Antitumor effects of BPCO on liver cancer cells

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-09-02 DOI:10.1080/10286020.2025.2467318

Shan-Bin Li , Tong-Shi-Yao Zhao , Zhen Ye , Jian Zou , Xi Yuan , Xian-Li Zhou , Cheng-Qin Liang , Kang-Zhi Li , Lan-Zhen Huang

引用次数: 0

Abstract

Esculetin is a coumarin compound with anticancer, antioxidant, and anti-inflammatory activities. In this study, we synthesized an esculetin derivative, 6,7-bis(Pentyloxy)-2H-Chromen-2-One (BPCO), through etherification. BPCO inhibited the proliferation of HepG2 cells in a dose- and time-dependent manner. It also inhibited cell migration, promoted apoptosis, and caused cell cycle arrest at the G1 phase. Additionally, BPCO downregulated the expression levels of Bcl-2 and Bcl-XL and upregulated the expression levels of Bax and Bak. This study shows that BPCO inhibits hepatocellular carcinoma cell proliferation and induces apoptosis, providing a basis for further study of BPCO as an antitumor agent.

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BPCO 对肝癌细胞的抗肿瘤作用

Esculetin是一种具有抗癌、抗氧化和抗炎活性的香豆素化合物。在本研究中，我们通过醚化合成了一种esculetin衍生物6,7-bis(Pentyloxy)-2H-Chromen-2-One （BPCO）。BPCO对HepG2细胞的增殖具有剂量依赖性和时间依赖性。抑制细胞迁移，促进细胞凋亡，使细胞周期阻滞于G1期。BPCO下调Bcl-2和Bcl-XL的表达水平，上调Bax和Bak的表达水平。本研究表明BPCO抑制肝癌细胞增殖并诱导凋亡，为进一步研究BPCO作为抗肿瘤药物提供了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.