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Utilizing network pharmacology and experimental validation to explore the mechanisms of the Qijiafuzheng formula promoting CD8+ T-cell infiltration in the microenvironment of lung adenocarcinoma through STAT1/CXCL10.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-03-03 DOI: 10.1080/10286020.2025.2467311
Tao Yang, Jian Chen, Zhao-Nan He, Zhong Li, Min Jiang
{"title":"Utilizing network pharmacology and experimental validation to explore the mechanisms of the Qijiafuzheng formula promoting CD8+ T-cell infiltration in the microenvironment of lung adenocarcinoma through STAT1/CXCL10.","authors":"Tao Yang, Jian Chen, Zhao-Nan He, Zhong Li, Min Jiang","doi":"10.1080/10286020.2025.2467311","DOIUrl":"https://doi.org/10.1080/10286020.2025.2467311","url":null,"abstract":"<p><p>Qijiafuzheng formula (QJFZF), a Traditional Chinese Medicine used to treat lung cancer and mitigate chemotherapy side effects, was studied to clarify its impact on the tumor immune microenvironment (TIME). Using network pharmacology and experimental validation, 39 overlapping targets were identified from 579 QJFZF-related and 752 lung adenocarcinoma (LUAD)-TIME targets. Key genes (CCL3, IL10, CXCL10, FOXP3, CD86) correlated negatively with tumor purity and positively with CD8+ T-cell infiltration. CXCL10 emerged as the core target, with experiments showing QJFZF activates the STAT1/CXCL10 pathway to enhance CD8+ T-cell recruitment in LUAD-TIME. This study elucidates QJFZF's immunomodulatory mechanisms, supporting its clinical application.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-19"},"PeriodicalIF":1.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling the neuroprotective mystery of Kaixinsan: identifying and validating the neuroprotective ingredients under the perspective of gut - brain axis regulation.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-03-03 DOI: 10.1080/10286020.2025.2468310
Jia-Le Ren, Xiao-Li Zhang, Li-Juan Zhao, Gui-Ying Wen, Jia-Fan Liu, Qing-Yu Meng, Zhen Yang, Li-Li Song, Yan-Jun Zhang
{"title":"Unveiling the neuroprotective mystery of Kaixinsan: identifying and validating the neuroprotective ingredients under the perspective of gut - brain axis regulation.","authors":"Jia-Le Ren, Xiao-Li Zhang, Li-Juan Zhao, Gui-Ying Wen, Jia-Fan Liu, Qing-Yu Meng, Zhen Yang, Li-Li Song, Yan-Jun Zhang","doi":"10.1080/10286020.2025.2468310","DOIUrl":"https://doi.org/10.1080/10286020.2025.2468310","url":null,"abstract":"<p><p>Kaixinsan (KXS) shows potential in treating cognitive dysfunction and can regulate the gut-brain axis. However, its effective components remain unclear. In this study, the components of KXS extract distributed in serum, brain, heart, liver, lung, kidney, and ileum were detected. By analyzing the number and the concentration of identified components distributed in different tissues, potential active components of KXS were obtained. Then, the screened components were confirmed by evaluating their ability to inhibit Aβ<sub>25-35</sub>-induced neuronal apoptosis in SH-SY5Y cells. Finally, Ginsenoside Rg1, Ginsenoside Ro, α-asarone, 2,4,5-trimethoxybenzoic acid, and 3',6-disinapoylsucrose were found to be the potential active ingredients of KXS.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-18"},"PeriodicalIF":1.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction. 更正。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-03-01 Epub Date: 2024-08-14 DOI: 10.1080/10286020.2024.2390261
{"title":"Correction.","authors":"","doi":"10.1080/10286020.2024.2390261","DOIUrl":"10.1080/10286020.2024.2390261","url":null,"abstract":"","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"478"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monoterpenoid indole alkaloids from the stems and leaves of Tabernaemontana bovina and their potential antiproliferative activities.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-25 DOI: 10.1080/10286020.2025.2459604
Shu-Ri Li, Xiao-Ya Fu, Ye-Ping Liu, Rui Qiu, Bing-Yan Sun, Jing-Su Yu, An-Jiao Wu, Hui Yang, Yan-Ping Liu, Yan-Hui Fu
{"title":"Monoterpenoid indole alkaloids from the stems and leaves of <i>Tabernaemontana bovina</i> and their potential antiproliferative activities.","authors":"Shu-Ri Li, Xiao-Ya Fu, Ye-Ping Liu, Rui Qiu, Bing-Yan Sun, Jing-Su Yu, An-Jiao Wu, Hui Yang, Yan-Ping Liu, Yan-Hui Fu","doi":"10.1080/10286020.2025.2459604","DOIUrl":"https://doi.org/10.1080/10286020.2025.2459604","url":null,"abstract":"<p><p>A phytochemical study on the stems and leaves of <i>Tabernaemontana bovina</i> led to the isolation and identification of a new monoterpenoid indole alkaloid, taberboviline (<b>1</b>), together with seven known monoterpenoid indole alkaloids (2-8). The chemical structure of <b>1</b> was elucidated on the basis of extensive spectral data analyses and the known compounds were identified by comparing their experimental spectral data with the reported data in the literature. All isolated indole alkaloids were evaluated for their antiproliferative activities against five human cancer cell lines <i>in vitro</i>. Monoterpenoid indole alkaloids <b>1</b>-<b>8</b> exhibited notable antiproliferative activities against five human cancer cell lines with IC<sub>50</sub> values ranging from 0.58 ± 0.05 to 26.19 ± 0.16 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioactive steroids from marine-derived fungi: a review (2015-2023).
