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A new anti-inflammatory monoterpenoid indole alkaloid from the trunk of Nauclea officinalis. 一种新型抗炎单萜类吲哚生物碱。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-09-15 DOI: 10.1080/10286020.2025.2558638
Shuo-Guo Li, Zheng-Ran Zou, Jing-Yu Quan, Xiao-Feng Zheng, An-Qi Hu, Xu-Hua Yu, Zi-Yao Liang, Yue Sun, Lin Lin, Shu-Mei Wang, Long Fan
{"title":"A new anti-inflammatory monoterpenoid indole alkaloid from the trunk of <i>Nauclea officinalis</i>.","authors":"Shuo-Guo Li, Zheng-Ran Zou, Jing-Yu Quan, Xiao-Feng Zheng, An-Qi Hu, Xu-Hua Yu, Zi-Yao Liang, Yue Sun, Lin Lin, Shu-Mei Wang, Long Fan","doi":"10.1080/10286020.2025.2558638","DOIUrl":"https://doi.org/10.1080/10286020.2025.2558638","url":null,"abstract":"<p><p>Two monoterpenoid indole alkaloids including one undescribed alkaloid, naucleficine B (<b>1</b>), and a known alkaloid glycoside, strictosamide (<b>2</b>) were isolated from ethyl acetate fraction of the 95% ethanol extract from the trunk of <i>Nauclea officinalis</i>, together with three known non-alkaloid components, (+)-medioresinol (<b>3</b>), protocatechuic acid (<b>4</b>), and benzoic acid (<b>5</b>). Their structures were elucidated on the basis of extensive spectroscopic analysis and X-ray diffraction. Compounds <b>1</b> and <b>2</b> exhibited potent anti-inflammatory effects in cigarette smoke extract (CSE)-stimulated RAW 264.7 and THP-1 macrophages. These compounds significantly suppressed nitric oxide (NO) generation, reduced the secretion of inflammatory mediators, and inhibited the activation of inflammation-related proteins.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-16"},"PeriodicalIF":1.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Network pharmacology analysis and experimental validation of Yinma Jiedu Granule in the treatment of acute pharyngitis. 茵麻解毒颗粒治疗急性咽炎的网络药理学分析及实验验证。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-09-15 DOI: 10.1080/10286020.2025.2549894
Qiu-Zhu Chen, Yue-Qi Jiang, Gen Li, Cai-Xia Zang, Jing-Wei Ma, Yang Yang, Yi-Rong Dong, Jin-Rong Wang, Ning Zhou, Xing Yang, Fang-Fang Li, Xiu-Qi Bao, Dan Zhang
{"title":"Network pharmacology analysis and experimental validation of Yinma Jiedu Granule in the treatment of acute pharyngitis.","authors":"Qiu-Zhu Chen, Yue-Qi Jiang, Gen Li, Cai-Xia Zang, Jing-Wei Ma, Yang Yang, Yi-Rong Dong, Jin-Rong Wang, Ning Zhou, Xing Yang, Fang-Fang Li, Xiu-Qi Bao, Dan Zhang","doi":"10.1080/10286020.2025.2549894","DOIUrl":"https://doi.org/10.1080/10286020.2025.2549894","url":null,"abstract":"<p><p>Yinma Jiedu Granules (YMJD) is a classical Chinese medicinal formula for alleviating inflammatory conditions, such as acute bronchitis and tracheitis. In this study, network pharmacology identified <i>AKT1</i>, <i>IL6,</i> and <i>IL1B</i> as hub genes, and molecular docking confirmed their binding to active ingredients (naringenin, quercetin, and aloe-emodin). Moreover, pathway enrichment analysis indicated YMJD alleviated acute pharyngitis by suppressing oxidative stress and PI3K-AKT signaling pathway. In acute pharyngitis rat model, YMJD improved the symptoms of acute pharyngitis. Mechanistic study showed that YMJD inhibited oxidative stress and inflammatory response through downregulation of PI3K/AKT/mTOR signaling pathway, providing evidence for YMJD to treat acute pharyngitis.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-20"},"PeriodicalIF":1.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunosuppressive sesquiterpene phenols from the marine sponge Dactylospongia elegans. 海海绵中免疫抑制倍半萜酚类物质。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-09-13 DOI: 10.1080/10286020.2025.2558639
Bo Hu, Hai-Yan Chen, Zhe Ning, Xin-Yuan Wang, Xiao-Ling Lu, Hao-Bing Yu
