深海来源真菌西多曲霉DFFSCS007的三个新的萜类衍生物。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-12-28 DOI:10.1080/10286020.2024.2443086

Xu-Meng Ren, Ke-Yue Wu, Shu-Hua Qi

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引用次数: 0

摘要

从深海源真菌sydowii Aspergillus DFFSCS007中分离得到3个新的萜类衍生物(1S,6R,7S)-hydrobenzosydowic acid(1)、(1r,6S,7S)-hydrobenzosydowic acid(2)和(7r,10R)-11- de羟基-异-10-hydroxysydowic acid(3)，以及已知的类似物(S)-2-（1-（4-硝基苯甲酰）吡咯烷-2-carboxamido）苯甲酸(4)和4-carboxydiorcinol三羟基丁基酯(5)。通过光谱分析确定了它们的结构。含硝基苯基团的化合物4为首次从自然界分离得到。并对1-5的抑菌活性和1-3的细胞毒性进行了评价。

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Three new terpenoid derivatives from the deep-sea-derived fungus Aspergillus sydowii DFFSCS007.

Three new terpenoid derivatives (1S,6R,7S)-hydrobenzosydowic acid (1), (1 R,6S,7S)-hydrobenzosydowic acid (2), and (7 R,10R)-11-dehydroxy-iso-10-hydroxysydowic acid (3), along with the known analogues (S)-2-(1-(4-nitrobenzoyl)pyrrolidine-2-carboxamido)benzoic acid (4) and trihydroxybutyl ester of 4-carboxydiorcinol (5) were isolated from the deep-sea-derived fungus Aspergillus sydowii DFFSCS007. Their structures were determined by spectroscopic analysis. Compound 4 with a nitrobenzene group was isolated from nature for the first time. The antibacterial activities of 1-5 and cytotoxicity of 1-3 were also evaluated.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.