Withaferin A通过抑制角质形成细胞的氧化应激改善牛皮癣样皮肤病变。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-04-25 DOI:10.1080/10286020.2025.2492825

Ming-Yi Zhang, Yu-Chang Liu, Xing-Yu Liu, Di-Wei Chen, Chao Han, Xin Shen, You-Xiang Ding, Xiao-Ping Wang, Ai-Ping Shi

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引用次数: 0

摘要

牛皮癣是一种慢性疾病，其发病机制与遗传和免疫因素有关。研究表明，大多数患者都经历了高水平的氧化应激，这可能导致炎症或损伤。Withaferin A是一种具有多种药理活性的天然产物，具有抗肿瘤和抗炎作用。我们研究了水杨酸对咪喹莫特（IMQ）诱导的银屑病小鼠的治疗作用。治疗后小鼠表皮病理有明显改善。WA通过降低表皮氧化应激诱导的IL-1β、IL-6和IFN-γ的产生来抑制炎症。此外，WA可以使巨噬细胞从促炎状态转变为抗炎状态。

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Withaferin A ameliorates psoriasis-like skin lesions by suppressing oxidative stress in keratinocytes.

Psoriasis is a chronic disease with elusive pathogenesis linked to genetic, and immune factors. Studies have shown most patients have experienced high levels of oxidative stress, which can lead to inflammation or damage. Withaferin A is a natural product with multiple pharmacological activities, including anti-tumor and anti-inflammatory effects. We investigated the effects of WA in treating Imiquimod (IMQ)-induced psoriasis mice. The epidermal pathology of mice was significantly improved after treatment. WA inhibited inflammation by decreasing the production of IL-1β, IL-6, and IFN-γ, which were induced by epidermal oxidative stress. Additionally, WA can shift the macrophage status from pro-inflammatory to anti-inflammatory.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.