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Journal of Asian Natural Products Research最新文献

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Monoterpene indole glycoalkaloids from the hook-bearing branches of Uncaria rhynchophylla 钩藤含钩枝中的单萜吲哚甘氨酰生物碱。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-01-02 DOI: 10.1080/10286020.2024.2410460
Lu Rao , Fei Chen , Ming-Hui Gao , Jun-Jie Tan , Shi-Jin Qu , Chang-Heng Tan
{"title":"Monoterpene indole glycoalkaloids from the hook-bearing branches of Uncaria rhynchophylla","authors":"Lu Rao ,&nbsp;Fei Chen ,&nbsp;Ming-Hui Gao ,&nbsp;Jun-Jie Tan ,&nbsp;Shi-Jin Qu ,&nbsp;Chang-Heng Tan","doi":"10.1080/10286020.2024.2410460","DOIUrl":"10.1080/10286020.2024.2410460","url":null,"abstract":"<div><div>Twelve monoterpene indole glycoalkaloids, comprising of three new ones, 19-<em>epi</em>-rhynchophylloside A (<strong>1</strong>), 7-<em>epi</em>-rhynchophylloside A (<strong>2</strong>), and 7-<em>epi</em>-anthocephalusine A (<strong>3</strong>), were isolated from the hook-bearing branches of <em>Uncaria rhynchophylla</em>. The structures and absolute configurations of <strong>1–3</strong> were elucidated by analysis of MS, NMR, ECD, and single-crystal X-ray diffraction or TDDFT-ECD calculations. Glycoalkaloids <strong>1</strong> and <strong>3</strong> showed significant immunosuppressive activity against the proliferation of B lymphocyte induced by LPS with broad selective index.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 1","pages":"Pages 31-37"},"PeriodicalIF":1.3,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harmine inhibits the proliferation and migration and promotes the apoptosis of colon cancer cells via inhibition of the FAK/AKT and ERK1/2/CREB signaling pathways Harmine 通过抑制 FAK/AKT 和 ERK1/2/CREB 信号通路，抑制结肠癌细胞的增殖和迁移，并促进其凋亡。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-01-02 DOI: 10.1080/10286020.2024.2361767
Fu-Hong Liu , Xing-Cheng Lin , Yu-Wei Liu , Tian-Tian Zhang , Yang-Bo Zhang , Zhuo-Long Xie , Yuan Zhan , Ping Hu
{"title":"Harmine inhibits the proliferation and migration and promotes the apoptosis of colon cancer cells via inhibition of the FAK/AKT and ERK1/2/CREB signaling pathways","authors":"Fu-Hong Liu ,&nbsp;Xing-Cheng Lin ,&nbsp;Yu-Wei Liu ,&nbsp;Tian-Tian Zhang ,&nbsp;Yang-Bo Zhang ,&nbsp;Zhuo-Long Xie ,&nbsp;Yuan Zhan ,&nbsp;Ping Hu","doi":"10.1080/10286020.2024.2361767","DOIUrl":"10.1080/10286020.2024.2361767","url":null,"abstract":"<div><div>Harmine is present in a variety of medicinal plants, and its effects on colon cancer cells remain unclear. Here, we found that harmine exhibited significant inhibitory effects on the proliferation of colon cancer cells by inhibiting the phosphorylation levels of the FAK/AKT and ERK1/2/CREB. Furthermore, harmine also inhibited the migration of colon cancer cells and suppressed the expression levels of MMP-2, MMP-9, and VEGF. Additionally, harmine-induced apoptosis in colon cancer cells by regulating the expression of Bcl-2 and Bax. In conclusion, our findings suggest that harmine exerts a significant inhibitory effect on the development of colon cancer cells.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 1","pages":"Pages 75-87"},"PeriodicalIF":1.3,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three new cyclopentanoid monoterpenes from the roots of Picrorhiza scrophulariiflora 来自 Picrorhiza scrophulariiflora 根部的三种新的环戊烷单萜烯。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-01-02 DOI: 10.1080/10286020.2024.2408547