{"title":"Immunosuppressive sesquiterpene phenols from the marine sponge <i>Dactylospongia elegans</i>.","authors":"Bo Hu, Hai-Yan Chen, Zhe Ning, Xin-Yuan Wang, Xiao-Ling Lu, Hao-Bing Yu","doi":"10.1080/10286020.2025.2558639","DOIUrl":"https://doi.org/10.1080/10286020.2025.2558639","url":null,"abstract":"<p><p>Two new sesquiterpene phenols, dactyltone A (<b>1</b>) and dactyltone B (<b>2</b>), were isolated from the marine sponge <i>Dactylospongia elegans</i> collected from the South China Sea. Their structures were elucidated by comprehensive spectroscopic analysis (including NMR and HRESIMS) combined with experimental and calculated electronic circular dichroism (ECD) data. Notably, the carbonylation at C-2 observed in ring A of marine sponge-derived sesquiterpene phenols represents an uncommon structural feature. Biological evaluation revealed that both compounds showed selective immunosuppressive activity, specifically inhibiting ConA-induced T-cell proliferation with IC<sub>50</sub> values of 6.53 μM and 9.85 μM for <b>1</b> and <b>2</b>, respectively, while demonstrating no significant antibacterial or cytotoxic effects at tested concentrations.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Network pharmacology approach and experimental verification of Manzufei decoction in the treatment of chronic obstructive pulmonary disease. 曼祖肺汤治疗慢性阻塞性肺疾病的网络药理学方法及实验验证。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-09-11 DOI: 10.1080/10286020.2025.2558646
Xin Liu, Chun-Ye Hu, Zheng-Huan Li, Hong-Mei Yang, Cheng-Xin Zhang, Hong Li, Guo-Ming Tang, Yang Chen
{"title":"Network pharmacology approach and experimental verification of Manzufei decoction in the treatment of chronic obstructive pulmonary disease.","authors":"Xin Liu, Chun-Ye Hu, Zheng-Huan Li, Hong-Mei Yang, Cheng-Xin Zhang, Hong Li, Guo-Ming Tang, Yang Chen","doi":"10.1080/10286020.2025.2558646","DOIUrl":"https://doi.org/10.1080/10286020.2025.2558646","url":null,"abstract":"<p><p>Manzufei decoction (MZFD) effectively treats COPD, but its mechanisms are unclear. Combining network pharmacology and experimental validation, we identified 168 bioactive components in MZFD and 265 potential targets. Network analysis pinpointed 4 core compounds. Comparing 1167 COPD-related targets revealed 114 overlapping therapeutic targets. Enrichment analysis implicated key pathways, notably AKT signaling. Molecular docking confirmed strong binding of quercetin to AKT and MUC5AC. Animal studies demonstrated that MZFD inhibits AKT signaling pathway activation, reduces MUC5AC protein expression in lung tissue and lung inflammation, thereby alleviating lung injury in AECOPD model rats.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-25"},"PeriodicalIF":1.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two new tetralones from the endophytic fungus Annulohypoxylon stygium A888 内生真菌annlohypoxylon stygium A888的两个新四克隆体。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-09-02 DOI: 10.1080/10286020.2025.2464683
Zhi-Shen Shao , Yu-Chan Chen , Wei-Peng Ma , Sai-Ni Li , Hong-Xin Liu , Wei-Min Zhang , Xiao-Ying Chen
{"title":"Two new tetralones from the endophytic fungus Annulohypoxylon stygium A888","authors":"Zhi-Shen Shao ,&nbsp;Yu-Chan Chen ,&nbsp;Wei-Peng Ma ,&nbsp;Sai-Ni Li ,&nbsp;Hong-Xin Liu ,&nbsp;Wei-Min Zhang ,&nbsp;Xiao-Ying Chen","doi":"10.1080/10286020.2025.2464683","DOIUrl":"10.1080/10286020.2025.2464683","url":null,"abstract":"<div><div>Two new tetralones, annulohyporins A (<strong>1</strong>) and B (<strong>2</strong>), along with thirteen known compounds (<strong>3</strong>–<strong>15</strong>), were isolated from the ethyl acetate extract of solid fermentation of the endophytic fungus <em>Annulohypoxylon stygium</em> A888, which was isolated from the medicinal plant <em>Aquilaria sinensis</em>. The structures of annulohyporins A and B were established by detailed analyses of ultraviolet-visible spectroscopy (UV), infrared spectroscopy (IR), mass spectrometry (MS), electronic circular dichroism (ECD) calculations and nuclear magnetic resonance (NMR). Bioactivity assay showed that compounds <strong>3</strong> and <strong>4</strong> had significant α-glucosidase inhibitory activities with IC<sub>50</sub> values of 64.00 and 32.90 µM, respectively.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 9","pages":"Pages 1270-1277"},"PeriodicalIF":1.3,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioactive steroids from marine-derived fungi: a review (2015–2023) 海洋真菌中生物活性类固醇的研究进展（2015-2023）。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-09-02 DOI: 10.1080/10286020.2025.2464690
