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Journal of Asian Natural Products Research最新文献

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Design, synthesis, and inhibition of novel ferulic acid derivatives on free fatty acid induced cellular lipid accumulation.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-23 DOI: 10.1080/10286020.2025.2459600
Ying-Ying Liu, Yi-Fan Xu, Xin-Ru Li, Qi-Pan Fan, Jia-Hao Liu, Si-Yu Zhou, Yu-Qing Qian, Ming-Dong Li
{"title":"Design, synthesis, and inhibition of novel ferulic acid derivatives on free fatty acid induced cellular lipid accumulation.","authors":"Ying-Ying Liu, Yi-Fan Xu, Xin-Ru Li, Qi-Pan Fan, Jia-Hao Liu, Si-Yu Zhou, Yu-Qing Qian, Ming-Dong Li","doi":"10.1080/10286020.2025.2459600","DOIUrl":"https://doi.org/10.1080/10286020.2025.2459600","url":null,"abstract":"<p><p>Abnormal accumulation of hepatocyte lipids is a hallmark feature of NAFLD. Ferulic acid (FA), an ingredient with antioxidant activity in Chinese herbs, can be used to treat NAFLD by activating AMPK phosphorylation. In this study, we synthesized ten acrylic acid derivatives <b>A1-A10</b>. The inhibition of lipid accumulation showed that most target compounds could inhibit lipid accumulation at 400 μM; compound <b>A3</b> showed a better inhibitory effect than other compounds. Molecular docking results proved that <b>A3</b> could bind to PPARγ, and multiple binding sites existed in both the ferulic acid cohort and the substituted benzene cohort.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-16"},"PeriodicalIF":1.3,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eriodictyol inhibits the proliferation and inflammatory response in keratinocytes in psoriasis through inactivating DYRK1A-mediated endoplasmic reticulum stress.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-23 DOI: 10.1080/10286020.2024.2446301
Rui Yuan, Qi-Chao Sun, Yue-Peng An, Qing Zhang, Qiong Zhang, Yue Li
{"title":"Eriodictyol inhibits the proliferation and inflammatory response in keratinocytes in psoriasis through inactivating DYRK1A-mediated endoplasmic reticulum stress.","authors":"Rui Yuan, Qi-Chao Sun, Yue-Peng An, Qing Zhang, Qiong Zhang, Yue Li","doi":"10.1080/10286020.2024.2446301","DOIUrl":"https://doi.org/10.1080/10286020.2024.2446301","url":null,"abstract":"<p><p>Our work is conducted to reveal the impacts of eriodictyol on psoriasis. CCK-8 and EdU assays measured HaCaT cell proliferation. ELISA detected the activities of inflammatory cytokines and chemokines. Western blot examined the expressions of proliferation-, inflammation- and ERS-associated proteins. Molecular docking predicted the binding affinity of eriodictyol to DYRK1A. RT-qPCR and Western blot analyzed DYRK1A expression. Eriodictyol inhibited the proliferation and inflammatory response in M5-challenged HaCaT cells. Eriodictyol targeted and down-regulated DYRK1A expression. DYRK1A overexpression abolished the impacts of eriodictyol on M5-stimulated HaCaT cells. Conclusively, eriodictyol might suppress ERS mediated by DYRK1A to elicit anti-psoriasis functions.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.3,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two new tetralones from the endophytic fungus Annulohypoxylon stygium A888.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-22 DOI: 10.1080/10286020.2025.2464683
Zhi-Shen Shao, Yu-Chan Chen, Wei-Peng Ma, Sai-Ni Li, Hong-Xin Liu, Wei-Min Zhang, Xiao-Ying Chen
