Ninh Khac Ban, Dan Thi Thuy Hang, Tran My Linh, Ninh Khac Thanh Tung, Bui Van Thanh, Bui Huu Tai, Phan Van Kiem, Nguyen Phuong Thao
{"title":"Dammarane-type saponins from the leaves of <i>Sapium sebiferum</i> with inhibitory effects on NO production.","authors":"Ninh Khac Ban, Dan Thi Thuy Hang, Tran My Linh, Ninh Khac Thanh Tung, Bui Van Thanh, Bui Huu Tai, Phan Van Kiem, Nguyen Phuong Thao","doi":"10.1080/10286020.2026.2726157","DOIUrl":"https://doi.org/10.1080/10286020.2026.2726157","url":null,"abstract":"<p><p>Chromatographic separation of the leaves of <i>Sapium sebiferum</i> afforded two previously undescribed dammarane-type triterpenoid glycosides, sapibisides A and B (<b>1</b> and <b>2</b>), together with 12 related known analogues (<b>3</b>-<b>14</b>). The structures of these compounds were elucidated by extensive analysis of HRESIMS, 1D and 2D NMR spectroscopic data and comparison with previously reported data. The inhibitory activities of compounds <b>1</b>-<b>14</b> against LPS-induced NO production in RAW264.7 macrophages were evaluated. Compounds <b>1</b>, <b>3</b>, <b>9</b>, and <b>13</b> exhibited moderate inhibitory activity, with IC<sub>50</sub> values ranging from 31.2 to 45.7 <i>μ</i>M, compared to the positive control, dexamethasone, which showed an IC<sub>50</sub> value of 13.6 <i>μ</i>M.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.6,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chen-Xue Song, Zi-Ming Wang, Mei-Jia Yan, Zi-Jia Wang, Qiang Zhang, Yong-Hong Jiang, Tao Yu, Jian Zheng, Zhi-Song Cao, Yang Wang, Zhi-Wei Hu
{"title":"Comprehensive metabolite profiling of 10-methoxycamptothecin in rats by ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.","authors":"Chen-Xue Song, Zi-Ming Wang, Mei-Jia Yan, Zi-Jia Wang, Qiang Zhang, Yong-Hong Jiang, Tao Yu, Jian Zheng, Zhi-Song Cao, Yang Wang, Zhi-Wei Hu","doi":"10.1080/10286020.2025.2601281","DOIUrl":"10.1080/10286020.2025.2601281","url":null,"abstract":"<p><p>10-Methoxycamptothecin (MCPT), a natural camptothecin derivative, shows notable anticancer activity. Using UPLC-QTOF-MS, this study characterized MCPT metabolite profiles in rats, detecting 14 metabolites in urine, 5 in bile, 7 in feces, and 2 in plasma. The findings indicated that phase I metabolites of MCPT were primarily formed via demethylation, demethoxylation, and hydroxylation, while phase II metabolites mainly included glucuronide and sulfate of MCPT and its phase I metabolites. MCPT, hydroxycamptothecin, and the subsequent glucuronide conjugates were the predominant forms of MCPT in rats. This study provided a comprehensive overview of the metabolite profile of MCPT in rats.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1348-1359"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preparation of HS-CoFe<sub>2</sub>O<sub>4</sub>/Cu(ΙΙ) as a natural based magnetic catalyst.","authors":"Azam Meydani, Mohammad Ali Amrollahi","doi":"10.1080/10286020.2025.2587642","DOIUrl":"10.1080/10286020.2025.2587642","url":null,"abstract":"<p><p>In this research, HS-CoFe<sub>2</sub>O<sub>4</sub>/Cu(ΙΙ) has been synthesized as a novel, natural based and recoverable magnetic composite with high catalytic activity. The structure of this magnetic natural based catalyst was investigated and approved using various analytical tools such as FT-IR, EDX-map, X-ray diffraction (XRD), VSM and FE-SEM. Among the advantages of the developed catalyst, one can point to compatibility with the environment, easy preparation and separation, reusability and low production cost. According to the principles of green chemistry, this study seeks to highlight the possibility of applying renewable and cheap materials and preparing catalysts with waste materials. The synthesized HS-CoFe<sub>2</sub>O<sub>4</sub>/Cu(ΙΙ) has shown high catalytic activity for the preparation of bis(indolyl)methane and dihydropyrano[2,3-c]pyrazole derivatives.