肠道细菌羧酸酯酶代谢产物及赤霉素C潜在的抗肿瘤分子机制分析。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-01-10 DOI:10.1080/10286020.2024.2441823

Jian-Ye Song, Xiang Hui, Ru Feng, Yi Zhao, Jia-Chun Hu, Jing-Yu Jin, Jin-Yue Lu, Hui Xu, Jing-Yue Wang, Heng-Tong Zuo, Meng-Liang Ye, Yan Wang

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引用次数: 0

摘要

鹿皮苷C （AgrC）是一种具有多种药理特性的化合物。然而，其抗肿瘤潜能尚未得到充分研究。AgrC的低生物利用度表明它与肠道细菌有很强的联系。因此，我们鉴定并量化了肠道微生物群中的四种AgrC代谢物。分子对接和基于抑制剂的实验表明，羧酸酯酶在AgrC代谢中起关键作用。AgrC及其代谢物均能抑制CT-26细胞的活性，潜在的抗肿瘤靶点有待进一步探索。此外，AgrC显著提高了丙酸、丁酸、戊酸和异戊酸的水平。这为AgrC的抗肿瘤作用提供了新的认识。

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Analysis of intestinal bacterial carboxylesterase-mediated metabolites and the potential antitumour molecular mechanism of angoroside C.

Angoroside C (AgrC) is a compound with many pharmacological properties. However, its antitumour potential has not been well studied. The low bioavailability of AgrC suggests a strong link to gut bacteria. Therefore, we identified and quantified four AgrC metabolites in gut microbiota. Molecular docking and inhibitor-based experiments demonstrated that carboxylesterase played a key role in AgrC metabolism. Both AgrC and its metabolites inhibited the viability of CT-26 cells, and potential antitumour targets were further explored. Additionally, AgrC significantly increased the levels of propionic, butyric, valeric and isovaleric acids. This provides a new insight for the antitumour effects of AgrC.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.