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Journal of Asian Natural Products Research最新文献

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Quantitative predictive model for screening optimal processing methods of Polygonati rhizoma. 筛选何首乌最佳加工方法的定量预测模型。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-08-16 DOI: 10.1080/10286020.2024.2390496
Shi-Jie Bi, An-Lei Yuan, Zi-Jun Chen, Yue Ren, Kai-Yang Liu, Chao-Qun Liu, Zhen-Zhen Xu, Ze-Wen Wang, Yan-Ling Zhang
{"title":"Quantitative predictive model for screening optimal processing methods of <i>Polygonati</i> rhizoma.","authors":"Shi-Jie Bi, An-Lei Yuan, Zi-Jun Chen, Yue Ren, Kai-Yang Liu, Chao-Qun Liu, Zhen-Zhen Xu, Ze-Wen Wang, Yan-Ling Zhang","doi":"10.1080/10286020.2024.2390496","DOIUrl":"https://doi.org/10.1080/10286020.2024.2390496","url":null,"abstract":"<p><p><i>Polygonati</i> rhizoma (Huangjing in Chinese) is a common clinical tonic with the traditional effects of tonifying Qi, nourishing Yin. However, the lack of precise control of processing parameters has led to the uneven quality of processed Huangjing. A prediction model using the CRITIC method optimizes processing by correlating method, component contents, and biological activity, ensuring consistent quality and efficacy.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioactive prenylated c6–c3 derivatives from the roots of Illicium brevistylum 从Illicium brevistylum的根中提取的具有生物活性的前炔基c6-c3衍生物。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-08-14 DOI: 10.1080/10286020.2024.2365437
{"title":"Bioactive prenylated c6–c3 derivatives from the roots of Illicium brevistylum","authors":"","doi":"10.1080/10286020.2024.2365437","DOIUrl":"10.1080/10286020.2024.2365437","url":null,"abstract":"<div><div>Three new prenylated C<sub>6</sub>–C<sub>3</sub> compounds (<strong>1–3</strong>), together with two known prenylated C<sub>6</sub>–C<sub>3</sub> compounds (<strong>4–5</strong>) and one known C<sub>6</sub>–C<sub>3</sub> derivative (<strong>6</strong>), were isolated from the roots of <em>Illicium brevistylum</em> A. C. Smith. The structures of <strong>1–3</strong> were elucidated by spectroscopic methods including 1D and 2D NMR, HRESIMS, CD experiments and ECD calculations. The structure of illibrefunone A (<strong>1</strong>) was confirmed by single-crystal X-ray diffraction analysis. All compounds were evaluated in terms of their anti-inflammatory potential on nitric oxide (NO) generation in lipopolysaccharide-stimulated murine RAW264.7 macrophages and murine BV2 microglial cells, antiviral activity against Coxsackievirus B3 (CVB3) and influenza virus A/Hanfang/359/95 (H3N2). Compounds <strong>3</strong> and <strong>4</strong> exhibited potent inhibitory effects on the production of NO in RAW 264.7 cells with IC<sub>50</sub> values of 20.57 and 12.87 μM respectively, which were greater than those of dexamethasone (positive control). Compounds <strong>1</strong> and <strong>4–6</strong> exhibited weak activity against Coxsackievirus B3, with IC<sub>50</sub> values ranging from 25.87 to 33.33 μM.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141419215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction. 更正。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-08-14 DOI: 10.1080/10286020.2024.2390261
{"title":"Correction.","authors":"","doi":"10.1080/10286020.2024.2390261","DOIUrl":"https://doi.org/10.1080/10286020.2024.2390261","url":null,"abstract":"","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genome mining for ribosomally synthesized and post-translationally modified peptides (RiPPs) in Streptomyces bacteria. 链霉菌中核糖体合成和翻译后修饰肽（RiPPs）的基因组挖掘。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-08-14 DOI: 10.1080/10286020.2024.2390510
Abdullah Al Mamun, Khorshed Alam, Farjana Akter Koly, Farjana Showline Chaity, Jannatul Ferdous, Saiful Islam
{"title":"Genome mining for ribosomally synthesized and post-translationally modified peptides (RiPPs) in <i>Streptomyces</i> bacteria.","authors":"Abdullah Al Mamun, Khorshed Alam, Farjana Akter Koly, Farjana Showline Chaity, Jannatul Ferdous, Saiful Islam","doi":"10.1080/10286020.2024.2390510","DOIUrl":"https://doi.org/10.1080/10286020.2024.2390510","url":null,"abstract":"<p><p>Ribosomally synthesized post-translationally modified peptides (RiPPs) are a novel category of bioactive natural products (NPs). <i>Streptomyces</i> bacteria are a potential source of many bioactive NPs. Limited opportunities are available to characterize all the bioactive NP gene clusters. In this study, 410 sequences of <i>Streptomyces</i> were analyzed for RiPPs through genome mining using the National Center for Biotechnology Information (NCBI), by combining BAGEL and anti-SMASH. A total of 4098 RiPPs were found; including both classified (lanthipeptide, RiPP-like, bacteriocin, LAPs, lassopeptide, thiopeptides) and nonclassified RiPPs. Soil was identified as a rich habitat for RiPPs. These data may offer alternative future remedies for various health issues.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kaempferol inhibited invasion and metastasis of gastric cancer cells by targeting AKT/GSK3β pathway based on network pharmacology and molecular docking. 基于网络药理学和分子对接的山奈酚通过靶向AKT/GSK3β通路抑制胃癌细胞的侵袭和转移