Xin-Yue Li , Jie Zhou , Guo-Ru Shi , Wan-Qi Zhang , Ming-Hui Sun , Jing-Han Zhang , Xin-Li Ma , Gu Zhao , Yan-Fei Liu , De-Quan Yu
{"title":"Three new cyclopentanoid monoterpenes from the roots of Picrorhiza scrophulariiflora","authors":"Xin-Yue Li ,&nbsp;Jie Zhou ,&nbsp;Guo-Ru Shi ,&nbsp;Wan-Qi Zhang ,&nbsp;Ming-Hui Sun ,&nbsp;Jing-Han Zhang ,&nbsp;Xin-Li Ma ,&nbsp;Gu Zhao ,&nbsp;Yan-Fei Liu ,&nbsp;De-Quan Yu","doi":"10.1080/10286020.2024.2408547","DOIUrl":"10.1080/10286020.2024.2408547","url":null,"abstract":"<div><div>Three new cyclopentanoid monoterpenes, neopiscrocins A–C (<strong>1</strong>–<strong>3</strong>), together with 14 known compounds (<strong>4</strong>–<strong>17</strong>), were isolated from the roots of <em>Picrorhiza scrophulariiflora</em>. The structres of these compounds were elucidated on the basis of their spectroscopic data. All compounds were evaluated for cytotoxicity against six human tumor cell lines (PC9, PANC1, HCT-116, Hep-G2, BGC-823, and MCF-7), hepatoprotective activity and anti-inflammatory activity.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 1","pages":"Pages 38-46"},"PeriodicalIF":1.3,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bis-piperidine alkaloids from the peels of Areca catechu 从Areca catechu果皮中提取的双哌啶生物碱。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-01-02 DOI: 10.1080/10286020.2024.2372383
Xia Zhang , Fang-Xin Wang , Zi-Wei Li , Song Wang , Shi-Qing Zhang , Min Song , Xiao-Qi Zhang
{"title":"Bis-piperidine alkaloids from the peels of Areca catechu","authors":"Xia Zhang ,&nbsp;Fang-Xin Wang ,&nbsp;Zi-Wei Li ,&nbsp;Song Wang ,&nbsp;Shi-Qing Zhang ,&nbsp;Min Song ,&nbsp;Xiao-Qi Zhang","doi":"10.1080/10286020.2024.2372383","DOIUrl":"10.1080/10286020.2024.2372383","url":null,"abstract":"<div><div>Four new alkaloids, arecatines A–D (<strong>1</strong>–<strong>4</strong>), were isolated from the peels of <em>Areca catechu</em>. Compound <strong>1</strong> is an unusual piperidine-pyridine hybrid alkaloid, whereas compounds <strong>2</strong>–<strong>4</strong> feature bis-piperidine alkaloids. Their structures were elucidated by UV, IR, HRESIMS, and NMR spectra analysis. The molecular docking analysis indicated that compound <strong>3</strong> exhibited the best binding affinity with the GABA<sub>A</sub> receptor, indicating its potential anti-epilepsy activity.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 1","pages":"Pages 11-17"},"PeriodicalIF":1.3,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Online identification of chemical constituents in Mongolian medicine Zhachong-13 pills by UHPLC-Q-exactive Orbitrap MS 超高效液相色谱-Q-反应式 Orbitrap MS 在线鉴定蒙药扎冲十三味丸中的化学成分
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-01-02 DOI: 10.1080/10286020.2024.2379981
Cai-Yun Tian , Qing-Rui Yang , Ling-Xuan Fan , Yu-Mei Yang , Bo-Wen Gao , Jian-Bo Yang
{"title":"Online identification of chemical constituents in Mongolian medicine Zhachong-13 pills by UHPLC-Q-exactive Orbitrap MS","authors":"Cai-Yun Tian ,&nbsp;Qing-Rui Yang ,&nbsp;Ling-Xuan Fan ,&nbsp;Yu-Mei Yang ,&nbsp;Bo-Wen Gao ,&nbsp;Jian-Bo Yang","doi":"10.1080/10286020.2024.2379981","DOIUrl":"10.1080/10286020.2024.2379981","url":null,"abstract":"<div><div>Zhachong-13 pills (ZC-13), as a traditional prescription of Mongolian medicine, are often used in the clinical practice of Mongolian hospitals for the treatment of stroke and rheumatic arthritis. In this experiment, UHPLC-Q-Exactive Orbitrap MS was used to explore the chemical composition of ZC-13. The results showed that 315 compounds were identified or inferred, including 56 alkaloids, 77 2-(2-phenylethyl)chromones, 61 flavonoids, 31 tannins, 8 coumarins, 16 lignans, 21 terpenoids, 5 amino acids, 19 organic acids, and 21 other components. In addition, the pharmacological activities related to anti-cerebral ischemia of these components were summarized. This result laid a foundation for further study on the pharmacodynamic material basis of ZC-13 and provided a scientific basis for the formulation of ZC-13 quality specifications.