Shan-Bin Li , Tong-Shi-Yao Zhao , Zhen Ye , Jian Zou , Xi Yuan , Xian-Li Zhou , Cheng-Qin Liang , Kang-Zhi Li , Lan-Zhen Huang
{"title":"Antitumor effects of BPCO on liver cancer cells","authors":"Shan-Bin Li , Tong-Shi-Yao Zhao , Zhen Ye , Jian Zou , Xi Yuan , Xian-Li Zhou , Cheng-Qin Liang , Kang-Zhi Li , Lan-Zhen Huang","doi":"10.1080/10286020.2025.2467318","DOIUrl":"10.1080/10286020.2025.2467318","url":null,"abstract":"<div><div>Esculetin is a coumarin compound with anticancer, antioxidant, and anti-inflammatory activities. In this study, we synthesized an esculetin derivative, 6,7-bis(Pentyloxy)-2H-Chromen-2-One (BPCO), through etherification. BPCO inhibited the proliferation of HepG2 cells in a dose- and time-dependent manner. It also inhibited cell migration, promoted apoptosis, and caused cell cycle arrest at the G1 phase. Additionally, BPCO downregulated the expression levels of Bcl-2 and Bcl-XL and upregulated the expression levels of Bax and Bak. This study shows that BPCO inhibits hepatocellular carcinoma cell proliferation and induces apoptosis, providing a basis for further study of BPCO as an antitumor agent.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 9","pages":"Pages 1366-1378"},"PeriodicalIF":1.3,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mei-Li Li , Kun Pang , Lei Qiao , Zhi-Qiang Guan , Chao-Ju Gong , Song-Tao Li , Zhi-Ming Tang , Yi-Ling Zhang , Ji-Cun Ding
{"title":"Resveratrol affects proliferation, apoptosis and migration of fibroblast cells as well as inhibits COL1A1/2 and TGFB2/3 gene expression","authors":"Mei-Li Li , Kun Pang , Lei Qiao , Zhi-Qiang Guan , Chao-Ju Gong , Song-Tao Li , Zhi-Ming Tang , Yi-Ling Zhang , Ji-Cun Ding","doi":"10.1080/10286020.2025.2462610","DOIUrl":"10.1080/10286020.2025.2462610","url":null,"abstract":"<div><div>Primary fibroblasts isolated from pterygium and skin pathological scar were identified by immunofluorescence staining. It was found by CCK8 and TUNEL that high-dose resveratrol, a Chinese medicine monomer, could inhibit proliferation, promote apoptosis and restrain migration. Explored by whole-transcriptome sequencing and LC-MS/MS, 1531 up-regulated mRNAs, 1022 down-regulated mRNAs, 79 up-regulated proteins and 84 down-regulated proteins were identified in resveratrol-treated pterygium fibroblasts. It was shown by KEGG, GO, PPI and the following bioinformatics analysis that resveratrol may affect proliferation, apoptosis and migration of fibroblast through TGFB2/3 and COL1A1/2.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 9","pages":"Pages 1311-1331"},"PeriodicalIF":1.3,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ying-Ying Liu , Yi-Fan Xu , Xin-Ru Li , Qi-Pan Fan , Jia-Hao Liu , Si-Yu Zhou , Yu-Qing Qian , Ming-Dong Li
{"title":"Design, synthesis, and inhibition of novel ferulic acid derivatives on free fatty acid induced cellular lipid accumulation","authors":"Ying-Ying Liu , Yi-Fan Xu , Xin-Ru Li , Qi-Pan Fan , Jia-Hao Liu , Si-Yu Zhou , Yu-Qing Qian , Ming-Dong Li","doi":"10.1080/10286020.2025.2459600","DOIUrl":"10.1080/10286020.2025.2459600","url":null,"abstract":"<div><div>Abnormal accumulation of hepatocyte lipids is a hallmark feature of NAFLD. Ferulic acid (FA), an ingredient with antioxidant activity in Chinese herbs, can be used to treat NAFLD by activating AMPK phosphorylation. In this study, we synthesized ten acrylic acid derivatives <strong>A1-A10</strong>. The inhibition of lipid accumulation showed that most target compounds could inhibit lipid accumulation at 400 μM; compound <strong>A3</strong> showed a better inhibitory effect than other compounds. Molecular docking results proved that <strong>A3</strong> could bind to PPARγ, and multiple binding sites existed in both the ferulic acid cohort and the substituted benzene cohort.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 9","pages":"Pages 1278-1293"},"PeriodicalIF":1.3,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tao Yang , Jian Chen , Zhao-Nan He , Zhong Li , Min Jiang