{"title":"Two new tetralones from the endophytic fungus <i>Annulohypoxylon stygium</i> A888.","authors":"Zhi-Shen Shao, Yu-Chan Chen, Wei-Peng Ma, Sai-Ni Li, Hong-Xin Liu, Wei-Min Zhang, Xiao-Ying Chen","doi":"10.1080/10286020.2025.2464683","DOIUrl":"https://doi.org/10.1080/10286020.2025.2464683","url":null,"abstract":"<p><p>Two new tetralones, annulohyporins A (<b>1</b>) and B (<b>2</b>), along with thirteen known compounds (<b>3</b>-<b>15</b>), were isolated from the ethyl acetate extract of solid fermentation of the endophytic fungus <i>Annulohypoxylon stygium</i> A888, which was isolated from the medicinal plant <i>Aquilaria sinensis</i>. The structures of annulohyporins A and B were established by detailed analyses of ultraviolet-visible spectroscopy (UV), infrared spectroscopy (IR), mass spectrometry (MS), electronic circular dichroism (ECD) calculations and nuclear magnetic resonance (NMR). Bioactivity assay showed that compounds <b>3</b> and <b>4</b> had significant α-glucosidase inhibitory activities with IC<sub>50</sub> values of 64.00 and 32.90 µM, respectively.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genistein resists castration-resistant prostate cancer by inhibiting the androgen receptor pathway. 染料木素通过抑制雄激素受体通路来抵御耐受性前列腺癌。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-22 DOI: 10.1080/10286020.2025.2464695
Xiao-Ping Yu, Lu-Jie Zheng, Jia-Li Yan, Yan Luo, Xiao-Long Song, Tian-Yu Fu, Xiao-Li Peng, Jing-Chang Du, Bin Han, Fei Li, Yan-Feng Zhu
{"title":"Genistein resists castration-resistant prostate cancer by inhibiting the androgen receptor pathway.","authors":"Xiao-Ping Yu, Lu-Jie Zheng, Jia-Li Yan, Yan Luo, Xiao-Long Song, Tian-Yu Fu, Xiao-Li Peng, Jing-Chang Du, Bin Han, Fei Li, Yan-Feng Zhu","doi":"10.1080/10286020.2025.2464695","DOIUrl":"https://doi.org/10.1080/10286020.2025.2464695","url":null,"abstract":"<p><p>Prostate cancer is a prevalent malignancy, often diagnosed at advanced stages and associated with poor prognosis. Genistein, a soybean isoflavone, has demonstrated antitumor effects against castration-resistant prostate cancer <i>in vivo</i>. Our results indicate that genistein effectively downregulates the expression of key enzymes involved in the <i>de novo</i> synthesis pathway, namely AKR1C3, SRD5A2, CYP11A1, and 3βHSD, thus blocking androgen synthesis in CRPC cells. Additionally, genistein inhibits the activation and nuclear translocation of the AR. Collectively, these findings support the potential of genistein as a therapeutic agent for CRPC, highlighting its role in both inhibiting androgen synthesis and disrupting AR signaling.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-17"},"PeriodicalIF":1.3,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring sulphated polysaccharides from marine bivalves: Unveiling potent anti-gastric cancer activity through cell cycle arrest and apoptosis.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-22 DOI: 10.1080/10286020.2025.2468319
Deepakrajasekar Padmanaban, Pavithra Rajkumar, Mahalakshmi Vijayakumar, Vennila Jayaprakash, Niranjni Sekar, Rajasekar Valayapathi, Aarthi Azhagudurai, Arulvasu Chinnasamy
{"title":"Exploring sulphated polysaccharides from marine bivalves: Unveiling potent anti-gastric cancer activity through cell cycle arrest and apoptosis.","authors":"Deepakrajasekar Padmanaban, Pavithra Rajkumar, Mahalakshmi Vijayakumar, Vennila Jayaprakash, Niranjni Sekar, Rajasekar Valayapathi, Aarthi Azhagudurai, Arulvasu Chinnasamy","doi":"10.1080/10286020.2025.2468319","DOIUrl":"https://doi.org/10.1080/10286020.2025.2468319","url":null,"abstract":"<p><p>This study investigates the extraction of partially purified sulphated polysaccharides from marine bivalves through enzymatic digestion followed by sequential deproteinization and evaluates their anti-gastric cancer activity. Chemical analysis confirmed high uronic acid and sulfate content, with FT-IR validating characteristic functional groups. <i>Donax variabilis</i> polysaccharide demonstrated significant, dose-dependent anti-proliferative effects against AGS cells. Mechanistic studies revealed morphological changes, ROS generation, LDH release, and mitochondrial membrane disruption, leading to apoptosis. Flow cytometry confirmed G0/G1 phase arrest. These findings suggest that <i>D. variabilis</i> sulphated polysaccharides exhibit potent anti-gastric cancer properties, likely through oxidative stress and mitochondrial dysfunction, warranting further investigation for therapeutic applications.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-22"},"PeriodicalIF":1.3,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antitumor effects of BPCO on liver cancer cells. BPCO 对肝癌细胞的抗肿瘤作用