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 1","pages":"Pages 47-61"},"PeriodicalIF":1.3,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new biflavanol from bark of Nothotsuga longibracteata. 从长苞木杉树皮中分离出一种新的双黄烷醇。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-01-01 DOI: 10.1080/10286020.2024.2446282
Yi-Lin Wu, Min-Jian Dong, Cheng-Xin Sun, Mao-Sheng Zhang, Shi-Ji Xiao
{"title":"A new biflavanol from bark of <i>Nothotsuga longibracteata</i>.","authors":"Yi-Lin Wu, Min-Jian Dong, Cheng-Xin Sun, Mao-Sheng Zhang, Shi-Ji Xiao","doi":"10.1080/10286020.2024.2446282","DOIUrl":"https://doi.org/10.1080/10286020.2024.2446282","url":null,"abstract":"<p><p>Seven flavanol derivatives, including three biflavanoids (<b>1</b>-<b>3</b>), two flavonoids (<b>4</b> and <b>5</b>), and two spirobiflavonoids (<b>6</b> and <b>7</b>), were isolated from the bark of <i>Nothotsuga longibracteata</i>. The structure of the undescribed compound <b>1</b> was elucidated based on HR-ESIMS, NMR spectroscopy, and electronic circular dichroism (ECD) calculations. All isolated flavanol derivatives were screened for their antioxidant capacity to scavenge DPPH and ABTS<sup>+</sup>.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Compound FLZ attenuates neuroinflammation through inhibiting Src/PTEN/Akt signaling pathway. 化合物FLZ通过抑制Src/PTEN/Akt信号通路减轻神经炎症。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-01-01 DOI: 10.1080/10286020.2024.2435981
Fang-Fang Li, Yuan-Peng Zheng, Gen Li, Yang Yang, Jing-Wei Ma, Cai-Xia Zang, Deng Tao, Li Li, Xiu-Qi Bao, Dan Zhang
{"title":"Compound FLZ attenuates neuroinflammation through inhibiting Src/PTEN/Akt signaling pathway.","authors":"Fang-Fang Li, Yuan-Peng Zheng, Gen Li, Yang Yang, Jing-Wei Ma, Cai-Xia Zang, Deng Tao, Li Li, Xiu-Qi Bao, Dan Zhang","doi":"10.1080/10286020.2024.2435981","DOIUrl":"https://doi.org/10.1080/10286020.2024.2435981","url":null,"abstract":"<p><p>Compound FLZ has neuroprotective effects on Parkinson's disease (PD), while the precise mechanism remains unclear. In this study, we found that FLZ decreased PTEN/Akt activity in LPS-challenged BV2 cells. Neuroinflammatory responses suppressed by FLZ were abolished when PTEN or Src was inhibited. Additionally, FLZ weakened the interactions of Src and PTEN, and attenuated Src phosphorylation once PETN was inhibited, but failed to decrease PTEN phosphorylation when Src was silenced. Eventually, we elaborated that FLZ bound to Src directly and inhibited its activity. Collectively, FLZ attenuated neuroinflammation through inhibiting Src/PTEN/Akt pathway, paving the way for clinical use of FLZ to treat PD.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-17"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three new terpenoid derivatives from the deep-sea-derived fungus Aspergillus sydowii DFFSCS007. 深海来源真菌西多曲霉DFFSCS007的三个新的萜类衍生物。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-12-28 DOI: 10.1080/10286020.2024.2443086
Xu-Meng Ren, Ke-Yue Wu, Shu-Hua Qi