Xue-Yang Ma , Huan-Nan Wang , Li-Xiang Sun , Jin Sun , Shi-Hao Jin , Fang-Xu Dai , Chun-Mei Sai , Zhen Zhang
{"title":"Bioactive steroids from marine-derived fungi: a review (2015–2023)","authors":"Xue-Yang Ma ,&nbsp;Huan-Nan Wang ,&nbsp;Li-Xiang Sun ,&nbsp;Jin Sun ,&nbsp;Shi-Hao Jin ,&nbsp;Fang-Xu Dai ,&nbsp;Chun-Mei Sai ,&nbsp;Zhen Zhang","doi":"10.1080/10286020.2025.2464690","DOIUrl":"10.1080/10286020.2025.2464690","url":null,"abstract":"<div><div>Marine fungi, rich in unique secondary metabolites with diverse activities, are a valuable source for novel lead compounds. Steroids, a prominent class of bioactive compounds from marine fungi, have been extensively studied for their diverse pharmacological properties. This review describes the structural diversity, bioactivities, and sources of 175 marine fungal steroids (2015–2023), mainly from <em>Aspergillus</em>, <em>Penicillium</em>, <em>Talaromyces</em>, etc., in seaweed, mangroves, sediments, and marine animals like sponges and corals. Among them, 74 steroids exhibit antibacterial, antitumor, enzyme inhibitory, antiviral, and other activities, providing valuable leads for steroid drug development and advancing marine pharmaceutical research.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 9","pages":"Pages 1236-1262"},"PeriodicalIF":1.3,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monoterpenoid indole alkaloids from the stems and leaves of Tabernaemontana bovina and their potential antiproliferative activities 牛黄茎叶中单萜类吲哚类生物碱及其潜在的抗增殖活性。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-09-02 DOI: 10.1080/10286020.2025.2459604
Shu-Ri Li , Xiao-Ya Fu , Ye-Ping Liu , Rui Qiu , Bing-Yan Sun , Jing-Su Yu , An-Jiao Wu , Hui Yang , Yan-Ping Liu , Yan-Hui Fu
{"title":"Monoterpenoid indole alkaloids from the stems and leaves of Tabernaemontana bovina and their potential antiproliferative activities","authors":"Shu-Ri Li ,&nbsp;Xiao-Ya Fu ,&nbsp;Ye-Ping Liu ,&nbsp;Rui Qiu ,&nbsp;Bing-Yan Sun ,&nbsp;Jing-Su Yu ,&nbsp;An-Jiao Wu ,&nbsp;Hui Yang ,&nbsp;Yan-Ping Liu ,&nbsp;Yan-Hui Fu","doi":"10.1080/10286020.2025.2459604","DOIUrl":"10.1080/10286020.2025.2459604","url":null,"abstract":"<div><div>A phytochemical study on the stems and leaves of <em>Tabernaemontana bovina</em> led to the isolation and identification of a new monoterpenoid indole alkaloid, taberboviline (<span><span><strong>1</strong></span></span>), together with seven known monoterpenoid indole alkaloids (<span><span>2.</span></span>, <span><span>3.</span></span>, <span><span>4.</span></span>, <span><span>5.</span></span>, <span><span>6.</span></span>, <span><span>7.</span></span>, <span><span>8.</span></span>). The chemical structure of <strong>1</strong> was elucidated on the basis of extensive spectral data analyses and the known compounds were identified by comparing their experimental spectral data with the reported data in the literature. All isolated indole alkaloids were evaluated for their antiproliferative activities against five human cancer cell lines <em>in vitro</em>. Monoterpenoid indole alkaloids <strong>1</strong>–<strong>8</strong> exhibited notable antiproliferative activities against five human cancer cell lines with IC<sub>50</sub> values ranging from 0.58 ± 0.05 to 26.19 ± 0.16 μM.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 9","pages":"Pages 1379-1387"},"PeriodicalIF":1.3,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genistein resists castration-resistant prostate cancer by inhibiting the androgen receptor pathway 染料木素通过抑制雄激素受体通路来抵御耐受性前列腺癌。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-09-02 DOI: 10.1080/10286020.2025.2464695
Xiao-Ping Yu , Lu-Jie Zheng , Jia-Li Yan , Yan Luo , Xiao-Long Song , Tian-Yu Fu , Xiao-Li Peng , Jing-Chang Du , Bin Han , Fei Li , Yan-Feng Zhu
