Qiu Meng, Li-Ming Liu, Dong-Ping Xu, Guo Chen, Tong-Tong Gu
{"title":"Design, synthesis and anti-tumor activity of oleanolic acid derivatives targeting EGFR.","authors":"Yan-Qiu Meng, Li-Ming Liu, Dong-Ping Xu, Guo Chen, Tong-Tong Gu","doi":"10.1080/10286020.2025.2515260","DOIUrl":"https://doi.org/10.1080/10286020.2025.2515260","url":null,"abstract":"<p><p>With computer-aided drug design (CADD) technology, a total of 12 inhibitors of EGFR based on oleanolic acid (<b>OA</b>) derivatives were designed and synthesized with modification at C-3 and C-28 positions of <b>OA</b>. Their structures were confirmed by <sup>1</sup>H-NMR,<sup>13</sup>C-NMR and ESI-MS. The anti-tumor activities of these novel analogues were evaluated by MTT assay, and the results showed that the derivatives <b>I<sub>6</sub></b> and <b>II<sub>2</sub></b> had stronger cytotoxicity on A549 and MCF-7 cancer cells, which may be potential candidate compounds for tumor therapy.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Apoptotic effect of carvacrol on different cancer cells and its potential as an active medicine ingredient. 香芹酚对不同肿瘤细胞的凋亡作用及其作为活性药物成分的潜力。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-06-18 DOI: 10.1080/10286020.2025.2517669
Müge Musmula, Senem Akkoc
{"title":"Apoptotic effect of carvacrol on different cancer cells and its potential as an active medicine ingredient.","authors":"Müge Musmula, Senem Akkoc","doi":"10.1080/10286020.2025.2517669","DOIUrl":"https://doi.org/10.1080/10286020.2025.2517669","url":null,"abstract":"<p><p>Apoptosis is the programmed death of cells that have lost their function, have been damaged, or are no longer needed in the organism. Genes that control this process are overexpressed in some tumors. Carvacrol, a terpenoid, has been shown to inhibit tumor growth and induce apoptosis in cancerous cells, increasing caspase activity, DNA fragmentation, and the expression of the Bax protein, while decreasing Bcl-2 expression. In this review, the effects of carvacrol on various cancers and its potential as a drug are summarized.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-18"},"PeriodicalIF":1.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and antitumor activity of silibinin derivatives targeting VEGFR. 靶向VEGFR的水飞蓟宾衍生物的合成及抗肿瘤活性研究。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-06-18 DOI: 10.1080/10286020.2025.2515250
Lei Gao, Liang-Feng Zhang, Yan Li, Chao-Hui Zhang, Yan-Qiu Meng
{"title":"Synthesis and antitumor activity of silibinin derivatives targeting VEGFR.","authors":"Lei Gao, Liang-Feng Zhang, Yan Li, Chao-Hui Zhang, Yan-Qiu Meng","doi":"10.1080/10286020.2025.2515250","DOIUrl":"https://doi.org/10.1080/10286020.2025.2515250","url":null,"abstract":"<p><p>Totally 10 inhibitors of VEGFR based on silibinin derivatives were designed and synthesized with the modification on the hydroxyl group at C-3 and C-7 positions of silibinin through acylation, selective aminolysis, alkylation, oxidation, and dehydrogenation reactions. Their structures were confirmed by MS, <sup>1</sup>H NMR, and <sup>13</sup>C NMR. <i>In vitro</i> activity assay showed that these compounds can inhibit cell proliferation of A549 and SGC7901 cells, especially compounds <b>I<sub>3</sub></b> and <b>I<sub>8</sub></b> showed better inhibitory activity on these tumor cells, and similar to the positive control drug lapatinib, which may be potential candidate compounds for tumor therapy.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
C19-Diterpenoid alkaloids from two plants of Aconitum sinoaxillare and Aconitum chasmanthum. 从乌头和乌头两种植物中提取c19 -二萜类生物碱。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-06-11 DOI: 10.1080/10286020.2025.2513492
Ling-Feng Tian, Mei-Zhen Ye, Ting-Ting Li, Qiao Long, Shu Wang, Min Zhang, Lin Chen, Shuai Huang, Xian-Li Zhou
{"title":"C<sub>19</sub>-Diterpenoid alkaloids from two plants of <i>Aconitum sinoaxillare</i> and <i>Aconitum chasmanthum</i>.","authors":"Ling-Feng Tian, Mei-Zhen Ye, Ting-Ting Li, Qiao Long, Shu Wang, Min Zhang, Lin Chen, Shuai Huang, Xian-Li Zhou","doi":"10.1080/10286020.2025.2513492","DOIUrl":"https://doi.org/10.1080/10286020.2025.2513492","url":null,"abstract":"<p><p>Five new compounds (<b>1</b>-<b>5</b>) were isolated from the whole plants of two species of <i>Aconitum</i>, including two aconitine-type C<sub>19</sub>-diterpenoid alkaloids, sinoaxidines A (<b>1</b>) and B (<b>2</b>) and a franchetine-type C<sub>19</sub>-diterpenoid alkaloid, sinoaxidine C (<b>3</b>) from <i>Aconitum sinoaxillare</i> W. T. Wang. Two aconitine-type C<sub>19</sub>-diterpenoid alkaloids, chasmanthumines A (<b>4</b>) and B (<b>5</b>) from <i>Aconitum chasmanthum</i> Stapf, and forty known diterpenoid alkaloids were also isolated. The structures of all compounds were identified based on extensive IR, 1D, 2D NMR and HR-ESI-MS data analysis. Compound <b>6</b> exhibited potent inhibitory effects on the production of NO in RAW 264.7 cells with IC<sub>50</sub> of 29.60 <i>μ</i>M respectively.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.3,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diterpenoids from the soft coral Pachyclavularia violacea and their anti-inflammatory activities. 软珊瑚Pachyclavularia violacea中的二萜类化合物及其抗炎活性。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-06-05 DOI: 10.1080/10286020.2025.2511896
