从鸢尾块茎中分离出具有抗炎活性的新型吡咯烷类生物碱和新型异黄酮。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-06-21 DOI:10.1080/10286020.2025.2514687

Wan-Qi Yang, Meng-Yuan Cui, Yun-Peng Qin, Kai-Dong Liu, Yong Xu, Ying-Ying Dong, Jing Qu

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引用次数: 0

摘要

从鸢尾块茎中分离到了新的吡咯烷类生物碱Solanpyrrole B(1)和新的异黄酮5,7,4',5'-四羟基- 6,3 '-二甲氧基异黄酮(2)，以及12个已知化合物（3 ~ 14）。通过NMR、UV、IR、HR-ESI-MS等光谱分析对化合物的化学结构进行了鉴定。化合物1和2 （10 μM）抑制NF-κB信号通路，减少LPS诱导的RAW264.7巨噬细胞和BV2小胶质细胞NO的释放，具有抗炎活性。化合物1、2、11分别对HCT116细胞（IC50 = 9.16±1.59 μM）、HGC27细胞（IC50 = 7.98±1.07 μM）、U87MG细胞（IC50 = 2.81±0.18 μM）具有显著的细胞毒活性。

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A novel pyrrolidine alkaloid and a novel isoflavone with anti-inflammatory activity from the tubers of Arisaema franchetianum.

Solanpyrrole B (1), a new pyrrolidine alkaloid and 5,7,4',5'-tetrahydroxy-6, 3'-dimethoxyisoflavone (2), a new isoflavone, along with 12 known compounds (3-14), were isolated from the tubers of Arisaema franchetianum. The chemical structures of these compounds were identified by using spectroscopic analysis (NMR, UV, IR, HR-ESI-MS). Compounds 1 and 2 (10 μM) exhibited anti-inflammatory activities in inhibiting the NF-κB signaling pathway, reducing the release of NO from RAW264.7 macrophages and BV2 microglia induced by LPS. Compounds 1, 2 and 11 exhibited significant cytotoxic activity against HCT116 cells (IC₅₀ = 9.16 ± 1.59 μM), HGC27 cells (IC₅₀ = 7.98 ± 1.07 μM), U87MG (IC₅₀ = 2.81 ± 0.18 μM), respectively.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.