Total synthesis of albafuran B and its osteogenic differentiation promoting effect on human mesenchymal stem cells.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-06-03 DOI:10.1080/10286020.2025.2509762

Wan-Dong Liu, Yue Jing, Bin Wang, Lin-Lin Tian, Jian Li, Xiu-Shan Yin, Hua Zhang

引用次数: 0

Abstract

In the current project, the total synthesis of albafuran B was achieved in four steps and 19.3% overall yield, involving two key reactions of the one-pot Corey-Fuchs reaction and Suzuki coupling. Using the same protocol, two analogs, moracin C and 4'-farnesyl-moracin M, were also successfully synthesized. The effect of albafuran B on the osteogenic differentiation of human umbilical cord-derived and adipose-derived mesenchymal stem cells was evaluated via alkaline phosphatase staining and alizarin red S staining. The assay results revealed that albafuran B showed good osteogenic differentiation promoting activity toward both cell lines.

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白afuran B的合成及其对人间充质干细胞成骨分化的促进作用。

本项目共分4步合成了白氟脲B，总产率为19.3%，其中包括一锅Corey-Fuchs反应和Suzuki偶联两个关键反应。用同样的方法，成功地合成了moracin C和4′-法尼基-moracin M两种类似物。通过碱性磷酸酶染色和茜素红S染色观察阿巴非伦B对人脐带源性和脂肪源性间充质干细胞成骨分化的影响。实验结果显示，白afuran B对两种细胞系均有良好的成骨分化促进活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.