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-22 DOI: 10.1080/10286020.2025.2467318
Shan-Bin Li, Tong-Shi-Yao Zhao, Zhen Ye, Jian Zou, Xi Yuan, Xian-Li Zhou, Cheng-Qin Liang, Kang-Zhi Li, Lan-Zhen Huang
{"title":"Antitumor effects of BPCO on liver cancer cells.","authors":"Shan-Bin Li, Tong-Shi-Yao Zhao, Zhen Ye, Jian Zou, Xi Yuan, Xian-Li Zhou, Cheng-Qin Liang, Kang-Zhi Li, Lan-Zhen Huang","doi":"10.1080/10286020.2025.2467318","DOIUrl":"https://doi.org/10.1080/10286020.2025.2467318","url":null,"abstract":"<p><p>Esculetin is a coumarin compound with anticancer, antioxidant, and anti-inflammatory activities. In this study, we synthesized an esculetin derivative, 6,7-bis(Pentyloxy)-2H-Chromen-2-One (BPCO), through etherification. BPCO inhibited the proliferation of HepG2 cells in a dose- and time-dependent manner. It also inhibited cell migration, promoted apoptosis, and caused cell cycle arrest at the G1 phase. Additionally, BPCO downregulated the expression levels of Bcl-2 and Bcl-XL and upregulated the expression levels of Bax and Bak. This study shows that BPCO inhibits hepatocellular carcinoma cell proliferation and induces apoptosis, providing a basis for further study of BPCO as an antitumor agent.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.3,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytotoxic iridoid glycosides from the aerial parts of Paederia yunnanensis.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-21 DOI: 10.1080/10286020.2025.2467321
Jiang Hu, Gui-Hua Yu, Feng-Ming Xu, Tao Lv, Qiang Li, Jing-Yi Zhang
{"title":"Cytotoxic iridoid glycosides from the aerial parts of <i>Paederia yunnanensis</i>.","authors":"Jiang Hu, Gui-Hua Yu, Feng-Ming Xu, Tao Lv, Qiang Li, Jing-Yi Zhang","doi":"10.1080/10286020.2025.2467321","DOIUrl":"https://doi.org/10.1080/10286020.2025.2467321","url":null,"abstract":"<p><p>Three previously undescribed iridoid glycosides, 6<i>α-O</i>-<i>trans</i>-sinapoyl-paederosidic acid ethyl ester (<b>1</b>), 6'-<i>O</i>-<i>trans</i>-feruloyl-paederosidic acid methyl ester (<b>2</b>), and 10-<i>O</i>-<i>trans</i>-<i>p</i>-coumaroyl-(4<i>S</i>,6<i>R</i>)-3,4-dihydro-3<i>β</i>-ethoxypaederoside (<b>3</b>), were isolated from the 90% EtOH extract of the aerial parts of <i>Paederia yunnanensis</i>. The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (<sup>1</sup>H-<sup>1</sup>H COSY, HMQC, and HMBC) NMR spectrometry, HR-ESI-MS, as well as ECD data. The isolated compounds were tested <i>in vitro</i> for cytotoxic activity against five tumor cell lines. These results revealed that <b>3</b> exhibited some cytotoxicities against all the tested tumor cell lines with IC<sub>50</sub> value less than 20.0 μM and provided a scientific basis for further processing and utilization of <i>P. yunnanensis</i>.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resveratrol affects proliferation, apoptosis and migration of fibroblast cells as well as inhibits COL1A1/2 and TGFB2/3 gene expression.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-18 DOI: 10.1080/10286020.2025.2462610
Mei-Li Li, Kun Pang, Lei Qiao, Zhi-Qiang Guan, Chao-Ju Gong, Song-Tao Li, Zhi-Ming Tang, Yi-Ling Zhang, Ji-Cun Ding