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-24 DOI: 10.1080/10286020.2025.2464690
Xue-Yang Ma, Huan-Nan Wang, Li-Xiang Sun, Jin Sun, Shi-Hao Jin, Fang-Xu Dai, Chun-Mei Sai, Zhen Zhang
{"title":"Bioactive steroids from marine-derived fungi: a review (2015-2023).","authors":"Xue-Yang Ma, Huan-Nan Wang, Li-Xiang Sun, Jin Sun, Shi-Hao Jin, Fang-Xu Dai, Chun-Mei Sai, Zhen Zhang","doi":"10.1080/10286020.2025.2464690","DOIUrl":"https://doi.org/10.1080/10286020.2025.2464690","url":null,"abstract":"<p><p>Marine fungi, rich in unique secondary metabolites with diverse activities, are a valuable source for novel lead compounds. Steroids, a prominent class of bioactive compounds from marine fungi, have been extensively studied for their diverse pharmacological properties. This review describes the structural diversity, bioactivities, and sources of 175 marine fungal steroids (2015-2023), mainly from <i>Aspergillus</i>, <i>Penicillium</i>, <i>Talaromyces</i>, etc., in seaweed, mangroves, sediments, and marine animals like sponges and corals. Among them, 74 steroids exhibit antibacterial, antitumor, enzyme inhibitory, antiviral, and other activities, providing valuable leads for steroid drug development and advancing marine pharmaceutical research.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-27"},"PeriodicalIF":1.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimization of ultrasonic-assisted extraction of flavonoids from Ficus carica leaves and its chemical composition, antioxidant and UVB-protective properties.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-24 DOI: 10.1080/10286020.2025.2467324
Wei Liu, Meriem Fizir, Jia-Wei Shi, Lu-Xing Zhang, Wei Lin, Zhi-Liang Chen, Jing Ding
{"title":"Optimization of ultrasonic-assisted extraction of flavonoids from <i>Ficus carica</i> leaves and its chemical composition, antioxidant and UVB-protective properties.","authors":"Wei Liu, Meriem Fizir, Jia-Wei Shi, Lu-Xing Zhang, Wei Lin, Zhi-Liang Chen, Jing Ding","doi":"10.1080/10286020.2025.2467324","DOIUrl":"https://doi.org/10.1080/10286020.2025.2467324","url":null,"abstract":"<p><p>This study explored the protective effects of <i>Ficus carica</i> leaves (FCLs) against UVB radiation. Using response surface methodology (RSM), optimal extraction conditions for flavonoids were established, yielding 35.28 mg/g. HPLC-MS/MS analysis identified the components and various tests assessed their antioxidant and UVB protective capabilities. A sunscreen formulation with 0.10 wt% FCLs achieved an SPF of 25.6, surpassing commercial products (SPF 25). Additionally, FCLs extracts reduced <i>E. coli</i> mortality and protected zebrafish tail fin from damage after UVB exposure. These findings suggest FCLs are promising for sunscreen and antioxidant applications and may benefit psoriasis and vitiligo treatment.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-19"},"PeriodicalIF":1.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design, synthesis, and inhibition of novel ferulic acid derivatives on free fatty acid induced cellular lipid accumulation.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-23 DOI: 10.1080/10286020.2025.2459600
Ying-Ying Liu, Yi-Fan Xu, Xin-Ru Li, Qi-Pan Fan, Jia-Hao Liu, Si-Yu Zhou, Yu-Qing Qian, Ming-Dong Li
{"title":"Design, synthesis, and inhibition of novel ferulic acid derivatives on free fatty acid induced cellular lipid accumulation.","authors":"Ying-Ying Liu, Yi-Fan Xu, Xin-Ru Li, Qi-Pan Fan, Jia-Hao Liu, Si-Yu Zhou, Yu-Qing Qian, Ming-Dong Li","doi":"10.1080/10286020.2025.2459600","DOIUrl":"https://doi.org/10.1080/10286020.2025.2459600","url":null,"abstract":"<p><p>Abnormal accumulation of hepatocyte lipids is a hallmark feature of NAFLD. Ferulic acid (FA), an ingredient with antioxidant activity in Chinese herbs, can be used to treat NAFLD by activating AMPK phosphorylation. In this study, we synthesized ten acrylic acid derivatives <b>A1-A10</b>. The inhibition of lipid accumulation showed that most target compounds could inhibit lipid accumulation at 400 μM; compound <b>A3</b> showed a better inhibitory effect than other compounds. Molecular docking results proved that <b>A3</b> could bind to PPARγ, and multiple binding sites existed in both the ferulic acid cohort and the substituted benzene cohort.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-16"},"PeriodicalIF":1.3,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eriodictyol inhibits the proliferation and inflammatory response in keratinocytes in psoriasis through inactivating DYRK1A-mediated endoplasmic reticulum stress.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-23 DOI: 10.1080/10286020.2024.2446301
