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Journal of Asian Natural Products Research最新文献

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Eriodictyol inhibits the proliferation and inflammatory response in keratinocytes in psoriasis through inactivating DYRK1A-mediated endoplasmic reticulum stress 戊二醇通过灭活dyrk1a介导的内质网应激，抑制银屑病中角质形成细胞的增殖和炎症反应。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-03 DOI: 10.1080/10286020.2024.2446301
Rui Yuan , Qi-Chao Sun , Yue-Peng An , Qing Zhang , Qiong Zhang , Yue Li
{"title":"Eriodictyol inhibits the proliferation and inflammatory response in keratinocytes in psoriasis through inactivating DYRK1A-mediated endoplasmic reticulum stress","authors":"Rui Yuan ,&nbsp;Qi-Chao Sun ,&nbsp;Yue-Peng An ,&nbsp;Qing Zhang ,&nbsp;Qiong Zhang ,&nbsp;Yue Li","doi":"10.1080/10286020.2024.2446301","DOIUrl":"10.1080/10286020.2024.2446301","url":null,"abstract":"<div><div>Our work is conducted to reveal the impacts of eriodictyol on psoriasis. CCK-8 and EdU assays measured HaCaT cell proliferation. ELISA detected the activities of inflammatory cytokines and chemokines. Western blot examined the expressions of proliferation-, inflammation- and ERS-associated proteins. Molecular docking predicted the binding affinity of eriodictyol to DYRK1A. RT-qPCR and Western blot analyzed DYRK1A expression. Eriodictyol inhibited the proliferation and inflammatory response in M5-challenged HaCaT cells. Eriodictyol targeted and down-regulated DYRK1A expression. DYRK1A overexpression abolished the impacts of eriodictyol on M5-stimulated HaCaT cells. Conclusively, eriodictyol might suppress ERS mediated by DYRK1A to elicit anti-psoriasis functions.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 7","pages":"Pages 1025-1037"},"PeriodicalIF":1.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Minor indoloquinolizidine monoterpene alkaloids from an aqueous extract of the hook-bearing stem of Uncaria rhynchophylla 钩钩藤茎水提物中微量吲哚喹啉单萜生物碱。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-03 DOI: 10.1080/10286020.2025.2509764
Jin-Qiu Ren , Xiao-Qiang Lei , Qing-Lan Guo , Jian-Gong Shi
{"title":"Minor indoloquinolizidine monoterpene alkaloids from an aqueous extract of the hook-bearing stem of Uncaria rhynchophylla","authors":"Jin-Qiu Ren ,&nbsp;Xiao-Qiang Lei ,&nbsp;Qing-Lan Guo ,&nbsp;Jian-Gong Shi","doi":"10.1080/10286020.2025.2509764","DOIUrl":"10.1080/10286020.2025.2509764","url":null,"abstract":"<div><div>Six minor undescribed indoloquinolizidine monoterpene alkaloids, uncarrhynchophyllines F − K (<strong>1 </strong>−<strong> 6</strong>), were isolated from an aqueous decoction of the hook-bearing stems of <em>Uncaria rhynchophylla</em> (gou-teng). Their structures were determined by spectroscopic data analysis in combination with electron circular dichroism (ECD) and NMR calculations. Compounds <strong>1 </strong>−<strong> 4</strong> are rare indoloquinolizidine iminium zwitterions, while <strong>5</strong> exhibited protective effects against APAP induced liver cell injury.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 7","pages":"Pages 983-994"},"PeriodicalIF":1.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resveratrol: a potential alternative therapeutic agent for patients suffering from chronic obstructive pulmonary disease (COPD) 白藜芦醇：慢性阻塞性肺疾病（COPD）患者的潜在替代治疗剂。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-03 DOI: 10.1080/10286020.2025.2459597
Ong Yan Ren , Yasmeen Siddiqui , Mohammed Tahir Ansari , Asgar Ali
