Resveratrol: a potential alternative therapeutic agent for patients suffering from chronic obstructive pulmonary disease (COPD)

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-07-03 DOI:10.1080/10286020.2025.2459597

Ong Yan Ren , Yasmeen Siddiqui , Mohammed Tahir Ansari , Asgar Ali

引用次数: 0

Abstract

This review explores the therapeutic potential of resveratrol, focusing on its molecular and cellular effects on Chronic Obstructive Pulmonary Disease (COPD), bioavailability enhancement strategies, and development challenges for applications in food, pharmaceuticals, and postharvest sectors. Resveratrol protects lungs by activating SIRT1, reducing oxidative stress via ROS regulation through Nrf2-mediated antioxidant enzymes. It shows promise as an alternative to corticosteroids in COPD and cancer treatment. Encapsulation innovations in resveratrol offer opportunities for food fortification, minimizing risks of chemical degradation and isomerization during storage, paving the way for its broader utility in health and nutrition applications.

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白藜芦醇：慢性阻塞性肺疾病（COPD）患者的潜在替代治疗剂。

本文综述了白藜芦醇的治疗潜力，重点介绍了其对慢性阻塞性肺疾病（COPD）的分子和细胞作用、生物利用度增强策略以及在食品、制药和采采后领域应用的开发挑战。白藜芦醇通过激活SIRT1保护肺部，通过nrf2介导的抗氧化酶通过ROS调节减少氧化应激。它有望成为慢性阻塞性肺病和癌症治疗中皮质类固醇的替代品。白藜芦醇的封装创新为食品强化提供了机会，最大限度地减少了储存期间化学降解和异构化的风险，为其在健康和营养应用中的更广泛用途铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.