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-08-12 DOI: 10.1080/10286020.2024.2387756
Xia-Qing Gao, Hai-Long Li, Meng Wang, Chun-Ting Yang, Rong Su, Li-Hua Shao
{"title":"Kaempferol inhibited invasion and metastasis of gastric cancer cells by targeting AKT/GSK3β pathway based on network pharmacology and molecular docking.","authors":"Xia-Qing Gao, Hai-Long Li, Meng Wang, Chun-Ting Yang, Rong Su, Li-Hua Shao","doi":"10.1080/10286020.2024.2387756","DOIUrl":"https://doi.org/10.1080/10286020.2024.2387756","url":null,"abstract":"<p><p>This study aims to explore the mechanisms of the inhibitory effect of kaempferol on the invasion and metastasis of gastric cancer (GC) cells through network pharmacology prediction and experimental verification. It identifies core targets via PPI network analysis and finds that kaempferol binds to these targets well. <i>In vitro</i> experiments showed that kaempferol could inhibit the proliferation, colony formation, migration and invasion of GC cells. Western blotting indicated kaempferol may reduce AKT and GSK3β phosphorylation, leading to lower expression of invasion-related genes SRC, MMP9, CXCR4, KDR, and MMP2. Overall, kaempferol may prevent migration and invasion of GC cells via the AKT/GSK3β signaling pathway.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrated ceRNAs regulating relationship and bioinformatics analysis to study the molecular mechanisms of the inhibition of puerarin on bladder cancer cell. 综合ceRNAs调控关系和生物信息学分析，研究葛根素抑制膀胱癌细胞的分子机制。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-08-12 DOI: 10.1080/10286020.2024.2390508
Yu-Yang Ma, Wen Gao, Hao Wang, Hao Xu, Deng Pan, Jing-Kai Wang, Peng Xu, Hai-Luo Wang, Kun Pang
{"title":"Integrated ceRNAs regulating relationship and bioinformatics analysis to study the molecular mechanisms of the inhibition of puerarin on bladder cancer cell.","authors":"Yu-Yang Ma, Wen Gao, Hao Wang, Hao Xu, Deng Pan, Jing-Kai Wang, Peng Xu, Hai-Luo Wang, Kun Pang","doi":"10.1080/10286020.2024.2390508","DOIUrl":"https://doi.org/10.1080/10286020.2024.2390508","url":null,"abstract":"<p><p>Based on previous experiments, we demonstrated puerarin inhibited the proliferation of BC T24 cells. To further explore the molecular mechanisms, whole transcriptome sequencing combined with bioinformatics analysis was performed. The results showed puerarin significantly inhibited T24 proliferation and pathway enrichment analysis of differentially expressed RNAs were mainly enriched in Cell cycle, PI3K/AKT, Ras family chromatin remodeling. lncRNAs and circRNAs may regulate miRNAs, thereby regulating the expression of ITGA1, PAK2 and UTRN. The predicted upstream transcription factor ERG and puerarin were well docked, which may be one of the underlying mechanisms by which puerarin inhibiting BC cells.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141971157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Four new homoisoflavonoids from Caesalpinia pulcherrima. 从 Caesalpinia pulcherrima 中提取的四种新的同异黄酮。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-08-09 DOI: 10.1080/10286020.2024.2387307
Yu-Cheng Zheng, Wen-Jian Gu, Ren-Geng Shu, Pu-Zhao Zhang
{"title":"Four new homoisoflavonoids from <i>Caesalpinia pulcherrima</i>.","authors":"Yu-Cheng Zheng, Wen-Jian Gu, Ren-Geng Shu, Pu-Zhao Zhang","doi":"10.1080/10286020.2024.2387307","DOIUrl":"https://doi.org/10.1080/10286020.2024.2387307","url":null,"abstract":"<p><p>Four new homoisoflavonoids, 7-hydroxy-3-[hydroxy(4'-methoxyphenyl)methyl]-benzopyran-4-one (<b>1</b>), (3<i>R</i>)<b><i>-</i></b>7, 8-dihydroxy-3-(4'-methoxybenzyl)-chroman-4-one (<b>2</b>), 7-hydroxy-3-(2'-hydroxy-4'-methoxybenzyl)-chroman-4-one (<b>3</b>), and 7-hydroxy-3-(2'-hydroxy-4'-methoxybenzyl)-benzopyran-4-one (<b>4</b>), were isolated from the seeds of <i>Caesalpinia pulcherrima</i>. The structures of new compounds were elucidated by MS and NMR spectra. Their absolute configurations were assigned using electronic circular dichroism spectrum. Compounds <b>2</b> and <b>4</b> exhibited cytotoxic effects on MCF-7/TAM cells with the IC<sub>50</sub> values of 101.4 ± 0.03 and 93.02 ± 0.03 <i>μ</i>M, respectively.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A review on phytochemicals as combating weapon for multidrug resistance in cancer. 综述植物化学物质作为抗击癌症多药耐药性的武器。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-08-09 DOI: 10.1080/10286020.2024.2386678