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1295-1311"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145742911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cardioprotective potential of punicalagin: an evidence-based review.","authors":"Gurjeet Kaur, Rupali Chauhan, Gauri Kashyap, Jayant Goyal, Neeraj Mittal, Parveen Kumar, Sushma Devi","doi":"10.1080/10286020.2026.2626963","DOIUrl":"10.1080/10286020.2026.2626963","url":null,"abstract":"<p><p>This evidence-based review highlights the cardioprotective potential of punicalagin, a major polyphenolic ellagitannin from <i>Punica granatum</i> L., focusing on its pharmacological mechanisms in cardiovascular disease (CVD) pathogenesis. Preclinical studies demonstrate that punicalagin reduces oxidative stress via Nrf2/HO-1 and AMPK pathways, suppresses inflammatory cytokines (TNF-α, IL-1β, IL-6) through NF-κB and MAPK inhibition, improves endothelial function by upregulating eNOS, and modulates lipid metabolism through ApoB100 binding and cholesterol efflux. Clinical trials further support these effects, showing improvements in lipid profile, blood pressure, and carotid intima-media thickness. Punicalagin's multitarget actions support its translational potential in the management of CVD.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1245-1268"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147306196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis and antibacterial activity of naringenin derivatives containing selenocyanate moiety.","authors":"Zhi-Ping Liu, Mai-Xia Liu, Chun-Rui Cai, Chun-Fang Gan, Jian-Guo Cui, Yan-Min Huang","doi":"10.1080/10286020.2025.2611908","DOIUrl":"10.1080/10286020.2025.2611908","url":null,"abstract":"<p><p>To control plant pathogen infections, we synthesized naringenin derivatives bearing selenocyanate moieties and assayed their antibacterial activity against <i>Xanthomonas axonopodis</i> pv<i>. citri</i>, <i>Xanthomonas oryzae</i> pv<i>. oryzae</i>, and <i>Xanthomonas oryzae</i> pv<i>. oryzicola via</i> the microbroth dilution method. Structures were confirmed by <sup>1</sup>H NMR, <sup>13</sup>C NMR and HRMS. Compounds <b>4a</b> and <b>4b</b> featuring ether substitution at the 7-hydroxyl of naringenin showed potent activity against <i>X. axonopodis</i> pv. <i>citri</i> (EC<sub>50</sub>: 0.33-0.38 μg/ml) and <i>X. oryzae</i> pv. <i>Oryzicola</i> (EC<sub>50</sub>: 0.36-0.75 μg/ml), while <b>5b</b> and <b>8c</b> outperformed chlorothalonil against <i>X. oryzae</i> pv. <i>Oryzae</i> (EC<sub>50</sub>: 1.05-1.42 μg/ml). This study provides valuable insights for developing novel plant disease control agents.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1312-1325"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145933434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yu-Zhi Lin, Hao-Wen Luo, Xin-Yi Chen, Hai-Jie Wu, Chuang-Jun Li, Jie Ma, Guang-Yue Su, Sen Zhang, Ying-Da Zang, Dong-Ming Zhang
{"title":"Design, synthesis, and biological evaluation of 7-O-methyesculin esters as potent inhibitors of renal fibrosis.","authors":"Yu-Zhi Lin, Hao-Wen Luo, Xin-Yi Chen, Hai-Jie Wu, Chuang-Jun Li, Jie Ma, Guang-Yue Su, Sen Zhang, Ying-Da Zang, Dong-Ming Zhang","doi":"10.1080/10286020.2025.2600553","DOIUrl":"10.1080/10286020.2025.2600553","url":null,"abstract":"<p><p>Renal fibrosis is a global health challenge with limited therapies. 7-O-methyesculin (7-ME), derived from Cortex Fraxini (Qinpi), shows notable anti-inflammatory and anti-fibrotic properties. To enhance its membrane permeability and biological activity, we performed structural optimization and synthesized 18 6'-O-acyl 7-ME esters to improve lipophilicity and efficacy. Most derivatives displayed significant anti-fibrotic effects. Among them, <b>EA-8</b> and <b>EA-10</b> were more active than 7-ME against key fibrosis markers, including α-SMA, fibronectin and P-Smad3, while upregulating the protective protein E-cadherin. Mechanistic studies indicated that these compounds suppress the TGF-β1/Smad3 signaling pathway, providing a promising strategy for developing effective anti-fibrotic therapeutics.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1286-1294"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145768161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
De-Min Li, Rui Yuan, Xue Bai, Hai-Zhu Zhang, Ying Wang