{"title":"Utilizing network pharmacology and experimental validation to explore the mechanisms of the Qijiafuzheng formula promoting CD8+ T-cell infiltration in the microenvironment of lung adenocarcinoma through STAT1/CXCL10","authors":"Tao Yang , Jian Chen , Zhao-Nan He , Zhong Li , Min Jiang","doi":"10.1080/10286020.2025.2467311","DOIUrl":"10.1080/10286020.2025.2467311","url":null,"abstract":"<div><div>Qijiafuzheng formula (QJFZF), a Traditional Chinese Medicine used to treat lung cancer and mitigate chemotherapy side effects, was studied to clarify its impact on the tumor immune microenvironment (TIME). Using network pharmacology and experimental validation, 39 overlapping targets were identified from 579 QJFZF-related and 752 lung adenocarcinoma (LUAD)-TIME targets. Key genes (CCL3, IL10, CXCL10, FOXP3, CD86) correlated negatively with tumor purity and positively with CD8+ T-cell infiltration. CXCL10 emerged as the core target, with experiments showing QJFZF activates the STAT1/CXCL10 pathway to enhance CD8+ T-cell recruitment in LUAD-TIME. This study elucidates QJFZF’s immunomodulatory mechanisms, supporting its clinical application.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 9","pages":"Pages 1347-1365"},"PeriodicalIF":1.3,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Baicalein: unveiling the multifaceted marvel of hepatoprotection and beyond","authors":"Ashish Dogra","doi":"10.1080/10286020.2025.2481273","DOIUrl":"10.1080/10286020.2025.2481273","url":null,"abstract":"<div><div>Flavonoids are bioactive compounds derived from plants that play a crucial role in human health. Baicalein is a prominent phytoconstituent with multifaceted therapeutic potential against various diseases. This review explores recent advancements in understanding baicalein’s hepatoprotective action against different toxicity models (acetaminophen, cisplatin, doxorubicin, CCL<sub>4</sub>, monocrotaline, & d-galactosamine). Furthermore, we report the key pharmacological activities of baicalein against neurotoxicity (6-OHDA, rotenone, d-galactose, stroke, alzheimer, & sclerosis), inflammation (arthritis, pulmonary fibrosis, & LPS-induced sepsis), cancer (breast, prostate, gall bladder, gastric, & pancreatic), & diabetes. Overall, baicalein has potential to influence diverse biological networks, making it a promising candidate for both dietary supplementation and therapeutic development.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 9","pages":"Pages 1223-1235"},"PeriodicalIF":1.3,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Regulatory mechanisms and therapeutic potential of natural microglia inhibitors in Parkinson's disease.","authors":"Ting-Ting Jin, Rui-Zhen Shi, Jian-Wen Shi, Fei Liu, Yong-Xin Liang","doi":"10.1080/10286020.2025.2544148","DOIUrl":"https://doi.org/10.1080/10286020.2025.2544148","url":null,"abstract":"<p><p>Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases affecting the central nervous system. The pathogenesis of PD is complex, and its etiology remains poorly understood. Recently, it has been suggested that neuroinflammation caused by overactivated microglia plays a significant role in the occurrence and development of PD. The use of anti-inflammatory medication to delay or prevent the occurrence and progression of PD has become a hot topic of research in this field. This review introduces the inflammatory mechanism of PD, the related inflammatory factors, and the progress of using natural anti-inflammatory drugs for PD prevention and treatment.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-22"},"PeriodicalIF":1.3,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jie Sun, Xue-Rou Zhang, Yan Liu, Xiao-Juan Zhang, Zhen-Xing Fang, Bing-You Yang, Yuan-Yuan Zhou
