Drimane sesquiterpenoids from cultures of the basidiomycete Panellus pusillus.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-08-22 DOI:10.1080/10286020.2025.2549892

Prapairat Seephonkai, Rachada Chanphen, Patchanee Auncharoen, Thitiya Boonpratuang, Tuksaporn Thummarukcharoen, Aphidech Sangdee, Masahiko Isaka

引用次数: 0

Abstract

In the quest for novel compounds with potent activities against human infectious diseases from fungi in Thailand, cultures of the basidiomycete Panellus pusillus strain TBRC-BCC 43793 were chemically investigated. A new drimane sesquiterpenoid, 1β-hydroxypereniporin A (1), together with a known drimane, 6β-hydroxy-isodrimenin, was isolated using silica gel column chromatography and preparative High Performance Liquid Chromatography (HPLC). Its structure was elucidated on the basis of the spectroscopic method. The isolated compounds were inactive in the antiplasmodial, antimycobacterial, and antibacterial activity assays.

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板栗担子菌培养物的驱动力倍半萜类化合物。

为了从泰国真菌中寻找具有抗人类传染病有效活性的新化合物，对担子菌Panellus pusillus菌株TBRC-BCC 43793进行了化学研究。采用硅胶柱层析和制备型高效液相色谱（HPLC）分离得到了一种新的驱动力类倍半萜类化合物1β-羟基双烯孔蛋白A(1)和一种已知的驱动力类化合物6β-羟基异驱动力蛋白。利用光谱学方法对其结构进行了分析。分离得到的化合物在抗疟原虫、抗真菌和抗菌活性试验中均无活性。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.