Chen-Lu Du, Xue-Yao Zhao, Xiao Xiao, Chuan Zhang, Yue-Wei Guo, Liang Chen, Yan-Wei Wu, Song-Wei Li
{"title":"Diterpenoids from the soft coral <i>Pachyclavularia violacea</i> and their anti-inflammatory activities.","authors":"Chen-Lu Du, Xue-Yao Zhao, Xiao Xiao, Chuan Zhang, Yue-Wei Guo, Liang Chen, Yan-Wei Wu, Song-Wei Li","doi":"10.1080/10286020.2025.2511896","DOIUrl":"https://doi.org/10.1080/10286020.2025.2511896","url":null,"abstract":"<p><p>The detailed chemical investigation of the South China Sea soft coral <i>Pachyclavularia violacea</i>, led to the isolation and characterization of a new casbane-type diterpenoid, 7,8-epoxy-casbene (<b>1</b>), along with seven known compounds (<b>2</b>-<b>8</b>). Their structures were determined by extensive spectroscopic analysis, quantum mechanical nuclear magnetic resonance (QM-NMR) method, time-dependent density functional theory electronic circular dichroism (TDDFT-ECD) calculation, and comparison with the spectral data previously reported in the literature. In <i>in vitro</i> bioassays, the anti-inflammatory activities of the isolated compounds were evaluated in the lipopolysaccharide (LPS)-induced RAW 264.7 cells, and compounds <b>6</b>-<b>8</b> displayed interesting inhibitory effects on LPS-induced tumor necrosis factor (TNF)-<i>α</i> protein release with half-maximal inhibitory concentration (IC<sub>50</sub>) values of 201.1, 231.7, and 66.21 µM, respectively.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical constituents of Erythrina speciosa. 赤藓属植物的化学成分。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-06-04 DOI: 10.1080/10286020.2025.2513489
Xi Yang, Yong-Chun Gao, Ya-Ping Chen, Li-Qin Wang
{"title":"Chemical constituents of <i>Erythrina speciosa</i>.","authors":"Xi Yang, Yong-Chun Gao, Ya-Ping Chen, Li-Qin Wang","doi":"10.1080/10286020.2025.2513489","DOIUrl":"https://doi.org/10.1080/10286020.2025.2513489","url":null,"abstract":"<p><p>Three unreported pterocarpans, erystrictin D (<b>1</b>) and a pair of diastereoisomers, erystrictins E/F (<b>2a/2b</b>), along with fifteen known compounds (<b>3</b>-<b>17</b>) were isolated from <i>Erythrina speciosa.</i> Their structures were established by extensive spectroscopic analyses, including HRESIMS, 1D and 2D NMR, and electronic circular dichroism (ECD) spectra. All the compounds were isolated from this plant for the first time. Compounds <b>1</b>-<b>3</b>, <b>5</b> and <b>6</b> were evaluated for their inhibitory activities against a panel of cancer cell lines by MTS method. Compound <b>1</b> showed inhibitory activities against HepG2 and SW480 cells, with IC<sub>50</sub> values of 3.160 ± 0.069 and 6.575 ± 0.525 <i>μ</i>M, respectively; compound <b>5</b> against HepG2 cells, with IC<sub>50</sub> value of 22.05 ± 0.83 <i>μ</i>M.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leptols A and B, one meroterpenoid and one coumarin hybrid from the leaves of Melicope pteleifolia and its anti-inflammation in BV2 cells. 百里果叶片瘦素A、B、甲硫萜类和香豆素杂种化合物及其对BV2细胞的抗炎作用。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-06-04 DOI: 10.1080/10286020.2025.2509767
He-Lin Wei, Jing-Jing Sun, Jia-Qi Chen, Tao Wang, Jun Li, Peng-Fei Tu
{"title":"Leptols A and B, one meroterpenoid and one coumarin hybrid from the leaves of Melicope pteleifolia and its anti-inflammation in BV2 cells.","authors":"He-Lin Wei, Jing-Jing Sun, Jia-Qi Chen, Tao Wang, Jun Li, Peng-Fei Tu","doi":"10.1080/10286020.2025.2509767","DOIUrl":"https://doi.org/10.1080/10286020.2025.2509767","url":null,"abstract":"<p><p>One meroterpenoid and one coumarin hybrid, namely leptols A (<b>1</b>) and B (<b>2</b>), respectively, and seven known chromone analogues have been isolated from the leaves of <i>Melicope pteleifolia</i>. The structures were elucidated on the basis of spectroscopic methods (UV, IR, HRMS, and NMR), and the absolute configuration was determined by comparing its experimental and calculated OR values. These isolates were evaluated for anti-inflammatory activities on the lipopolysaccharide (LPS) induced nitric oxide (NO) production in BV2 microglial cells, and compound <b>1</b> exhibited potential nitric oxide inhibitory activities with IC<sub>50</sub> value of 12.0 µM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expanding the role of alpha lipoic acid for psychiatric and neurological health. 扩大α硫辛酸对精神和神经健康的作用。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-06-03 DOI: 10.1080/10286020.2025.2509765