{"title":"Two new compounds from the green walnut husks of <i>Juglans mandshurica</i>.","authors":"Jie Sun, Xue-Rou Zhang, Yan Liu, Xiao-Juan Zhang, Zhen-Xing Fang, Bing-You Yang, Yuan-Yuan Zhou","doi":"10.1080/10286020.2025.2547692","DOIUrl":"https://doi.org/10.1080/10286020.2025.2547692","url":null,"abstract":"<p><p>Two new compounds (<b>1-2</b>) and thirteen known tetrahydroaphcosterones (<b>3-15</b>) were isolated from the green walnut husks of <i>Juglans mandshurica</i>, with structures elucidated via spectroscopic analyses. Cytotoxicity screening against BGC-823, A-549, and HepG-2 cancer cell lines revealed that compound <b>12</b> inhibited A-549 with the IC<sub>50</sub> value of (54.94 ± 1.72) μM. Compounds <b>3-4</b> and <b>10-12</b> inhibited HepG-2, and the IC<sub>50</sub> values were (62.53 ± 2.52), (51.95 ± 0.65), (63.90 ± 0.30), (66.60 ± 1.35), (61.07 ± 0.31) μM. Compounds <b>4</b> and <b>12</b> inhibited BGC-823 at 60 μM. This study identifies bioactive components and provides a chemical foundation for clinical preparation development.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yu-Yao Liu, Ya Chen, Qi-Qi Wang, Xi Zhang, Xiao-Xia Ma, Xing-De Wu, Jia Su
{"title":"Yatein-induced DNA damage of breast cancer cells by interfering with DNA topoisomerase IIα.","authors":"Yu-Yao Liu, Ya Chen, Qi-Qi Wang, Xi Zhang, Xiao-Xia Ma, Xing-De Wu, Jia Su","doi":"10.1080/10286020.2025.2544144","DOIUrl":"https://doi.org/10.1080/10286020.2025.2544144","url":null,"abstract":"<p><p>DNA topoisomerase IIα (TOP2A) plays a key role in resolving DNA topological stress during replication, transcription, and chromosome segregation. Yatein, a biogenic precursor of deoxypodophyllotoxin possesses antitumor effects. Herein, we explored its antitumor effect in breast cancer. Yatein significantly inhibited the proliferation of breast cancer cells by MTT, colony formation, EdU assay, and cell cycle analysis. Moreover, yatein suppressed the stemness of cancer cells, causing inhibition of migration and epithelial-mesenchymal transition. Mechanism study revealed that yatein inhibited TOP2A activity and stabilized TOP2A-DNA cleavage complexes, caused DNA damage and apoptosis, suggesting its potential in the treatment of breast cancer.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.3,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fugal exopolysaccharides, potential applications and future prospective.","authors":"Varish Ahmad","doi":"10.1080/10286020.2025.2544138","DOIUrl":"https://doi.org/10.1080/10286020.2025.2544138","url":null,"abstract":"<p><p>Exopolysaccharides from fungi [EPSs] have been acknowledged over the past 20 years as high-value macromolecules. These products have a variety of requests in the pharmaceutical, medical, food, and other industries. Apart from anticancer and antiviral potential, they also increase the nutrient content of human food and the aridity of the soil. The general outline of the present study covers the characteristics, purification, and analysis of fungal EPS and the applications thereof in human welfare. It is enough to say that chemicals with the required bioactivity may be produced or extracted from the fungi via genetic, biochemical, and technological manipulation.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-20"},"PeriodicalIF":1.3,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Drimane sesquiterpenoids from cultures of the basidiomycete <i>Panellus pusillus</i>.","authors":"Prapairat Seephonkai, Rachada Chanphen, Patchanee Auncharoen, Thitiya Boonpratuang, Tuksaporn Thummarukcharoen, Aphidech Sangdee, Masahiko Isaka","doi":"10.1080/10286020.2025.2549892","DOIUrl":"https://doi.org/10.1080/10286020.2025.2549892","url":null,"abstract":"<p><p>In the quest for novel compounds with potent activities against human infectious diseases from fungi in Thailand, cultures of the basidiomycete <i>Panellus pusillus</i> strain TBRC-BCC 43793 were chemically investigated. A new drimane sesquiterpenoid, 1<i>β</i>-hydroxypereniporin A (<b>1</b>), together with a known drimane, 6<i>β</i>-hydroxy-isodrimenin, was isolated using silica gel column chromatography and preparative High Performance Liquid Chromatography (HPLC). Its structure was elucidated on the basis of the spectroscopic method. The isolated compounds were inactive in the antiplasmodial, antimycobacterial, and antibacterial activity assays.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.3,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}