Chemical constituents of Erythrina speciosa.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-06-04 DOI:10.1080/10286020.2025.2513489

Xi Yang, Yong-Chun Gao, Ya-Ping Chen, Li-Qin Wang

引用次数: 0

Abstract

Three unreported pterocarpans, erystrictin D (1) and a pair of diastereoisomers, erystrictins E/F (2a/2b), along with fifteen known compounds (3-17) were isolated from Erythrina speciosa. Their structures were established by extensive spectroscopic analyses, including HRESIMS, 1D and 2D NMR, and electronic circular dichroism (ECD) spectra. All the compounds were isolated from this plant for the first time. Compounds 1-3, 5 and 6 were evaluated for their inhibitory activities against a panel of cancer cell lines by MTS method. Compound 1 showed inhibitory activities against HepG2 and SW480 cells, with IC₅₀ values of 3.160 ± 0.069 and 6.575 ± 0.525 μM, respectively; compound 5 against HepG2 cells, with IC₅₀ value of 22.05 ± 0.83 μM.

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赤藓属植物的化学成分。

从赤藓属植物中分离到3个未报道的翼虫类化合物赤藓素D(1)和一对非对映异构体赤藓素E/F (2a/2b)，以及15个已知化合物（3 ~ 17）。通过广泛的光谱分析，包括hresms， 1D和2D NMR以及电子圆二色性（ECD）光谱确定了它们的结构。所有化合物均为首次从该植物中分离得到。用MTS法测定了化合物1 ~ 3、5、6对肿瘤细胞的抑制活性。化合物1对HepG2和SW480细胞有抑制作用，IC50值分别为3.160±0.069 μM和6.575±0.525 μM；化合物5对HepG2细胞的IC50值为22.05±0.83 μM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.