从山核桃绿核桃壳中提取的两种新化合物。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-08-25 DOI:10.1080/10286020.2025.2547692

Jie Sun, Xue-Rou Zhang, Yan Liu, Xiao-Juan Zhang, Zhen-Xing Fang, Bing-You Yang, Yuan-Yuan Zhou

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引用次数: 0

摘要

从山核桃绿核桃壳中分离得到2个新化合物（1-2）和13个已知的四氢萘酮（3-15），并通过波谱分析对其结构进行了鉴定。对BGC-823、A-549和HepG-2癌细胞的细胞毒筛选表明，化合物12抑制A-549的IC50值为（54.94±1.72）μM。化合物3 - 4和10 - 12抑制HepG-2 IC50值(62.53±2.52),(51.95±0.65),(63.90±0.30),(66.60±1.35),(61.07±0.31)μM。化合物4和12在60 μM下对BGC-823有抑制作用。本研究鉴定了生物活性成分，为临床制剂开发提供了化学基础。

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Two new compounds from the green walnut husks of Juglans mandshurica.

Two new compounds (1-2) and thirteen known tetrahydroaphcosterones (3-15) were isolated from the green walnut husks of Juglans mandshurica, with structures elucidated via spectroscopic analyses. Cytotoxicity screening against BGC-823, A-549, and HepG-2 cancer cell lines revealed that compound 12 inhibited A-549 with the IC₅₀ value of (54.94 ± 1.72) μM. Compounds 3-4 and 10-12 inhibited HepG-2, and the IC₅₀ values were (62.53 ± 2.52), (51.95 ± 0.65), (63.90 ± 0.30), (66.60 ± 1.35), (61.07 ± 0.31) μM. Compounds 4 and 12 inhibited BGC-823 at 60 μM. This study identifies bioactive components and provides a chemical foundation for clinical preparation development.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.