Sharwan Gupta, Anuradha Mehra, Rekha Sangwan
{"title":"A review on phytochemicals as combating weapon for multidrug resistance in cancer.","authors":"Sharwan Gupta, Anuradha Mehra, Rekha Sangwan","doi":"10.1080/10286020.2024.2386678","DOIUrl":"https://doi.org/10.1080/10286020.2024.2386678","url":null,"abstract":"<p><p>One can recognize multidrug resistance (MDR) and residue as a biggest difficulty in cancer specialist. Chemotherapy-resistant cancer may be successfully treated by combining MDR-reversing phytochemicals with anticancer drugs. Though, clinical application of phytochemicals either alone or in conjunction with chemotherapy is still in its early stages or requires more research to determine their safety and efficacy. In this review we highlighted topics related to MDR in cancer, including an introduction to subject, mechanism of action of efflux pump, specific proteins involved in drug resistance, altered drug targets, increased drug metabolism, and potential role of phytochemicals in overcoming drug resistance.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141909868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new isocoumarin derivative from endophytic fungus Pezicula neosporulosa VDB39 from Vaccinium dunalianum. 一种新的异香豆素衍生物，来自于越橘内生真菌新孢子瘤 Pezicula neosporulosa VDB39。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-08-02 DOI: 10.1080/10286020.2024.2385367
Yuan-Cao Shu, Zhi-Yu Zhang, Xiao-Man Fu, Wei-Lin Zeng, Guo-Lei Zhu, Xiao-Qin Yang, Si-Da Xie, Wei-Hua Wang, Ping Zhao
{"title":"A new isocoumarin derivative from endophytic fungus <i>Pezicula neosporulosa</i> VDB39 from <i>Vaccinium dunalianum</i>.","authors":"Yuan-Cao Shu, Zhi-Yu Zhang, Xiao-Man Fu, Wei-Lin Zeng, Guo-Lei Zhu, Xiao-Qin Yang, Si-Da Xie, Wei-Hua Wang, Ping Zhao","doi":"10.1080/10286020.2024.2385367","DOIUrl":"https://doi.org/10.1080/10286020.2024.2385367","url":null,"abstract":"<p><p>Four isocoumarin derivatives (<b>1-4</b>) and five phenols (<b>5-9</b>) were obtained from the endophytic fungus <i>Pezicula neosporulosa</i> VDB39, which was isolated from the branches of <i>Vaccinium dunalianum</i> Wight (Ericaceae). Compound <b>1</b> is a new derivative of isocoumarin. The structures were elucidated by spectroscopic methods. Single X-ray crystallography confirmed the absolute configuration of compound <b>1</b>. Additionally, the antiphytopathogenic fungi activity of isocoumarin derivatives (<b>1-4</b>) was evaluated.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141878751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Four new lycoctonine-type C19-diterpenoid alkaloids from the whole plants of Delphinium kamaonense. 从Delphinium kamaonense全株中提取的四种新的莱克多宁型C19-二萜生物碱。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-07-31 DOI: 10.1080/10286020.2024.2385370
Xing-Yao Li, Rui-Sheng Chen, Guo-Chang Li, Kai-Cheng Du, Lan-Tao Lai, Yu-Meng Wang, Da-Li Meng
{"title":"Four new lycoctonine-type C<sub>19</sub>-diterpenoid alkaloids from the whole plants of <i>Delphinium kamaonense</i>.","authors":"Xing-Yao Li, Rui-Sheng Chen, Guo-Chang Li, Kai-Cheng Du, Lan-Tao Lai, Yu-Meng Wang, Da-Li Meng","doi":"10.1080/10286020.2024.2385370","DOIUrl":"https://doi.org/10.1080/10286020.2024.2385370","url":null,"abstract":"<p><p>Four new lycoctonine-type C<sub>19</sub>-diterpenoid alkaloids kamaonensines H-K (<b>1-4</b>) have been isolated from the whole plants of <i>Delphinium kamaonense</i>, together with 12 known compounds (<b>5-16</b>). Interestingly, kamaonensines <b>1-3</b> contained a rare nitrone (immine N-oxide) moiety, respectively. Their structures were established by spectroscopic analyses. The active evaluation of compounds (<b>1-16</b>) by LPS induced RAW 264.7 macrophages showed that compounds <b>4</b> and <b>8</b> displayed strong anti-inflammatory activities. While compounds <b>11</b> and <b>12</b> also showed strong cytotoxicities by the RAW 264.7 cell viability assay.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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