钩钩藤茎水提物中微量吲哚喹啉单萜生物碱。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-06-09 DOI:10.1080/10286020.2025.2509764

Jin-Qiu Ren, Xiao-Qiang Lei, Qing-Lan Guo, Jian-Gong Shi

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引用次数: 0

摘要

从钩藤钩茎水煎液中分离得到6个未描述的吲哚喹啉单萜生物碱F - K（1 - 6）。通过光谱数据分析、电子圆二色性（ECD）和核磁共振计算确定了它们的结构。化合物1 ~ 4是罕见的吲哚喹诺嗪类亚胺两性离子，而化合物5对APAP诱导的肝细胞损伤具有保护作用。

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Minor indoloquinolizidine monoterpene alkaloids from an aqueous extract of the hook-bearing stem of Uncaria rhynchophylla.

Six minor undescribed indoloquinolizidine monoterpene alkaloids, uncarrhynchophyllines F - K (1 - 6), were isolated from an aqueous decoction of the hook-bearing stems of Uncaria rhynchophylla (gou-teng). Their structures were determined by spectroscopic data analysis in combination with electron circular dichroism (ECD) and NMR calculations. Compounds 1 - 4 are rare indoloquinolizidine iminium zwitterions, while 5 exhibited protective effects against APAP induced liver cell injury.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.