{"title":"Effect-constituent index-based quality assessment of Anemarrhenae Rhizoma before and after processing.","authors":"De-Min Li, Rui Yuan, Xue Bai, Hai-Zhu Zhang, Ying Wang","doi":"10.1080/10286020.2025.2594773","DOIUrl":"10.1080/10286020.2025.2594773","url":null,"abstract":"<p><p>Anemarrhenae Rhizoma was investigated to establish an effect-constituent index (ECI) for quality control by analyzing its chemical and bioactivity changes after processing. Antiinflammatory effects were assessed via COX-2 inhibition. Chemical profiles of 30 batches were analyzed using UPLC-Q-TOF-MS/MS, followed by spectrum-effect modeling and molecular docking. Processing increased mangiferin and decreased neomangiferin (<i>p</i> < .05). COX-2 inhibition rose by ∼180% (<i>p</i> < .01); mangiferin potency increased 2.8-fold (<i>p</i> < .05). Mangiferin showed the strongest correlation (Wi = 0.97326) and high COX-2 binding affinity (-5.67 kcal mol<sup>-1</sup>). This study identifies mangiferin as a key quality marker and establishes a quality control model based on the ECI.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1326-1347"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145742939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Research on the effects and mechanisms of the Yiqi Huoxue Recipe in improving renal injury in diabetic nephropathy through the HIF-1 pathway.","authors":"Wen-Di Niu, Hao-Wei Liang, Lue Hong, Jin-Xing He, Jia-Hui Qian, Fei Pan, Zhi-Wei Xu, Hui Wang","doi":"10.1080/10286020.2025.2602695","DOIUrl":"10.1080/10286020.2025.2602695","url":null,"abstract":"<p><p>This study investigates the therapeutic effects and mechanisms of the Yiqi Huoxue Recipe (YHR) on renal injury in Diabetic nephropathy (DN). Through mass spectrometry analysis, animal experiments, and network pharmacology approaches, it was found that YHR can ameliorate renal function indicators and pathological changes in DN rats, and reduce cell apoptosis. Mechanistic studies indicate that YHR alleviates hyperglycemia-induced renal inflammation and damage by inhibiting the HIF-1 signaling pathway, thereby improving DN.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1412-1436"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yu-Wei Ma, Zhan-Tao Li, Meng-Hui Jia, Judick Yap Wei Hoong, Zao Yang
{"title":"Ephedrae Herba and Armeniacae Semen Amarum combination alleviates LPS-induced acute lung injury by targeting the TLR4/NF-κB and NLRP3 pathways.","authors":"Yu-Wei Ma, Zhan-Tao Li, Meng-Hui Jia, Judick Yap Wei Hoong, Zao Yang","doi":"10.1080/10286020.2025.2596733","DOIUrl":"10.1080/10286020.2025.2596733","url":null,"abstract":"<p><p>ALI is a severe clinical syndrome with limited treatment options beyond corticosteroids, which cause significant adverse effects. This study demonstrates that the herbal combination EAC significantly attenuates LPS-induced ALI through dual pathway inhibition. EAC suppresses TLR4/NF-κB and NLRP3 inflammasome signaling, thereby inhibiting MyD88-mediated NF-κB activation, NLRP3 inflammasome assembly, caspase-1 activation, and GSDMD-|mediated pyroptosis. Consequently, EAC reduces proinflammatory cytokine production (IL-1β, IL-18) and restores the balance between inflammatory and anti-inflammatory responses, offering a promising therapeutic alternative to conventional corticosteroids for ALI treatment.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1390-1411"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145768134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pham Thi Cham, Le Thi Vien, Ninh Thi Ngoc, Tran Thi Hong Hanh, Nguyen The Cuong, Nguyen Xuan Cuong, Nguyen Hoai Nam
{"title":"Benzopyran derivatives from <i>Melicope pteleifolia</i>.","authors":"Pham Thi Cham, Le Thi Vien, Ninh Thi Ngoc, Tran Thi Hong Hanh, Nguyen The Cuong, Nguyen Xuan Cuong, Nguyen Hoai Nam","doi":"10.1080/10286020.2025.2594774","DOIUrl":"10.1080/10286020.2025.2594774","url":null,"abstract":"<p><p>Phytochemical investigation of <i>M. pteleifolia</i> branches and leaves led to the isolation of seven benzopyran derivatives, including five new ones named melicopols A - E (<b>2 </b>-<b> 6</b>). The chemical structures were confirmed by extensive analysis of the 1D, 2D NMR, CD, and HR-QTOF mass spectra. The absolute configuration 1'<i>S</i> of leptol A (<b>1</b>) was firstly confirmed by experimental and calculated ECD data. Their cytotoxic activity on three human cancer cell lines HepG2 (hepatoma), SK-LU-1 (lung), and MCF7 (breast) was also evaluated using SRB assay.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1269-1277"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145742918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}