Ishu Garg, Harish Kumar, Raj Kumari, Anupama Singh, Ravi Maurya, Rashi Pandey, Shruti Bhatt
{"title":"Expanding the role of alpha lipoic acid for psychiatric and neurological health.","authors":"Ishu Garg, Harish Kumar, Raj Kumari, Anupama Singh, Ravi Maurya, Rashi Pandey, Shruti Bhatt","doi":"10.1080/10286020.2025.2509765","DOIUrl":"https://doi.org/10.1080/10286020.2025.2509765","url":null,"abstract":"<p><p>With the rise in health and neurological concerns around the globe, nutraceuticals are surpassing the harms of drug treatment. Alpha-lipoic acid, an organosulfur naturally abundant biomolecule that has potent protective and therapeutic effects in psychiatric and neurological disorders. Studies targeting alpha-lipoic acid in the brain have concluded that it modulates oxidative stress, neuronal aging, apoptosis, mitochondrial dysfunction, neuro-inflammation, cellular signaling, neurotransmission, and receptor functioning. Various clinical studies have been conducted, yielding satisfactory results indicating alpha-lipoic acid as a therapeutic agent for neurodegenerative and psychiatric disorders. However, further studies are still required to use alpha-lipoic acid as a monotherapeutic agent and to design a dosage regimen. The article aims to demonstrate alpha-lipoic acid as a potent biomolecule for curing and preventing psychiatric and neural disorders.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-31"},"PeriodicalIF":1.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Total synthesis of albafuran B and its osteogenic differentiation promoting effect on human mesenchymal stem cells. 白afuran B的合成及其对人间充质干细胞成骨分化的促进作用。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-06-03 DOI: 10.1080/10286020.2025.2509762
Wan-Dong Liu, Yue Jing, Bin Wang, Lin-Lin Tian, Jian Li, Xiu-Shan Yin, Hua Zhang
{"title":"Total synthesis of albafuran B and its osteogenic differentiation promoting effect on human mesenchymal stem cells.","authors":"Wan-Dong Liu, Yue Jing, Bin Wang, Lin-Lin Tian, Jian Li, Xiu-Shan Yin, Hua Zhang","doi":"10.1080/10286020.2025.2509762","DOIUrl":"https://doi.org/10.1080/10286020.2025.2509762","url":null,"abstract":"<p><p>In the current project, the total synthesis of albafuran B was achieved in four steps and 19.3% overall yield, involving two key reactions of the one-pot Corey-Fuchs reaction and Suzuki coupling. Using the same protocol, two analogs, moracin C and 4'-farnesyl-moracin M, were also successfully synthesized. The effect of albafuran B on the osteogenic differentiation of human umbilical cord-derived and adipose-derived mesenchymal stem cells was evaluated <i>via</i> alkaline phosphatase staining and alizarin red S staining. The assay results revealed that albafuran B showed good osteogenic differentiation promoting activity toward both cell lines.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endophytic microorganisms in lichen: rising stars in the biomedicine field deserving broader recognition. 地衣内生微生物：生物医学领域的后起之星，值得更广泛的认识。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-05-28 DOI: 10.1080/10286020.2025.2501030
Jia-Na Zhu, Meng-Long Liu, Qiu-Hua He, Hai-Yan Ding
{"title":"Endophytic microorganisms in lichen: rising stars in the biomedicine field deserving broader recognition.","authors":"Jia-Na Zhu, Meng-Long Liu, Qiu-Hua He, Hai-Yan Ding","doi":"10.1080/10286020.2025.2501030","DOIUrl":"https://doi.org/10.1080/10286020.2025.2501030","url":null,"abstract":"<p><p>Lichens are renowned for their ability to thrive in extreme environments and for producing unique metabolites with considerable bioactive potential. However, their medicinal value remains largely underexplored, primarily due to slow growth rates and habitat specificity. Notably, endolichenic microorganisms, particularly fungi, are the predominant producers of these bioactive compounds, which exhibit antimicrobial, antiviral, and anticancer properties. Investigating these microorganisms and their metabolites presents promising biomedical opportunities, underscoring the importance of sustainably utilizing lichen resources and discovering novel compounds. This paper reviews the diversity and bioactive potential of endophytic microorganisms in lichens, providing valuable insights for the exploration of natural resources.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-19"},"PeriodicalIF":1.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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