{"title":"Resveratrol: a potential alternative therapeutic agent for patients suffering from chronic obstructive pulmonary disease (COPD)","authors":"Ong Yan Ren ,&nbsp;Yasmeen Siddiqui ,&nbsp;Mohammed Tahir Ansari ,&nbsp;Asgar Ali","doi":"10.1080/10286020.2025.2459597","DOIUrl":"10.1080/10286020.2025.2459597","url":null,"abstract":"<div><div>This review explores the therapeutic potential of resveratrol, focusing on its molecular and cellular effects on Chronic Obstructive Pulmonary Disease (COPD), bioavailability enhancement strategies, and development challenges for applications in food, pharmaceuticals, and postharvest sectors. Resveratrol protects lungs by activating SIRT1, reducing oxidative stress via ROS regulation through Nrf2-mediated antioxidant enzymes. It shows promise as an alternative to corticosteroids in COPD and cancer treatment. Encapsulation innovations in resveratrol offer opportunities for food fortification, minimizing risks of chemical degradation and isomerization during storage, paving the way for its broader utility in health and nutrition applications.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 7","pages":"Pages 951-965"},"PeriodicalIF":1.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sesquiterpenes with anti-inflammatory activity from the stems and branches of Melicope patulinervia 山核桃茎、枝中具有抗炎活性的倍半萜素。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-03 DOI: 10.1080/10286020.2025.2508874
Sai Li , En-Lian Du , Qi Gong , Fei Chen , Jun-Jie Tan , Shi-Jin Qu , Hai-Yan Zhang , Chang-Heng Tan
{"title":"Sesquiterpenes with anti-inflammatory activity from the stems and branches of Melicope patulinervia","authors":"Sai Li ,&nbsp;En-Lian Du ,&nbsp;Qi Gong ,&nbsp;Fei Chen ,&nbsp;Jun-Jie Tan ,&nbsp;Shi-Jin Qu ,&nbsp;Hai-Yan Zhang ,&nbsp;Chang-Heng Tan","doi":"10.1080/10286020.2025.2508874","DOIUrl":"10.1080/10286020.2025.2508874","url":null,"abstract":"<div><div>Five new sesquiterpenes comprising three zieranes, melicopatulones A–C (<strong>1</strong>–<strong>3</strong>) and two guaianes, melicopatulones D–E (<strong>5</strong>–<strong>6</strong>), were isolated from the stems and branches of <em>Melicope patulinervia</em>, together with melicodenones B (<strong>4</strong>), C (<strong>7</strong>) and D (<strong>8</strong>). Their structures with absolute configurations were elucidated on the basis of analysis of MS, NMR, and TDDFT-ECD calculations. Sesquiterpenes <strong>1</strong>, <strong>2</strong> and <strong>6</strong> exhibited significant inhibitory effect at 10 µM on lipopolysaccharide-induced NO production in BV-2 microglial cells.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 7","pages":"Pages 977-982"},"PeriodicalIF":1.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cannabinoid receptor ligands with potential therapeutic applications and mechanisms of action: a versatile natural therapeutic agent. 具有潜在治疗应用和作用机制的大麻素受体配体：一种多功能天然治疗剂。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-07-02 DOI: 10.1080/10286020.2025.2522396
Shivendra Mani Tripathi, Sharda Sambhakar, Sudhanshu Mishra, Rishabha Malviya, Sathvik Belagodu Sridhar
{"title":"Cannabinoid receptor ligands with potential therapeutic applications and mechanisms of action: a versatile natural therapeutic agent.","authors":"Shivendra Mani Tripathi, Sharda Sambhakar, Sudhanshu Mishra, Rishabha Malviya, Sathvik Belagodu Sridhar","doi":"10.1080/10286020.2025.2522396","DOIUrl":"https://doi.org/10.1080/10286020.2025.2522396","url":null,"abstract":"<p><p>The endocannabinoid system (ECS) is a complex signaling network essential for regulating various physiological processes in the body. Selective cannabinoid receptor ligands have been developed to modulate specific ECS signaling pathways, offering potential therapeutic benefits. These ligands, with high selectivity and affinity for cannabinoid receptors, demonstrate potential in managing diverse medical conditions. Standardizing dosing is crucial to ensure reliable therapeutic effects, as cannabinoids may exhibit biphasic effects. Combination strategies involving both CB1 and CB2 receptor modulation show promise in managing complex conditions, including chronic pain, autoimmune disorders, and neurodegenerative diseases.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-20"},"PeriodicalIF":1.3,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ginseng: a traditional medicine and food homologous plant. 人参：一种传统医药和食品同源植物。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-06-28 DOI: 10.1080/10286020.2025.2514689