{"title":"Resveratrol affects proliferation, apoptosis and migration of fibroblast cells as well as inhibits COL1A1/2 and TGFB2/3 gene expression.","authors":"Mei-Li Li, Kun Pang, Lei Qiao, Zhi-Qiang Guan, Chao-Ju Gong, Song-Tao Li, Zhi-Ming Tang, Yi-Ling Zhang, Ji-Cun Ding","doi":"10.1080/10286020.2025.2462610","DOIUrl":"https://doi.org/10.1080/10286020.2025.2462610","url":null,"abstract":"<p><p>Primary fibroblasts isolated from pterygium and skin pathological scar were identified by immunofluorescence staining. It was found by CCK8 and TUNEL that high-dose resveratrol, a Chinese medicine monomer, could inhibit proliferation, promote apoptosis and restrain migration. Explored by whole-transcriptome sequencing and LC-MS/MS, 1531 up-regulated mRNAs, 1022 down-regulated mRNAs, 79 up-regulated proteins and 84 down-regulated proteins were identified in resveratrol-treated pterygium fibroblasts. It was shown by KEGG, GO, PPI and the following bioinformatics analysis that resveratrol may affect proliferation, apoptosis and migration of fibroblast through TGFB2/3 and COL1A1/2.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-21"},"PeriodicalIF":1.3,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new isocoumarin derivative from endophytic fungus Pezicula neosporulosa VDB39 from Vaccinium dunalianum 一种新的异香豆素衍生物，来自于越橘内生真菌新孢子瘤 Pezicula neosporulosa VDB39。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-01 DOI: 10.1080/10286020.2024.2385367
Yuan-Cao Shu , Zhi-Yu Zhang , Xiao-Man Fu , Wei-Lin Zeng , Guo-Lei Zhu , Xiao-Qin Yang , Si-Da Xie , Wei-Hua Wang , Ping Zhao
{"title":"A new isocoumarin derivative from endophytic fungus Pezicula neosporulosa VDB39 from Vaccinium dunalianum","authors":"Yuan-Cao Shu ,&nbsp;Zhi-Yu Zhang ,&nbsp;Xiao-Man Fu ,&nbsp;Wei-Lin Zeng ,&nbsp;Guo-Lei Zhu ,&nbsp;Xiao-Qin Yang ,&nbsp;Si-Da Xie ,&nbsp;Wei-Hua Wang ,&nbsp;Ping Zhao","doi":"10.1080/10286020.2024.2385367","DOIUrl":"10.1080/10286020.2024.2385367","url":null,"abstract":"<div><div>Four isocoumarin derivatives (<strong>1–4</strong>) and five phenols (<strong>5–9</strong>) were obtained from the endophytic fungus <em>Pezicula neosporulosa</em> VDB39, which was isolated from the branches of <em>Vaccinium dunalianum</em> Wight (Ericaceae). Compound <strong>1</strong> is a new derivative of isocoumarin. The structures were elucidated by spectroscopic methods. Single X-ray crystallography confirmed the absolute configuration of compound <strong>1</strong>. Additionally, the antiphytopathogenic fungi activity of isocoumarin derivatives (<strong>1–4</strong>) was evaluated.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 2","pages":"Pages 267-273"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141878751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New cembranoid with potent anti-inflammatory effect isolated from Boswellia sacra by inactivating the NF-κB signaling pathway 通过使 NF-κB 信号通路失活，从乳香中分离出具有强效抗炎作用的新型cembranoid。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-01 DOI: 10.1080/10286020.2024.2372390
Xiao-Rong Yin , Zhen Yuan , Wei-Feng Wang , Bing-Yang Zhang , Lu-Qiong Wang , Feng Qiu , Feng Zhao
{"title":"New cembranoid with potent anti-inflammatory effect isolated from Boswellia sacra by inactivating the NF-κB signaling pathway","authors":"Xiao-Rong Yin ,&nbsp;Zhen Yuan ,&nbsp;Wei-Feng Wang ,&nbsp;Bing-Yang Zhang ,&nbsp;Lu-Qiong Wang ,&nbsp;Feng Qiu ,&nbsp;Feng Zhao","doi":"10.1080/10286020.2024.2372390","DOIUrl":"10.1080/10286020.2024.2372390","url":null,"abstract":"<div><div><em>Boswellia sacra</em> has the properties of activating blood circulation, fixing pain, subduing swelling and promoting muscle growth. However, the anti-inflammatory active ingredients and molecular mechanisms of <em>Boswellia sacra</em> are still not clearly explored. <em>Boswellia sacra</em> was grounded and extracted using 95% ethanol, the extracts were separated by column chromatography preparation to give compounds. Spectral analysis and quantum calculations confirmed the structures of compounds and identified compound <strong>1</strong> as a new compound. Compounds <strong>1</strong>–<strong>3</strong> showed potent inhibitory activities and their effects on inflammatory mediator NO and inflammatory cytokines were examined by ELISA assay. Furthermore, their modulatory mechanism on inflammatory signal pathways was explored.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 2","pages":"Pages 249-266"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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