姜黄素体内代谢的研究进展。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-12-18 DOI:10.1080/10286020.2024.2420619

Shi-Jie Zhong, Ya-Dong Xing, Lu-Yao Dong, Yi Chen, Nan Liu, Zeng-Ming Wang, Hui Zhang, Ai-Ping Zheng

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引用次数: 0

摘要

姜黄素具有多种生物学功能，尤其是抗氧化和抗炎特性，但其生物利用度和药动学特性较低，阻碍了临床试验的开展。为了达到治疗效果，了解姜黄素的体内代谢是至关重要的。本文综述了PubMed、b谷歌Scholar和中国知网对姜黄素代谢的研究现状。本文概述了姜黄素通过口服和静脉注射在体内的代谢过程。提示姜黄素进入人体后，可能发生氧化、还原、结合和微生物群落影响。

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Progress in the study of curcumin metabolism in vivo.

Curcumin has diverse biological functions, especially antioxidant and anti-inflammatory properties, but clinical trials have been hindered by its low bioavailability and pharmacokinetic properties. To achieve therapeutic efficacy, understanding curcumin's in vivo metabolism is crucial. We reviewed current research on curcumin metabolism in PubMed, Google Scholar, and CNKI. This article outlines curcumin's metabolic processes in the body via oral and intravenous injection. It suggests that upon entering the human body, curcumin may undergo oxidation, reduction, binding, and microbial community influence.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.