Xiao-Xue Song, En-Lin Liu, Xiao-Wei Du
{"title":"Ginseng: a traditional medicine and food homologous plant.","authors":"Xiao-Xue Song, En-Lin Liu, Xiao-Wei Du","doi":"10.1080/10286020.2025.2514689","DOIUrl":"https://doi.org/10.1080/10286020.2025.2514689","url":null,"abstract":"<p><p>Ginseng (<i>Panax ginseng</i> CA Meyer), a perennial herb belonging to the Araliaceae family, has been cultivated and used in China for over 2,000 years. Ginseng, a renowned medicinal plant, is highly valued for its health benefits and is among the top herbal medicines in traditional Chinese medicine. Its roots, leaves, and stems are utilized for medicinal and edible purposes. This paper reviews the cultivation history, chemical constituents, and pharmacological activities of ginseng, which is rich in ginsenosides and other bioactive compounds. It provides a reference for the comprehensive development and utilization of this medicinal plant.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.3,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on the synthesis, structural characterization, and anti-hepatoma cell proliferation effects of sulfated alfalfa polysaccharides. 硫酸酸化紫花苜蓿多糖的合成、结构表征及抗肝癌细胞增殖作用研究。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-06-27 DOI: 10.1080/10286020.2025.2521824
Lang Qiu, Jia-Yi Wang, Dan-Qi Li, Xue-Gui Liu, Pin-Yi Gao
{"title":"Study on the synthesis, structural characterization, and anti-hepatoma cell proliferation effects of sulfated alfalfa polysaccharides.","authors":"Lang Qiu, Jia-Yi Wang, Dan-Qi Li, Xue-Gui Liu, Pin-Yi Gao","doi":"10.1080/10286020.2025.2521824","DOIUrl":"https://doi.org/10.1080/10286020.2025.2521824","url":null,"abstract":"<p><p>A water-soluble polysaccharide (APS) from <i>Medicago Sativa</i> L. (alfalfa) stems was sulfated via the chlorosulfonic acid (CSA)-pyridine (Pyr) method under three conditions, yielding SAPS-1, SAPS-2, and SAPS-3. Structural characterization (HPGPC, NMR, FT-IR, SEM) confirmed successful sulfation and increased water solubility. SAPSs 1-3 exhibited superior scavenging of DPPH, ABTS, and OH radicals compared to APS. Both APS and SAPSs 1-3 inhibited hepatoma cell (HepG2, Hep3B) proliferation <i>in vitro</i>. Cell cycle analysis showed APS-induced G0/G1 arrest, while SAPS-3 exhibited biphasic regulation by maintaining G0/G1 arrest and stimulating S-phase accumulation. The CSA-Pyr technique enhanced the inhibitory effects, offering promise for developing bioactive compounds from alfalfa biomass.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-18"},"PeriodicalIF":1.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel pyrrolidine alkaloid and a novel isoflavone with anti-inflammatory activity from the tubers of Arisaema franchetianum. 从鸢尾块茎中分离出具有抗炎活性的新型吡咯烷类生物碱和新型异黄酮。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-06-21 DOI: 10.1080/10286020.2025.2514687
Wan-Qi Yang, Meng-Yuan Cui, Yun-Peng Qin, Kai-Dong Liu, Yong Xu, Ying-Ying Dong, Jing Qu