Rui Yuan, Qi-Chao Sun, Yue-Peng An, Qing Zhang, Qiong Zhang, Yue Li
{"title":"Eriodictyol inhibits the proliferation and inflammatory response in keratinocytes in psoriasis through inactivating DYRK1A-mediated endoplasmic reticulum stress.","authors":"Rui Yuan, Qi-Chao Sun, Yue-Peng An, Qing Zhang, Qiong Zhang, Yue Li","doi":"10.1080/10286020.2024.2446301","DOIUrl":"https://doi.org/10.1080/10286020.2024.2446301","url":null,"abstract":"<p><p>Our work is conducted to reveal the impacts of eriodictyol on psoriasis. CCK-8 and EdU assays measured HaCaT cell proliferation. ELISA detected the activities of inflammatory cytokines and chemokines. Western blot examined the expressions of proliferation-, inflammation- and ERS-associated proteins. Molecular docking predicted the binding affinity of eriodictyol to DYRK1A. RT-qPCR and Western blot analyzed DYRK1A expression. Eriodictyol inhibited the proliferation and inflammatory response in M5-challenged HaCaT cells. Eriodictyol targeted and down-regulated DYRK1A expression. DYRK1A overexpression abolished the impacts of eriodictyol on M5-stimulated HaCaT cells. Conclusively, eriodictyol might suppress ERS mediated by DYRK1A to elicit anti-psoriasis functions.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.3,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two new tetralones from the endophytic fungus Annulohypoxylon stygium A888.
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-22 DOI: 10.1080/10286020.2025.2464683
Zhi-Shen Shao, Yu-Chan Chen, Wei-Peng Ma, Sai-Ni Li, Hong-Xin Liu, Wei-Min Zhang, Xiao-Ying Chen
{"title":"Two new tetralones from the endophytic fungus <i>Annulohypoxylon stygium</i> A888.","authors":"Zhi-Shen Shao, Yu-Chan Chen, Wei-Peng Ma, Sai-Ni Li, Hong-Xin Liu, Wei-Min Zhang, Xiao-Ying Chen","doi":"10.1080/10286020.2025.2464683","DOIUrl":"https://doi.org/10.1080/10286020.2025.2464683","url":null,"abstract":"<p><p>Two new tetralones, annulohyporins A (<b>1</b>) and B (<b>2</b>), along with thirteen known compounds (<b>3</b>-<b>15</b>), were isolated from the ethyl acetate extract of solid fermentation of the endophytic fungus <i>Annulohypoxylon stygium</i> A888, which was isolated from the medicinal plant <i>Aquilaria sinensis</i>. The structures of annulohyporins A and B were established by detailed analyses of ultraviolet-visible spectroscopy (UV), infrared spectroscopy (IR), mass spectrometry (MS), electronic circular dichroism (ECD) calculations and nuclear magnetic resonance (NMR). Bioactivity assay showed that compounds <b>3</b> and <b>4</b> had significant α-glucosidase inhibitory activities with IC<sub>50</sub> values of 64.00 and 32.90 µM, respectively.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genistein resists castration-resistant prostate cancer by inhibiting the androgen receptor pathway. 染料木素通过抑制雄激素受体通路来抵御耐受性前列腺癌。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-02-22 DOI: 10.1080/10286020.2025.2464695
Xiao-Ping Yu, Lu-Jie Zheng, Jia-Li Yan, Yan Luo, Xiao-Long Song, Tian-Yu Fu, Xiao-Li Peng, Jing-Chang Du, Bin Han, Fei Li, Yan-Feng Zhu
{"title":"Genistein resists castration-resistant prostate cancer by inhibiting the androgen receptor pathway.","authors":"Xiao-Ping Yu, Lu-Jie Zheng, Jia-Li Yan, Yan Luo, Xiao-Long Song, Tian-Yu Fu, Xiao-Li Peng, Jing-Chang Du, Bin Han, Fei Li, Yan-Feng Zhu","doi":"10.1080/10286020.2025.2464695","DOIUrl":"https://doi.org/10.1080/10286020.2025.2464695","url":null,"abstract":"<p><p>Prostate cancer is a prevalent malignancy, often diagnosed at advanced stages and associated with poor prognosis. Genistein, a soybean isoflavone, has demonstrated antitumor effects against castration-resistant prostate cancer <i>in vivo</i>. Our results indicate that genistein effectively downregulates the expression of key enzymes involved in the <i>de novo</i> synthesis pathway, namely AKR1C3, SRD5A2, CYP11A1, and 3βHSD, thus blocking androgen synthesis in CRPC cells. Additionally, genistein inhibits the activation and nuclear translocation of the AR. Collectively, these findings support the potential of genistein as a therapeutic agent for CRPC, highlighting its role in both inhibiting androgen synthesis and disrupting AR signaling.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-17"},"PeriodicalIF":1.3,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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