{"title":"Three new terpenoid derivatives from the deep-sea-derived fungus <i>Aspergillus sydowii</i> DFFSCS007.","authors":"Xu-Meng Ren, Ke-Yue Wu, Shu-Hua Qi","doi":"10.1080/10286020.2024.2443086","DOIUrl":"https://doi.org/10.1080/10286020.2024.2443086","url":null,"abstract":"<p><p>Three new terpenoid derivatives (1<i>S</i>,6<i>R</i>,7<i>S</i>)-hydrobenzosydowic acid (<b>1</b>), (1 <i>R</i>,6<i>S</i>,7<i>S</i>)-hydrobenzosydowic acid (<b>2</b>), and (7 <i>R</i>,10<i>R</i>)-11-dehydroxy-iso-10-hydroxysydowic acid (<b>3</b>), along with the known analogues (<i>S</i>)-2-(1-(4-nitrobenzoyl)pyrrolidine-2-carboxamido)benzoic acid (<b>4</b>) and trihydroxybutyl ester of 4-carboxydiorcinol (<b>5</b>) were isolated from the deep-sea-derived fungus <i>Aspergillus sydowii</i> DFFSCS007. Their structures were determined by spectroscopic analysis. Compound <b>4</b> with a nitrobenzene group was isolated from nature for the first time. The antibacterial activities of <b>1</b>-<b>5</b> and cytotoxicity of <b>1</b>-<b>3</b> were also evaluated.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progress in the study of curcumin metabolism in vivo. 姜黄素体内代谢的研究进展。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-12-18 DOI: 10.1080/10286020.2024.2420619
Shi-Jie Zhong, Ya-Dong Xing, Lu-Yao Dong, Yi Chen, Nan Liu, Zeng-Ming Wang, Hui Zhang, Ai-Ping Zheng
{"title":"Progress in the study of curcumin metabolism <i>in vivo</i>.","authors":"Shi-Jie Zhong, Ya-Dong Xing, Lu-Yao Dong, Yi Chen, Nan Liu, Zeng-Ming Wang, Hui Zhang, Ai-Ping Zheng","doi":"10.1080/10286020.2024.2420619","DOIUrl":"https://doi.org/10.1080/10286020.2024.2420619","url":null,"abstract":"<p><p>Curcumin has diverse biological functions, especially antioxidant and anti-inflammatory properties, but clinical trials have been hindered by its low bioavailability and pharmacokinetic properties. To achieve therapeutic efficacy, understanding curcumin's <i>in vivo</i> metabolism is crucial. We reviewed current research on curcumin metabolism in PubMed, Google Scholar, and CNKI. This article outlines curcumin's metabolic processes in the body via oral and intravenous injection. It suggests that upon entering the human body, curcumin may undergo oxidation, reduction, binding, and microbial community influence.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-19"},"PeriodicalIF":1.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meroterpenoids from Rhododendron racemosum and their anti-inflammatory activities. 总状杜鹃花中萜类化合物及其抗炎活性。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2024-12-18 DOI: 10.1080/10286020.2024.2431813
Si-Xuan Liu, Si-Yang Dai, Yong-Fu Lu, Chun-Lin Guo, Chang Li, Yi-Hui Yang, Yue-Hu Pei
{"title":"Meroterpenoids from <i>Rhododendron racemosum</i> and their anti-inflammatory activities.","authors":"Si-Xuan Liu, Si-Yang Dai, Yong-Fu Lu, Chun-Lin Guo, Chang Li, Yi-Hui Yang, Yue-Hu Pei","doi":"10.1080/10286020.2024.2431813","DOIUrl":"https://doi.org/10.1080/10286020.2024.2431813","url":null,"abstract":"<p><p>Three meroterpenoids, including one new compound, ranhuadujuanine E (<b>1</b>), one new natural product, methyl (<i>E</i>)-3-(3,7-dimethylocta-2,6-dien-1-yl)-2,4-dihydroxy-6-methylbenzoate (<b>2</b>), and one known compound, ranhuadujuanine D (<b>3</b>), along with two known sesquiterpenoids (<b>4</b>-<b>5</b>) were isolated from <i>Rhododendron racemosum</i>. Their structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configuration of C-6' in compound <b>1</b> was assigned by using Snatzke's method. Compounds <b>1</b>-<b>3</b> had inhibitory effects on LPS-induced NO release in RAW264.7 cells.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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