{"title":"A novel pyrrolidine alkaloid and a novel isoflavone with anti-inflammatory activity from the tubers of <i>Arisaema franchetianum</i>.","authors":"Wan-Qi Yang, Meng-Yuan Cui, Yun-Peng Qin, Kai-Dong Liu, Yong Xu, Ying-Ying Dong, Jing Qu","doi":"10.1080/10286020.2025.2514687","DOIUrl":"10.1080/10286020.2025.2514687","url":null,"abstract":"<p><p>Solanpyrrole B (<b>1</b>), a new pyrrolidine alkaloid and 5,7,4',5'-tetrahydroxy-6, 3'-dimethoxyisoflavone (<b>2</b>), a new isoflavone, along with 12 known compounds (<b>3</b>-<b>14</b>), were isolated from the tubers of <i>Arisaema franchetianum</i>. The chemical structures of these compounds were identified by using spectroscopic analysis (NMR, UV, IR, HR-ESI-MS). Compounds <b>1</b> and <b>2</b> (10 <i>μ</i>M) exhibited anti-inflammatory activities in inhibiting the NF-κB signaling pathway, reducing the release of NO from RAW264.7 macrophages and BV2 microglia induced by LPS. Compounds <b>1</b>, <b>2</b> and <b>11</b> exhibited significant cytotoxic activity against HCT116 cells (IC<sub>50</sub> = 9.16 ± 1.59 <i>μ</i>M), HGC27 cells (IC<sub>50</sub> = 7.98 ± 1.07 <i>μ</i>M), U87MG (IC<sub>50</sub> = 2.81 ± 0.18 <i>μ</i>M), respectively.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.3,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New modified silybin derivatives: design, synthesis, and preliminary evaluation of antitumor activity. 新型改性水飞蓟宾衍生物：设计、合成及抗肿瘤活性初步评价。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-06-18 DOI: 10.1080/10286020.2025.2515257
Yan-Qiu Meng, Chao-Hui Zhang, Dong-Ping Xu, Lei Gao, Yan Li
{"title":"New modified silybin derivatives: design, synthesis, and preliminary evaluation of antitumor activity.","authors":"Yan-Qiu Meng, Chao-Hui Zhang, Dong-Ping Xu, Lei Gao, Yan Li","doi":"10.1080/10286020.2025.2515257","DOIUrl":"https://doi.org/10.1080/10286020.2025.2515257","url":null,"abstract":"<p><p>Based on the molecular docking of Epidermal Growth Factor Receptor inhibitors and known small molecules, key amino acid fragments and active groups were analyzed through computer-aided drug design techniques. Subsequently, these active functional groups were introduced at positions C-23 and C-7 of silybin to design and synthesize 12 novel silybin derivatives. The structures of these innovative silybin analogues were confirmed by nuclear magnetic resonance and mass spectrometry. Moreover, the antitumor activities of these novel analogues were evaluated by MTT assay. As a result, compounds <b>I<sub>2</sub></b> and <b>I<sub>8</sub></b> exhibited greater cytotoxicity against tumor cells compared to silybin and positive control drugs such as gefitinib. In conclusion, our study synthesized 12 novel silybin derivatives and identified compounds <b>I<sub>2</sub></b> and <b>I<sub>8</sub></b> as potential candidates or cancer therapy.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design, synthesis, and biological evaluation of bergapten derivatives as potent anti-pancreatic cancer agents. bergapten衍生物作为有效的抗胰腺癌药物的设计、合成和生物学评价。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-06-18 DOI: 10.1080/10286020.2025.2514692
Ying Yue, Jia-Rong Liu, Nan Wang, Xing-Rong Wang, Jun-Yi Ma, Jun-Li Yang
{"title":"Design, synthesis, and biological evaluation of bergapten derivatives as potent anti-pancreatic cancer agents.","authors":"Ying Yue, Jia-Rong Liu, Nan Wang, Xing-Rong Wang, Jun-Yi Ma, Jun-Li Yang","doi":"10.1080/10286020.2025.2514692","DOIUrl":"https://doi.org/10.1080/10286020.2025.2514692","url":null,"abstract":"<p><p>Bergapten, a natural product from <i>Zanthoxylum bungeanum</i> Maxim., exhibits anticancer, antibacterial, anti-inflammatory, and hypolipidemic effects. A derivative, FSG-Y5 showed potent activity against pancreatic cancer cells PANC-1 (IC<sub>50</sub> = 2.31 ± 0.25 µM) and CFPAC-1 (IC<sub>50</sub> = 4.41 ± 0.47 µM), inhibiting their survival, migration, and invasion while inducing apoptosis <i>via</i> Bax and Cleaved caspase-3 regulation. FSG-Y5 also suppressed pancreatic cancer organoids and zebrafish tumor growth in a concentration and time-dependent manner. These findings highlight bergapten derivatives as promising anticancer candidates, with FSG-Y5 as a potential anti-pancreatic cancer agent for further study.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-17"},"PeriodicalIF":1.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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