{"title":"Genistein resists castration-resistant prostate cancer by inhibiting the androgen receptor pathway","authors":"Xiao-Ping Yu ,&nbsp;Lu-Jie Zheng ,&nbsp;Jia-Li Yan ,&nbsp;Yan Luo ,&nbsp;Xiao-Long Song ,&nbsp;Tian-Yu Fu ,&nbsp;Xiao-Li Peng ,&nbsp;Jing-Chang Du ,&nbsp;Bin Han ,&nbsp;Fei Li ,&nbsp;Yan-Feng Zhu","doi":"10.1080/10286020.2025.2464695","DOIUrl":"10.1080/10286020.2025.2464695","url":null,"abstract":"<div><div>Prostate cancer is a prevalent malignancy, often diagnosed at advanced stages and associated with poor prognosis. Genistein, a soybean isoflavone, has demonstrated antitumor effects against castration-resistant prostate cancer <em>in vivo</em>. Our results indicate that genistein effectively downregulates the expression of key enzymes involved in the <em>de novo</em> synthesis pathway, namely AKR1C3, SRD5A2, CYP11A1, and 3βHSD, thus blocking androgen synthesis in CRPC cells. Additionally, genistein inhibits the activation and nuclear translocation of the AR. Collectively, these findings support the potential of genistein as a therapeutic agent for CRPC, highlighting its role in both inhibiting androgen synthesis and disrupting AR signaling.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 9","pages":"Pages 1294-1310"},"PeriodicalIF":1.3,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three new limonoids with high oxidation from the fruits of Aglaia edulis 从菖蒲果实中提取三种新的高氧化类柠檬素。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-09-02 DOI: 10.1080/10286020.2025.2482075
Han-Sheng Lv , Hou-Li Jiang , Yu-Jin Sun , Ping Ying , Qiang Zheng , Ling-Yi Kong , Jun Luo
{"title":"Three new limonoids with high oxidation from the fruits of Aglaia edulis","authors":"Han-Sheng Lv ,&nbsp;Hou-Li Jiang ,&nbsp;Yu-Jin Sun ,&nbsp;Ping Ying ,&nbsp;Qiang Zheng ,&nbsp;Ling-Yi Kong ,&nbsp;Jun Luo","doi":"10.1080/10286020.2025.2482075","DOIUrl":"10.1080/10286020.2025.2482075","url":null,"abstract":"<div><div>Agledulines L-N (<strong>1 − 3</strong>), three previously undescribed limonoids with the A/D-ring-seco structural characteristics and high degree oxidation, along with the three reported compounds (<strong>4 − 6</strong>), were isolated from the fruits of <em>Aglaia edulis</em>. The structures of <strong>1 − 3</strong> were elucidated by NMR data, HRESIMS, ECD spectra, and circular dichroism exciton chirality method. The furan rings in <strong>1</strong> and <strong>2</strong> were oxidized to <em>γ</em>-hydroxy-butene lactone moiety, and the tautomerism of hemiacetal C-21 contributed to the disappearance of NMR signals in the segments. The biological evaluation showed that <strong>1 − 3</strong> had no anti-inflammatory activity by inhibiting NO release in LPS-activated RAW264.7 macrophages.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 9","pages":"Pages 1263-1269"},"PeriodicalIF":1.3,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Xiexin Tang restores gut barrier function by regulating the differentiation of CD4+ T cells via GPRs and HDACs in T2DM rats 泻心汤通过GPRs和hdac调节T2DM大鼠CD4+ T细胞的分化，恢复肠道屏障功能。
IF 1.3 3区 医学
Journal of Asian Natural Products Research Pub Date : 2025-09-02 DOI: 10.1080/10286020.2025.2459603
Mei-Juan Liu , Yun Zhang , Ke Zhu , Wen-Wen Li , Chen Liu , Shu Jiang , Er-Xin Shang , Jin-Ao Duan
{"title":"Xiexin Tang restores gut barrier function by regulating the differentiation of CD4+ T cells via GPRs and HDACs in T2DM rats","authors":"Mei-Juan Liu ,&nbsp;Yun Zhang ,&nbsp;Ke Zhu ,&nbsp;Wen-Wen Li ,&nbsp;Chen Liu ,&nbsp;Shu Jiang ,&nbsp;Er-Xin Shang ,&nbsp;Jin-Ao Duan","doi":"10.1080/10286020.2025.2459603","DOIUrl":"10.1080/10286020.2025.2459603","url":null,"abstract":"<div><div>This study aimed to explore the potential mechanism of Xiexin Tang in improving type 2 diabetes mellitus from the perspective of intestinal barrier function. The results indicated that Xiexin Tang could notably promote the expression of GPRs while suppressing the expression of HDACs in colon epithelial cells, then significantly elevate the levels of TGF-β1 and IL-18 to regulate the differentiation of T cells and further maintain the intestinal immune homeostasis. Meanwhile, it could markedly inhibit the inflammatory signaling pathway to improve intestinal barrier function, relieving type 2 diabetes mellitus.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 9","pages":"Pages 1332-1346"},"PeriodicalIF":1.3,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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