Regulatory mechanisms and therapeutic potential of natural microglia inhibitors in Parkinson's disease.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-08-28 DOI:10.1080/10286020.2025.2544148

Ting-Ting Jin, Rui-Zhen Shi, Jian-Wen Shi, Fei Liu, Yong-Xin Liang

引用次数: 0

Abstract

Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases affecting the central nervous system. The pathogenesis of PD is complex, and its etiology remains poorly understood. Recently, it has been suggested that neuroinflammation caused by overactivated microglia plays a significant role in the occurrence and development of PD. The use of anti-inflammatory medication to delay or prevent the occurrence and progression of PD has become a hot topic of research in this field. This review introduces the inflammatory mechanism of PD, the related inflammatory factors, and the progress of using natural anti-inflammatory drugs for PD prevention and treatment.

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天然小胶质细胞抑制剂在帕金森病中的调节机制和治疗潜力。

帕金森病（PD）是影响中枢神经系统的最常见的神经退行性疾病之一。PD的发病机制是复杂的，其病因尚不清楚。近年来，人们认为小胶质细胞过度活化引起的神经炎症在PD的发生发展中起着重要作用。利用抗炎药物延缓或预防帕金森病的发生和进展已成为该领域的研究热点。本文就帕金森病的炎症机制、相关炎症因子以及利用天然抗炎药物防治帕金森病的研究进展作一综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.