Hongjingtian alleviates arsenic-induced hepatocyte injury by inhibiting oxidative stress and endoplasmic reticulum stress.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-04-26 DOI:10.1080/10286020.2025.2481290

Jiang-Tao Cao, Hai-Wen Li, Jia-Qi Chen, Hai-Long Lv, Yu-Feng Jiang

引用次数: 0

Abstract

This study explored Hongjingtian's (HJT) protective effects against arsenic-induced hepatotoxicity. NaAsO₂ (8 μM, 24 h)-damaged hepatocytes treated with HJT (50/100 mg/L) showed restored cell viability via CCK-8/LDH assays. HJT reduced arsenic-induced ROS, improved mitochondrial membrane potential, elevated SOD/CAT activity, lowered MDA, and suppressed apoptosis by downregulating Caspase-3/Bax while upregulating Bcl-2. Additionally, HJT alleviated endoplasmic reticulum stress (ERS). Mechanistically, HJT attenuated arsenic-induced hepatocyte apoptosis by mitigating oxidative stress and ERS via ROS reduction.

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红景天通过抑制氧化应激和内质网应激减轻砷诱导的肝细胞损伤。

本研究探讨红景天（HJT）对砷致肝毒性的保护作用。HJT （50/100 mg/L）处理NaAsO2 （8 μM, 24 h）损伤的肝细胞，CCK-8/LDH检测显示细胞活力恢复。HJT通过下调Caspase-3/Bax和上调Bcl-2，降低砷诱导的ROS，改善线粒体膜电位，提高SOD/CAT活性，降低MDA，抑制细胞凋亡。此外，HJT还能减轻内质网应激（ERS）。机制上，HJT通过减少ROS减少氧化应激和ERS来减轻砷诱导的肝细胞凋亡。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.